Low-dose lisinopril in normotensive men with idiopathic oligospermia and infertility: A 5-year randomized, controlled, crossover pilot study

Clinical Pharmacology and Therapeutics

Volumn 91, Issue 4, 2012, Pages 582-589

  Mbah, A U ^a   Ndukwu, G O ^a,b   Ghasi, S I ^a   Shu, E N ^a   Ozoemena, F N ^a   Mbah, J O ^a   Onodugo, O D ^a   Ejim, E C ^a   Eze, M I ^a   Nkwo, P O ^a   Okonkwo, P O ^a  

^a UNIVERSITY OF NIGERIA   (Nigeria)

^b Nigeria National Petroluem Corporation   (Nigeria)

Author keywords

[No Author keywords available]

Indexed keywords

LISINOPRIL; PLACEBO;

ADULT; ARTHRALGIA; ARTICLE; BLOOD PRESSURE; CELL COUNT; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIZZINESS; EJACULATION; HUMAN; IDIOPATHIC DISEASE; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MALE INFERTILITY; OLIGOSPERMIA; PATIENT COMPLIANCE; PILOT STUDY; PREGNANCY RATE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SPERM; THORAX PAIN;

ADULT; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; INFERTILITY, MALE; LISINOPRIL; LONGITUDINAL STUDIES; MALE; OLIGOSPERMIA; PILOT PROJECTS; PREGNANCY; PREGNANCY RATE; SPERM COUNT; YOUNG ADULT;

EID: 84858794915     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2011.265     Document Type: Article

References (57)

