Differential contributions of impaired corneal sensitivity and reduced tear secretion to corneal epithelial disorders

Japanese Journal of Ophthalmology

Volumn 56, Issue 1, 2012, Pages 20-25

  Nishida, Teruo ^a,b   Chikama, Tai Ichiro ^a,c   Sawa, Mitsuru ^d   Miyata, Kazunori ^e   Matsui, Takaaki ^f   Shigeta, Kyoko ^g,h  

^a YAMAGUCHI UNIVERSITY HOSPITAL   (Japan)

^b YAMAGUCHI UNIVERSITY   (Japan)

^c HIROSHIMA UNIVERSITY HOSPITAL   (Japan)

^d NIHON UNIVERSITY   (Japan)

^e Miyata Eye Hospital   (Japan)

^f Ohshima Hospital of Ophthalmology   (Japan)

^g Choshi General City Hospital   (Japan)

^h Tokyo Women s Medical University   (Japan)

Author keywords

Corneal erosion; Corneal sensitivity; Persistent epithelial defect; Superficial punctate keratopathy; Tear secretion

Indexed keywords

ARTICLE; CAUSAL ATTRIBUTION; CONTROLLED STUDY; CORNEA DISEASE; CORNEA EROSION; CORNEA SENSIBILITY; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; FEMALE; HUMAN; JAPAN; KERATOPATHY; LACRIMATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK FACTOR; SCHIRMER TEST;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CORNEA; CORNEAL DISEASES; DIAGNOSTIC TECHNIQUES, OPHTHALMOLOGICAL; DOUBLE-BLIND METHOD; EPITHELIUM, CORNEAL; FEMALE; HUMANS; HYPESTHESIA; LACRIMAL APPARATUS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; TEARS; YOUNG ADULT;

EID: 84858864969     PISSN: 00215155     EISSN: 16132246     Source Type: Journal    
DOI: 10.1007/s10384-011-0105-4     Document Type: Article

References (41)

