Diverse Roles of G-Protein Coupled Receptors in the Regulation of Neurohypophyseal Hormone Secretion

Journal of Neuroendocrinology

Volumn 24, Issue 4, 2012, Pages 554-565

  Sladek, C D ^a   Song, Z ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Adrenergic; Angiotensin; Neurokinin; Oxytocin; Purinergic; Supraoptic nucleus; Vasopressin

Indexed keywords

4 AMINOBUTYRIC ACID; ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR; ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN RECEPTOR; ESTROGEN RECEPTOR; G PROTEIN COUPLED RECEPTOR; NEUROKININ; NEUROKININ 1 RECEPTOR; NEUROKININ 2 RECEPTOR; NEUROKININ 3 RECEPTOR; NEUROTRANSMITTER; NORADRENALIN; OXYTOCIN; POTASSIUM CHANNEL; PURINERGIC P2X RECEPTOR; PURINERGIC RECEPTOR; TANDEM PORE DOMAIN POTASSIUM CHANNEL; VASOPRESSIN;

HORMONE RELEASE; HUMAN; MAGNOCELLULAR NUCLEUS; NERVE CELL MEMBRANE POTENTIAL; NEUROHYPOPHYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; MODELS, BIOLOGICAL; NEURONS; OXYTOCIN; RECEPTORS, ADRENERGIC; RECEPTORS, ANGIOTENSIN; RECEPTORS, PURINERGIC; RECEPTORS, TACHYKININ; SUPRAOPTIC NUCLEUS; VASOPRESSINS;

EID: 84858829202     PISSN: 09538194     EISSN: 13652826     Source Type: Journal    
DOI: 10.1111/j.1365-2826.2011.02268.x     Document Type: Review

References (114)

1. Cunningham ET Jr, Sawchenko PE. Reflex control of magnocellular vasopressin and oxytocin secretion. Trends Neurosci 1991; 14: 406-411.
2. Cunningham JT, Nissen R, Renaud LP. Catecholamine depletion of the diagonal band reduces baroreflex inhibition of supraoptic neurons. Am J Physiol 1992; 263: R363-R367.
3. Cunningham JT, Nissen R, Renaud LP. Perinuclear zone and diagonal band lesions enhance angiotensin responses of rat supraoptic neurons. Am J Physiol 1994; 267: R916-R922.
4. Grindstaff RJ, Grindstaff RR, Sullivan MJ, Cunningham JT. Role of the locus ceruleus in baroreceptor regulation of supraoptic vasopressin neurons in the rat. Am J Physiol Regul Integr Comp Physiol 2000; 279: R306-R319.
5. Day TA, Sibbald JR. Solitary nucleus excitation of supraoptic vasopressin cells via adrenergic afferents. Am J Physiol 1989; 254: R711-R714.
6. Day TA, Sibbald JR. A1 cell group mediates solitary nucleus excitation of supraoptic vasopressin cells. Am J Physiology 1989; 257: R1020-R1026.
7. Day TA, Renaud LP, Sibbald JR. Excitation of supraoptic vasopressin cells by stimulation of the A1 noradrenaline cell group: failure to demonstrate role for established adrenergic or amino acid receptors. Brain Res 1990; 516: 91-98.
8. Day TA, Sibbald JR. Involvement of the A1 cell group in baroreceptor inhibition of neurosecretory vasopressin cells. Neurosci Lett 1990; 113: 156-162.
9. Day TA, Sibbald JR, Smith DW. A1 neurons and excitatory amino acid receptors in rat caudal medulla mediate vagal excitation of supraoptic vasopressin cells. Brain Res 1992; 594: 244-252.
10. Day TA, Sibbald JR, Khanna S. ATP mediates an excitatory noradrenergic neuron input to supraoptic vasopressin cells. Brain Res 1993; 607: 341-344.
11. Russell JA, Leng G, Douglas AJ. The magnocellular oxytocin system, the fount of maternity: adaptations in pregnancy. Front Neuroendocrinol 2003; 24: 27-61.
12. Decavel C, Van den Pol AN. GABA: a dominant neurotransmitter in the hypothalamus. J Comp Neurol 1990; 302: 1019-1037.
13. Van den Pol AN, Waurin JP, Dudek FE. Glutamate, the dominant excitatory transmitter in neuroendocrine regulation. Science 1990; 250: 1276-1278.
