A newly designed enteral formula containing whey peptides and fermented milk product protects mice against concanavalin A-induced hepatitis by suppressing overproduction of inflammatory cytokines

Clinical Nutrition

Volumn 31, Issue 2, 2012, Pages 283-289

  Kume, Hisae ^a   Okazaki, Keiko ^a   Yamaji, Taketo ^a   Sasaki, Hajime ^a  

^a MEIJI DAIRIES CORPORATION   (Japan)

Author keywords

Enteral formula; Hepatitis; IL 6; Inflammation; TNF ; Whey peptides

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GAMMA INTERFERON; INTERLEUKIN 6; MILK PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY WEIGHT; C57BL 6 MOUSE; CONTROLLED STUDY; DAIRY PRODUCT; HEPATITIS; HISTOPATHOLOGY; LIVER NECROSIS; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; ORGAN WEIGHT; PROTEIN BLOOD LEVEL; THERAPY EFFECT; TREATMENT RESPONSE;

ALANINE TRANSAMINASE; ANIMAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; ANIMALS; APOPTOSIS; BIOLOGICAL MARKERS; CONCANAVALIN A; CULTURED MILK PRODUCTS; DRUG-INDUCED LIVER INJURY; ENTERAL NUTRITION; INFLAMMATION; INTERFERON-GAMMA; INTERLEUKIN-6; LIVER; MALE; MICE; MICE, INBRED C57BL; MILK PROTEINS; NECROSIS; SPLEEN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84858748089     PISSN: 02615614     EISSN: 15321983     Source Type: Journal    
DOI: 10.1016/j.clnu.2011.10.012     Document Type: Article

References (31)

