Leptin-to-adiponectin, adiponectin-to-leptin ratios, and insulin are specific and sensitive markers associated with polycystic ovary syndrome: A case-control study from Bahrain

Metabolic Syndrome and Related Disorders

Volumn 10, Issue 2, 2012, Pages 98-102

  Golbahar, Jamal ^a   Das, Nagalla Mohan ^a   Al Ayadhi, Maha Adel ^a   Gumaa, Khalid ^a  

^a ARABIAN GULF UNIVERSITY   (Bahrain)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; CHOLESTEROL; INSULIN; LEPTIN; TRIACYLGLYCEROL;

ABNORMALLY HIGH SUBSTRATE CONCENTRATION IN BLOOD; ADOLESCENT; ADULT; ARTICLE; BAHRAIN; CASE CONTROL STUDY; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FEMALE; HUMAN; HYPERINSULINEMIA; HYPERLEPTINEMIA; HYPOADIPONECTINEMIA; INSULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT; OVARY POLYCYSTIC DISEASE; PREDICTION; PRIORITY JOURNAL; RISK FACTOR; SENSITIVITY AND SPECIFICITY; TRIACYLGLYCEROL BLOOD LEVEL;

ADIPONECTIN; ADOLESCENT; ADULT; BAHRAIN; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; DIAGNOSTIC TECHNIQUES, ENDOCRINE; FEMALE; HUMANS; INSULIN; LEPTIN; POLYCYSTIC OVARY SYNDROME; RISK FACTORS; SENSITIVITY AND SPECIFICITY; YOUNG ADULT;

EID: 84858853110     PISSN: 15404196     EISSN: 15578518     Source Type: Journal    
DOI: 10.1089/met.2011.0075     Document Type: Article

References (38)