1. Safarinejad, M.R. Infertility among couples in a population-based study in Iran: prevalence and associated risk factors. Int. J. Androl. 31, 303-314 (2008). (Pubitemid 351652025)
2. Attia, A.M., Al-Inany, H.G., Farquhar, C. & Proctor, M. Gonadotrophins for idiopathic male factor subfertility. Cochrane Database Syst. Rev. CD005071 (2007).
3. Cavallini, G., Crippa, A., Magli, M.C., Cavallini, N., Ferraretti, A.P. & Gianaroli, L. A study to sustain the hypothesis of the multiple genesis of oligoasthenoteratospermia in human idiopathic infertile males. Biol. Reprod. 79, 667-673 (2008).
4. Vandekerckhove, P., Lilford, R., Vail, A. & Hughes, E. Clomiphene or tamoxifen for diopathic oligo/asthenospermia. Cochrane Database Syst Rev. (2): CD000151.
5. Review. Update in: Cochrane Database Syst Rev. (4):CD000151 (1996).
6. Belaisch, J. [Medical treatment of male infertility]. Rev. Prat. 43, 965-969 (1993). (Pubitemid 23142518)
7. Kumar, R., Gautam, G. & Gupta, N.P. Drug therapy for idiopathic male infertility: rationale versus evidence. J. Urol. 176, 1307-1312 (2006). (Pubitemid 44307189)
8. Ghanem, H. & Shamloul, R. An evidence-based perspective to the medical treatment of male infertility: a short review. Urol. Int. 82, 125-129 (2009).
9. Aittomäki, K., Wennerholm, U.B., Bergh, C., Selbing, A., Hazekamp, J. & Nygren, K.G. Safety issues in assisted reproduction technology: should ICSI patients have genetic testing before treatment? A practical proposition to help patient information. Hum Reprod 19, 472-476 (2004). (Pubitemid 38344503)
10. Mbah, A.U. Normogonadotrophic, non-obstructive azoospermia: successful treatment of two cases using low-dose lisinopril (abstract). 24th Annual Scientific Conference of the Association of Physicians of Nigeria, 17-20th August 1999, Port Harcourt, Nigeria.
11. Saha, L., Garg, S.K., Bhargava, V.K. & Mazumdar, S. Role of angiotensinconverting enzyme inhibitor, lisinopril, on spermatozoal functions in rats. Methods Find. Exp. Clin. Pharmacol. 22, 159-162 (2000). (Pubitemid 30413256)
12. Okeahialam, B.N., Amadi, K. & Ameh, A.S. Effect of lisnopril, an angiotensin converting enzyme (ACE) inhibitor on spermatogenesis in rats. Arch. Androl. 52, 209-213 (2006).
13. Somlev, B. & Subev, M. Effect of kininase II inhibitors on bradykinin-stimulated bovine sperm motility. Theriogenology 50, 651-657 (1998). (Pubitemid 28491604)
14. Haidl, G. & Schill, W.B. Guidelines for drug treatment of male infertility. Drugs 41, 60-68 (1991). (Pubitemid 21920726)
15. Schill, W.B. & Michalopoulos, M. Treatment of male fertility disturbances. Current concepts. Drugs 28, 263-280 (1984).
16. Toshimori, K., Ito, C., Maekawa, M., Toyama, Y., Suzuki-Toyota, F. & Saxena, D.K. Impairment of spermatogenesis leading to infertility. Anat. Sci. Int. 79, 101-111 (2004). (Pubitemid 39232239)
17. Mathur, V., Murdia, A., Hakim, A.A., Suhalka, M.L., Shaktawat, G.S. & Kothari, L.K. Male infertility and the present status of its management by drugs. J. Postgrad. Med. 25, 90-96 (1979).
18. Karande, V.C. et al. Prospective randomized trial comparing the outcome and cost of in vitro fertilization with that of a traditional treatment algorithm as first-line therapy for couples with infertility. Fertil. Steril. 71, 468-475 (1999). (Pubitemid 29094123)
19. Griffiths, A., Dyer, S.M., Lord, S.J., Pardy, C., Fraser, I.S. & Eckermann, S. A costeffectiveness analysis of in-vitro fertilization by maternal age and number of treatment attempts. Hum. Reprod. 25, 924-931 (2010).
20. Lee, K.C. Fertility treatments and the cost of a healthy baby. Nurs. Womens. Health 15, 15-18 (2011).
21. Wølner-Hanssen, P. & Rydhstroem, H. Cost-effectiveness analysis of in-vitro fertilization: estimated costs per successful pregnancy after transfer of one or two embryos. Hum. Reprod. 13, 88-94 (1998). (Pubitemid 28075279)
22. Alatri, A., Tribout, B., Gencer, B., Calanca, L. & Mazzolai, L. [Thrombotic risk in assisted reproductive technology]. Rev. Med. Suisse 7, 357-360 (2011).
23. Chan, W.S. The 'ART' of thrombosis: a review of arterial and venous thrombosis in assisted reproductive technology. Curr. Opin. Obstet. Gynecol. 21, 207-218 (2009).
24. Maxwell, K.N., Cholst, I.N. & Rosenwaks, Z. The incidence of both serious and minor complications in young women undergoing oocyte donation. Fertil. Steril. 90, 2165-2171 (2008).
25. Allen, V.M., Wilson, R.D. & Cheung, A.; Genetics Committee of the Society of Obstetricians and Gynaecologists of Canada (SOGC); Reproductive Endocrinology Infertility Committee of the Society of Obstetricians and Gynaecologists of Canada (SOGC). Pregnancy outcomes after assisted reproductive technology. J. Obstet. Gynaecol. Can. 28, 220-250 (2006).
26. Bourrouillou, G., Mansat, A., Calvas, P., Pontonnier, F. & Colombies, P. [Chromosome anomalies and male infertility. A study of 1,444 subjects]. Bull. Assoc. Anat. (Nancy). 71, 29-31 (1987). (Pubitemid 19013805)
27. Miharu, N. Chromosome abnormalities in sperm from infertile men with normal somatic karyotypes: oligozoospermia. Cytogenet. Genome Res. 111, 347-351 (2005). (Pubitemid 41414488)
28. Schill, W.B. & Miska, W. Possible effects of the kallikrein-kinin system on male reproductive functions. Andrologia 24, 69-75 (1992).
29. Vandekerckhove, P., Lilford, R., Vail, A. & Hughes, E. Kinin-enhancing drugs for unexplained subfertility in men. Cochrane Database Syst Rev 2000 (2):CD000153. Review. Update in: Cochrane Database Syst Rev. (4):CD000153 (1996).
