Clinical value of MRI liver-specific contrast agents: A tailored examination for a confident non-invasive diagnosis of focal liver lesions

European Radiology

Volumn 19, Issue 2, 2009, Pages 342-357

  Ba Ssalamah, Ahmed ^a   Uffmann, Martin ^a   Saini, Sanjai ^b   Bastati, Nina ^a   Herold, Christian ^a   Schima, Wolfgang ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Characterization; Liver lesions; MR contrast agents

Indexed keywords

FERUCARBOTRAN; GADOBENATE DIMEGLUMINE; GADOLINIUM CHELATE; GADOXETIC ACID; MANGAFODIPIR; NUCLEAR MAGNETIC RESONANCE IMAGING AGENT; SUPERPARAMAGNETIC IRON OXIDE; TESLACAN; UNCLASSIFIED DRUG;

BACKACHE; BILE DUCT CARCINOMA; BOLUS INJECTION; CONTRAST ENHANCEMENT; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; DRUG EXCRETION; DRUG SAFETY; DRUG UPTAKE; FIBROLAMELLAR CARCINOMA; HUMAN; IMAGE ENHANCEMENT; IMAGE QUALITY; LIVER ADENOMA; LIVER CARCINOMA; LIVER CELL CARCINOMA; LIVER CYST; LIVER DISEASE; LIVER FOCAL NODULAR HYPERPLASIA; LIVER HEMANGIOMA; LIVER METASTASIS; NON INVASIVE MEASUREMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; REVIEW; TISSUE SPECIFICITY;

ADENOMA; CARCINOMA; CONTRAST MEDIA; CYSTS; FEMALE; GADOLINIUM; HEMANGIOMA; HEPATOCYTES; HUMANS; LIVER NEOPLASMS; MAGNETIC RESONANCE IMAGING; NEOPLASM METASTASIS; REPRODUCIBILITY OF RESULTS;

EID: 59249083168     PISSN: 09387994     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00330-008-1172-x     Document Type: Review

References (70)