14. Wang YF, Hatton GI. Dominant role of betagamma subunits of G-proteins in oxytocin-evoked burst firing. J Neurosci 2007; 27: 1902-1912.
15. Hazell GG, Hindmarch CC, Pope GR, Roper JA, Lightman SL, Murphy D, O'Carroll AM, Lolait SJ. G protein-coupled receptors in the hypothalamic paraventricular and supraoptic nuclei - serpentine gateways to neuroendocrine homeostasis. Front Neuroendocrinol 2011; Jul 23. [Epub ahead of print].
16. Armstrong WE, Sladek CD, Sladek JR Jr. Characterization of noradrenergic control of vasopressin release by the organ-cultured rat hypothalamo-neurohypophyseal system. Endocrinology 1982; 111: 273-279.
17. Day TA, Ferguson AV, Renaud LP. Facilitatory influence of noradrenergic afferents on the excitability of rat paraventricular nucleus neurosecretory cells. J Physiol (Lond) 1984; 355: 237-249.
18. Day TA, Randle JCR, Renaud LP. Opposing alpha- and beta-adrenergic mechanisms mediate dose-dependent actions of noradrenaline on supraoptic vasopressin neurones in vivo. Brain Res 1985; 358: 171-179.
19. Day TA, Renaud LP. Electrophysical evidence that noradrenergic afferents selectively facilitate the activity of supraoptic vasopressin neurons. Brain Res 1984; 303: 233-240.
20. Randle JCR, Borque CW, Renaud LP. Alpha 1-adrenergic receptor activation depolarizes rat supraoptic neurosecretory neurons in vitro. Am J Physiol Regul Integr Comp Physiol 1986; 251: R569-R574.
21. Randle JCR, Mazurek M, Kneifel D, Dufresne J, Renaud LP. Alpha-1-receptor activation releases vasopressin and oxytocin from perfused rat hypothalamic explants. NeurosciLett 1986; 65: 219-223.
22. Sladek CD, Yagil C. Diverse effects of norepinephrine on vasopressin release may reflect modulation by hypotonicity. J Neuroendocrinol 1990; 2: 363-367.
23. Armstrong WE, Gallagher MJ, Sladek CD. Noradrenergic stimulation of supraoptic neuronal activity and vasopressin release in vitro: mediation by a alpha-1-receptor. Brain Res 1986; 365: 192-197.
24. Kapoor JR, Sladek CD. Purinergic and adrenergic agonists synergize in stimulating vasopressin and oxytocin release. J Neurosci 2000; 20: 8868-8875.
25. Buller KM, Khanna S, Sibbald JR, Day TA. Central noradrenergic neurons signal via ATP to elicit vasopressin response to haemorrhage. Neuroscience 1996; 73: 637-642.
26. 3H]noradrenaline from rat hypothalamic slices: origin and modulation by α2-adrenoceptors. Neuroscience 1998; 82: 511-520.
27. Gomes DA, Song Z, Stevens W, Sladek CD. Sustained stimulation of vasopressin and oxytocin release by ATP and phenylephrine requires recruitment of desensitization resistant P2X purinergic receptors. Am J Physiol Regu Integr Comp 2009; 297: R940-R949.
28. North RA. Molecular physiology of P2X receptors. Physiol Rev 2002; 82: 1013-1067.
29. Song Z, Vijayaraghavan S, Sladek CD. Simultaneous exposure to ATP and phenylephrine induces a sustained elevation in the intracellular calcium concentration in supraoptic neurons. Am J Physiol Regul Integr Comp Physiol 2006; 291: R37-R45.
30. Gordon GRJ, Baimoukhametova DV, Hewitt SA, Kosala WRA, Rajapaksha JS, Fisher TE, Bains JS. Norepinephrine triggers release of glial ATP to increase postsynaptic efficacy. Nat Neurosci 2005; 8: 1078-1086.
31. 1D adrenergic receptor messenger RNA in oxytocin- and corticotropin-releasing hormone-synthesizing neurons in the rat paraventricular nucleus. Neuroscience 1999; 91: 639-649.
32. Acosta-Martinez M, Fiber JM, Brown RD, Etgen AM. Localization of alpha1B-adrenergic receptor in female rat brain regions involved in stress and neuroendocrine function. Neurochem Int 1999; 35: 383-391.
33. Song Z, Gomes DA, Stevens W, Sladek CD. Multiple alpha1-adrenergic receptor subtypes support synergistic stimulation of vasopressin and oxytocin release by ATP and phenylephrine. Am J Physiol Regul Integr Comp Physiol 2010; 299: R1529-R1537.