30. Donnelly, E.T., Lewis, S.E., McNally, J.A. & Thompson, W. In vitro fertilization and pregnancy rates: the influence of sperm motility and morphology on IVF outcome. Fertil. Steril. 70, 305-314 (1998). (Pubitemid 28361486)
31. Joshi, N., Kodwany, G., Balaiah, D., Parikh, M. & Parikh, F. The importance of computer-assisted semen analysis and sperm function testing in an IVF program. Int. J. Fertil. Menopausal Stud. 41, 46-52 (1996). (Pubitemid 26084274)
32. Chan, S.Y. et al. Predictive value of sperm morphology and movement characteristics in the outcome of in vitro fertilization of human oocytes. J. In Vitro Fert. Embryo Transf. 6, 142-148 (1989). (Pubitemid 19249527)
33. Naz, R.K. & Sellamuthu, R. Receptors in spermatozoa: are they real? J. Androl. 27, 627-636 (2006). (Pubitemid 44520802)
34. Roberts, M. & Jarvi, K. Steps in the investigation and management of low semen volume in the infertile man. Can. Urol. Assoc. J. 3, 479-485 (2009).
35. Hagaman, J.R. et al. Angiotensin-converting enzyme and male fertility. Proc. Natl. Acad. Sci. U.S.A. 95, 2552-2557 (1998). (Pubitemid 28145980)
36. Esther, C.R. et al. The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice. J. Clin. Invest. 99, 2375-2385 (1997).
37. Fuchs, S. et al. Male fertility is dependent on dipeptidase activity of testis ACE. Nat. Med. 11, 1140-2; author reply 1142 (2005). (Pubitemid 43093652)
38. Esther, C.R. Jr, Howard, T.E., Marino, E.M., Goddard, J.M., Capecchi, M.R. & Bernstein, K.E. Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility. Lab. Invest. 74, 953-965 (1996). (Pubitemid 26152664)
39. Ramaraj, P., Kessler, S.P., Colmenares, C. & Sen, G.C. Selective restoration of male fertility in mice lacking angiotensin-converting enzymes by spermspecific expression of the testicular isozyme. J. Clin. Invest. 102, 371-378 (1998). (Pubitemid 28335196)
40. Barrière, P., Roch, M., L'Hermite, A., Sagot, P., Lopes, P. & Charbonnel, B. [Evaluation of the probability of the occurrence of pregnancy during oligoastheno-teratospermia]. Rev. Fr. Gynecol. Obstet. 84, 101-105 (1989). (Pubitemid 19066136)
41. Pribylov, S.A. [Pulmonary hypertension, endothelial dysfunction, and their correction with lisinopril in patients with heart failure in combination of ischemic heart disease and chronic obstructive pulmonary disease]. Kardiologiia 46, 36-40 (2006). (Pubitemid 44606470)
42. Khabibulina, M.M. [Evaluation of long-term therapy influence with angiotensin converting enzyme inhibitor lisinopril on morphofunctional parameters of the left ventricle, peripheral artery endothelium disfunction and painless myocardial ischemia in premenopausal women with hypertension]. Kardiologiia 50, 16-21 (2010).
43. Sangole, N.V. & Dadkar, V.N. Adverse drug reaction monitoring with angiotensin converting enzyme inhibitors: A prospective, randomized, open-label, comparative study. Indian J. Pharmacol. 42, 27-31 (2010).
44. Lacourciére, Y. The incidence of cough: a comparison of lisinopril, placebo and telmisartan, a novel angiotensin II antagonist. Telmisartan Cough Study Group. Int. J. Clin. Pract. 53, 99-103 (1999). (Pubitemid 29131365)
45. Israili, Z.H. & Hall, W.D. Cough and angioneurotic edema associated with angiotensin-converting enzyme inhibitor therapy. A review of the literature and pathophysiology. Ann. Intern. Med. 117, 234-242 (1992).
46. Just, P.M. The positive association of cough with angiotensin-converting enzyme inhibitors. Pharmacotherapy 9, 82-87 (1989). (Pubitemid 19123198)
47. Yeo, W.W. & Ramsay, L.E. Persistent dry cough with enalapril: incidence depends on method used. J. Hum. Hypertens. 4, 517-520 (1990). (Pubitemid 20375045)
48. Fletcher, A.E. et al. Quality of life on antihypertensive therapy: a randomized double-blind controlled trial of captopril and atenolol. J. Hypertens. 8, 463-466 (1990). (Pubitemid 20347080)
49. Os, I., Bratland, B., Dahlöf, B., Gisholt, K., Syvertsen, J.O. & Tretli, S. Female sex as an important determinant of lisinopril-induced cough. Lancet 339, 372 (1992).
50. Yeo, W.W., Higgins, K.S., Foster, G., Jackson, P.R. & Ramsay, L.E. Effect of dose adjustment on enalapril-induced cough and the response to inhaled capsaicin. Br. J. Clin. Pharmacol. 39, 271-276 (1995).
51. Kidd, S.A., Eskenazi, B. & Wyrobek, A.J. Effects of male age on semen quality and fertility: a review of the literature. Fertil. Steril. 75, 237-248 (2001). (Pubitemid 32112097)
52. Levitas, E., Lunenfeld, E., Weisz, N., Friger, M. & Potashnik, G. Relationship between age and semen parameters in men with normal sperm concentration: analysis of 6022 semen samples. Andrologia 39, 45-50 (2007). (Pubitemid 46568665)
53. MacLeod, J. & Wang, Y. Male fertility potential in terms of semen quality: a review of the past, a study of the present. Fertil. Steril. 31, 103-116 (1979). (Pubitemid 9110878)
54. Yogev, L. et al. Seasonal variations in pre-and post-thaw donor sperm quality. Hum. Reprod. 19, 880-885 (2004). (Pubitemid 38456052)
55. World Health Organization. World Health Organization Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interactions 4th ed. (Cambridge University Press, Cambridge, UK, 1999).
56. Clinical Diagnosis by Laboratory Method. (eds. Davidson, I. & Henry, J.B.) 340-500 (ELBS, NewYork, 1979).
57. SPSS Reference Guide (SPSS Inc., Chicago, IL, 1990)