Studies of the cell proliferative inhibition and apoptosis induced by Saxifragifolin D on HepG2/ADM cells

Chinese Pharmacological Bulletin

Volumn 28, Issue 1, 2012, Pages 34-38

  Shi, Jun Min ^a   Zhang, Dong Mei ^a   Yao, Nan ^a   Feng, Guo Pei ^b   Wang, Ying ^a   Kurihara, Hiroshi ^a   Ye, Wen Cai ^a  

^a JINAN UNIVERSITY   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Apoptosis; c Raf MEK ERK; Caspase activation; HepG2 ADM cells; Mitochondria dysfunction; Saxifragifolin D

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; FLUORESCEIN ISOTHIOCYANATE; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROCASPASE 3; PROCASPASE 9; PROPIDIUM IODIDE; RAF PROTEIN; SAXIFRAGIFOLIN D; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL ASSAY; CELL CYCLE; CELL CYCLE G1 PHASE; CELL GROWTH; CELL MEMBRANE POTENTIAL; CELL PROLIFERATION; CELL STRAIN HEPG2; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOCHONDRION; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

EID: 84858981729     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: 10.3969/j.issn.1001-1978.2012.009     Document Type: Article

References (21)

1. The People's Republic of China Ministry of Health Series. 2008 China Health Statistical Yearbook[M]. Beijing: Peking Union Medical College Press,2008:214-6.
2. Bosch F X, Ribes J, Cléries R, et al. Epidemiology of hepatocellular carcinoma[J]. Clin Liver Dis,2005,9(2):191-211.
3. Bosch F X, Ribes J, Diaz M, et al. Primary liver cancer: worldwide incidence and trends[J]. Gastroenterol,2004,127:5-16.
4. Llovet J M, Burroughs A, Bruix J. Hepatocellular carcinoma[J]. Lancet,2003,362(9399):1907-17. (Pubitemid 37518510)
5. Parikh S, Hyman D. Hepatocellular cancer: a guide for the internist[J]. Am J Med,2007,120(3):194-202. (Pubitemid 46341174)
6. Chinese materia medica editorial board. Chinese Materia Medica[M], Shanghai: Shanghai Science and Technology Press,1999:87-9.
7. Wang Y, Zhang D M, Ye W C, et al. Triterpenoid saponins from Androsace umbellata and their anti-proliferative activities in human hepatoma cells[J]. Planta Med,2008,74:1280-4.
8. Zhang D M, Wang Y, Tang M K, et al. Saxifragifolin B from Androsace umhellata induced apoptosis on human hepatoma cells[J]. Biochem Biophys Res Commun,2007,362(3):759-65. (Pubitemid 47368159)
9. Park J H, Kwak J H, Khoo J H, et al. Cytotoxic effects of triterpenoid saponins from Androsace umbellata against multidrug resistance (MDR) and non-MDR cells[J]. Arch Pharm Res,2010,33(8):1175-80.
10. Li H J, Zheng X L, Liu X L, et al. Signal transduction in trialkyltin compounds-induced tumor cell apoptosis mechanism trialkyltin compounds-induced tumor cell apoptosis[J]. Chin Pharmacol Bull,2006,22(12):1419-24.
11. Tin M M, Cho C H, Chan K, et al. Astragalus saponins induce growth inhibition and apoptosis in human colon cancer cells and tumor xenograft[J]. Carcinogenesis,2007,28(6):1347-55. (Pubitemid 47062696)
12. Harikumar K B, Sung B, Pandey M K, et al. Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway[J]. Mol Pharmacol, 2010,77(5):818-27.
13. Wang H, Haridas V, Gutterman J U, et al. Natural triterpenoid avicins selectively induce tumor cell death[J]. Commun Integr Biol,2010,3(3):205-8.
14. Kroemer G, Dallaporta B, Resche-Rigon M. The mitochondrial death/life regulator in apoptosis and necrosis[J]. Annu Rev Physiol,1998,60:619-42. (Pubitemid 28157889)
15. Montagut C, Settleman J. Targeting the RAF-MEK-ERK pathway in cancer therapy[J]. Cancer Lett,2009,283(2):125-34.
16. Pratilas C A, Solit D B. Targeting the mitogen-activated protein kinase pathway: physiological feedback and drug response[J]. Clin Cancer Res,2010,16(13):3329-34.
17. Shen H, Xu W, Luo W, et al. Upregulation of mdr1 gene is related to activation of the MAPK/ERK signal transduction pathway and YB-1 nuclear translocation in B-cell lymphoma[J]. Exp Hematol,2011,39(5):558-69.
18. Wei N, Sun H, Wang F, et al. H1, a novel derivative of tetrandrine reverse P-glycoprotein-mediated multidrug resistance by inhibiting transport function and expression of P-glycoprotein[J]. Cancer Chemother Pharmacol,2011,67(5):1017-25.
19. Li D J, Zhang Y Z, Huang W, et al. To inhibit ERK for enhancing chemotherapy sensitivity of drug-resistance cell lines of leukemia and ovarian carcinoma[J]. J Exp Hematol,2003,11(6):595-9.
20. Zhang L J, Chen S, Wu P, et al. Inhibition of MEK blocks GRP78 up-regulation and enhances apoptosis induced by ER stress in gastric cancer cells[J]. Cancer Lett,2009,274(1):40-6.
21. Yang F, Liu H, Zhang X D, et al. Inhibition of MEK sensitizes human breast carcinoma cells to endoplasmic reticulum pathway's apoptosis[J]. Chin Pharmacol Bull,2009,25(6):778-82.