Preischemic and postischemic administration of AEOL10113 reduces infarct size in a rat model of myocardial ischemia and reperfusion

Journal of Cardiovascular Pharmacology

Volumn 41, Issue 5, 2003, Pages 714-719

  Lubbers, Nathan L ^a   Polakowski, James S ^a   Crapo, James D ^b   Wegner, Craig D ^a   Cox, Bryan F ^a  

^a ABBOTT LABORATORIES   (United States)

^b NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

AEOL10113; Ischemia; Myocardial infarction; Reperfusion; Superoxide dismutase mimetic

Indexed keywords

AEOL 10113; MANGANESE TETRAKIS(N ETHYLPYRIDINIUM 2 YL)PORPHYRIN; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; ENZYME ACTIVITY; HEART INFARCTION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; LEFT CORONARY ARTERY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEMODYNAMIC PROCESSES; MALE; METALLOPORPHYRINS; MOLECULAR MIMICRY; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE; TIME FACTORS;

EID: 0037407537     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200305000-00007     Document Type: Article

References (18)

1. Jolly SR, Kane WJ, Bailie MB, et al. Canine myocardial reperfusion injury: its reduction by the combined administration of superoxide dismutase and catalase. Circ Res. 1984;54:277-85.
2. Ambrosio G, Becker LC, Hutchins GM, et al. Reduction in experimental infarct size by recombinant human superoxide dismutase: insights into the pathophysiology of reperfusion injury. Circulation. 1986;74:1424-33.
3. Chi L, Tamura Y, Hoff PT, et al. Effect of superoxide dismutase on myocardial infarct size in the canine heart after 6 hours of regional ischemia and reperfusion: a demonstration of myocardial salvage. Circ Res. 1989;64:665-75.
4. Patel BS, Jeroudi MO, O'Neill PG, et al. Effect of human recombinant superoxide dismutase on canine myocardial infarction. Am J Physiol. 1990;258:H369-80.
5. Tanaka M, Stoler RC, FitzHarris GP, et al. Evidence against the "early protection-delayed death" hypothesis of superoxide dismutase therapy in experimental myocardial infarction: polyethylene glycol-superoxide dismutase plus catalase does not limit myocardial infarct size in dogs. Circ Res. 1990;67:636-44.
6. Rabinovitch HD, Privalle CT, Fridovich I. Effects of paraquat on the green alga Dunaliella salina: protection by a mimic of superoxide dismutase, Desferal-Mn(IV). Free Rad Biol Med. 1987;3:125-31.
7. Nagano T, Hirano T, Hirobe M. Superoxide dismutase mimics based on iron in vivo. J Biol Chem. 1989;264:9243-9.
8. Day BJ, Shawen S, Liochev SI, et al. A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced endothelial cell injury, in vitro. J Pharmacol Exp Ther. 1995;275:1227-32.
9. Black SC, Schasteen CS, Weiss RH, et al. Inhibition of in vivo myocardial ischemic and reperfusion injury by a synthetic manganese-based superoxide dismutase mimetic. J Pharmacol Exp Ther. 1994;270:1208-15.
10. Omar BA, McCord JM. Interstitial equilibration of superoxide dismutase correlates with its protective effect in the isolated rabbit heart. J Mol Cell Cardiol. 1991;23:149-59.
11. Gallagher KP, Buda AJ, Pace D, et al. Failure of superoxide dismutase and catalase to alter size of infarction in conscious dogs after 3 hours of occlusion followed by reperfusion. Circulation. 1986;73:1065-76.
12. Uraizee A, Reimer KA, Murry CE, et al. Failure of superoxide dismutase to limit infarct size after 40 minutes of ischemia and 4 days of reperfusion in dogs. Circulation. 1987;75:1237-48.
13. Konorev EA, Kennedy CM, Kalyanaraman B. Cell-permeable superoxide dismutase and glutathione peroxidase mimetics afford superior protection against doxorubicin-induced cardiotoxicity: the role of reactive oxygen and nitrogen intermediates. Arch Biochem Biophys. 1999;368:421-8.
14. Vanden Hoek TL, Li C, Shao Z, et al. Significant levels of oxidants are generated by isolated cardiomyocytes during ischemia prior to reperfusion. J Mol Cell Cardiol. 1997;29:2571-83.
15. Becker LB, Vanden Hoek TL, Shao ZH, et al. Generation of superoxide in cardiomyocytes during ischemia before reperfusion. Am J Physiol. 1999;277:H2240-6.
16. Mackenson GB, Patel M, Sheng H, et al. Neuroprotection from delayed postischemic administration of metalloporphyrin catalytic antioxidant. J Neurosci. 2001;21:4582-92.
17. Bouloumie A, Bauersachs J, Linz W, et al. Endothelial dysfunction coincides with an enhanced nitric oxide synthase expression and superoxide anion production. Hypertension. 1997;30:934-41.
18. Schnackenberg CG, Welch WJ, Wilcox CS. Normalization of blood pressure and renal vascular resistance in SHR with a membrane permeable superoxide dismutase mimetic: role of nitric oxide. Hypertension. 1998;32:59-64.