Plasma citrulline concentration as a marker for disease activity in patients with Crohn's disease

Journal of Clinical Gastroenterology

Volumn 46, Issue 4, 2012, Pages 308-310

  Elkhatib, Imad ^a   Buchman, Alan L ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

citrulline, biomaker; Crohns disease; small intestine

Indexed keywords

CITRULLINE;

ADULT; AGED; AMINO ACID BLOOD LEVEL; ARTICLE; CLINICAL ASSESSMENT; COLON DISEASE; COMPUTER ASSISTED TOMOGRAPHY; CROHN DISEASE; DISEASE ACTIVITY; ENDOSCOPY; FEMALE; HUMAN; INTESTINE RESECTION; ION PAIR CHROMATOGRAPHY; KIDNEY FAILURE; LIVER FAILURE; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SCORING SYSTEM; SMALL INTESTINE DISEASE;

ADOLESCENT; ADULT; AGED; BIOLOGICAL MARKERS; CITRULLINE; CROHN DISEASE; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; STATISTICS, NONPARAMETRIC; TOMOGRAPHY, X-RAY COMPUTED; YOUNG ADULT;

EID: 84858866505     PISSN: 01920790     EISSN: 15392031     Source Type: Journal    
DOI: 10.1097/MCG.0b013e31822b80e0     Document Type: Article

References (24)

1. Rabier D, Kamoun P. Metabolism of citrulline in man. Amino Acids. 1995;9:299-316. (Pubitemid 26018300)
2. Windmueller HG, Spaeth AE. Uptake and metabolism of plasma glutamine by the small intestine. J Biol Chem. 1974;249:5070-5079.
3. Mouille B, Morel E, Robert V, et al. Metabolic capacity for Lcitrulline synthesis from ammonia in rat isolated colonocytes. Biochim Biophys Acta. 1999;1427:401-407. (Pubitemid 29229762)
4. Mouille B, Robert V, Blachier F. Adaptive increase in ornithine production and decrease in ammonia metabolism in rat colonocytes after hyperproteic diet ingestion. Am J Physiol Gastrointest Liver Physiol. 2004;287:G344-G345.
5. Crenn P, Messing B, Cynober L. Citrulline as a biomarker of intestinal failure due to enterocyte mass reduction. Clin Nutr. 2008;27:328-339.
6. Mandel H, Levy N, Izkovitch S, et al. Elevated plasma citrulline and arginine due to consumption of Citrullus vulgaris (watermelon). J Inherit Metab Dis. 2005;28:467-472. (Pubitemid 40753674)
7. Crenn P, Coudray-Lucas C, Thuillier F, et al. Postabsorptive plasma citrulline concentration is a marker of absorptive enterocyte mass and intestinal failure in humans. Gastroenterology. 2000;119:1496-1505. (Pubitemid 32198675)
8. Rhoads JM, Plunkett E, Galanko J, et al. Serum citrulline levels correlate with enteral tolerance and bowel length in infants with short bowel syndrome. J Pediatrics. 2005;146:542-547. (Pubitemid 40469721)
9. Crenn P, Vahedi K, Lavergne-Slove A, et al. Plasma citrulline: a marker of enterocyte mass in villous atrophy-associated small bowel disease. Gastroenterology. 2003;124:1210-1219. (Pubitemid 36531797)
10. Blijlevens NMA, Lutgens LCHW, Schattenberg AVMB, et al. Citrulline: a potentially simple quantitative marker of intestinal epithelial damage following myeloablative therapy. Bone Marrow Transpl. 2004;34:193-196. (Pubitemid 39136824)
11. Herbers AH, Feuth T, Donnelly JP, et al. Citrulline-based assessment score: first choice for measuring and monitoring intestinal failure after high-dose chemotherapy. Annal Oncol. 2010;21:1706-1711.
12. Lutgens LCHW, Blijlevens NMA, Deutz NEP, et al. Monitoring myeloablative therapy-induced small bowel toxicity by serum citrulline concentration. Cancer. 2005;103:191-199. (Pubitemid 39665473)
13. Lutgens LC, Deutz N, Granzier-Peeters M, et al. Plasma citrulline concentrations: a surrogate end point for radiationinduced mucosal atrophy of the small bowel: a feasibility study in 23 patients. Int J Radiat Oncol Biol Phys. 2004;60:275-285. (Pubitemid 39165495)
14. Lutgens LCHW, Deutz NEP, Gueulette J, et al. Citrulline: a physiologic marker enabling quantitation and monitoring of epithelial radiation-induced small bowel damage. Int J Radiation Oncol Biol Phys. 2003;57:1067-1074. (Pubitemid 37324125)
15. Gondolesi G, Ghirardo S, Raymond K, et al. The value of plasma citrulline to predict mucosal injury in intestinal allografts. Am J Transplant. 2006;6:2786-2790. (Pubitemid 44571701)
16. Pappas PA, Tzakis AG, Gaynor JJ, et al. An analysis of the association between serum citrulline and acute rejection among 26 recipients of intestinal transplant. Am J Transpl. 2004;4: 1124-1132. (Pubitemid 38868604)
17. David AI, Selvaggi G, Ruiz P, et al. Blood citrulline level is an exclusionary marker for significant acute rejection after intestinal transplantation. Transplantation. 2007;84:1077-1081. (Pubitemid 350125347)
18. Papadia C, Sherwood RA, Kalantzis T, et al. Plasma citrulline concentration: a reliable marker of small bowel absorptive capacity independent of intestinal inflammation. Am J Gastroenterol. 2007;102:1-9.
19. Pappas PA, Saudubray JM, Tzakis AG, et al. Serum citrulline as a marker of acute cellular rejection for intestinal transplantation. Transplant Proc. 2002;34:915-917. (Pubitemid 34556857)
20. Harvey RF, Bradshaw JM. A simple index of Crohns disease activity. Lancet. 1980;1:514.
21. Slocum RH, Cummings JG. Amino acid analyis of physiological specimens. In: Hommes FA, ed. Techniques in Diagnostic Human Biochemical Genetics. New York: Wiley-Liss; 1991: 87-126.
22. Spackman DH, Stein WH, Moore S. Automatic recording apparatus for use in chromatography of amino acids. Anal Chem. 1958;30:1190-1206.
23. Buchman AL, Katz S, Fang JC, et al. Teduglutide, a novel mucosally active analog of glucagon-like peptide-2 (GLP-2) for the treatment of moderate to severe Crohns disease. Inflamm Bowel Dis. 2010;16:962-973.
24. De Dombal FT, Softley A. IOIBD report no Observer variation in calculating indices of severity and activity in Crohns disease. International Organization for the Study of Inflammatory Bowel Disease. Gut. 1987;28:474-481. (Pubitemid 17056886)