Hyperbranched polyglycerols as trimodal imaging agents: Design, biocompatibility, and tumor uptake

Bioconjugate Chemistry

Volumn 23, Issue 3, 2012, Pages 372-381

  Saatchi, Katayoun ^a   Soema, Peter ^a   Gelder, Nikolaus ^a   Misri, Ripen ^a   McPhee, Kelly ^a   Baker, Jennifer H E ^a   Reinsberg, Stefan A ^a   Brooks, Donald E ^b   Häfeli, Urs O ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCOMPATIBILITY; BLOOD VESSELS; FLUORESCENCE; MAGNETIC RESONANCE; MAGNETIC RESONANCE IMAGING; RADIOACTIVITY;

AGENT DESIGN; FLUORESCENCE MARKERS; HIGH RESOLUTION; HIGH SENSITIVITY; HYPERBRANCHED POLYGLYCEROLS; IMAGING AGENT; IMAGING MODALITY; LONG CIRCULATING; TRIMODAL IMAGING; TUMOR UPTAKE;

TUMORS;

FLUORESCENT DYE; FLUORESCENT HYPERBRANCHED POLYGLYCEROL DERIVATIVE; GADOLINIUM; GLYCEROL DERIVATIVE; HYPERBRANCHED POLYGLYCEROL DERIVATIVE; HYPERBRANCHED POLYGLYCEROL GADOLINIUM; HYPERBRANCHED POLYGLYCEROL IN 111; INDIUM 111; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTRAST ENHANCEMENT; DRUG DESIGN; DRUG STRUCTURE; DRUG UPTAKE; HUMAN; HUMAN CELL; MACROMOLECULE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TUMOR GROWTH;

EID: 84858738210     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc200280g     Document Type: Article

References (37)

