Peripheral low intensity sign in hepatic hemangioma: Diagnostic pitfall in hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI of the liver

Journal of Magnetic Resonance Imaging

Volumn 35, Issue 4, 2012, Pages 852-858

  Tamada, Tsutomu ^a   Ito, Katsuyoshi ^a   Ueki, Ai ^a   Kanki, Akihiko ^a   Higaki, Atsushi ^a   Higashi, Hiroki ^a   Yamamoto, Akira ^a  

^a KAWASAKI MEDICAL SCHOOL   (Japan)

Author keywords

Gd EOB DTPA; hemangioma; liver; magnetic resonance (MR); neoplasm metastasis

Indexed keywords

GADOXETIC ACID;

ADULT; AGED; ARTICLE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DIAGNOSTIC ERROR; FEMALE; HUMAN; INFORMED CONSENT; LIVER HEMANGIOMA; LIVER METASTASIS; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RANK SUM TEST;

ADULT; AGED; AGED, 80 AND OVER; ARTIFACTS; CONTRAST MEDIA; FALSE POSITIVE REACTIONS; FEMALE; GADOLINIUM DTPA; HEMANGIOMA; HUMANS; LIVER; LIVER NEOPLASMS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 84858727857     PISSN: 10531807     EISSN: 15222586     Source Type: Journal    
DOI: 10.1002/jmri.23514     Document Type: Article

References (30)

