Early basal insulin therapy decreases new-onset diabetes after renal transplantation

Journal of the American Society of Nephrology

Volumn 23, Issue 4, 2012, Pages 739-749

  Hecking, Manfred ^a   Haidinger, Michael ^a   Döller, Dominik ^a   Werzowa, Johannes ^a   Tura, Andrea ^b   Zhang, Jinyao ^c   Tekoglu, Hilal ^a   Pleiner, Johannes ^a   Wrba, Thomas ^a   Rasoul Rockenschaub, Susanne ^a   Muḧlbacher, Ferdinand ^a   Schmaldienst, Sabine ^a   Druml, Wilfred ^a   Hörl, Walter H ^a   Krebs, Michael ^a   Wolzt, Michael ^a   Pacini, Giovanni ^b   Port, Friedrich K ^c   Saëmann, Marcus D ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b CNR   (Italy)

^c ARBOR RESEARCH COLLABORATIVE FOR HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C; ISOPHANE INSULIN; ORAL ANTIDIABETIC AGENT; SHORT ACTING INSULIN; TACROLIMUS;

ADULT; ARTICLE; CELL FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG DOSE TITRATION; FEMALE; FOLLOW UP; GLUCOSE BLOOD LEVEL; GRAFT RECIPIENT; HEALTH CARE QUALITY; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; INSULIN SENSITIVITY; INSULIN TREATMENT; KIDNEY FUNCTION; KIDNEY TRANSPLANTATION; MALE; NEW ONSET DIABETES AFTER TRANSPLANTATION; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; WEIGHT CHANGE;

EID: 84859001694     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2011080835     Document Type: Article

References (47)

