-
2
-
-
33751581755
-
Pipeline problems are increasing the urge to merge
-
Frantz, S. Pipeline problems are increasing the urge to merge. Nat Rev Drug Discov 5, 977, 2006.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 977
-
-
Frantz, S.1
-
4
-
-
77953881193
-
Big pharma reassesses orphan drug sector
-
Conway, B. Big pharma reassesses orphan drug sector. Wall Street BioBeat, 30, 5, 2010.
-
(2010)
Wall Street BioBeat
, vol.30
, Issue.5
-
-
Conway, B.1
-
5
-
-
33846436170
-
-
Services DoHaH Bethesda, MD: US Department of Health and Human Services Accessed September 25, 2010
-
Services DoHaH. Regenerative Medicine. Bethesda, MD: US Department of Health and Human Services, 2006. /info/scireport/2006report.htm . Accessed September 25, 2010.
-
(2006)
Regenerative Medicine
-
-
-
7
-
-
0021232701
-
Permanent coverage of large burn wounds with autologous cultured human epithelium
-
Gallico, G.G., 3rd, O'Connor, N.E., Compton, C.C., Kehinde, O., and Green, H. Permanent coverage of large burn wounds with autologous cultured human epithelium. N Engl J Med 311, 448, 1984.
-
(1984)
N Engl J Med
, vol.311
, pp. 448
-
-
Gallico Iii, G.G.1
O'Connor, N.E.2
Compton, C.C.3
Kehinde, O.4
Green, H.5
-
8
-
-
0033113380
-
Skin: The first tissue-engineered products
-
Parenteau, N. Skin: the first tissue-engineered products. Sci Am 280, 83, 1999.
-
(1999)
Sci Am
, vol.280
, pp. 83
-
-
Parenteau, N.1
-
9
-
-
0032491416
-
Embryonic stem cell lines derived from human blastocysts
-
Thomson, J.A., Itskovitz-Eldor, J., Shapiro, S.S., Waknitz, M.A., Swiergiel, J.J., Marshall, V.S., et al. Embryonic stem cell lines derived from human blastocysts. Science 282, 1145, 1998.
-
(1998)
Science
, vol.282
, pp. 1145
-
-
Thomson, J.A.1
Itskovitz-Eldor, J.2
Shapiro, S.S.3
Waknitz, M.A.4
Swiergiel, J.J.5
Marshall, V.S.6
-
10
-
-
0033515827
-
Multilineage potential of adult human mesenchymal stem cells
-
Pittenger, M.F., Mackay, A.M., Beck, S.C., Jaiswal, R.K., Douglas, R., Mosca, J.D., et al. Multilineage potential of adult human mesenchymal stem cells. Science 284, 143, 1999.
-
(1999)
Science
, vol.284
, pp. 143
-
-
Pittenger, M.F.1
MacKay, A.M.2
Beck, S.C.3
Jaiswal, R.K.4
Douglas, R.5
Mosca, J.D.6
-
11
-
-
36248966518
-
Induction of pluripotent stem cells from adult human fibroblasts by defined factors
-
Takahashi,K., Tanabe,K., Ohnuki,M.,Narita, M., Ichisaka, T., Tomoda, K., et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861, 2007.
-
(2007)
Cell
, vol.131
, pp. 861
-
-
Takahashi, K.1
Tanabe, K.2
Ohnuki, M.3
Narita, M.4
Ichisaka, T.5
Tomoda, K.6
-
12
-
-
66049135249
-
Generation of induced pluripotent stem cells using recombinant proteins
-
Zhou, H., Wu, S., Joo, J.Y., Zhu, S., Han, D.W., Lin, T., et al. Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell 4, 381, 2009.
-
(2009)
Cell Stem Cell
, vol.4
, pp. 381
-
-
Zhou, H.1
Wu, S.2
Joo, J.Y.3
Zhu, S.4
Han, D.W.5
Lin, T.6
-
13
-
-
77958536106
-
Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA
-
Warren, L., Manos, P.D., Ahfeldt, T., Loh, Y.H., Li, H., Lau, F., et al. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 7, 618, 2010.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 618
-
-
Warren, L.1
Manos, P.D.2
Ahfeldt, T.3
Loh, Y.H.4
Li, H.5
Lau, F.6
-
14
-
-
78650870731
-
Hurdles in tissue engineering/regenerative medicine product commercialization: A survey of North American academia and industry
-
Johnson, P.C., Bertram, T.A., Tawil. B., and Hellman, K.B. Hurdles in tissue engineering/regenerative medicine product commercialization: a survey of North American academia and industry. Tissue Eng Part A 17, 5, 2011.