1. Condeelis, J. and Weissleder, R. (2010) In vivo imaging in cancer Cold Spring Harbor Perspectives in Biology 2, a003848
2. O'Connor, J. P., Jackson, A., Parker, G. J., and Jayson, G. C. (2007) DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents Br. J. Cancer 96, 189-95 (Pubitemid 46160619)
3. Tofts, P. S., Brix, G., and Buckley, D. L. 1999, Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols J. Magn. Reson. Imaging 10, 223-32 (Pubitemid 29463104)
4. Sunder, A., Hanselmann, R., Mulhaupt, R., and Frey, H. (1999) Controlled synthesis of hyperbranched polyglycerols by ring-opening multibranching polymerization Macromolecules 32, 4240-4246
5. Frey, H. and Haag, R. (2002) Dendritic polyglycerol: a new versatile biocompatible-material J. Biotechnol. 90, 257-67 (Pubitemid 34186233)
6. Kainthan, R. K., Muliawan, E. B., Hatzikiriakos, S. G., and Brooks, D. E. (2006) Synthesis, characterization, and viscoelastic properties of high molecular weight hyperbranched polyglycerols Macromolecules 39, 7708-7717 (Pubitemid 44826459)
7. Cheng, Y., Zhao, L., Li, Y., and Xu, T. (2011) Design of biocompatible dendrimers for cancer diagnosis and therapy: current status and future perspectives Chem. Soc. Rev. 40, 2673-703
8. Kainthan, R. K. and Brooks, D. E. (2007) In vivo biological evaluation of high molecular weight hyperbranched polyglycerols Biomaterials 28, 4779-87 (Pubitemid 47285344)
9. Kainthan, R. K., Hester, S. R., Levin, E., Devine, D. V., and Brooks, D. E. (2007) In vitro biological evaluation of high molecular weight hyperbranched polyglycerols Biomaterials 28, 4581-90 (Pubitemid 47259174)
10. Kainthan, R. K., Gnanamani, M., and Ganguli, M. 2006, Blood compatibility of novel water soluble hyperbranched polyglycerol-based multivalent cationic polymers and their interaction with DNA Biomaterials 27, 5377-90 (Pubitemid 44109897)
11. Kainthan, R. K., Janzen, J., Levin, E., Devine, D. V., and Brooks, D. E. (2006) Biocompatibility testing of branched and linear polyglycidol Biomacromolecules 7, 703-9
12. Hoffman, A. S. (1998) A commentary on the advantages and limitations of synthetic polymer-biomolecule conjugates, in Biorelated polymers and gels (Okano, T., Ed.) pp 231-248, Academic Press, Boston.
13. Kainthan, R. K., Janzen, J., Kizhakkedathu, J. N., Devine, D. V., and Brooks, D. E. (2008) Hydrophobically derivatized hyperbranched polyglycerol as a human serum albumin substitute Biomaterials 29, 1693-1704
14. Kainthan, R. K. and Brooks, D. E. (2008) Unimolecular micelles based on hydrophobically derivatized hyperbranched polyglycerols: biodistribution studies Bioconjugate Chem. 19, 2231-8
15. Kainthan, R. K., Mugabe, C., Burt, H. M., and Brooks, D. E. (2008) Unimolecular micelles based on hydrophobically derivatized hyperbranched polyglycerols: ligand binding properties Biomacromolecules 9, 886-895 (Pubitemid 351560479)
16. Rossi, N. A. A., Constantinescu, I., Brooks, D. E., Scott, M. D., and Kizhakkedathu, J. N. (2010) Enhanced cell surface polymer grafting in concentrated and nonreactive aqueous polymer solutions J. Am. Chem. Soc. 132, 3423-3430
17. Rossi, N. A., Constantinescu, I., Kainthan, R. K., Brooks, D. E., Scott, M. D., and Kizhakkedathu, J. N. (2010) Red blood cell membrane grafting of multi-functional hyperbranched polyglycerols Biomaterials 31, 4167-78
18. Moore, S. and Stein, W. H. (1948) Photometric ninhydrin method for use in the chromatography of amino acids J. Biol. Chem. 176, 367-88
19. Moore, S. and Stein, W. H. (1954) A modified ninhydrin reagent for the photometric determination of amino acids and related compounds J. Biol. Chem. 211, 907-13
20. Lorenzen, A. and Kennedy, S. W. (1993) A fluorescence-based protein assay for use with a microplate reader Anal. Biochem. 214, 346-8 (Pubitemid 23300401)
21. Pieters, R., Huismans, D. R., Leyva, A., and Veerman, A. J. P. (1989) Comparison of the rapid automated MTT-assay with a dye exclusion assay for chemosensitivity testing in childhood leukaemia Br. J. Cancer 59, 217-220 (Pubitemid 19072720)
22. Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., and Walter, P. (2008) Renewal by multipotent stem cells: Blood cell formation, Mol. Biol. Cell, 5 th ed., pp 1450-1462, Garland Science, New York.
23. Patrono, C. and Davi, G. (2008) Platelet activation and atherothrombosis-Reply N. Engl. J. Med. 358, 1638-1639
24. Bally, M. B., Mayer, L. D., Hope, M. J., and Nayar, R. (1993) Pharmacodynamics of liposomal drug carriers: Methodological considerations, in Liposome Technology, 2 nd ed., (Gregoriadis, G., Ed.) pp 27-41, Vol III, CRC Press, Boca Raton.
25. Collins, T. J. (2007) ImageJ for microscopy Biotechniques 43, 25-30
26. Haacke, E. M., Brown, R. W., Thompson, M. R., and Venkatesan, R. (1999) Magnetic Resonance Imaging: Physical Principles and Sequence Design, Wiley-Liss, New York.
27. Dowell, N. G. and Tofts, P. S. (2007) Fast, accurate, and precise mapping of the RF field in vivo using the 180 degrees signal null Magn. Reson. Med. 58, 622-30 (Pubitemid 350154975)
28. Abramoff, M. D., Magelhaes, P. J., and Ram, S. J. (2004) Image Processing with ImageJ Biophoton. Int. 7, 36-42
29. Liu, Y., Liu, G., and Hnatowich, D. J. (2010) A brief review of chelators for radiolabeling oligomers Materials 3, 3204-3217
30. Martell, A. E., Motekaitis, R. J., Clarke, E. T., Delgado, R., Sun, Y., and Ma, R. (1996) Stability constants of metal complexes of macrocyclic ligands with pendant donor groups Supramol. Chem. 6, 353-363 (Pubitemid 126521612)
31. De Leon-Rodriguez, L. M. and Kovacs, Z. (2008) The synthesis and chelation chemistry of DOTA-peptide conjugates Bioconjugate Chem. 19, 391-402 (Pubitemid 351294908)
32. Liu, S. (2004) The role of coordination chemistry in the development of target-specific radiopharmaceuticals Chem. Soc. Rev. 33, 445-61 (Pubitemid 39461952)
33. Reichert, D. E., Lewis, J., and Anderson, C. J. (1999) Metal complexes as diagnostic tools Coord. Chem. Rev. 184, 3-66
34. Kobuchi, Y., Ito, T., and Ogiwara, A. (1988) A model for rouleaux pattern formation of red blood cells J. Theor. Biol. 130, 129-145
35. Porter, R. S., Kaplan, J. L., and Homeier, B. P., Eds. (2011) Common Medical Tests: Blood Tests, in The Merck Manuals Online Medical Library, Merck & Co., Whitehouse Station, NJ, USA.
36. Maeda, H. (2010) Tumor-selective delivery of macromolecular drugs via the EPR effect: background and future prospects Bioconjugate Chem. 21, 797-802
37. Dreher, M. R., Liu, W., Michelich, C. R., Dewhirst, M. W., Yuan, F., and Chilkoti, A. (2006) Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers J. Natl. Cancer Inst. 98, 335-44 (Pubitemid 43338213)