1. Nishida T. Saika S. Cornea and sclea: anatomy and physiology. In: Krachmer JH, Mannis MJ, Holland EJ, editors. Cornea, 3rd ed. St. Louis: Mosby; 2010. p. 3-24.
2. Gipson IK, Joyce NC, Zieske JD. The anatomy and cell biology of the human cornea, limbus, counjunctiva, and adnexa. In: Foster CS, Azar DT, Dohlman CH, editors. Smolin and Thoft's the cornea. Scientific foundation and clinical practice. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 1-35.
3. Nishida T. The cornea: stasis and dynamics. Nippon Ganka Gakkai zasshi. 2008;112:179-212. (in Japanese).
4. Cohen EJ, Rapuano CJ. Corneal changes from ocular surgery. In: Kaufman HE, Barron BA, Dohlman CH, editors. The cornea. 2nd ed. Newton: Butterworth-Heinemann; 1998. p. 673-96.
5. Faulkner WJ, Varley GA. Corneal diagnostic techniques. In: Krachmer JH, Mannis MJ, Holland EJ, editors. Cornea, 3rd ed. St Louis: Mosby; 2010. p. 131-8.
6. Gulati A, Dana R. Keratoconjunctivitis sicca: clinical aspects. In: Foster CS, Azar DT, Dohlman CH, editors. Smolin and Thoft's the cornea. Scientific foundation and clinical practice. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 603-27.
7. Kenyon KR, Ghinelli E, Chaves HV. Morphology and pathologic response in corneal and conjunctival disease. In: Foster CS, Azar DT, Dohlman CH, editors. Smolin and Thoft's the cornea. Scientific foundation and clinical practice. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 103-40.
8. Parrish CM, Chandler JW. Corneal trauma. In: Kaufman HE, Barron BA, Dohlman CH, editors. The cornea. 2nd ed. Newton: Butterworth-Heinemann; 1998. p. 633-71.
9. Watkins A, Macaluso DM, Feldman ST. Pathogenesis of sterile corneal erosions and ulcerations. In: Krachmer JH, Mannis MJ, Holland EJ, editors. Cornea, 2nd ed. St Louis: Mosby; 2005. p. 151-64.
10. Nishida T, Tanaka T. Extracellular matrix and growth factors in corneal wound healing. Curr Opin Ophthalmol. 1996;7:2-11. (Pubitemid 26396537)
11. Zieske JD. Extracellular matrix and wound healing. Curr Opin Ophthalmol. 2001;12:237-41. (Pubitemid 32751679)
12. Chang BH, Groos EBJ. Neurotrophic keratitis. In: Krachmer JH, Mannis MH, Holland EJ, editors. Cornea, 3rd ed. St Louis: Mosby; 2010. p. 1101-9.
13. Nishida T. Neurotrophic mediators and corneal wound healing. Ocul Surf. 2005;3:194-202. (Pubitemid 41645655)
14. Nishida T, Yanai R. Advances in treatment for neurotrophic keratopathy. Curr Opin Ophthalmol. 2009;20:276-81.
15. Yamada M, Ogata M, Kawai M, Mashima Y. Decreased substance P concentrations in tears from patients with corneal hypesthesia. Am J Ophthalmol. 2000;129:671-2. (Pubitemid 30323739)
16. Dogru M, Katakami C, Inoue M. Tear function and ocular surface changes in noninsulin-dependent diabetes mellitus. Ophthalmology. 2001;108:586-92. (Pubitemid 32179902)
17. Jones LT. The lacrimal secretory system and its treatment. J All India Ophthalmol Soc. 1966;14:191-6.
18. Sawa M, Miyata K, Nishida T, Mishima H, Otori T. A nationwide survey on the incidence and modes of treatment of corneal epithelial disorders. Ganka. 1993;35:1507-12.
19. Davies MS. Corneal anaesthesia after alcohol injection of the trigeminal sensory root. Examination of 100 anaesthetic corneae. Br J Ophthalmol. 1970;54:577-86.
20. Mackie IA. Role of the corneal nerves in destructive disease of the cornea. Trans Ophthalmol Soc UK. 1978;98:343-7. (Pubitemid 9188854)
21. Onofrio BM. Radiofrequency percutaneous Gasserian ganglion lesions: results in 140 patients with trigeminal pain. J Neurosurg. 1975;42:132-9.
22. Cavanagh HD, Pihlaja D, Thoft RA, Dohlman CH, et al. The pathogenesis and treatment of persistent epithelial defects. Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol. 1976;81: 754-69.
23. Cobo LM. Corneal complications of herpes zoster ophthalmicus. Prevention and treatment. Cornea. 1988;7:50-6.
24. Liesegang TJ. Corneal complications from herpes zoster ophthalmicus. Ophthalmology. 1985;92:316-24. (Pubitemid 15099091)
25. Liesegang TJ. Ocular herpes simplex infection: pathogenesis and current therapy. Mayo Clin Proc. 1988;63:1092-105.
26. Hyndiuk RA, Kazarian EL, Schultz RO, Seideman S. Neurotrophic corneal ulcers in diabetes mellitus. Arch Ophthalmol. 1977; 95:2193-6. (Pubitemid 8261059)
27. Lockwood A, Hope-Ross M, Chell P. Neurotrophic keratopathy and diabetes mellitus. Eye. 2006;20:837-9. (Pubitemid 44316996)
28. Rosenwasser GOD. Complications of topical ocular anesthetics. Int Ophthalmol Clin. 1989;29:153-8. (Pubitemid 19211176)
29. Rosenwasser GOD, Holland S, Pflugfelder SC, Lugo M, Heidemann DG, Culbertson WW, et al. Topical anesthetic abuse. Ophthalmology. 1990;97:967-72. (Pubitemid 20251122)
30. Yamada N, Yanai R, Inui M, Nishida T. Sensitizing effect of substance P on corneal epithelial migration induced by IGF-1, fibronectin, or interleukin-6. Invest Ophthalmol Vis Sci. 2005;46: 833-9. (Pubitemid 41321018)
31. Nishida T, Nakagawa S, Manabe R. Clinical evaluation of fibronectin eyedrops on epithelial disorders after herpetic keratitis. Ophthalmology. 1985;92:213-6. (Pubitemid 15137762)
32. Tsubota K, Goto E, Shimmura S, Shimazaki J. Treatment of persistent corneal epithelial defect by autologous serum application. Ophthalmology. 1999;106:1984-9.
33. Young AL, Cheng ACO, Ng HK, Cheng LL, Leung GYS, Lam DSC. The use of autologous serum tears in persistent corneal epithelial defects. Eye. 2004;18:609-14. (Pubitemid 38961454)
34. Wilczynski M. The use of autologous serum in the treatment of the ocular surface diseases. Klin Oczna. 2009;111:363-8.
35. Jeng BHMD, Dupps WJJMDP. Autologous serum 50% eyedrops in the treatment of persistent corneal epithelial defects. Cornea. 2009;28:1104-8.
36. Chikama T-I, Fukuda K, Morishige N, Nishida T. Treatment of neurotrophic keratopathy with substance-P-derived peptide (FGLM) and insulin-like growth factor I. Lancet. 1998;351: 1783-4. (Pubitemid 28269191)
37. Yamada N, Matsuda R, Morishige N, Yanai R, Chikama T-I, Nishida T, et al. Open clinical study of eye-drops containing tetrapeptides derived from substance P and insulin-like growth factor-1 for treatment of persistent corneal epithelial defects associated with neurotrophic keratopathy. Br J Ophthalmol. 2008; 92:896-900. (Pubitemid 351969664)
38. Nishida T, Chikama TI, Morishige N, Yanai R, Yamada N, Saito J. Persistent epithelial defects due to neurotrophic keratopathy treated with a substance P-derived peptide and insulin-like growth factor 1. Jpn J Ophthalmol. 2007;51:442-7.
39. Lambiase A, Rama P, Bonini S, Caprioglio G, Aloe L. Topical treatment with nerve growth factor for corneal neurotrophic ulcers. N Engl J Med. 1998;338:1174-80. (Pubitemid 28180745)
40. Dunn SP, Heidemann DG, Chow CYC, Crockford D, Turjman N, Angel J, et al. Treatment of chronic nonhealing neurotrophic corneal epithelial defects with thymosin beta 4. Arch Ophthalmol. 2010;128:636-8.
41. Sosne G, Qiu P, Kurpakus-Wheater M, Matthew H. Thymosin beta4 and corneal wound healing: visions of the future. Ann N Y Acad Sci. 2010;1194:190-8.