34. Song Z, Vijayaraghavan S, Sladek CD. ATP increases intracellular calcium in supraoptic neurons by activation of both P2X and P2Y purinergic receptors. Am J Physiol Regul Integr Comp Physiol 2007; 292: R423-R431.
35. von Kugelgen I. Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol Ther 2006; 110: 415-432.
36. Song Z, Gomes DA, Stevens W. Role of purinergic P2Y1 receptors in regulation of vasopressin and oxytocin secretion. Am J Physiol Regul Integr Comp Physiol 2009; 297: R478-R484.
37. Lakshmi S, Joshi PG. Co-activation of P2Y2 receptor and TRPV channel by ATP: implications for ATP induced pain. Cell Mol Neurobiol 2005; 25: 819-832.
38. Sharif Naeini R, Witty MF, Seguela P, Bourque CW. An N-terminal variant of Trpv1 channel is required for osmosensory transduction. Nat Neurosci 2006; 9: 93-98.
39. Chakfe Y, Bourque CW. Excitatory peptides and osmotic pressure modulate mechanosensitive cation channels in concert. Nat Neurosci 2000; 3: 572-579.
40. Chakfe Y, Bourque CW. Peptidergic excitation of supraoptic nucleus neurons: involvement of stretch-inactivated cation channels. Exp Neurol 2001; 171: 210-218.
41. Kukkonen JP. A menage a trois made in heaven: G-protein-coupled receptors, lipids and TRP channels. Cell Calcium 2011; 50: 9-26.
42. Sladek CD, Blair ML, Ramsay DJ. Further studies on the role of angiotensin in the osmotic control of vasopressin release by the organ cultured rat hypothalamo-neurohypophyseal system. Endocrinology 1982; 111: 599-607.
43. Sladek CD, Joynt RJ. Role of angiotensin in the osmotic control of vasopressin release by the organ-cultured rat hypothalamo-neurohypophyseal system. Endocrinology 1980; 106: 173-178.
44. Mori M, Tsushima H, Matsuda T. Substance P injected into the hypothalamic supraoptic nucleus causes antidiuresis through the release of arginine-vasopressin in water-loaded and ethanol-anesthetized rats. Jpn J Pharmacol 1993; 62: 49-56.
45. Eguchi T, Takano Y, Hatae T, Saito R, Nakayama Y, Shigeyoshi Y, Okamura H, Krause JE, Kamiya H. Antidiuretic action of tachykinin NK-3 receptor in the rat paraventricular nucleus. Brain Res 1996; 743: 49-55.
46. Nakajima Y, Tsuchida K, Negishi M, Ito S, Nakanishi S. Direct linkage of three tachykinin receptors to stimulation of both phosphatidylinositol hydrolysis and cyclic AMP cascades in transfected Chinese hamster ovary cells. J Biol Chem 1992; 267: 2437-2442.
47. Kapoor JR, Sladek CD. Substance P and NPY differentially potentiate ATP and adrenergic stimulated vasopressin and oxytocin release. Am J Physiol Regul Integr Comp Physiol 2001; 280: R69-R78.
48. Hay DWP, Giardina GAM, Griswold DE, Underwood DC, Kotzer C, Bush B, Potts W, Sandhu P, Lundberg D, Foley JJ, Schmidt DB, Martin LD, Kilian D, Legos JJ, Barone FC, Luttmann MA, Grugni M, Raveglia LF, Sarau HM. Nonpeptide tachykinin receptor antagonists. III. SB 235375, a low central nervous system-penetrant, potent and selective neurokinin-3 receptor antagonist, inhibits citric acid-induced cough and airways hyper-reactivity in guinea pigs. J Pharmacol Exp Ther 2002; 300: 314-323.
49. Howe HE, Somponpun SJ, Sladek CD. Role of neurokinin 3 receptors in supraoptic vasopressin and oxytocin neurons. J Neurosci 2004; 24: 10103-10110.
50. Sladek CD, Fisher KY, Sidorowicz HE, Mathiasen JR. cAMP regulation of vasopressin mRNA content in hypothalamo-neurohypophyseal explants. Am J Physiology 1996; 271: R554-R560.
51. Morales D, Madigan J, Cullinane S, Chen J, Heath M, Oz M, Oliver JA, Landry DW. Reversal by vasopressin of intractable hypotension in the late phase of hemorrhagic shock. Circulation 1999; 100: 226-229.
