Pseudomonas aeruginosa cif defines a distinct class of α/ βepoxide hydrolases utilizing a his/tyr ring-opening pair

Protein and Peptide Letters

Volumn 19, Issue 2, 2012, Pages 186-193

  Bahl, Christopher D ^a   Madden, Dean R ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

; Cystic fibrosis; Dehalogenases; Enzyme mechanism; Epoxide hydrolases; Hydrolase phylogeny; Protein structure; Site directed mutagenesis; X ray crystallography

Indexed keywords

ALPHA EPOXIDE HYDROLASE; BETA EPOXIDE HYDROLASE; EPOXIDE HYDROLASE; EPOXIDE HYDROLASE CIF; HISTIDINE; TYROSINE; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

AMINO ACID SUBSTITUTION; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MECHANISM; GENE MUTATION; HYDROGEN BOND; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYLOGENY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; PSEUDOMONAS AERUGINOSA; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS;

BACTERIAL PROTEINS; CATALYTIC DOMAIN; ENZYME ACTIVATION; EPOXIDE HYDROLASES; HISTIDINE; HYDROLYSIS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PSEUDOMONAS AERUGINOSA; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE; VIRULENCE FACTORS;

NEGIBACTERIA; PSEUDOMONAS AERUGINOSA;

EID: 84858830632     PISSN: 09298665     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986612799080392     Document Type: Article

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