Baclofen inhibits guinea pig magnocellular neurones via activation of an inwardly rectifying K+ conductance

Journal of Physiology

Volumn 551, Issue 1, 2003, Pages 295-308

  Slugg, Robert M ^a   Zheng, Shi Xi ^a   Fang, Yuan ^a   Kelly, Martin J ^a,b   Rønnekleiv, Oline K ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; BACLOFEN; BIOCYTIN; INWARDLY RECTIFYING POTASSIUM CHANNEL; POTASSIUM ION; TETRODOTOXIN; VASOPRESSIN; VASOPRESSIN RECEPTOR; NEUROPHYSIN;

ANIMAL TISSUE; CONTROLLED STUDY; FEMALE; GENE SEQUENCE; GENETIC LINKAGE; GIANT CELL; GUINEA PIG; HYPERPOLARIZATION; HYPOTHALAMUS; IMMUNOCYTOCHEMISTRY; IN SITU HYBRIDIZATION; INTRACELLULAR RECORDING; MALE; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; POTASSIUM CONDUCTANCE; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVIEW; SIGNAL TRANSDUCTION; SUPRAOPTIC NUCLEUS; THALAMUS MIDLINE NUCLEUS; VOLTAGE CLAMP; ACTION POTENTIAL; ANIMAL CELL; ANTERIOR HYPOTHALAMUS; ARTICLE; ELECTROPHYSIOLOGY; ENZYME ACTIVATION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MAGNOCELLULAR NUCLEUS; MEMBRANE CONDUCTANCE; MEMBRANE POTENTIAL; MEMBRANE STEADY POTENTIAL; MORPHOLOGY; NEUROMODULATION; OPTIC CHIASM; OXYGENATION; PARAVENTRICULAR THALAMIC NUCLEUS; PREOPTIC AREA;

ANIMALS; BACLOFEN; ELECTROPHYSIOLOGY; FEMALE; GABA AGONISTS; GABA ANTAGONISTS; GUINEA PIGS; IMMUNOHISTOCHEMISTRY; MALE; NEURAL INHIBITION; NEURONS; ORGANOPHOSPHORUS COMPOUNDS; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RECEPTORS, GABA-B; RNA, MESSENGER; SUPRAOPTIC NUCLEUS;

EID: 0041854176     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2003.041319     Document Type: Review

References (53)