52. Katz FH, Smith JA, Lock JP, Loeffel DE. Plasma vasopressin variation and renin activity in normal active humans. Horm Res 1979; 10: 289-302.
53. Sakamoto H, Matsuda K, Hosokawa K, Nishi M, Morris JF, Prossnitz ER, Kawata M. Expression of G protein-coupled receptor-30, a G protein-coupled membrane estrogen receptor, in oxytocin neurons of the rat paraventricular and supraoptic nuclei. Endocrinology 2007; 148: 5842-5850.
54. Somponpun S, Sladek CD. Role of estrogen receptor β in regulation of vasopressin and oxytocin release in vitro. Endocrinology 2002; 143: 2899-2904.
55. Smith KL, Patterson M, Dhillo WS, Patel SR, Semjonous NM, Gardiner JV, Ghatei MA, Bloom SR. Neuropeptide S stimulates the hypothalamo-pituitary-adrenal axis and inhibits food intake. Endocrinology 2006; 147: 3510-3518.
56. de Gasparo M, Catt KJ, Inagami T, Wright JW, Unger T. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev 2000; 52: 415-472.
57. Sladek CD, Joynt RJ. Angiotensin stimulation of vasopressin release from the rat hypothalamo-neurohypophyseal system in organ culture. Endocrinology 1979; 104: 148-153.
58. Okuya S, Inenaga K, Kaneko T, Yamashita H. Angiotensin II sensitive neurons in the supraoptic nucleus, subfornical organ and anteroventral third ventricle of rats in vitro. Brain Res 1987; 402: 58-67.
59. Roper P, Callaway J, Shevchenko T, Teruyama R, Armstrong W. AHP's, HAP's and DAP's: how potassium currents regulate the excitability of rat supraoptic neurones. J Comput Neurosci 2003; 15: 367-389.
60. + channel in brain neurons. J Neurophysiol 1996; 76: 2131-2136.
61. Luscher C, Slesinger PA. Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease. Nat Rev Neurosci 2010; 11: 301-315.
62. + channels. Cell Signal 1997; 9: 551-573.
63. Yamada M, Inanobe A, Kurachi Y. G protein regulation of potassium ion channels. Pharmacol Rev 1998; 50: 723-760.
64. Osborne PB, Vidovic M, Chieng B, Hill CE, Christie MJ. Expression of mRNA and functional alpha(1)-adrenoceptors that suppress the GIRK conductance in adult rat locus coeruleus neurons. Br J Pharmacol 2002; 135: 226-232.
65. Schrader LA, Tasker JG. Modulation of multiple potassium currents by metabotropic glutamate receptors in neurons of the hypothalamic supraoptic nucleus. J Neurophysiol 1997; 78: 3428-3437.
66. + channels GIRK1 and GIRK2 mRNAs in the supraoptic nucleus of the rat and possible role involved. Neuroreport 2001; 12: 1007-1010.
67. Saenz del Burgo L, Cortes R, Mengod G, Zarate J, Echevarria E, Salles J. Distribution and neurochemical characterization of neurons expressing GIRK channels in the rat brain. J Comp Neurol 2008; 510: 581-606.
68. Koike-Tani M, Collins JM, Kawano T, Zhao P, Zhao Q, Kozasa T, Nakajima S, Nakajima Y. Signal transduction pathway for the substance P-induced inhibition of rat Kir3 (GIRK) channel. J Physiol 2005; 564: 489-500.
69. Kawano T, Zhao P, Floreani CV, Nakajima Y, Kozasa T, Nakajima S. Interaction of Galphaq and Kir3, G protein-coupled inwardly rectifying potassium channels. Mol Pharmacol 2007; 71: 1179-1184.
70. Song Z, Sladek CD. Angiotensin II induced increase in intracellular calcium in supraoptic nucleus neurons. VIIth World Congress on Neurohypophyseal Hormones, Regensburg, Germany (Abstract) 2007.
71. + channel, is modulated by multiple neurotransmitters in motoneurons. Neuron 2000; 25: 399-410.
72. + channels in magnocellular neurosecretory cells of the supraoptic nucleus. J Physiol (Lond) 2003; 546: 625-639.
73. Haley GE, Flynn FW. Agonist and hypertonic saline-induced trafficking of the NK3-receptors on vasopressin neurons within the paraventricular nucleus of the hypothalamus. Am J Physiol Regul Integr Comp Physiol 2006; 290: R1242-R1250.