1. Perilongo G, Shafford EA (1999) Liver tumours. Eur J Cancer 35(6):953-958 discussion 958-959
2. Jones EC, Chezmar JL, Nelson RC, Bernardino ME (1992) The frequency and significance of small (less than or equal to 15 mm) hepatic lesions detected by CT. AJR Am J Roentgenol 158(3):535-539
3. Ba-Ssalamah A, Fakhrai N, Matzek WK, Herneth AM, Stadler A, Bastati N, Herold CJ, Schima W (2007) Magnetic resonance imaging of liver malignancies. Top Magn Reson Imaging 18(6):445-455
4. Morana G, Salviato E, Guarise A (2007) Contrast agents for hepatic MRI. Cancer Imaging 7(Spec No A):S24-S27
5. Ersoy H, Rybicki FJ (2007) Biochemical safety profiles of gadolinium-based extracellular contrast agents and nephrogenic systemic fibrosis. J Magn Reson Imaging 26(5):1190-1197
6. Niendorf HP, Alhassan A, Geens VR, Clauss W (1994) Safety review of gadopentetate dimeglumine. Extended clinical experience after more than five million applications. Invest Radiol 29(Suppl 2):S179-S182
7. Semelka RC, Helmberger TK (2001) Contrast agents for MR imaging of the liver. Radiology 218(1):27-38
8. Reimer P, Schneider G, Schima W (2004) Hepatobiliary contrast agents for contrast-enhanced MRI of the liver: Properties, clinical development and applications. Eur Radiol 14(4):559-578
9. Hammerstingl R, Zangos S, Schwarz W, Rosen T, Bechstein WO, Balzer T, Vogl TJ (2002) Contrast-enhanced MRI of focal liver tumors using a hepatobiliary MR contrast agent: Detection and differential diagnosis using Gd-EOB-DTPA-enhanced versus Gd-DTPA-enhanced MRI in the same patient. Acad Radiol 9(Suppl 1):S119-S120
10. Schima W, Saini S, Petersein J, Weissleder R, Harisinghani M, Mayo-Smith W, Hahn PF (1999) MR imaging of the liver with Gd-BOPTA: Quantitative analysis of T1-weighted images at two different doses. J Magn Reson Imaging 10(1):80-83
11. Zech CJ, Herrmann KA, Reiser MF, Schoenberg SO (2007) MR imaging in patients with suspected liver metastases: Value of liver-specific contrast agent Gd-EOB-DTPA. Magn Reson Med Sci 6(1):43-52
12. Halavaara J, Breuer J, Ayuso C, Balzer T, Bellin MF, Blomqvist L, Carter R, Grazioli L, Hammerstingl R, Huppertz A, Jung G, Krause D, Laghi A, Leen E, Lupatelli L, Marsili L, Martin J, Pretorius ES, Reinhold C, Stiskal M, Stolpen AH (2006) Liver tumor characterization: Comparison between liver-specific gadoxetic acid disodium-enhanced MRI and biphasic CT-a multicenter trial. J Comput Assist Tomogr 30(3):345-354
13. Stroszczynski C, Gaffke G, Gnauck M, Streitparth F, Wieners G, Lopez-Haninnen E (2004) Current status of MRI diagnostics with liver-specific contrast agents. Gd-EOB-DTPA and Gd-BOPTA. Radiologe 44(12):1185-1191
14. Huppertz A, Haraida S, Kraus A, Zech CJ, Scheidler J, Breuer J, Helmberger TK, Reiser MF (2005) Enhancement of focal liver lesions at gadoxetic acid-enhanced MR imaging: Correlation with histopathologic findings and spiral CT-initial observations. Radiology 234(2):468-478
15. Morana GGL, Schneider G et al (2002) Hypervascular hepatic lesions: dynamic late enhancement pattern with Gd-BOPTA. Acad Radiol 9(Suppl 2):S476-S479
16. Oudkerk M, Torres CG, Song B, Konig M, Grimm J, Fernandez-Cuadrado J, Op de Beeck B, Marquardt M, van Dijk P, de Groot JC (2002) Characterization of liver lesions with mangafodipir trisodium-enhanced MR imaging: multicenter study comparing MR and dual-phase spiral CT. Radiology 223(2):517-524
17. Scharitzer M, Schima W, Schober E, Reimer P, Helmberger TK, Holzknecht N, Stadler A, Ba-Ssalamah A, Weber M, Wrba F (2005) Characterization of hepatocellular tumors: Value of mangafodipir-enhanced magnetic resonance imaging. J Comput Assist Tomogr 29(2):181-190