1. Hopkinson ZE, Sattar N, Fleming R et al. Polycystic ovarian syndrome: The metabolic syndrome comes to gynaecology. BMJ 1998;317:329-332.
2. Balen A, Michelmore K. What is polycystic ovary syndrome? Are national views important? Hum Reprod 2002;17:2219-2227.
3. Azziz R, Woods KS, Reyna Ret al. The prevalence and features of the polycystic ovary syndrome in an unselected population. J Clin Endocrinol Metab 2004;89:2745-2749.
4. Koivunen R, Laatikainen T, Tomás C et al. The prevalence of polycystic ovaries in healthy women. Acta Obstet Gynecol Scand 1999;78:137-141.
5. Barber TM, McCarthy MI, Wass JA et al. Obesity and polycystic ovary syndrome. Clin Endocrinol 2006;65:137-145.
6. Azziz R. In: Current Concepts On Pathogenesis And Clinical Care. The Polycystic Ovary Syndrome, 2nd ed., vol. 5. Springer; 2007.
7. Motta DA. Metformin in the treatment of polycystic ovary syndrome. Curr Pharm Des 2008;14:2121-2125.
8. Mitchell M, Armstrong DT, Robker RL et al. Adipokines: Implications for female fertility and obesity. Reproduction 2005;130:583-597.
9. Panidis D, Kourtis A, Farmakiotis D et al. Serum adiponectin levels in women with polycystic ovary syndrome. Hum Reprod 2003;18:1790-1796.
10. Matsuzawa Y, Funahashi T, et al. Adiponectin and metabolic syndrome. Arterioscler Thromb Vasc Biol 2004; 24:29-33.
11. Huerta M. Adiponectin and leptin: Potential tools in the differential diagnosis of pediatric diabetes. Endocr Metabol Disord 2006;7:187-196.
12. Matsuda M, Shimomura I, Sata M et al. Role of adiponectin in preventing vascular stenosis: The missing link of adipovascular axis. J Biol Chem 2002;277:37487-37491.
13. Jung C-H, Rhee E-J, Choi J-H et al. The relationship of adiponectin/leptin ratio with homeostasis model assessment insulin resistance index and metabolic syndrome in apparently healthy Korean male adults. Korean Diabetes J 2010;34: 237-243.
14. Inoue M, Maehata E, Yano M et al. Correlation between the adiponectin-leptin ratio and parameters of insulin resistance in patients with type 2 diabetes. Metabolism 2005;54: 281-286.
15. Finucane FM, Luan J, Wareham NJ et al. European Group for the Study of Insulin Resistance: Relationship between Insulin Sensitivity and Cardiovascular Disease Risk Study Group, Savage DB. Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals. Diabetologia 2009;52:2345-2349.
16. Zaletel J, Barlovic DP, Prezelj J. Adiponectin-leptin ratio: A useful estimate of insulin resistance in patients with type 2 diabetes. J Endocrinol Invest 2010;33:514-518.
17. Norata GD, Raselli S, Grigore L et al. Leptin:adiponectin ratio is an independent predictor of intima-media thickness of the common carotid artery. Stroke 2007;38:2844-2846.
18. Mojiminiyi OA, Abdella NA, Al Arouj M et al. Adiponectin, insulin resistance and clinical expression of the metabolic syndrome in patients with type 2 diabetes. Int J Obes 2007; 31:213-220.
19. Tajtakova M, Petrasova D, Pidanicova A et al. Serum levels of leptin, adiponectin, retinol binding protein 4 and leptin/adiponectin molar ratio as another possible marker of insulin resistance in obese. Bratisl Lek Listy 2010;111:212-215.
20. Karakas M, Zierer A, Herder C et al. Leptin, adiponectin, their ratio and risk of Coronary Heart Disease: Results from the MONICA/KORA Augsburg Study 1984-2002. Atherosclerosis 2010;209:220-225.
21. Hall JI, Vora N, Langworthy R et al. Leptin/adiponectin ratio in patients with coronary heart disease: Comparing subjects with and without metabolic syndrome. Ann Clin Biochem 2011;48: 327-331.
22. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 2004;19:41-47.
23. Ferriman D, Gallwey J. Clinical assessment of body hair growth in women. J Clin Endocrinol Metab 1961;21:1440-1447.
24. Goodarzi MO, Dumesic DA, Chazenbalk G et al. Polycystic ovary syndrome: Etiology, pathogenesis and diagnosis. Nat Rev Endocrinol 2011;7:219-231.
25. Sangraula H, Paudel KR, Sharma M. Metformin and troglitazone in the treatment of female infertility associated with polycystic ovarian syndrome. J Nepal Med Assoc 2009;48:335-339.
26. Gray SL, Vidal-Puig AJ. Adipose tissue expandability in the maintenance of metabolic homeostasis. Nutr Rev 2007;65: S7-S12.
27. Remsberg KE, Talbott EO, Zborowski JV et al. Evidence for competing effects of body mass, hyperinsulinemia, insulin resistance, and androgens on leptin levels among lean, overweight, and obese women with polycystic ovary syndrome. Fertil Steril 2002;78:479-486.
28. Erel CT, Senturk LM, Kaleli S et al. Is serum leptin level regulated by thyroid functions, lipid metabolism and insulin resistance in polycystic ovary syndrome? Gynecol Endocrinol 2003;17:223-229.
29. Saleh HA, El-Nwaem MA, El-Bordiny MM et al. Serum leptin elevation in obese women with PCOs: A continuing controversy. J Assist Reprod Genet 2004;21:361-366.
30. Solin MS, Ball MJ, Robertson I et al. Relationship of serum leptin to total and truncal body fat. Clin Sci 1997; 93:581-584.
31. Sanchez-Rodriguez M, Garcia-Sanchez A, Retana-Ugalde R et al. Serum leptin levels and blood pressure in the overweight elderly. Arch Med Res 2000;31: 425-428.
32. Toulis KA, Goulis DG, Farmakiotis D et al. Adiponectin levels in women with polycystic ovary syndrome: A systematic review and a meta-analysis. Hum Reprod Update 2009;15:297-307.
33. Hotta K, Funahashi T, Arita Y et al. Plasma concentrations of a novel, adipose specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 2000;20:1595-1599.
34. Legro RS, Kunselman AR, Dunaif A. Prevalence and predictors of dyslipidemia in women with polycystic ovary syndrome. Am J Med 2001;111:607-613.
35. Berneis K, Rizzo M, Lazzarini V et al. Atherogenic lipoprotein phenotype and low-density lipoproteins size and subclasses in women with polycystic ovary syndrome. J Clin Endocrinol Metab 2007;92:186-189.
36. Lecke SB, Mattei F, Morsch DM et al. Abdominal subcutaneous fat gene expression and circulating levels of leptin and adiponectin in polycystic ovary syndrome. Fertil Steril 2011;95:2044-2049.
37. Moran LJ, Meyer C, Hutchison SK et al. Novel inflammatory markers in overweight women with and without polycystic ovary syndrome and following pharmacological intervention. J Endocrinol Invest 2010;33:258-265.
38. Kern PA, Di Gregorio GB, Lu T et al. Adiponectin expression from human adipose tissue relation to obesity, insulin resistance, and tumor necrosis factor-A expression. Diabetes 2003;52:1779-1785.