Physical capacity, respiratory quotient and energy expenditure during exercise in male patients with schizophrenia compared with healthy controls

European Psychiatry

Volumn 27, Issue 3, 2012, Pages 206-212

  Nilsson, B M ^a   Olsson, R M ^b   Oman A ^a   Wiesel, F A ^a   Ekselius, L ^a   Forslund, A H ^a,b  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Body weight; Energy expenditure; Oxygen uptake capacity; Physical capacity; Respiratory quotient; Schizophrenia

Indexed keywords

ADULT; ANAEROBIC METABOLISM; ARTICLE; BICYCLE ERGOMETRY; BODY FAT; BODY MASS; BODY WEIGHT; CALORIMETRY; CARBOHYDRATE METABOLISM; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE DURATION; ENERGY EXPENDITURE; EXERCISE; EXHAUSTION; HEART RATE; HUMAN; MALE; MENTAL PATIENT; OXIDATION; OXYGEN CONSUMPTION; PHYSICAL CAPACITY; PRIORITY JOURNAL; RESPIRATORY QUOTIENT; SCHIZOPHRENIA; WORKLOAD;

ADULT; ENERGY METABOLISM; EXERCISE; EXERCISE TEST; HUMANS; MALE; MIDDLE AGED; OXYGEN CONSUMPTION; PHYSICAL FITNESS; SCHIZOPHRENIA;

EID: 84858863020     PISSN: 09249338     EISSN: 17783585     Source Type: Journal    
DOI: 10.1016/j.eurpsy.2010.06.007     Document Type: Article

References (52)