18. Helmberger TK, Laubenberger J, Rummeny E, Jung G, Sievers K, Dohring W, Meurer K, Reiser MF (2002) MRI characteristics in focal hepatic disease before and after administration of MnDPDP: Discriminant analysis as a diagnostic tool. Eur Radiol 12(1):62-70
19. Wang C, Ahlstrom H, Eriksson B, Lonnemark M, McGill S, Hemmingsson A (1998) Uptake of mangafodipir trisodium in liver metastases from endocrine tumors. J Magn Reson Imaging 8(3):682-686
20. Bluemke DA, Weber TM, Rubin D, de Lange EE, Semelka R, Redvanly RD, Chezmar J, Outwater E, Carlos R, Saini S, Holland GA, Mammone JF, Brown JJ, Milestone B, Javitt MC, Jacobs P (2003) Hepatic MR imaging with ferumoxides: Multicenter study of safety and effectiveness of direct injection protocol. Radiology 228(2):457-464
21. Saini S, Stark DD, Hahn PF, Wittenberg J, Brady TJ, Ferrucci JT Jr (1987) Ferrite particles: A superparamagnetic MR contrast agent for the reticuloendothelial system. Radiology 162(1 Pt 1):211-216
22. Reimer P, Muller M, Marx C, Wiedermann D, Muller R, Rummeny EJ, Ebert W, Shamsi K, Peters PE (1998) T1 effects of a bolus-injectable superparamagnetic iron oxide, SH U 555 A: Dependence on field strength and plasma concentration-preliminary clinical experience with dynamic T1-weighted MR imaging. Radiology 209(3):831-836
23. Ba-Ssalamah A, Heinz-Peer G, Schima W, Schibany N, Schick S, Prokesch RW, Kaider A, Teleky B, Wrba F, Lechner G (2000) Detection of focal hepatic lesions: Comparison of unenhanced and SHU 555 A-enhanced MR imaging versus biphasic helical CTAP. J Magn Reson Imaging 11(6):665-672
24. Montet X, Lazeyras F, Howarth N, Mentha G, Rubbia-Brandt L, Becker CD, Vallee JP, Terrier F (2004) Specificity of SPIO particles for characterization of liver hemangiomas using MRI. Abdom Imaging 29(1):60-70
25. Klatskin GCH (1993) Histopathology of the liver. Oxford University Press, New York
26. Mortele KJ, Ros PR (2001) Cystic focal liver lesions in the adult: differential CT and MR imaging features. Radiographics 21(4):895-910
27. Reddy KR, Kligerman S, Levi J, Livingstone A, Molina E, Franceschi D, Badalamenti S, Jeffers L, Tzakis A, Schiff ER (2001) Benign and solid tumors of the liver: Relationship to sex, age, size of tumors, and outcome. Am Surg 67(2):173-178
28. Soyer P, Dufresne AC, Somveille E, Scherrer A (1997) Hepatic cavernous hemangioma: Appearance on T2-weighted fast spin-echo MR imaging with and without fat suppression. AJR Am J Roentgenol 168(2):461-465
29. Semelka RC, Brown ED, Ascher SM, Patt RH, Bagley AS, Li W, Edelman RR, Shoenut JP, Brown JJ (1994) Hepatic hemangiomas: A multi-institutional study of appearance on T2-weighted and serial gadolinium-enhanced gradient-echo MR images. Radiology 192(2):401-406
30. Marti-Bonmati L, Casillas C, Graells M, Masia L (1999) Atypical hepatic hemangiomas with intense arterial enhancement and early fading. Abdom Imaging 24(2):147-152
31. Danet IM, Semelka RC, Braga L, Armao D, Woosley JT (2003) Giant hemangioma of the liver: MR imaging characteristics in 24 patients. Magn Reson Imaging 21(2):95-101
32. Bennett GL, Petersein A, Mayo-Smith WW, Hahn PF, Schima W, Saini S (2000) Addition of gadolinium chelates to heavily T2-weighted MR imaging: Limited role in differentiating hepatic hemangiomas from metastases. AJR Am J Roentgenol 174(2):477-485
33. Ba-Ssalamah A, Happel B, Kettenbach J, Dirisamer A, Wrba F, Langle F, Schima W (2004) [MRT of the liver. Clinical significance of nonspecific and liver-specific MRT contrast agents]. Radiologe 44(12):1170-1184
34. Mitchell DG, Saini S, Weinreb J, De Lange EE, Runge VM, Kuhlman JE, Parisky Y, Johnson CD, Brown JJ, Schnall M et al (1994) Hepatic metastases and cavernous hemangiomas: Distinction with standard- and triple-dose gadoteridol-enhanced MR imaging. Radiology 193(1):49-57