1. Kasiske BL, Snyder JJ, Gilbertson D, Matas AJ: Diabetes mellitus after kidney transplantation in the United States. Am J Transplant 3: 178-185, 2003 (Pubitemid 36323115)
2. Krentz AJ, Wheeler DC: New-onset diabetes after transplantation: A threat to graft and patient survival. Lancet 365: 640-642, 2005 (Pubitemid 40260875)
3. Woodward RS, Schnitzler MA, Baty J, Lowell JA, Lopez-Rocafort L, Haider S, Woodworth TG, Brennan DC: Incidence and cost of newonset diabetes mellitus among U.S. wait-listed and transplanted renal allograft recipients. Am J Transplant 3: 590-598, 2003 (Pubitemid 36612842)
4. Hjelmesaeth J, Hartmann A, Leivestad T, Holdaas H, Sagedal S, Olstad M, Jenssen T: The impact of early-diagnosed new-onset posttransplantation diabetes mellitus on survival and major cardiac events. Kidney Int 69: 588-595, 2006 (Pubitemid 43164454)
5. Cosio FG, Kudva Y, van der Velde M, Larson TS, Textor SC, Griffin MD, Stegall MD: New onset hyperglycemia and diabetes are associated with increased cardiovascular risk after kidney transplantation. Kidney Int 67: 2415-2421, 2005 (Pubitemid 41623405)
6. Ojo AO, Hanson JA, Wolfe RA, Leichtman AB, Agodoa LY, Port FK: Long-term survival in renal transplant recipients with graft function. Kidney Int 57: 307-313, 2000 (Pubitemid 30227779)
7. Davidson J, Wilkinson A, Dantal J, Dotta F, Haller H, Hernández D, Kasiske BL, Kiberd B, Krentz A, Legendre C, Marchetti P, Markell M, van der Woude FJ, Wheeler DC International Expert Panel: New-onset diabetes after transplantation: 2003 International consensus guidelines. Proceedings of an international expert panel meeting. Barcelona, Spain, 19 February 2003. Transplantation 75[Suppl]: SS3-SS24, 2003
8. Ilkova H, Glaser B, Tunçkale A, Bagriaçik N, Cerasi E: Induction of longterm glycemic control in newly diagnosed type 2 diabetic patients by transient intensive insulin treatment. Diabetes Care 20: 1353-1356, 1997 (Pubitemid 27366805)
9. Li Y, Xu W, Liao Z, Yao B, Chen X, Huang Z, Hu G, Weng J: Induction of long-termglycemic control in newly diagnosed type 2 diabetic patients is associatedwith improvement of beta-cell function.Diabetes Care 27: 2597-2602, 2004 (Pubitemid 39441457)
10. McFarlane SI, Chaiken RL, Hirsch S, Harrington P, Lebovitz HE, Banerji MA: Near-normoglycaemic remission in African-Americans with type 2 diabetes mellitus is associated with recovery of beta cell function. Diabet Med 18: 10-16, 2001 (Pubitemid 32158102)
11. Ryan EA, Imes S, Wallace C: Short-term intensive insulin therapy in newly diagnosed type 2 diabetes. Diabetes Care 27: 1028-1032, 2004 (Pubitemid 38579760)
12. Wajchenberg BL: Beta-cell failure in diabetes and preservation by clinical treatment. Endocr Rev 28: 187-218, 2007
13. Rolla A: The pathophysiological basis for intensive insulin replacement. Int J Obes Relat Metab Disord 28[Suppl 2]: S3-S7, 2004
14. Weng J, Li Y, Xu W, Shi L, Zhang Q, Zhu D, Hu Y, Zhou Z, Yan X, Tian H, Ran X, Luo Z, Xian J, Yan L, Li F, Zeng L, Chen Y, Yang L, Yan S, Liu J, Li M, Fu Z, Cheng H: Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial. Lancet 371: 1753-1760, 2008 (Pubitemid 351697950)
15. Holman RR, Thorne KI, Farmer AJ, Davies MJ, Keenan JF, Paul S, Levy JC 4-T Study Group: Addition of biphasic, prandial, or basal insulin to oral therapy in type 2 diabetes. N Engl J Med 357: 1716-1730, 2007 (Pubitemid 350005153)
16. Bry L, Chen PC, Sacks DB: Effects of hemoglobin variants and chemically modified derivatives on assays for glycohemoglobin. Clin Chem 47: 153-163, 2001 (Pubitemid 32142912)
17. McAuley KA, Williams SM, Mann JI, Walker RJ, Lewis-Barned NJ, Temple LA, Duncan AW: Diagnosing insulin resistance in the general population. Diabetes Care 24: 460-464, 2001 (Pubitemid 32198413)
18. Sharif A, Ravindran VK, Dunseath G, Luzio SD, Owens DR, Baboolal K: Impending hyperglycemia in normoglycemic renal transplant recipients-an experimental predictive surrogate. Transplantation 89: 1341-1346, 2010
19. Nathan DM, Kuenen J, Borg R, Zheng H, Schoenfeld D, Heine RJ A1c- Derived Average Glucose Study Group: Translating the A1C assay into estimated average glucose values. Diabetes Care 31: 1473-1478, 2008
20. van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R: Intensive insulin therapy in critically ill patients. N Engl J Med 345: 1359-1367, 2001
21. Van den Berghe G, Schetz M, Vlasselaers D, Hermans G, Wilmer A, Bouillon R, Mesotten D: Clinical review: Intensive insulin therapy in critically ill patients: NICE-SUGAR or Leuven blood glucose target? J Clin Endocrinol Metab 94: 3163-3170, 2009
22. Finfer S, Chittock DR, Su SY, Blair D, Foster D, Dhingra V, Bellomo R, Cook D, Dodek P, Henderson WR, Hébert PC, Heritier S, Heyland DK, McArthur C, McDonald E, Mitchell I, Myburgh JA, Norton R, Potter J, Robinson BG, Ronco JJ NICE-SUGAR Study Investigators: Intensive versus conventional glucose control in critically ill patients. N Engl J Med 360: 1283-1297, 2009
23. Brunkhorst FM, Engel C, Bloos F, Meier-Hellmann A, Ragaller M, Weiler N, Moerer O, Gruendling M, Oppert M, Grond S, Olthoff D, Jaschinski U, John S, Rossaint R, Welte T, Schaefer M, Kern P, Kuhnt E, Kiehntopf M, Hartog C, Natanson C, Loeffler M, Reinhart K German Competence Network Sepsis (SepNet): Intensive insulin therapy and pentastarch resuscitation in severe sepsis.NEngl J Med358: 125-139, 2008