-
(2011)
Tissue Eng Part A
, vol.17
, pp. 5
-
-
Johnson, P.C.1
Bertram, T.A.2
Tawil, B.3
Hellman, K.B.4
-
15
-
-
34047265274
-
National hospital discharge survey
-
2008
-
DeFrances, C.J., Lucas, C.A., Buie, V.C., and Golosinskiy, A. 2006 National Hospital Discharge Survey. Natl Health Stat Rep 1, 2008.
-
(2006)
Natl Health Stat Rep
, vol.1
-
-
Defrances, C.J.1
Lucas, C.A.2
Buie, V.C.3
Golosinskiy, A.4
-
16
-
-
84858962093
-
Design and operation of the national hospital discharage survey:1988 Redesign
-
ed. Hyattsville, M.D: Center for Disease Control and Prevention
-
Dennison, C.F., and Pokras, R. Design and operation of the national hospital discharage survey: 1988 Redesign. In: Statistics NCfH, ed. Hyattsville, M.D: Center for Disease Control and Prevention, 2000.
-
(2000)
Statistics NCfH
-
-
Dennison, C.F.1
Pokras, R.2
-
17
-
-
84869871354
-
-
Health NIo Bethesda MD: National Institutes of Health 2010 Accessed May 19, 2011
-
Health NIo. Research Portfolio Online Reporting Tools (RePORT). Bethesda, MD: National Institutes of Health 2010. http://report.nih.gov/. Accessed May 19, 2011.
-
Research Portfolio Online Reporting Tools (RePORT)
-
-
-
18
-
-
1842486565
-
Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms
-
Kinnaird, T., Stabile, E., Burnett, M.S., Shou, M., Lee, C.W., Barr, S., et al. Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms. Circulation 109, 1543, 2004.
-
(2004)
Circulation
, vol.109
, pp. 1543
-
-
Kinnaird, T.1
Stabile, E.2
Burnett, M.S.3
Shou, M.4
Lee, C.W.5
Barr, S.6
-
19
-
-
24944565414
-
Stem celltherapy for ischemic heart failure
-
Rosenstrauch, D., Poglajen, G., Zidar, N., and Gregoric, I.D. Stem celltherapy for ischemic heart failure. Tex Heart Inst J 32, 339, 2005.
-
(2005)
Tex Heart Inst J
, vol.32
, pp. 339
-
-
Rosenstrauch, D.1
Poglajen, G.2
Zidar, N.3
Gregoric, I.D.4
-
20
-
-
41149106402
-
The myoblast autologous grafting in ischemic cardiomyopathy (MAGIC) trial: First randomized placebo-controlled study of myoblast transplantation
-
Menasche, P., Alfieri, O., Janssens, S., McKenna, W., Reichenspurner, H., Trinquart, L., et al. The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) trial: first randomized placebo-controlled study of myoblast transplantation. Circulation 117, 1189, 2008.
-
(2008)
Circulation
, vol.117
, pp. 1189
-
-
Menasche, P.1
Alfieri, O.2
Janssens, S.3
McKenna, W.4
Reichenspurner, H.5
Trinquart, L.6
-
21
-
-
0035846616
-
Endorsed by the heart failure society of America
-
ACC/AHA Guidelines for the Evaluation and Management of Chronic Heart Failure in the Adult: Executive Summary A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines Committee to Revise the 1995 Guidelines for the Evaluation and Management of Heart Failure): Developed in Collaboration With the International Society for Heart and Lung Transplantation
-
Hunt, S.A., Baker, D.W., Chin, M.H., Cinquegrani, M.P., Feldman, A.M., Francis, G.S., et al. ACC/AHA Guidelines for the Evaluation and Management of Chronic Heart Failure in the Adult: Executive Summary A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1995 Guidelines for the Evaluation and Management of Heart Failure): Developed in Collaboration With the International Society for Heart and Lung Transplantation; Endorsed by the Heart Failure Society of America. Circulation 104, 2996, 2001.
-
(2001)
Circulation
, vol.104
, pp. 2996
-
-
Hunt, S.A.1
Baker, D.W.2
Chin, M.H.3
Cinquegrani, M.P.4
Feldman, A.M.5
Francis, G.S.6
-
22
-
-
84858962095
-
-
DOPPS. Annual Report of the Dialysis Outcomes and Practice Patterns Study: Hemodialysis Data 1999-2008 Ann Arbor: Ann Arbor Research Collaborative for Health
-
DOPPS. Annual Report of the Dialysis Outcomes and Practice Patterns Study: Hemodialysis Data 1999-2008. Annual Report of the Dialysis Outcomes and Practice Patterns Study. Ann Arbor: Ann Arbor Research Collaborative for Health; 2009.