74. Jensen DD, Sundstrom K, Flynn FW. Expression of the nuclear transport protein importin ss-1 and its association with the neurokinin 3 receptor in the rat hypothalamus following acute hyperosmotic challenge. Neuroscience 2010; 170: 1020-1027.
75. Takahashi K, Tanaka A, Hara M, Nakanishi S. The primary structure and gene organization of human substance P and neuromedin K receptors. Eur J Biochem 1992; 204: 1024-1033.
76. Takeda Y, Chou KB, Takeda J, Sachais BS, Krause JE. Molecular cloning, structural characterization and functional expression of the human substance P receptor. Biochem Biophys Res Commun 1991; 179: 1232-1240.
77. Sladek CD, Stevens W, Levinson SR, Song Z, Jensen DD, Flynn FW. Characterization of nuclear neurokinin 3 receptor expression in rat brain. Neuroscience 2011; 196: 35-48.
78. Somponpun SJ, Johnson AK, Beltz T, Sladek CD. Estrogen receptor-alpha expression in osmosensitive elements of the lamina terminalis: regulation by hypertonicity. Am J Physiol Regul Integr Comp Physiol 2004; 287: R661-R669.
79. Somponpun SJ, Sladek CD. Osmotic regulation of estrogen receptor-β in rat vasopressin and oxytocin neurons. J Neurosci 2003; 23: 4261-4269.
80. Flynn FW, Jensen DD, Thakar A, Xu X, Flynn SW, Zhang Z. Neurokinin 3 receptor forms a complex with acetylated histone H3 and H4 in hypothalamic neurons following hyperosmotic challenge. Am J Physiol Regul Integr Comp Physiol 2011; 301: R822-R831.
81. Allfrey VG, Faulkner R, Mirsky AE. Acetylation and methylation of histones and their possible role in the regulation of RNA synthesis. Proc Natl Acad Sci USA 1964; 51: 786-794.
82. Hebbes TR, Thorne AW, Crane-Robinson C. A direct link between core histone acetylation and transcriptionally active chromatin. EMBO J 1988; 7: 1395-1402.
83. Levesque M, Parent R, Parent A. Cellular and subcellular localization of neurokinin-1 and neurokinin-3 receptors in primate globus pallidus. Eur J Neurosci 2006; 23: 2760-2772.
84. Lessard A, Grady EF, Bunnett NW, Pickel VM. Predominant surface distribution of neurokinin-3 receptors in non-dopaminergic dendrites in the rat substantia nigra and ventral tegmental area. Neuroscience 2007; 144: 1393-1408.
85. Lessard A, Savard M, Gobeil F Jr, Pierce JP, Pickel VM. The neurokinin-3 (NK3) and the neurokinin-1 (NK1) receptors are differentially targeted to mesocortical and mesolimbic projection neurons and to neuronal nuclei in the rat ventral tegmental area. Synapse 2009; 63: 484-501.
86. 1) receptor in brain neurons. Endocrinology 1998; 139: 365-375.
87. Kinsey CG, Bussolati G, Bosco M, Kimura T, Pizzorno MD, Chernin MI, Cassoni P, Novak JF. Constitutive and ligand-induced nuclear localization of oxytocin receptor. J Cell Mol Med 2007; 11: 96-110.
88. Thomas WG, Qian H, Smith NJ. When 6 is 9: 'uncoupled' AT1 receptors turn signalling on its head. Cell Mol Life Sci 2004; 61: 2687-2694.
89. Pin J-P, Duvoisin R. Review: neurotransmitter receptors I. The metabotropic glutamate receptors: structure and functions. Neuropharmacology 1995; 34: 1-26.
90. Morsette DJ, Sidorowicz HE, Sladek CD. Role of metabotropic glutamate receptors in the regulation of vasopressin and oxytocin release from the rat hypothalamo-neurohypophyseal explants. Am J Physiol Regul Integr Comp Physiol 2001; 281: R452-R458.
91. B receptors in magnocellular neurosecretory cells of male, virgin female and lactating rats. J Neuroendocrinol 2005; 17: 413-423.
92. Xu J, Wojcik WJ. Gamma aminobutyric acid B receptor-mediated inhibition of adenylate cyclase in cultured cerebellar granule cells: blockade by islet-activating protein. J Pharmacol Exp Ther 1986; 239: 568-573.
