Novel anti-HIV-1 activity produced by conjugating unsulfated dextran with polyl-lysine

Antiviral Research

Volumn 94, Issue 1, 2012, Pages 89-97

  Nakamura, Kosuke ^a,f   Ohtsuki, Takahiro ^b,g   Mori, Haruyo ^c   Hoshino, Hiroo ^b   Hoque, Ariful ^b   Oue, Atsushi ^b   Kano, Fumie ^a   Sakagami, Hiromi ^a   Tanamoto, Ken ichi ^d   Ushijima, Hiroshi ^e   Kawasaki, Nana ^f   Akiyama, Hiroshi ^f   Ogawa, Haruko ^a  

^a OCHANOMIZU UNIVERSITY   (Japan)

^b GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c OSAKA PREFECTURAL INSTITUTE OF PUBLIC HEALTH   (Japan)

^d MUSASHINO UNIVERSITY   (Japan)

^e AINO UNIVERSITY   (Japan)

^f NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^g TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

Polyl lysine; Conjugation; Dextran; HIV 1 suppression; Pseudoproteoglycan; Unsulfated glycan

Indexed keywords

ANTIVIRUS AGENT; DEXTRAN; DEXTRAN SULFATE; HEPARIN; POLYLYSINE; PROTEOGLYCAN;

AMINATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CD4+ T LYMPHOCYTE; CHEMICAL COMPOSITION; CONJUGATE; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; VIRUS ATTACHMENT; VIRUS ENTRY;

ANIMALS; ANTI-HIV AGENTS; CELL LINE; DEXTRANS; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; MALE; MICE; MICE, INBRED BALB C; POLYLYSINE; PROTEOGLYCANS; VIRUS INTERNALIZATION; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84858990918     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2012.02.011     Document Type: Article

References (31)

