Treatment of chronic nonhealing neurotrophic corneal epithelial defects with thymosin beta 4

Archives of Ophthalmology

Volumn 128, Issue 5, 2010, Pages 636-638

  Dunn, Steven P ^a,b   Heidemann, David G ^b   Chow, Christopher Y C ^b   Crockford, David ^c   Turjman, Nabila ^c   Angel, Janet ^c   Allan, Christian B ^c   Sosne, Gabriel ^d  

^a WAYNE STATE UNIVERSITY   (United States)

^b WILLIAM BEAUMONT HOSPITAL   (United States)

^c RegeneRx Biopharmaceuticals Inc   (United States)

^d WAYNE STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

THYMOSIN BETA4;

ADULT; AGED; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CASE REPORT; CHRONIC DISEASE; CORNEA EPITHELIUM; FEMALE; HUMAN; KERATOPATHY; MALE; PRIORITY JOURNAL; SLIT LAMP; TREATMENT DURATION; TREATMENT OUTCOME; WOUND HEALING;

AGED, 80 AND OVER; CHRONIC DISEASE; COMPASSIONATE USE TRIALS; CORNEAL DISEASES; DIABETES COMPLICATIONS; EPITHELIUM, CORNEAL; FEMALE; HERPES ZOSTER OPHTHALMICUS; HUMANS; MALE; MIDDLE AGED; OPHTHALMIC SOLUTIONS; THYMOSIN;

EID: 77952113150     PISSN: 00039950     EISSN: 15383601     Source Type: Journal    
DOI: 10.1001/archophthalmol.2010.53     Document Type: Article

References (5)

1. Lambiase A, Rama P, Aloe L, Bonini S. Management of neurotrophic keratopathy. Curr Opin Ophthalmol. 1999;10(4):270-276.
2. Sosne G, Chan CC, Thai K, et al. Thymosin beta 4 promotes corneal wound healing and modulates inflammatory mediators in vivo. Exp Eye Res. 2001;72(5):605-608.
3. Sosne G, Szliter EA, Barrett R, Kernacki KA, Kleinman H, Hazlett LD. Thymosin beta 4 promotes corneal wound healing and decreases inflammation in vivo following alkali injury. Exp Eye Res. 2002;74(2):293-299.
4. Sosne G, Christopherson PL, Barrett RP, Fridman R. Thymosin-beta4 modulates corneal matrix metalloproteinase levels and polymorphonuclear cell infiltration after alkali injury. Invest Ophthalmol Vis Sci. 2005;46(7):2388-2395.
5. Qiu P, Kurpakus-Wheater M, Sosne G. Matrix metalloproteinase activity is necessary for thymosin beta 4 promotion of epithelial cell migration. J Cell Physiol. 2007;212(1):165-173.