1. Beck SG, Birnstiel S, Pouliot WA & Choi KC (1995). Baclofen concentration-response curves differ between hippocampal subfields. Neuroreport 6, 310-312.
2. Boudaba C, Szabó K & Tasker JG (1996). Physiological mapping of local inhibitory inputs to the hypothalamic paraventricular nucleus. J Neurosci 16, 7151-7160.
3. Bourque CW (1998). Osmoregulation of vasopressin neurons: A synergy of intrinsic and synaptic processes. Prog Brain Res 119, 59-76.
4. Bourque CW & Renaud LP (1990). Electrophysiology of mammalian magnocellular vasopressin and oxytocin neurosecretory neurones. Front Neuroendocrinol 11, 183-212.
5. B receptor agonists in mid-brain periaqueductal gray neurones in vitro. Br J Pharmacol 116, 1583-1588.
6. B-receptors increase the same potassium conductance in rat lateral parabrachial neurones. Br J Pharmacol 95, 896-902.
7. Clark JA, Mezey E, Lam AS & Bonner TI (2000). Distribution of the GABA(B) receptor subunit gb2 in rat CNS. Brain Res 860, 41-52.
8. Crowley WR & Armstrong WE (1992). Neurochemical regulation of oxytocin secretion in lactation. Endocr Rev 13, 33-65.
9. Cui LN, Coderre E & Renaud LP (2000). GABA(B) presynaptically modulates suprachiasmatic input to hypothalamic paraventricular magnocellular neurones. Am J Physiol Regul Integr Comp Physiol 278, R1210-1216.
10. Decavel C & Van den Pol AN (1992). Converging GABA- and glutamate-immunoreactive axons make synaptic contact with identified hypothalamic neurosecretory neurones. J Comp Neurol 316, 104-116.
11. h) in immunocytochemically identified vasopressin and oxytocin neurones of guinea-pig supraoptic nucleus. J Neuroendocrinol 2, 261-265.
12. Erickson KR, Rønnekleiv OK & Kelly MJ (1993a). Electrophysiology of guinea-pig supraoptic neurones. Role of a hyperpolarization-activated cation current in phasic firing. J Physiol 460, 407-425.
13. Erickson KR, Rønnekleiv OK & Kelly MJ (1993b). Role of a T-type calcium current in supporting a depolarizing potential, damped oscillations, and phasic firing in vasopressinergic guinea pig supraoptic neurones. Neuroendocrinology 57, 789-800.
14. Fang Y & Rønnekleiv OK (1999). Cocaine upregulates the dopamine transporter in fetal rhesus monkey brain. J Neurosci 19, 8966-8978.
15. Ghamari-Langroudi M & Bourque CW (2000). Excitatory role of the hyperpolarization-activated inward current in phasic and tonic firing of rat supraoptic neurones. J Neurosci 20, 4855-4863.
16. Gribkoff VK & Dudek FE (1990). Effects of excitatory amino acid antagonists on synaptic responses of supraoptic neurones in slices of rat hypothalamus. J Neurophysiol 63, 60-71.
17. B receptor activation in rat supraoptic neurones. J Physiol 509, 371-383.
18. Hermes MLHJ, Ruijter JM, Klop A, Buijs RM & Renaud LP (2000). Vasopressin increases GABAergic inhibition of rat hypothalamic paraventricular nucleus neurones in vitro. J Neurophysiol 83, 705-711.
19. Hille B (2001). Potassium channels and chloride channels. In Ionic Channels of Excitable Membranes, ed. Hille B, pp. 131-162. Sinauer, Massachusetts.
20. B receptor-mediated inhibition of spontaneous action potential discharge in rat supraoptic neurones in vitro. Brain Res 813, 88-96.
21. Jhamandas JH & Renaud LP (1987). Bicuculline blocks an inhibitory baroreflex input to supraoptic vasopressin neurones. Am J Physiol 252, R947-952.
22. Jourdain P, Poulain DA, Theodosis DT & Israel JM (1996). Electrical properties of oxytocin neurons in organotypic cultures from postnatal rat hypothalamus. J Neurophysiol 76, 2772-2785.
23. B receptors on rat supraoptic magnocellular neurones. J Physiol 504, 113-126.
24. B-receptor subtypes assemble into functional heteromeric complexes. Nature 396, 683-687.
25. + channels. Neurobiol 95, 14991-14996.
26. B receptors modulate organum vasculosum lamina terminalis-evoked postsynaptic currents in rat hypothalamic supraoptic neurones. Neurosciencc 98, 129-133.
27. B receptors presynaptically modulate excitatory synaptic transmission in the rat supraoptic nucleus in vitro. J Neurophysiol 76, 1166-1179.
28. B response in hypothalamic neurones. Neuroendocrinology 64, 114-123.