1. Mahfouz AE, Hamm B, Wolf KJ,. Peripheral washout: a sign of malignancy on dynamic gadolinium-enhanced MR images of focal liver lesions. Radiology 1994; 190: 49-52.
2. Danet IM, Semelka RC, Leonardou P, et al. Spectrum of MRI appearances of untreated metastases of the liver. AJR Am J Roentgenol 2003; 181: 809-817.
3. Stern W, Schick F, Kopp AF, et al. Dynamic MR imaging of liver metastases with Gd-EOB-DTPA. Acta Radiol 2000; 41: 255-262.
4. Vogl TJ, Kümmel S, Hammerstingl R, et al. Liver tumors: comparison of MR imaging with Gd-EOB-DTPA and Gd-DTPA. Radiology 1996; 200: 59-67.
5. Reimer P, Rummeny EJ, Daldrup HE, et al. Enhancement characteristics of liver metastases, hepatocellular carcinomas, and hemangiomas with Gd-EOB-DTPA: preliminary results with dynamic MR imaging. Eur Radiol 1997; 7: 275-280.
6. Huppertz A, Balzer T, Blakeborough A, et al. Improved detection of focal liver lesions at MR imaging: multicenter comparison of gadoxetic acid-enhanced MR images with intraoperative findings. Radiology 2004; 230: 266-275.
7. Hammerstingl R, Huppertz A, Breuer J, et al. Diagnostic efficacy of gadoxetic acid (Primovist)-enhanced MRI and spiral CT for a therapeutic strategy: comparison with intraoperative and histopathologic findings in focal liver lesions. Eur Radiol 2008; 18: 457-467.
8. Halavaara J, Breuer J, Ayuso C, et al. Liver tumor characterization: comparison between liver-specific gadoxetic acid disodium-enhanced MRI and biphasic CT-a multicenter trial. J Comput Assist Tomogr 2006; 30: 345-354.
9. Motosugi U, Ichikawa T, Sou H, et al. Distinguishing hypervascular pseudolesions of the liver from hypervascular hepatocellular carcinomas with gadoxetic acid-enhanced MR imaging. Radiology 2010; 256: 151-158.
10. Ahn SS, Kim MJ, Lim JS, Hong HS, Chung YE, Choi JY,. Added value of gadoxetic acid-enhanced hepatobiliary phase MR imaging in the diagnosis of hepatocellular carcinoma. Radiology 2010; 255: 459-466.
11. Zech CJ, Herrmann KA, Reiser MF, Schoenberg SO,. MR imaging in patients with suspected liver metastases: value of liver-specific contrast agent Gd-EOB-DTPA. Magn Reson Med Sci 2007; 6: 43-52.
12. Shimada K, Isoda H, Hirokawa Y, Arizono S, Shibata T, Togashi K,. Comparison of gadolinium-EOB-DTPA-enhanced and diffusion-weighted liver MRI for detection of small hepatic metastases. Eur Radiol 2010; 20: 2690-2698.
13. Tamada T, Ito K, Yamamoto A, et al. Hepatic hemangiomas: evaluation of enhancement patterns at dynamic MRI with gadoxetate disodium. AJR Am J Roentgenol 2011; 196: 824-830.
14. Giovanoli O, Heim M, Terracciano L, Bongartz G, Ledermann HP,. MRI of hepatic adenomatosis: initial observations with gadoxetic acid contrast agent in three patients. AJR Am J Roentgenol 2008; 190: W290-293.
15. Ringe KI, Husarik DB, Sirlin CB, Merkle EM,. Gadoxetate disodium-enhanced MRI of the liver. Part 1. Protocol optimization and lesion appearance in the noncirrhotic liver. AJR Am J Roentgenol 2010; 195: 13-28.
16. Vilgrain V, Boulos L, Vullierme MP, Denys A, Terris B, Menu Y,. Imaging of atypical hemangiomas of the liver with pathologic correlation. Radiographics 2000; 20: 379-397.
17. Byun JH, Kim TK, Lee CW, et al. Arterioportal shunt: prevalence in small hemangiomas versus that in hepatocellular carcinomas 3 cm or smaller at two-phase helical CT. Radiology 2004; 232: 354-360.
18. Kim T, Federle MP, Baron RL, Peterson MS, Kawamori Y,. Discrimination of small hepatic hemangiomas from hypervascular malignant tumors smaller than 3 cm with three-phase helical CT. Radiology 2001; 219: 699-706.
19. Sasaki K, Ito K, Koike S, Fujita T, Okazaki H, Matsunaga N,. Differentiation between hepatic cyst and hemangioma: additive value of breath-hold, multisection fluid-attenuated inversion-recovery magnetic resonance imaging using half-Fourier acquisition single-shot turbo-spin-echo sequence. J Magn Reson Imaging 2005; 21: 29-36.
20. Ba-Ssalamah A, Uffmann M, Saini S, Bastati N, Herold C, Schima W,. Clinical value of MRI liver-specific contrast agents: a tailored examination for a confident non-invasive diagnosis of focal liver lesions. Eur Radiol 2009; 19: 342-357.
21. Larson RE, Semelka RC, Bagley AS, Molina PL, Brown ED, Lee JK,. Hypervascular malignant liver lesions: comparison of various MR imaging pulse sequences and dynamic CT. Radiology 1994; 192: 393-399.
22. Mitchell DG, Saini S, Weinreb J, et al. Hepatic metastases and cavernous hemangiomas: distinction with standard- and triple-dose gadoteridol-enhanced MR imaging. Radiology 1994; 193: 49-57.
23. Whitney WS, Herfkens RJ, Jeffrey RB, et al. Dynamic breath-hold multiplanar spoiled gradient-recalled MR imaging with gadolinium enhancement for differentiating hepatic hemangiomas from malignancies at 1.5 T. Radiology 1993; 189: 863-870.
24. Hamm B, Staks T, Mühler A, et al. Phase I clinical evaluation of Gd-EOB-DTPA as a hepatobiliary MR contrast agent: safety, pharmacokinetics, and MR imaging. Radiology 1995; 195: 785-792.
25. Tamada T, Ito K, Sone T, et al. Dynamic contrast-enhanced magnetic resonance imaging of abdominal solid organ and major vessel: comparison of enhancement effect between Gd-EOB-DTPA and Gd-DTPA. J Magn Reson Imaging 2009; 29: 636-640.
26. Goshima S, Kanematsu M, Watanabe H, et al. Hepatic hemangioma and metastasis: differentiation with gadoxetate disodium-enhanced 3-T MRI. AJR Am J Roentgenol. 2010; 195: 941-946.
27. Doo KW, Lee CH, Choi JW, Lee J, Kim KA, Park CM,. "Pseudo washout" sign in high-flow hepatic hemangioma on gadoxetic acid contrast-enhanced MRI mimicking hypervascular tumor. AJR Am J Roentgenol 2009; 193: W490-496.
28. Hanafusa K, Ohashi I, Himeno Y, Suzuki S, Shibuya H,. Hepatic hemangioma: findings with two-phase CT. Radiology 1995; 196: 465-469.
29. Ito K, Honjo K, Matsumoto T, Tanaka R, Nakada T, Nakanishi T,. Distinction of hemangiomas from hepatic tumors with delayed enhancement by incremental dynamic CT. J Comput Assist Tomogr 1992; 16: 572-577.
30. Ito K, Mitchell DG, Outwater EK, Szklaruk J, Sadek AG,. Hepatic lesions: discrimination of nonsolid, benign lesions from solid, malignant lesions with heavily T2-weighted fast spin-echo MR imaging. Radiology 1997; 204: 729-737.