1. Aoki T., Kaneko Y., Stefanski M.S., Nguyen T., Ting R.C. Curdlan sulfate and HIV-1. I. In vitro inhibitory effects of curdlan sulfate on HIV-1 infection. AIDS Res. Hum. Retroviruses 1991, 7:409-415.
2. Baba M., Pauwels R., Balzarini J., Arnout J., Desmyter J., De Clercq E. Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro. Proc. Natl. Acad. Sci. USA 1988, 85:6132-6136.
3. Baba M., Snoeck R., Pauwels R., de Clercq E. Sulfated polysaccharides are potent and selective inhibitors of various enveloped viruses, including herpes simplex virus, cytomegalovirus, vesicular stomatitis virus, and human immunodeficiency virus. Antimicrob. Agents Chemother. 1988, 32:1742-1745.
4. Balzarini J., Francois K.O., Van Laethem K., Hoorelbeke B., Renders M., Auwerx J., Liekens S., Oki T., Igarashi Y., Schols D. Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use. Antimicrob. Agents Chemother. 2010, 54:1425-1435.
5. Berger E.A., Doms R.W., Fenyo E.M., Korber B.T., Littman D.R., Moore J.P., Sattentau Q.J., Schuitemaker H., Sodroski J., Weiss R.A. A new classification for HIV-1. Nature 1998, 391:240.
6. Couffin-Hoarau A.C., Aubertin A.M., Boustta M., Schmidt S., Fehrentz J.A., Martinez J., Vert M. Peptide-poly(l-lysine citramide) conjugates and their in vitro anti-HIV behavior. Biomacromolecules 2009, 10:865-876.
7. De Clercq E. Antiretroviral drugs. Curr. Opin. Pharmacol. 2010, 10:507-515.
8. Habasque C., Aubry F., Jegou B., Samson M. Study of the HIV-1 receptors CD4, CXCR4, CCR5 and CCR3 in the human and rat testis. Mol. Hum. Reprod. 2002, 8:419-425.
9. Harlow E., Lane D. Detecting and quantitating antigens using the two-antibody sandwich assay 1988, A Laboratory Manual, Cold Spring Harbor Laboratory Press, New York, Antibodies, pp. 579-584.
10. Ito M., Baba M., Sato A., Pauwels R., De Clercq E., Shigeta S. Inhibitory effect of dextran sulfate and heparin on the replication of human immunodeficiency virus (HIV) in vitro. Antiviral Res. 1987, 7:361-367.
11. Lammers M., Neumann H., Chin J.W., James L.C. Acetylation regulates cyclophilin A catalysis, immunosuppression and HIV isomerization. Nat. Chem. Biol. 2010, 6:331-337.
12. Li J., Tang S., Hewlett I., Yang M. HIV-1 capsid protein and cyclophilin a as new targets for anti-AIDS therapeutic agents. Infect. Disord. Drug Targets 2007, 7:238-244.
13. Mastromarino P., Petruzziello R., Macchia S., Rieti S., Nicoletti R., Orsi N. Antiviral activity of natural and semisynthetic polysaccharides on the early steps of rubella virus infection. J. Antimicrob. Chemother. 1997, 39:339-345.
14. Mckeating, J., 1995. Quantitative Assay for Virus Neutralization. A Practical Approach, Virology and Immunology vol. 1, Oxford University Press, New York, pp. 118-127.
15. Mondor I., Ugolini S., Sattentau Q.J. Human immunodeficiency virus type 1 attachment to HeLa CD4 cells is CD4 independent and gp120 dependent and requires cell surface heparans. J. Virol. 1998, 72:3623-3634.
16. Nair V., Chi G. HIV integrase inhibitors as therapeutic agents in AIDS. Rev. Med. Virol. 2007, 17:277-295.
17. Nakagawa K., Nakamura K., Haishima Y., Yamagami M., Saito K., Sakagami H., Ogawa H. Pseudoproteoglycan (pseudoPG) probes that simulate PG macromolecular structure for screening and isolation of PG-binding proteins. Glycoconj. J. 2009, 26:1007-1017.
18. Ohshiro Y., Murakami T., Matsuda K., Nishioka K., Yoshida K., Yamamoto N. Role of cell surface glycosaminoglycans of human T cells in human immunodeficiency virus type-1 (HIV-1) infection. Microbiol. Immunol. 1996, 40:827-835.
19. Pearce-Pratt R., Phillips D.M. Sulfated polysaccharides inhibit lymphocyte-to-epithelial transmission of human immunodeficiency virus-1. Biol. Reprod. 1996, 54:173-182.
20. Rosa Borges A., Wieczorek L., Johnson B., Benesi A.J., Brown B.K., Kensinger R.D., Krebs F.C., Wigdahl B., Blumenthal R., Puri A., McCutchan F.E., Birx D.L., Polonis V.R., Schengrund C.L. Multivalent dendrimeric compounds containing carbohydrates expressed on immune cells inhibit infection by primary isolates of HIV-1. Virology 2010, 408:80-88.
21. Saha S.K., Brewer C.F. Determination of the concentrations of oligosaccharides, complex type carbohydrates, and glycoproteins using the phenol-sulfuric acid method. Carbohydr. Res. 1994, 254:157-167.
22. Salahuddin S.Z., Markham P.D., Wong-Staal F., Franchini G., Kalyanaraman V.S., Gallo R.C. Restricted expression of human T-cell leukemia-lymphoma virus (HTLV) in transformed human umbilical cord blood lymphocytes. Virology 1983, 129:51-64.
23. Saphire A.C., Bobardt M.D., Zhang Z., David G., Gallay P.A. Syndecans serve as attachment receptors for human immunodeficiency virus type 1 on macrophages. J. Virol. 2001, 75:9187-9200.
24. Shimizu N., Tanaka A., Mori T., Ohtsuki T., Hoque A., Jinno-Oue A., Apichartpiyakul C., Kusagawa S., Takebe Y., Hoshino H. A formylpeptide receptor, FPRL1, acts as an efficient coreceptor for primary isolates of human immunodeficiency virus. Retrovirology 2008, 5:52.
25. Soda Y., Shimizu N., Jinno A., Liu H.Y., Kanbe K., Kitamura T., Hoshino H. Establishment of a new system for determination of coreceptor usages of HIV based on the human glioma NP-2 cell line. Biochem. Biophys. Res. Commun. 1999, 258:313-321.
26. Towers G.J., Hatziioannou T., Cowan S., Goff S.P., Luban J., Bieniasz P.D. Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors. Nat. Med. 2003, 9:1138-1143.
27. Ueno R., Kuno S. Dextran sulphate, a potent anti-HIV agent in vitro having synergism with zidovudine. Lancet 1987, 1:1379.
28. Vives R.R., Imberty A., Sattentau Q.J., Lortat-Jacob H. Heparan sulfate targets the HIV-1 envelope glycoprotein gp120 coreceptor binding site. J. Biol. Chem. 2005, 280:21353-21357.
29. Weiler B.E., Schroder H.C., Stefanovich V., Stewart D., Forrest J.M., Allen L.B., Bowden B.J., Kreuter M.H., Voth R., Muller W.E. Sulphoevernan, a polyanionic polysaccharide, and the narcissus lectin potently inhibit human immunodeficiency virus infection by binding to viral envelope protein. J. Gen. Virol. 1990, 71:1957-1963.
30. Wilkin T.J., Gulick R.M. CCR5 Antagonism in HIV Infection: Current Concepts and Future Opportunities. Ann. Rev.Med. 2012, 76:6332-6343.
31. Zhang Y.J., Hatziioannou T., Zang T., Braaten D., Luban J., Goff S.P., Bieniasz P.D. Envelope-dependent, cyclophilin-independent effects of glycosaminoglycans on human immunodeficiency virus type 1 attachment and infection. J. Virol. 2002, 76:6332-6343.