Polyethylene glycosylation prolongs the stability of recombinant human paraoxonase-1

Toxicology Letters

Volumn 210, Issue 3, 2012, Pages 366-371

  Tiegang, Li ^a   Nana, Wang ^a   Heng, Dai ^a   Min, Zhao ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Escherichia coli; Organophosphate; Polyethylene glycosylation; Recombinant human paraoxonase 1

Indexed keywords

ACETYLCHOLINESTERASE; ARYLDIALKYLPHOSPHATASE 1; MACROGOL 20000; NICKEL; POLYETHYLENE; RECOMBINANT HUMAN PARAOXONASE 1; UNCLASSIFIED DRUG; ARYLDIALKYLPHOSPHATASE; ORGANOPHOSPHATE; RECOMBINANT PROTEIN;

AFFINITY CHROMATOGRAPHY; ANIMAL EXPERIMENT; ARTICLE; CHROMATOGRAPHY; CONTROLLED STUDY; DEAE SEPHAROSE FAST FLOW CHROMATOGRAPHY; ENZYME ACTIVITY; ESCHERICHIA COLI; GENE EXPRESSION SYSTEM; GLYCOSYLATION; INTOXICATION; MEAN RESIDENCE TIME; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PURIFICATION; RAT; ANIMAL; ENZYME STABILITY; HUMAN; KINETICS; METABOLISM; PROTEIN ENGINEERING; WISTAR RAT;

ESCHERICHIA COLI; ORYCTOLAGUS CUNICULUS; RATTUS;

ANIMALS; ARYLDIALKYLPHOSPHATASE; ENZYME STABILITY; GLYCOSYLATION; HUMANS; KINETICS; PHOSPHORIC ACID ESTERS; POLYETHYLENE; PROTEIN ENGINEERING; RATS; RATS, WISTAR; RECOMBINANT PROTEINS;

EID: 84858980472     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.02.019     Document Type: Article

References (21)

1. Benke G.M., Cheever K.L., Mirer F.E., Murphy S.D. Comparative toxicity, anticholinesterase action and metabolism of methylparathion and parathion in sunfish and mice. Toxicol. Appl. Pharmacol. 1974, 28(1):97-109.
2. Chilukuri N., Parikh K., Sun W., Naik R., Tipparaju P., Doctor B.P., Saxena A. Polyethylene glycosylation prolongs the circulatory stability of recombinant human butyrylcholinesterase. Chem. Biol. Interact. 2005, 157-158:115-121.
3. Costa L.G., Cole T.B., Furlong C.E. Polymorphisms of paraoxonase (PON1) and their significance in clinical toxicology of organophosphates. Clin. Toxicol. 2003, 41(1):37-45.
4. Costa L.G., McDonald B.E., Murphy S.D., Omenn G.S., Richter R.J., Motulsky A.G., Furlong C.E. Serum paraoxonase and its influence on paraoxon and chlorpyrifos oxon toxicity in rats. Toxicol. Appl. Pharmacol. 1990, 103:66-76.
5. Daniel R., Eric C., Patrick M. Human paraoxonase: a promising approach for pre-treatment and therapy of organophosphorus poisoning. Toxicology 2007, 233:47-59.
6. Dowd J.E., Riggs D.S. A comparison of estimates of Michaelis-Menten kinetics constants from various linear transformations. J. Biol. Chem. 1965, 240:863-869.
7. Eckerson H.W., Romson J., Wyte C., La Du B.N. The human serum paraoxonase polymorphism: identification of phenotypes by their response to salts. Am. J. Hum. Genet. 1983, 35:214-227.
8. Furlong C.E., Richter R.J., Seidel S.L., Costa L.G., Motulsky A.G. Spectrophotometric assays for the enzymatic hydrolysis of the active metabolites of chlorpyrifos and parathion by plasma paraoxonase/arylesterase. Anal. Biochem. 1989, 180:242-247.
9. Furlong C.E., Richter R.J., Seidel S.L., Motulsky A.G. Role of genetic polymorphism of human plasma paraoxonase/arylesterase in hydrolysis of the insecticide metabolites chlorpyrifos-oxon and paraoxon. Am. J. Hum. Genet. 1988, 43:230-238.
10. Gaidukov L., Dganit B., Shiri Y., Esmira N., Olga K., Rinal T., Dan S.T., Etgar L.N. In vivo administration of BL-3050: highly stable engineered PON1-HDL complexes. BMC Clin. Pharmacol. 2009, 9(18):1-13.
11. Geldermacher-Von M.M. Polymorphism of human serum paraoxonase. Hum. Genet. Suppl. 1978, 1:65-68.
12. Li W.F., Costa L.G., Furlong C.E. Serum paraoxonase status: a major factor in determining resistance to organophosphates. J. Toxicol. Environ. Health 1993, 40:337-346.
13. Li W.F., Costa L.G., Richter R.J., Hagen T., Shih D.M., Tward A., Lusis A.J., Furlong C.E. Catalytic efficiency determines the in vivo efficacy of PON1 for detoxifying organophosphorus compounds. Pharmacogenetics 2000, 10:767-779.
14. Main A.R. The role of A-esterase in the acute toxicity of paraoxon, TEPP and parathion. Can. J. Biochem. Physiol. 1956, 34:197-216.
15. Stevens R.C., Suzuki S.M., Cole T.B., Park S.S., Richter R.J., Furlong C.E. Engineered recombinant human paraoxonase 1 (rHuPON1) purified from Escherichia coli protects against organophosphate poisoning. Proc Natl. Aced. Sci. U.S.A. 2008, 105(35):12780-12784.
16. Suzuki S.M., Stevens R.C., Richter R.J., Cole T.B., Park S., Otto T.C., Cerasoli D.M., Lenz D.E., Furlong E.C. Engineering human PON1 in an E. coli expression system. Adv. Exp. Med. Biol. 2010, 660:37-45.
17. Voss G., Sachsse K. Red cell and plasma cholinesterase activities in microsamples of human and animal blood determined simultaneously by a modified acetylthiocholine/DTNB procedure. Toxicol. Appl. Pharmacol. 1970, 16:764-772.
18. Wang N.N., Yuan L., Dai H., Han Z.K., Zhao M. Effect of PON1 on dichlorvos toxicokinetics. Emerg. Med. J. 2011, 28(4):313-315.
19. Wang N.N., Dai H., Yuan L., Han Z.K., Zhao M. Study of paraoxonase-1 function on tissue damage of dichlorvos. Toxicol. Lett. 2010, 196(6):125-132.
20. Wolfe A.D., Rush R.S., Doctor B.P., Koplovitz I., Jones D. Acetylcholinesterase prophylaxis against organophosphate toxicity. Fundam. Appl. Toxicol. 1987, 9:266-270.
21. Wu S., Ye D.Q. Implementation of Ridit analysis in single unidirectional ordered data of multiple groups in SPSS. Chin. Health Stat. 2006, 23(6):554.