-
(2009)
Annual Report of the Dialysis Outcomes and Practice Patterns Study
-
-
-
23
-
-
35348860711
-
Subcoronary allograft aortic valve replacement: Parametric risk-hazard outcome analysis to a minimum of 20 years
-
Hickey, E., Langley, S.M., Allemby-Smith, O., Livesey, S.A., and Monro, J.L. Subcoronary allograft aortic valve replacement: parametric risk-hazard outcome analysis to a minimum of 20 years. Ann Thorac Surg 84, 1564, 2007.
-
(2007)
Ann Thorac Surg
, vol.84
, pp. 1564
-
-
Hickey, E.1
Langley, S.M.2
Allemby-Smith, O.3
Livesey, S.A.4
Monro, J.L.5
-
24
-
-
0032758944
-
Intermediate-term results in pediatric aortic valve replacement
-
Lupinetti, F.M., Duncan, B.W., Scifres, A.M., Fearneyhough, C.T., Kilian, K., Rosenthal, G.L., et al. Intermediate-term results in pediatric aortic valve replacement. Ann Thorac Surg 68, 521, 1999.
-
(1999)
Ann Thorac Surg
, vol.68
, pp. 521
-
-
Lupinetti, F.M.1
Duncan, B.W.2
Scifres, A.M.3
Fearneyhough, C.T.4
Kilian, K.5
Rosenthal, G.L.6
-
25
-
-
31044436046
-
Projections of US prevalence of arthritis and associated activity limitations
-
Hootman, J.M., and Helmick, C.G. Projections of US prevalence of arthritis and associated activity limitations. Arthritis Rheum 54, 226, 2006.
-
(2006)
Arthritis Rheum
, vol.54
, pp. 226
-
-
Hootman, J.M.1
Helmick, C.G.2
-
26
-
-
74949087489
-
Stem cells in human neurodegenerative disorders-time for clinical translation?
-
Lindvall, O., and Kokaia, Z. Stem cells in human neurodegenerative disorders-time for clinical translation? J Clin Invest 120, 29, 2010.
-
(2010)
J Clin Invest
, vol.120
, pp. 29
-
-
Lindvall, O.1
Kokaia, Z.2
-
27
-
-
44949257109
-
Subarachnoid placement of stem cells in neurological disorders
-
Mehta, T., Feroz, A., Thakkar, U., Vanikar, A., Shah, V., and Trivedi, H. Subarachnoid placement of stem cells in neurological disorders. Transplant Proc 40, 1145, 2008.
-
(2008)
Transplant Proc
, vol.40
, pp. 1145
-
-
Mehta, T.1
Feroz, A.2
Thakkar, U.3
Vanikar, A.4
Shah, V.5
Trivedi, H.6
-
28
-
-
70349759090
-
Commercial development of cell-based therapeutics: Strategic considerations along the drug to tissue spectrum
-
Parenteau, N.L. Commercial development of cell-based therapeutics: strategic considerations along the drug to tissue spectrum. Regen Med 4, 601, 2009.
-
(2009)
Regen Med
, vol.4
, pp. 601
-
-
Parenteau, N.L.1
-
29
-
-
77957230012
-
Neural grafting in Parkinson's disease problems and possibilities
-
Brundin, P., Barker, R.A., and Parmar, M. Neural grafting in Parkinson's disease problems and possibilities. Prog Brain Res 184, 265, 2010.
-
(2010)
Prog Brain Res
, vol.184
, pp. 265
-
-
Brundin, P.1
Barker, R.A.2
Parmar, M.3
-
30
-
-
77957235017
-
Neural grafting in Parkinson's disease unraveling the mechanisms underlying graft-induceddyskinesia
-
Lane, E.L., Bjorklund,A., Dunnett, S.B., andWinkler, C. Neural grafting in Parkinson's disease unraveling the mechanisms underlying graft- induceddyskinesia. Prog BrainRes 184, 295, 2010.
-
(2010)
Prog BrainRes
, vol.184
, pp. 295
-
-
Bjorklunda, L.L.E.1
Dunnett, S.B.2
Winkler, C.3
-
31
-
-
77955617871
-
Serotonergic neurons mediate dyskinesia side effects in Parkinson's patients with neural transplants
-
Politis, M., Wu, K., Loane, C., Quinn, N.P., Brooks, D.J., Rehncrona, S., et al. Serotonergic neurons mediate dyskinesia side effects in Parkinson's patients with neural transplants. Sci Transl Med 2, 38ra46, 2010.
