Anti-diabetic activity on ethanolic extracts of fruits of Terminalia chebula Retz. alloxan induced diabetic rats

American Journal of Drug Discovery and Development

Volumn 2, Issue 3, 2012, Pages 135-142

  Rajesh Kannan, V ^a   Stalin Rajasekar, G ^a   Rajesh, P ^a   Balasubramanian, V ^a   Ramesh, N ^a   King Solomon, E ^a   Nivas, D ^a   Chandru, S ^a  

^a BHARATHIDASAN UNIVERSITY   (India)

Author keywords

Anti diabetic; Pancreas; Serum and liver parameters; Terminalia chebula

Indexed keywords

ACID PHOSPHATASE; ALANINE AMINOTRANSFERASE; ALCOHOL; ALKALINE PHOSPHATASE; ALLOXAN; ASPARTATE AMINOTRANSFERASE; CATALASE; CHOLESTEROL; GLIBENCLAMIDE; GLUCOSE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; INSULIN; TERMINALIA CHEBULA EXTRACT; TRIACYLGLYCEROL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BEHAVIOR CHANGE; BIOCHEMISTRY; BLOOD SAMPLING; CELL NUCLEUS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CYTOPLASM; DIABETES MELLITUS; DRUG MECHANISM; FRUIT; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; INFLAMMATION; INSULIN BLOOD LEVEL; LD 50; LIPID LIVER LEVEL; MALE; MORTALITY; NONHUMAN; PANCREAS; RAT; SYMPTOM; TERMINALIA CHEBULA; TRIACYLGLYCEROL LIVER LEVEL; WEIGHT CHANGE;

EID: 84858809347     PISSN: 2150427X     EISSN: 21504296     Source Type: Journal    
DOI: 10.3923/ajdd.2012.135.142     Document Type: Article

References (23)

1. Afzalakhtar, M., M.H. Rahber-Bhatti and M. Aslam, 1997. Antibacterial activity of plant diffusate against Anthomonas campestris vp. citri. Int. J. Pes.t Manag., 43: 149-153.
2. Ahmad, M., F. Zaman, T. Sharif and CM. Zabta, 2008. Äntidiabetic and hypolipidemic effects of aqueous methanolic extract of acacia nilotica pods in alloxan-induced diabetic rabbits. Scand. J. Lab. Amm. Sei., 35: 29-34.
3. Ahmed, M.F, S.M. Kazim, S.S. Ghori, S.S. Mehjabeen, S.R. Ahmed, S.M. Ali and M. Ibrahim, 2010. Äntidiabetic activity of Vinca rosea extracts in Alloxan-induced diabetic rats. Int. J. Endocrmol, 10.1155/2010/841090.
4. Ahn, M.J., C.Y. Kim, J.S. Lee, T.G. Kim and S.H. Kim et al., 2002. Inhibition of HIV-I integrase by galloyl glucose from Terminalia chebula and flavonol glycoside gallates from EuphorbiapekinensisM. Plant. Med., 68: 457-459.
5. Aruna, R.V., B. Ramesh and V.N. Kartha, 1999. Effect of betacarotene on protein glycosylation in alloxan induced diabetic rats. Indian J. Exp. Biol., 37: 399-401.
6. Barthakur, N.N. and N.P. Arnold, 1991. Nutritive value of the Chebulic myrobalan (Terminalia chebula Retz.) and its potential as a food source. Food ehem., 40: 213-219.
7. Chigozie, I.J. and I.C. Chidinma, 2012. Hypoglycemic, Hypocholesterolemic and Ocular-protective effects of an aqueous extract of the rhizomes of Sansevieria senegambica Baker (Agavaceae) on alloxan-induced diabetic Wistar rats. Am. J. Biochem. Mol. Biol., 2: 48-66.
8. Chopra, R., S.L. Nayar and I.C. Chopra, 1956. Glossary of Indian Medicinal Plants. 1st Edn., National Institute of Science Communications, New Delhi, India.
9. Garber, 1998. Diabetes Mellitus. In: International Medicine, Stein, J.H. (Ed.). Mosby, St. Louis, USA, pp: 1850-1854.
10. Jothivel, N, S.P. Ponnusamy, M. Appachi, S. Singaravel and D. Rasilingam et al., 2007. Anti-diabetic activity of methanol leaf extract of Costus pictus D. Don in Alloxan induced diabetic rats. Karthikeyan Deivasigamani Sivakumar Thangavel. J. Health Sei, 53: 655-663.
11. Kaur, S, S. Arora, K. Kaur and S. Kumar, 2002. The in-vitro anti-mutagenic activity of triphala-An Indian herbal drug. Food Chem. Toxicol, 40: 527-534.
12. King, H., R.E. Aubert and W.H. Herman, 1998. Global burden of diabetes, 1995-2025: Prevalence, numerical estimates and projections. Diabetes Care, 22: 1414-1431.
13. Lowry, O.H., N.J. Rosebrough, A.L. Farr and R.J. Randall, 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193: 265-275.
14. Perry, L.M., 1980. Medicinal plants of east and Southeast Asia attributed properties and use. The Massachusetts Institute of Technology Press,. Cambridge London, pp: 80-81.
15. Priya, E.M., K.M. Gothandam and S. Karthikeyan, 2012. Anti-diabetic activity oi Feronia limonia and Artocarpus heterophyllus in streptozotocin induced diabetic rats. Am. J. Food Technol., 7: 43-49.
16. Ragunathan, V. and N. Sulochana, 1994. A new flavonol bioside form the Flowers of Hibiscus vitifolius Linn, and its hypoglycaemic activity. J. Ind. Chem. Societ., 71: 705-706.
17. Rhoads, R.K., Gokulananada and G.S. Tomat, 1996. Clinical evaluation of digon in the management of non-insulin dependent diabetes mellitus. Proceedings of the International Seminar on Free Radicals Mediated Diseases and Ayurveda, September 2-4, 1996, Faculty of Ayurveda, IMS, BHU, Varanasi, India.
18. Sabu, M.C. and R. Kuttan, 2002. Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J. Ethanopharmacol., 81: 155-160.
19. Saleem, A., M. Husheem, P. Harkonen and K. Pihalaja, 2002. Inhibition of cancer cell growth by crude extract and the phenolics of Terminalia chebula Retz fruit. J. Ethanopharmacol., 81:327-336.
20. Selvan, V.T., L. Mamkandan, S.G.P. Kumar, S.R.B.B. Kakoti and P. Gomathi et al, 2008. Antidiabetic and antioxidant effect of methanol extract of Artanema sesamoides in streptatozocin-induced diabetic rats. Int. J. Applied Res. Nat. Prod., 1: 25-33.
21. Singh, C, 1990. 2-Hydroxymicrometric acid, a pentacyclic triterpene from Terminalia chebula. Phytochemist, 29: 2348-2350.
22. Singh, R.P., B. Padmavathi and A.R. Rao, 2000. Modulatory influence of Adhatoda veisca (Justica adhatoda) leaf extract on the enzyme of xenobiotic metabolism, anti-oxidant status and lipid peroxidation in mice. Mol. Cell Biochem., 213: 99-109.
23. WHO, 1980. Second report of the WHO expert committee on diabetes mellitus. World Health Organization, Technical Report Series, 646. http://whqlibdoc.who.int/trsAVHO_TRS_646.pdf