29. Legendre P & Poulain DA (1992). Intrinsic mechanisms involved in the electrophysiological properties of the vasopressin-releasing neurones of the hypothalamus. Prog Neurobiol 38, 1-17.
30. B and μ-opioid receptor agonists. Evidence for convergence at a ligand-gated potassium conductance. Neuroendocrinology 54, 537-544.
31. Lu XY, Ghasemzadeh MB & Kalivas PW (1999). Regional distribution and cellular localization of gamma-aminobutyric acid subtype 1 receptor mRNA in the rat brain. J Comp Neurol 407, 166-182.
32. Luckman SM, Antonijevic I, Leng G, Dye S, Douglas AJ, Russell JA & Bicknell RJ (1994). The maintenance of normal parturition in the rat requires neurohypophysial oxytocin. J Neuroendocrinol 5, 7-12.
33. B receptors inhibits evoked IPSCs in rat magnocellular neurons in vitro. J Neurophysiol 79, 1508-1517.
34. Poulain DA & Wakerley JB (1982). Electrophysiology of hypothalamic magnocellular neurones secreting oxytocin and vasopressin. Neurosci 7, 773-808.
35. Pumford KM, Russell JA & Leng G (1993). Effects of the selective kappa-opioid agonist U50,488 upon the electrical activity of supraoptic neurones in morphine-tolerant and morphine-naive rats. Exp Brain Res 94, 237-246.
36. Randle JCR & Renaud LP (1987). Actions of γ-aminobutyric acid on rat supraoptic nucleus neurosecretory neurones in vitro. J Physiol 387, 629-647.
37. Renaud LP (1987). Magnocellular neuroendocrine neurones, update on intrinsic properties, synaptic inputs and neuropharmacology. Trends Neurosci 10, 498-502.
38. Richard D & Bourque CW (1995). Synaptic control of rat supraoptic neurones during osmotic stimulation of the organum vasculosum lamina terminalis in vitro. J Physiol 489, 567-577.
39. Roland BL & Sawchenko PE (1993). Local origins of some GABAergic projections to the paraventricular and supraoptic nuclei of the hypothalamus in the rat. J Comp Neurol 332, 123-143.
40. Rønnekleiv OK, Loose MD, Erickson KR & Kelly MJ (1990). A method for immunocytochemical identification of biocytin-labeled neurones following intracellular recording. Biotechniques 9, 432-438.
41. Russell JA, Leng G & Bicknell RJ (1995). Opioid tolerance and dependence in the magnocellular oxytocin system. A physiological mechanism. Exp Physiol 80, 307-340.
42. 1 receptors regulate synaptic transmission to rat substantia nigra reticulata neurones. J Physiol 505, 153-163.
43. + conductance in guinea pig paraventricular nucleus neurones. Abstr Soc Neurosci 26, 1946.
44. + conductance. Abstr Soc Neurosci 25, 702.
45. + conductance by orphanin-FQ/nociceptin in vasopressin-containing neurones. Neuroendocrinology 69, 385-396.
46. Stern JE, Li Y & Richards DS (2002) Post synaptic GABA(B) receptors in supraoptic oxytocin and vasopressin neurons. Prog Brain Res 139, 121-125.
47. Tasker JG, Boudaba C & Schrader LA (1998). Local glutamatergic and GABAergic synaptic circuits and metabotropic glutamate receptors in the hypothalamic paraventricular and supraoptic nuclei. Adv Exp Med Biol 449, 117-121.
48. B receptor-mediated inhibition of GABAergic neurones in the arcuate nucleus. Neuroreport 10, 2681-2687.
49. Wakerley JB & Lincoln DW (1973). The milk-ejection reflex of the rat, a 20- to 40-fold acceleration in the firing of paraventricular neurones during oxytocin release. J Endocrinol 57, 477-493.
50. White JH, Wise A, Main MJ, Green A, Fraser NJ, Disney GH, Barnes AA, Emson P, Foord SM & Marshall FH (1998). Heterodimerization is required for the formation of a functional GABAB receptor. Nature 396, 679-682.
51. Williams JT, Colmers WF & Pan ZZ (1988a). Voltage- and ligand-activated inwardly rectifying currents in dorsal raphe neurones in vitro. J Neurosci 8, 3499-3506.
52. Williams JT, North RA & Tokimasa T (1988b). Inward rectification of resting and opiate-activated potassium currents in rat locus coeruleus neurones. J Neurosci 8, 4299-4306.
53. Yang CR, Senatorov VV & Renaud LP (1994). Organum vasculosum lamina terminalis evoked postsynaptic responses in rat supraoptic neurones in vitro. J Physiol 477, 59-74.