35. Nguyen BN, Flejou JF, Terris B, Belghiti J, Degott C (1999) Focal nodular hyperplasia of the liver: A comprehensive pathologic study of 305 lesions and recognition of new histologic forms. Am J Surg Pathol 23(12):1441-1454
36. Ba-Ssalamah A, Schima W, Schmook MT, Linnau KF, Schibany N, Helbich T, Reimer P, Laengle F, Wrba F, Kurtaran A, Ryan M, Mann FA (2002) Atypical focal nodular hyperplasia of the liver: Imaging features of nonspecific and liver-specific MR contrast agents. AJR Am J Roentgenol 179(6):1447-1456
37. Rummeny E, Weissleder R, Sironi S, Stark DD, Comptom CC, Hahn PF, Saini S, Wittenberg J, Ferrucci JT (1989) Central scars in primary liver tumors: MR features, specificity, and pathologic correlation. Radiology 171(2):323-326
38. Grazioli L, Morana G, Kirchin MA, Schneider G (2005) Accurate differentiation of focal nodular hyperplasia from hepatic adenoma at gadobenate dimeglumine-enhanced MR imaging: Prospective study. Radiology 236(1):166-177
39. Grazioli L, Morana G, Federle MP, Brancatelli G, Testoni M, Kirchin MA, Menni K, Olivetti L, Nicoli N, Procacci C (2001) Focal nodular hyperplasia: Morphologic and functional information from MR imaging with gadobenate dimeglumine. Radiology 221(3):731-739
40. Ricci P, Laghi A, Cantisani V, Paolantonio P, Pacella S, Pagliara E, Arduini F, Pasqualini V, Trippa F, Filpo M, Passariello R (2005) Contrast-enhanced sonography with SonoVue: Enhancement patterns of benign focal liver lesions and correlation with dynamic gadobenate dimeglumine-enhanced MRI. AJR Am J Roentgenol 184(3):821-827
41. Bluemke DA, Sahani D, Amendola M, Balzer T, Breuer J, Brown JJ, Casalino DD, Davis PL, Francis IR, Krinsky G, Lee FT Jr., Lu D, Paulson EK, Schwartz LH, Siegelman ES, Small WC, Weber TM, Welber A, Shamsi K (2005) Efficacy and safety of MR imaging with liver-specific contrast agent: U.S. multicenter phase III study. Radiology 237(1):89-98
42. Precetti-Morel S, Bellin MF, Ghebontni L, Zaim S, Opolon P, Poynard T, Mathurin P, Cluzel P (1999) Focal nodular hyperplasia of the liver on ferumoxides-enhanced MR imaging: Features on conventional spin-echo, fast spin-echo and gradient-echo pulse sequences. Eur Radiol 9(8):1535-1542
43. Soe K (1992) Liver Pathology associated with the use of anabolic-androgenic steroids. Liver 12:73-79
44. Meissner K (1998) Hemorrhage caused by ruptured liver cell adenoma following long-term oral contraceptives: A case report. Hepatogastroenterology 45(19):224-225
45. Craig CPR, Edmonson HA (1989) Atlas of tumor pathology: Tumors of the liver and intrahepatic bile ducts. Armed forces Institute of Pathology, Washington DC
46. Paulson EK, McClellan JS, Washington K, Spritzer CE, Meyers WC, Baker ME (1994) Hepatic adenoma: MR characteristics and correlation with pathologic findings. AJR Am J Roentgenol 163(1):113-116
47. Chung KY, Mayo-Smith WW, Saini S, Rahmouni A, Golli M, Mathieu D (1995) Hepatocellular adenoma: MR imaging features with pathologic correlation. AJR Am J Roentgenol 165(2):303-308
48. Hussain SM, Zondervan PE, Ijzermans JN, Schalm SW, de Man RA, Krestin GP (2002) Benign versus malignant hepatic nodules: MR imaging findings with pathologic correlation. Radiographics 22(5):1023-1036 discussion 1037-1039
49. Kim MJ, Kim JH, Lim JS, Oh YT, Chung JJ, Choi JS, Lee WJ, Kim KW (2004) Detection and characterization of focal hepatic lesions: Mangafodipir vs. superparamagnetic iron oxide-enhanced magnetic resonance imaging. J Magn Reson Imaging 20(4):612-621
50. Sugarbaker PH, Kemeny N (1989) Management of metastatic cancer to the liver. Adv Surg 22:1-56
51. Danet IM, Semelka RC, Leonardou P, Braga L, Vaidean G, Woosley JT, Kanematsu M (2003) Spectrum of MRI appearances of untreated metastases of the liver. AJR Am J Roentgenol 181(3):809-817