1. Allison DB., Casey DE. Antipsychotic-induced weight gain: a review of the literature. J Clin Psychiatry 2001, 62(suppl. 7):22-31.
2. Astrand PO., Ryhming I. A nomogram for calculation of aerobic capacity (physical fitness) from pulse rate during sub-maximal work. J Appl Physiol 1954, 7:218-221.
3. Bergh U., Sjodin B., Forsberg A., Svedenhag J. The relationship between body mass and oxygen uptake during running in humans. Med Sci Sports Exerc 1991, 23:205-211.
4. Blaak E.E., Saris W.H. Substrate oxidation, obesity and exercise training. Best Pract Res Clin Endocrinol Metab 2002, 16:667-678.
5. Bolinder G., Noren A., Wahren J., De Faire U Long-term use of smokeless tobacco and physical performance in middle-aged men. Eur J Clin Invest 1997, 27:427-433.
6. Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc 1982, 14:377-381.
7. Bowman K.M., Eidson J.P., Burladge S.P. Biochemical studies in ten cases of dementia praecox. Boston Med Surg J 1922, 187:358-362.
8. Braceland FJ., Meduna LJ., Vaichulis JA. Delayed action of insulin in schizophrenia. Am J Psychiatry 1945, 102:108-110.
9. Carlsson C., Dencker S.J., Grimby G., Haggendal J. Circulatory studies during physical exercise in mentally disordered patients. I. Effects of large doses of chlorpromazine. Acta Med Scand 1968, 184:499-509.
10. Deimel H., Lohmann S. Physical capacity of schizophrenic patients. Rehabilitation (Stuttg) 1983, 22:81-85.
11. Dyrstad SM., Aandstad A., Hallen J. Aerobic fitness in young Norwegian men: a comparison between 1980 and 2002. Scand J Med Sci Sports 2005, 15:298-303.
12. Ekelund U., Franks PW., Wareham NJ., Aman J. Oxygen uptakes adjusted for body composition in normal-weight and obese adolescents. Obes Res 2004, 12:513-520.
13. Elman I., Borsook D., Lukas SE. Food intake and reward mechanisms in patients with schizophrenia: implications for metabolic disturbances and treatment with second-generation antipsychotic agents. Neuropsychopharmacology 2006, 31:2091-2120.
14. Fan X., Anderson E.J., Copeland P.M., Borba C.P., Nguyen D.D., Freudenreich O., et al. Higher fasting serum insulin is associated with increased resting energy expenditure in nondiabetic schizophrenia patients. Biol Psychiatry 2006, 60:1372-1377.
15. Filozof C., Gonzalez C. Predictors of weight gain: the biological-behavioural debate. Obes Rev 2000, 1:21-26.
16. Flyckt L., Borg J., Borg K., Ansved T., Edman G., Bjerkenstedt L., et al. Muscle biopsy, macro EMG, and clinical characteristics in patients with schizophrenia. Biol Psychiatry 2000, 47:991-999.
17. Forslund A.H., Johansson A.G., Sjodin A., Bryding G., Ljunghall S., Hambraeus L. Evaluation of modified multicompartment models to calculate body composition in healthy males. Am J Clin Nutr 1996, 63:856-862.
18. Goodpaster B.H., Wolfe R.R., Kelley D.E. Effects of obesity on substrate utilization during exercise. Obes Res 2002, 10:575-584.
19. Goran M., Fields D.A., Hunter G.R., Herd S.L., Weinsier R.L. Total body fat does not influence maximal aerobic capacity. Int J Obes Relat Metab Disord 2000, 24:841-848.
20. Gothelf D., Falk B., Singer P., Kairi M., Phillip M., Zigel L., et al. Weight gain associated with increased food intake and low habitual activity levels in male adolescent schizophrenic inpatients treated with olanzapine. Am J Psychiatry 2002, 159:1055-1057.
21. Graham K.A., Perkins D.O., Edwards L.J., Barrier R.C., Lieberman J.A., Harp J.B. Effect of olanzapine on body composition and energy expenditure in adults with first-episode psychosis. Am J Psychiatry 2005, 162:118-123.
22. Hoskins RG., Sleeper FH. Basal metabolism in schizophrenia. Arch Neurol Psychiatry 1929, 21:887-900.
23. Hulens M., Vansant G., Lysens R., Claessens A.L., Muls E. Exercise capacity in lean versus obese women. Scand J Med Sci Sports 2001, 11:305-309.
24. Kahn E.B., Ramsey L.T., Brownson R.C., Heath G.W., Howze E.H., Powell K.E., et al. The effectiveness of interventions to increase physical activity. A systematic review. Am J Prev Med 2002, 22:73-107.
25. Kay S.R., Fiszbein A., Opler L.A. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 1987, 13:261-276.
26. Lindamer L.A., McKibbin C., Norman G.J., Jordan L., Harrison K., Abeyesinhe S., et al. Assessment of physical activity in middle-aged and older adults with schizophrenia. Schizophr Res 2008, 104:294-301.
27. Maffeis C., Zaffanello M., Pellegrino M., Banzato C., Bogoni G., Viviani E., et al. Nutrient oxidation during moderately intense exercise in obese prepubertal boys. J Clin Endocrinol Metab 2005, 90:231-236.