-
(2010)
Sci Transl Med
, vol.2
-
-
Politis, M.1
Wu, K.2
Loane, C.3
Quinn, N.P.4
Brooks, D.J.5
Rehncrona, S.6
-
32
-
-
67249096636
-
Stem cell therapy for heart failure: Are arrrhymias a real safety concern?
-
Menasche, P. Stem Cell Therapy for Heart Failure: Are Arrrhymias a Real Safety Concern? Circulation 119, 2735, 2009.
-
(2009)
Circulation
, vol.119
, pp. 2735
-
-
Menasche, P.1
-
33
-
-
77951975829
-
Stem cell transplantation in multiple sclerosis
-
Uccelli, A., and Mancardi, G. Stem cell transplantation in multiple sclerosis. Curr Opin Neurol 23, 218, 2010.
-
(2010)
Curr Opin Neurol
, vol.23
, pp. 218
-
-
Uccelli, A.1
Mancardi, G.2
-
34
-
-
0034235801
-
Therapeutic liver repopulation in a mouse model of hypercholesterolemia
-
Mitchell, C., Mignon, A., Guidotti, J.E., Besnard, S., Fabre, M., Duverger, N., et al. Therapeutic liver repopulation in a mouse model of hypercholesterolemia. HumMol Genet 9, 1597, 2000.
-
(2000)
HumMol Genet
, vol.9
, pp. 1597
-
-
Mitchell, C.1
Mignon, A.2
Guidotti, J.E.3
Besnard, S.4
Fabre, M.5
Duverger, N.6
-
35
-
-
79958812975
-
Stem cell-based therapies for liver diseases: State of the art and new perspectives
-
Piscaglia, A.C., Campanale, M., Gasbarrini, A., and Gasbarrini, G. Stem cell-based therapies for liver diseases: state of the art and new perspectives. Stem Cells Int 2010, 259461, 2010.
-
(2010)
Stem Cells Int
, vol.2010
, pp. 259461
-
-
Piscaglia, A.C.1
Campanale, M.2
Gasbarrini, A.3
Gasbarrini, G.4
-
36
-
-
16644379606
-
The engineering of tissues using progenitor cells
-
Parenteau, N.L., Rosenberg, L., and Hardin-Young, J. The engineering of tissues using progenitor cells. Curr Top Dev Biol 64, 101, 2004.
-
(2004)
Curr Top Dev Biol
, vol.64
, pp. 101
-
-
Parenteau, N.L.1
Rosenberg, L.2
Hardin-Young, J.3
-
38
-
-
77953193333
-
Islet transplantation a decade later and strategies for filling a half-full glass
-
Robertson, R.P. Islet transplantation a decade later and strategies for filling a half-full glass. Diabetes 59, 1285, 2010.
-
(2010)
Diabetes
, vol.59
, pp. 1285
-
-
Robertson, R.P.1
-
39
-
-
84858953136
-
Cell replacement and regeneration therapy for diabetes
-
Jun, H.S. Cell replacement and regeneration therapy for diabetes. Korean Diabetes J 34, 77, 2010.
-
(2010)
Korean Diabetes J
, vol.34
, pp. 77
-
-
Jun, H.S.1
-
41
-
-
24944503491
-
Review:mesenchymal stem cells: Cell-based reconstructive therapy in orthopedics
-
Caplan, A.I. Review: mesenchymal stem cells: cell-based reconstructive therapy in orthopedics. Tissue Eng 11, 1198, 2005.
-
(2005)
Tissue Eng
, vol.11
, pp. 1198
-
-
Caplan, A.I.1
-
42
-
-
84858991353
-
-
USA Public Law 97-414 Accessed June 27 2011
-
US FDA Orphan Drug Act. USA Public Law 97-414, www.fda.gov/ RegulatoryInformation/Legislation/Federal FoodDrugandCosmeticActFDCAct/ SignificantAmendments totheFDCAct/OrphanDrugAct/default.htm. Accessed June 27, 2011.
-
US FDA Orphan Drug Act
-
-
-
43
-
-
78249271264
-
-
National Science Board Science and Engineering Indicators 2010 Accessed July.26.2010
-
National Science Board, Science and Engineering Indicators 2010.National Science Foundation, 2010. www.nsf.gov/statistics/seind10/. Accessed July.26.2010.
-
(2010)
National Science Foundation
-
-
|