93. Harayama N, Shibuya I, Tanaka K, Kabashima N, Ueta Y, Yamashita H. Inhibition of N- and P/Q-type calcium channels by postsynaptic GABAB receptor activation in rat supraoptic neurones. J Physiol 1998; 509: 371-383.
94. B receptors modulate the firing activity of supraoptic oxytocin and vasopressin neurones: role of calcium channels. J Neuroendocrinol 2004; 16: 119-130.
95. + conductance. J Physiol 2003; 551: 295-308.
96. Sladek CD, Armstrong WE. GABA antagonists stimulate vasopressin release from organ-cultured hypothalamo-neurohypophyseal explants. Endocrinology 1987; 120: 1576-1580.
97. Kim JS, Kim WB, Kim YB, Lee Y, Kim YS, Shen FY, Lee SW, Park D, Choi HJ, Hur J, Park JJ, Han HC, Colwell CS, Cho YW, Kim YI. Chronic hyperosmotic stress converts GABAergic inhibition into excitation in vasopressin and oxytocin neurons in the rat. J Neurosci 2011; 31: 13312-13322.
98. Orr-Urtreger A, Goldner FM, Saeki M, Lorenzo I, Goldberg L, DeBiasi M, Dani JA, Patrick JW, Beaudet AL. Mice deficient in the α7 neuronal nicotinic acetylcholine receptor lack α-bungarotoxin binding sites and hippocampal fast nicotinic currents. J Neurosci 1997; 17: 9166-9171.
99. Drisdel RC, Green WN. Neuronal α-bungarotoxin receptors are α7 subunit homomers. J Neurosci 2000; 20: 133-139.
100. 3H]alpha-bungarotoxin distribution in the rat brain after intraventricular injection. J Cell Biol 1976; 71: 956-963.
101. Segal M, Dudai Y, Amsterdam A. Distribution of an alpha-bungarotoxin-binding cholinergic nicotinic receptor in rat brain. Brain Res 1978; 148: 105-119.
102. Sladek CD, Knigge KM. Cholinergic stimulation of vasopressin release from the rat hypothalamo-neurohypophyseal system in organ culture. Endocrinology 1977; 101: 411-420.
103. Sladek CD, Joynt RJ. Characterization of cholinergic control of vasopressin release by the organ-cutured rat hypothalamo-neurohypophyseal system. Endocrinology 1979; 104: 659-663.
104. Ghamari-Langroudi M, Bourque CW. Muscarinic receptor modulation of slow afterhyperpolarization and phasic firing in rat supraoptic nucleus neurons. J Neurosci 2004; 24: 7718-7726.
105. Ellis LD, Krahe R, Bourque CW, Dunn RJ, Chacron MJ. Muscarinic receptors control frequency tuning through the downregulation of an A-type potassium current. J Neurophysiol 2007; 98: 1526-1537.
106. Stricker EM, Verbalis JG. Interaction of osmotic and volume stimuli in regulation of neurohypophyseal secretion in rats. Am J Physiology 1986; 250: R267-R275.
107. Dunn FL, Brennan TJ, Nelson AE, Robertson GL. The role of blood osmolarity and volume in regulating vasopressin secretion in the rat. J Clin Invest 1973; 52: 3212-3219.
108. Schrier RW. Water and sodium retention in edematous disorders: role of vasopressin and aldosterone. Am J Med 2006; 119: S47-S53.
109. Verbalis JG. Renal function and vasopressin during marathon running. Sports Med 2007; 37: 455-458.
110. Barnett-Norris J, Lynch D, Reggio PH. Lipids, lipid rafts and caveolae: their importance for GPCR signaling and their centrality to the endocannabinoid system. Life Sci 2005; 77: 1625-1639.
111. Prinster SC, Hague C, Hall RA. Heterodimerization of g protein-coupled receptors: specificity and functional significance. Pharmacol Rev 2005; 57: 289-298.
112. Ferre S, Ciruela F, Woods AS, Lluis C, Franco R. Functional relevance of neurotransmitter receptor heteromers in the central nervous system. Trends Neurosci 2007; 30: 440-446.
113. Franco R, Casado V, Cortes A, Mallol J, Ciruela F, Ferre S, Lluis C, Canela EI. G-protein-coupled receptor heteromers: function and ligand pharmacology. Br J Pharmacol 2008; 153(Suppl. 1): S90-S98.
114. Gordon GR, Bains JS. Noradrenaline triggers multivesicular release at glutamatergic synapses in the hypothalamus. J Neurosci 2005; 25: 11385-11395.