24. Gerstein HC, Miller ME, Byington RP, Goff DC Jr, Bigger JT, Buse JB, Cushman WC, Genuth S, Ismail-Beigi F, Grimm RH Jr, Probstfield JL, Simons-Morton DG, Friedewald WT Action to Control Cardiovascular Risk in Diabetes Study Group: Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 358: 2545-2559, 2008
25. Patel A, MacMahon S, Chalmers J, Neal B, Billot L, Woodward M, Marre M, Cooper M, Glasziou P, Grobbee D, Hamet P, Harrap S, Heller S, Liu L, Mancia G, Mogensen CE, Pan C, Poulter N, Rodgers A, Williams B, Bompoint S, de Galan BE, Joshi R, Travert F ADVANCE Collaborative Group: Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 358: 2560-2572, 2008 (Pubitemid 351831357)
26. Shah A, Kendall G, Demme RA, Taylor J, Bozorgzadeh A,Orloff M, Jain A, Abt P, Zand MS: Home glucometer monitoring markedly improves diagnosis of post renal transplant diabetes mellitus in renal transplant recipients. Transplantation 80: 775-781, 2005 (Pubitemid 41443759)
27. Beard JC, Halter JB, Best JD, Pfeifer MA, Porte D Jr: Dexamethasone-induced insulin resistance enhances B cell responsiveness to glucose level in normal men. Am J Physiol 247: E592-E596, 1984 (Pubitemid 15219551)
28. Vincenti F, Friman S, Scheuermann E, Rostaing L, Jenssen T, Campistol JM, Uchida K, Pescovitz MD, Marchetti P, Tuncer M, Citterio F,Wiecek A, Chadban S, El-Shahawy M, Budde K, Goto N DIRECT (Diabetes Incidence after Renal Transplantation: Neoral C Monitoring Versus Tacrolimus) Investigators: Results of an international, randomized trial comparing glucose metabolism disorders and outcome with cyclosporine versus tacrolimus. Am J Transplant 7: 1506-1514, 2007 (Pubitemid 46776239)
29. Sumrani NB, Delaney V, Ding ZK, Davis R, Daskalakis P, Friedman EA, Butt KM, Hong JH: Diabetes mellitus after renal transplantation in the cyclosporine era-an analysis of risk factors. Transplantation 51: 343-347, 1991
30. Chakkera HA, Weil EJ, Castro J, Heilman RL, Reddy KS, Mazur MJ, Hamawi K, Mulligan DC, Moss AA, Mekeel KL, Cosio FG, Cook CB: Hyperglycemia during the immediate period after kidney transplantation. Clin J Am Soc Nephrol 4: 853-859, 2009
31. The Diabetes Control and Complications Trial Research Group: The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329: 977-986, 1993
32. Nathan DM, Cleary PA, Backlund JY, Genuth SM, Lachin JM, Orchard TJ, Raskin P, Zinman B Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group: Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes.NEngl J Med353: 2643-2653, 2005
33. Sharif A, Baboolal K: Diagnostic application of the A(1c) assay in renal disease. J Am Soc Nephrol 21: 383-385, 2010
34. Oterdoom LH, de Vries AP, van Son WJ, van der Heide JJ, Ploeg RJ, Gansevoort RT, de Jong PE, Gans RO, Bakker SJ: Validation of insulin resistance indexes in a stable renal transplant population. Diabetes Care 28: 2424-2429, 2005 (Pubitemid 41384288)
35. Sharif A, Ravindran V, Moore RH, Dunseath G, Luzio S, Owens DR, Baboolal K: Insulin resistance indexes in renal transplant recipients maintained on tacrolimus immunosuppression. Transplantation 89: 327-333, 2010
36. Tura A, Kautzky-Willer A, Pacini G: Insulinogenic indices from insulin and C-peptide: Comparison of beta-cell function from OGTT and IVGTT. Diabetes Res Clin Pract 72: 298-301, 2006 (Pubitemid 43729143)
37. Luan FL, Stuckey LJ, Ojo AO: Abnormal glucose metabolism and metabolic syndrome in non-diabetic kidney transplant recipients early after transplantation. Transplantation 89: 1034-1039, 2010
38. Luan FL, Langewisch E, Ojo A: Metabolic syndrome and new onset diabetes after transplantation in kidney transplant recipients. Clin Transplant 24: 778-783, 2010
39. Urbaniak GC, Plous S: Research Randomizer (Version 3.0) [Computer software], from http://www.randomizer.org/ Accessed Retrieved on April 22, 2011, 2011. 2011
40. Ekberg H, Tedesco-Silva H, Demirbas A, Vítko S, Nashan B, Gürkan A, Margreiter R, Hugo C, Grinyó JM, Frei U, Vanrenterghem Y, Daloze P, Halloran PF ELITE-Symphony Study: Reduced exposure to calcineurin inhibitors in renal transplantation.NEngl J Med 357: 2562-2575, 2007 (Pubitemid 350294223)
41. Lawrence RD: Renal threshold for glucose: normal and in diabetics. BMJ 1: 766-768, 1940
42. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus: Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 20: 1183-1197, 1997
43. Bantle JP, Wylie-Rosett J, Albright AL, Apovian CM, Clark NG, Franz MJ, Hoogwerf BJ, Lichtenstein AH, Mayer-Davis E, Mooradian AD, Wheeler ML American Diabetes Association: Nutrition recommendations and interventions for diabetes: a position statement of the American Diabetes Association. Diabetes Care 31[Suppl 1]: S61-S78, 2008
44. Goldstein DE, Little RR, Wiedmeyer HM, England JD, McKenzie EM: Glycated hemoglobin: methodologies and clinical applications. Clin Chem 32[Suppl]: B64-B70, 1986
45. Mari A, Pacini G, Murphy E, Ludvik B, Nolan JJ: A model-basedmethod for assessing insulin sensitivity from the oral glucose tolerance test. Diabetes Care 24: 539-548, 2001 (Pubitemid 32198427)
46. Midtvedt K, Hjelmesaeth J, Hartmann A, Lund K, Paulsen D, Egeland T, Jenssen T: Insulin resistance after renal transplantation: the effect of steroid dose reduction and withdrawal. J Am Soc Nephrol 15: 3233-3239, 2004 (Pubitemid 39578856)
47. Fitzmaurice GM, Laird NM, Ware JH: Marginal models: generalized estimating equations, In: Applied Longitudinal Analysis, Hoboken, NJ, John Wiley & Sons, Inc, 2004, pp 291-324