28. 2 in athletes and untrained individuals. Ann Hum Biol 2007, 34:315-328.
29. Marra M., Scalfi L., Contaldo F., Pasanisi F. Fasting respiratory quotient as a predictor of long-term weight changes in non-obese women. Ann Nutr Metab 2004, 48:189-192.
30. Nadel ER., Horvath SM. Physiological responsiveness of schizoid adolescents to physical stress. Int J Neuropsychiatry 1967, 3:191-200.
31. Newcomer J.W. Antipsychotic medications: metabolic and cardiovascular risk. J Clin Psychiatry 2007, 68(suppl. 4):8-13.
32. Nilsson B.M., Forslund A.H., Olsson R.M., Hambraeus L., Wiesel F.A. Differences in resting energy expenditure and body composition between patients with schizophrenia and healthy controls. Acta Psychiatr Scand 2006, 114:27-35.
33. Osby U., Correia N., Brandt L., Ekbom A., Sparen P. Mortality and causes of death in schizophrenia in Stockholm county, Sweden. Schizophr Res 2000, 45:21-28.
34. Pajonk FG, Wobrock T, Gruber O, Scherk H, Berner D, Kaizl I, et al. Hippocampal plasticity in response to exercise in schizophrenia. Arch Gen Psychiatry 2010;67:133-43.
35. Prabakaran S., Swatton J.E., Ryan M.M., Huffaker S.J., Huang J.T., Griffin J.L., et al. Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress. Mol Psychiatry 2004, 9:684-697. [643].
36. Prince J.A., Harro J., Blennow K., Gottfries C.G., Oreland L. Putamen mitochondrial energy metabolism is highly correlated to emotional and intellectual impairment in schizophrenics. Neuropsychopharmacology 2000, 22:284-292.
37. Procyshyn R.M., Chau A., Tse G. Clozapine's effects on body weight and resting metabolic rate: a case series. Schizophr Res 2004, 66:159-162.
38. Ravussin E., Lillioja S., Knowler W.C., Christin L., Freymond D., Abbott W.G., et al. Reduced rate of energy expenditure as a risk factor for body-weight gain. N Engl J Med 1988, 318:467-472.
39. Ryan M.C., Collins P., Thakore J.H. Impaired fasting glucose tolerance in first-episode, drug-naive patients with schizophrenia. Am J Psychiatry 2003, 160:284-289.
40. Saha S., Chant D., McGrath J. A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time?. Arch Gen Psychiatry 2007, 64:1123-1131.
41. Seidell J.C., Muller D.C., Sorkin J.D., Andres R. Fasting respiratory exchange ratio and resting metabolic rate as predictors of weight gain: the Baltimore longitudinal study on aging. Int J Obes Relat Metab Disord 1992, 16:667-674.
42. Sharpe J.K., Stedman T.J., Byrne N.M., Hills A.P. Accelerometry is a valid measure of physical inactivity but not of energy expended on physical activity in people with schizophrenia. Schizophr Res 2006, 85:300-301.
43. Sharpe J.K., Stedman T.J., Byrne N.M., Hills A.P. Low-fat oxidation may be a factor in obesity among men with schizophrenia. Acta Psychiatr Scand 2009, 119:451-456.
44. Sharpe J.K., Stedman T.J., Byrne N.M., Wishart C., Hills A.P. Energy expenditure and physical activity in clozapine use: implications for weight management. Aust N Z J Psychiatry 2006, 40:810-814.
45. Thakore J.H., Mann J.N., Vlahos I., Martin A., Reznek R. Increased visceral fat distribution in drug-naive and drug-free patients with schizophrenia. Int J Obes Relat Metab Disord 2002, 26:137-141.
46. Uranova N., Bonartsev P., Brusov O., Morozova M., Rachmanova V., Orlovskaya D. The ultrastructure of lymphocytes in schizophrenia. World J Biol Psychiatry 2007, 8:30-37.
47. van Aggel-Leijssen D.P., Saris W.H., Wagenmakers A.J., Senden J.M., van Baak M.A. Effect of exercise training at different intensities on fat metabolism of obese men. J Appl Physiol 2002, 92:1300-1309.
48. van Nimwegen L.J., Storosum J.G., Blumer R.M., Allick G., Venema H.W., de Haan L., et al. Hepatic insulin resistance in antipsychotic naive schizophrenic patients: stable isotope studies of glucose metabolism. J Clin Endocrinol Metab 2008, 93:572-577.
49. 2-max penalizes women with larger percent body fat, not lean body mass. Med Sci Sports Exerc 1996, 28:1204-1208.
50. Ward L., Mason T. Aerobic capacity, weight gain and psychotropic medication. Br J Nurs 2000, 9:638-644.
51. Weir J.B. New methods for calculating metabolic rate with special reference to protein metabolism. 1949. Nutrition 1990, 6:213-221.
52. Zurlo F., Lillioja S., Esposito-Del Puente A., Nyomba B.L., Raz I., Saad M.F., et al. Low ratio of fat to carbohydrate oxidation as predictor of weight gain: study of 24-h RQ. Am J Physiol 1990, 259:E650-657.