1. Nathan C. Points of control in inflammation. Nature 2002, 420(6917):846-852.
2. Andersen E.S., Ruhwald M., Moessner B., Christensen P.B., Andersen O., Eugen-Olsen J., et al. Twelve potential fibrosis markers to differentiate mild liver fibrosis from cirrhosis in patients infected with chronic hepatitis C genotype 1. Eur J Clin Microbiol Infect Dis 2011.
3. Koziel M.J. Cytokines in viral hepatitis. Semin Liver Dis 1999, 19(2):157-169.
4. Picardi A., Gentilucci U.V., Zardi E.M., Caccavo D., Petitti T., Manfrini S., et al. TNF-alpha and growth hormone resistance in patients with chronic liver disease. J Interferon Cytokine Res 2003, 23(5):229-235.
5. Thompson M.E., Barkhuizen A. Fibromyalgia, hepatitis C infection, and the cytokine connection. Curr Pain Headache Rep 2003, 7(5):342-347.
6. McFarlane I.G. Pathogenesis of autoimmune hepatitis. Biomed Pharmacother 1999, 53(5-6):255-263.
7. Sakamoto K., Arakawa H., Mita S., Ishiko T., Ikei S., Egami H., et al. Elevation of circulating interleukin 6 after surgery: factors influencing the serum level. Cytokine 1994, 6(2):181-186.
8. Cohen J. The immunopathogenesis of sepsis. Nature 2002, 420(6917):885-891.
9. Osuchowski M.F., Welch K., Siddiqui J., Remick D.G. Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality. J Immunol 2006, 177(3):1967-1974.
10. Koch A., Gressner O.A., Sanson E., Tacke F., Trautwein C. Serum resistin levels in critically ill patients are associated with inflammation, organ dysfunction and metabolism and may predict survival of non-septic patients. Crit Care 2009, 13(3):R95.
11. Marshall K. Therapeutic applications of whey protein. Altern Med Rev 2004, 9(2):136-156.
12. Kume H., Okazaki K., Yamaguchi M., Tukahara M., Sasaki H. Anti-inflammatory effect of whey protein and whey-tripsinized peptides on Con A induced hepatitis in mice. Jpn Nutr Soc Pathol 2005, 8:15-21.
13. Kume H., Okazaki K., Sasaki H. Hepatoprotective effects of whey protein on D-galactosamine-induced hepatitis and liver fibrosis in rats. Biosci Biotechnol Biochem 2006, 70(5):1281-1285.
14. Sasaki H., Kume H. Nutrition and physiological effects of peptides from whey. Bull Int Dairy Fed 2007, 417:43-50.
15. Yamaji T., Kume H. Hepatoprotective effects of whey protein and whey peptides on hepatitis. Milk Sci 2008, 56(3):115-118.
16. Yamaguchi M., Yoshida K., Uchida M. Novel functions of bovine milk-derived alpha-lactalbumin: anti-nociceptive and anti-inflammatory activity caused by inhibiting cyclooxygenase-2 and phospholipase A2. Biol Pharm Bull 2009, 32(3):366-371.
17. Qin L., He J., Hanes R.N., Pluzarev O., Hong J.S., Crews F.T. Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment. J Neuroinflammation 2008, 5:10.
18. Tiegs G., Hentschel J., Wendel A.A. T cell-dependent experimental liver injury in mice inducible by concanavalin A. J Clin Invest 1992, 90(1):196-203.
19. Gantner F., Leist M., Lohse A.W., Germann P.G., Tiegs G. Concanavalin A-induced T-cell-mediated hepatic injury in mice: the role of tumor necrosis factor. Hepatology 1995, 21(1):190-198.
20. Schumann J., Wolf D., Pahl A., Brune K., Papadopoulos T., van Rooijen N., et al. Importance of Kupffer cells for T-cell-dependent liver injury in mice. Am J Pathol 2000, 157(5):1671-1683.
21. Kusters S., Gantner F., Kunstle G., Tiegs G. Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A. Gastroenterology 1996, 111(2):462-471.
22. Streetz K., Fregien B., Plumpe J., Korber K., Kubicka S., Sass G., et al. Dissection of the intracellular pathways in hepatocytes suggests a role for Jun kinase and IFN regulatory factor-1 in Con A-induced liver failure. J Immunol 2001, 167(1):514-523.
23. Mizuhara H., O'Neill E., Seki N., Ogawa T., Kusunoki C., Otsuka K., et al. T cell activation-associated hepatic injury: mediation by tumor necrosis factors and protection by interleukin 6. J Exp Med 1994, 179(5):1529-1537.
24. Bradham C.A., Plumpe J., Manns M.P., Brenner D.A., Trautwein C. Mechanisms of hepatic toxicity. I. TNF-induced liver injury. Am J Physiol 1998, 275(3 Pt 1):G387-G392.
25. Trautwein C., Rakemann T., Malek N.P., Plumpe J., Tiegs G., Manns M.P. Concanavalin A-induced liver injury triggers hepatocyte proliferation. J Clin Invest 1998, 101(9):1960-1969.
26. Lorea Baroja M., Kirjavainen P.V., Hekmat S., Reid G. Anti-inflammatory effects of probiotic yogurt in inflammatory bowel disease patients. Clin Exp Immunol 2007, 149(3):470-479.
27. Elmadfa I., Klein P., Meyer A.L. Immune-stimulating effects of lactic acid bacteria in vivo and in vitro. Proc Nutr Soc 2010, 69(3):416-420.
28. Chaves S., Perdigon G., de Moreno de LeBlanc A. Yoghurt consumption regulates the immune cells implicated in acute intestinal inflammation and prevents the recurrence of the inflammatory process in a mouse model. J Food Prot 2011, 74(5):801-811.
29. Cadenas S., Cadenas A.M. Fighting the stranger-antioxidant protection against endotoxin toxicity. Toxicology 2002, 180(1):45-63.
30. Simopoulos A.P. Genetic variants in the metabolism of omega-6 and omega-3 fatty acids: their role in the determination of nutritional requirements and chronic disease risk. Exp Biol Med (Maywood) 2010, 235(7):785-795.
31. Kim C.H. Retinoic acid, immunity, and inflammation. Vitam Horm 2011, 86:83-101.