52. Stern W, Schick F, Kopp AF, Reimer P, Shamsi K, Claussen CD, Laniado M (2000) Dynamic MR imaging of liver metastases with Gd-EOB-DTPA. Acta Radiol 41(3):255-262
53. Kim YK, Lee JM, Kim CS (2004) Gadobenate dimeglumine-enhanced liver MR imaging: Value of dynamic and delayed imaging for the characterization and detection of focal liver lesions. Eur Radiol 14(1):5-13
54. King LJ, Burkill GJ, Scurr ED, Vlavianos P, Murray-Lyons I, Healy JC (2002) MnDPDP enhanced magnetic resonance imaging of focal liver lesions. Clin Radiol 57(12):1047-1057
55. Ros PR, Freeny PC, Harms SE, Seltzer SE, Davis PL, Chan TW, Stillman AE, Muroff LR, Runge VM, Nissenbaum MA et al (1995) Hepatic MR imaging with ferumoxides: A multicenter clinical trial of the safety and efficacy in the detection of focal hepatic lesions. Radiology 196(2):481-488
56. Lai EC, Lau WY (2005) The continuing challenge of hepatic cancer in Asia. Surgeon 3(3):210-215
57. Mitchell DG (2000) MR imaging of cirrhosis and its complications. Abdom Imaging 25(5):455
58. Taouli B, Losada M, Holland A, Krinsky G (2004) Magnetic resonance imaging of hepatocellular carcinoma. Gastroenterology 127(5 Suppl 1):S144-S152
59. Grazioli L, Olivetti L, Fugazzola C, Benetti A, Stanga C, Dettori E, Gallo C, Matricardi L, Giacobbe A, Chiesa A (1999) The pseudocapsule in hepatocellular carcinoma: Correlation between dynamic MR imaging and pathology. Eur Radiol 9(1):62-67
60. Bartolozzi C, Crocetti L, Lencioni R, Cioni D, Della Pina C, Campani D (2007) Biliary and reticuloendothelial impairment in hepatocarcinogenesis: The diagnostic role of tissue-specific MR contrast media. Eur Radiol 17(10):2519-2530
61. Muramatsu Y, Nawano S, Takayasu K, Moriyama N, Yamada T, Yamasaki S, Hirohashi S (1991) Early hepatocellular carcinoma: MR imaging. Radiology 181(1):209-213
62. Grazioli L, Morana G, Caudana R, Benetti A, Portolani N, Talamini G, Colombari R, Pirovano G, Kirchin MA, Spinazzi A (2000) Hepatocellular carcinoma: Correlation between gadobenate dimeglumine-enhanced MRI and pathologic findings. Invest Radiol 35(1):25-34
63. Winter TC 3rd, Takayasu K, Muramatsu Y, Furukawa H, Wakao F, Koga H, Sakamoto M, Hirohashi S, Freeny PC (1994) Early advanced hepatocellular carcinoma: Evaluation of CT and MR appearance with pathologic correlation. Radiology 192(2):379-387
64. Pauleit D, Textor J, Bachmann R, Conrad R, Flacke S, Layer G, Kreft B, Schild H (2002) Hepatocellular carcinoma: Detection with gadolinium- and ferumoxides-enhanced MR imaging of the liver. Radiology 222(1):73-80
65. Craig JR, Peters RL, Edmondson HA, Omata M (1980) Fibrolamellar carcinoma of the liver: A tumor of adolescents and young adults with distinctive clinico-pathologic features. Cancer 46(2):372-379
66. McLarney JK, Rucker PT, Bender GN, Goodman ZD, Kashitani N, Ros PR (1999) Fibrolamellar carcinoma of the liver: Radiologic-pathologic correlation. Radiographics 19(2):453-471
67. Corrigan K, Semelka RC (1995) Dynamic contrast-enhanced MR imaging of fibrolamellar hepatocellular carcinoma. Abdom Imaging 20(2):122-125
68. Worawattanakul S, Semelka RC, Noone TC, Calvo BF, Kelekis NL, Woosley JT (1998) Cholangiocarcinoma: Spectrum of appearances on MR images using current techniques. Magn Reson Imaging 16(9):993-1003
69. Maetani Y, Itoh K, Watanabe C, Shibata T, Ametani F, Yamabe H, Konishi J (2001) MR imaging of intrahepatic cholangiocarcinoma with pathologic correlation. AJR Am J Roentgenol 176(6):1499-1507
70. Zheng WW, Zhou KR, Chen ZW, Shen JZ, Chen CZ, Zhang SJ (2002) Characterization of focal hepatic lesions with SPIO-enhanced MRI. World J Gastroenterol 8(1):82-86