A simple quantitation method for benzoylecgonine from oral fluid, blood, and urine samples used for determining 22 illicit and licit drugs by GC-MS with liquid-liquid extraction

Forensic Toxicology

Volumn 30, Issue 1, 2012, Pages 59-65

  Institóris, László ^a   Angyal, Vilmos ^b   Árok, Zsófia ^a   Kereszty, Éva ^a   Varga, Tibor ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b TEVA Pharmaceutical Works   (Hungary)

Author keywords

Benzoylecgonine; Blood; GC MS; Liquid liquid extraction; Oral fluid; Urine

Indexed keywords

BENZOYLECGONINE; ILLICIT DRUG; LICIT DRUG; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG URINE LEVEL; FLUID INTAKE; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF QUANTITATION; LIQUID LIQUID EXTRACTION; MASS SPECTROMETRY; PRIORITY JOURNAL;

EID: 84858699536     PISSN: 18608965     EISSN: 18608973     Source Type: Journal    
DOI: 10.1007/s11419-011-0128-z     Document Type: Article

References (19)

1. Kankaanpaa A, Gunnar T, Ariniemi K, Lillsunde P, Mykkanen S, Seppala T (2004) Single step procedure for gas chromatographymass spectrometry screening and quantitative determination of amphetamine-type stimulants and related drugs in blood, serum, oral fluid and urine samples. J Chromatogr B 810:57-68. doi: 10.1016/jchromb.2004.07.035 (Pubitemid 39195024)
2. Gunnar T, Ariniemi K, Lillsunde P (2005) Determination of 14 benzodiazepines and hydroxyl metabolites, zaleplon and zolpidem as tert-butyldimethylsilyl derivatives compared with other common silylating reagents in whole blood by gas chromatography-mass spectrometry. J Chromatogr B 818:175-189. doi:10.1016/jchromb.2004.12.032 (Pubitemid 40331822)
3. Gunnar T, Ariniemi K, Lillsunde P (2005) Validated toxicological determination of 30 drugs of abuse as optimized derivatives in oral fluid by long column fast gas chromatography/electron impact mass spectrometry. J Mass Spectrom 40:739-753. doi:10.1002/jms.846 (Pubitemid 40905239)
4. Kolbrich EA, Barnes AJ, Gorelick DA, Boyd SJ, Cone EJ, Huestis MA (2006) Major and minor metabolites of cocaine in human plasma following controlled subcutaneous cocaine administration. J Anal Toxicol 30:501-510 (Pubitemid 44600839)
5. Kato K, Hillsgrove M, Weinhold L, Gorelik DA, Darwin WD (1993) Cocaine and metabolite excretion in saliva under stimulated and nonstimulated conditions. J Anal Toxicol 17:338-341 (Pubitemid 23286733)
6. Gerlits J (1993) GC/MS quantitation of benzoylecgonine following liquid-liquid extraction of urine. J Forensic Sci 38:1210-1214
7. Álvarez I, Palos F, Bermejo AM, Fernández P, Tabernero MJ (2006) Simultaneous determination of methadone, cocaine and their metabolites in urine by GC-MS. Anal Lett 39:1393-1399. doi:10.1080/00032710600668699 (Pubitemid 43861096)
8. Thompson LK, Yousefnejad D, Kumor K, Sherer M, Cone EJ (1987) Confirmation of cocaine in human saliva after intravenous use. J Anal Toxicol 11:36-38 (Pubitemid 17067771)
9. Cámpora P, Bermejo AM, Tabernero MJ, Fernández P (2003) Quantitation of cocaine and its major metabolites in human saliva using gas chromatography-positive chemical ionization-mass spectrometry (GC-PCI-MS). J Anal Toxicol 27:270-274
10. Clauwaert K, Decaestecker T, Mortier K, Lambert W, Deforce D, Van Peteghem C, Van Bocxlaer J (2004) The determination of cocaine, benzoylecgonine, and cocaethylene in small volume oral fluid samples by liquid chromatography-quadrupole-time-offlight mass spectrometry. J Anal Toxicol 28:655-659 (Pubitemid 39489039)
11. Cognard E, Bouchonnet S, Staub C (2006) Validation of a gas chromatography-ion trap tandem mass spectrometry for simultaneous analyse of cocaine and its metabolites in saliva. J Pharm Biomed Anal 41:925-934. doi:10.1016/jpba.2006.01.041
12. Jufer R, Walsh SL, Cone EJ, Sampson-Cole A (2006) Effect of repeated cocaine administration on detection times in oral fluid and urine. J Anal Toxicol 30:458-462 (Pubitemid 44371488)
13. Langel K, Engblom C, Pehrsson A, Gunnar T, Ariniemi K, Lillsunde P (2008) Drug testing in oral fluid-evaluation of sample collection devices. J Anal Toxicol 32:393-401
14. Peters FT, Maurer HH (2002) Bioanalytical method validation and its implications for forensic and clinical toxicology - a review. Accred Qual Assur 7:441-449. doi:10.1007/s00769-002-0516-5 (Pubitemid 36165305)
15. Griesemer EC, Liu Y, Budd RD, Raftogianis L, Noguchi TT (1983) The determination of cocaine and its major metabolite, benzoylecgonine, in postmortem fluids and tissues by computerized gas chromatography-mass spectrometry. J Forensic Sci 28:894-900 (Pubitemid 13019393)
16. Chinn DM, Crouch DJ, Peat MA, Finkle BS, Jennison TA (1980) Gas chromatography-chemical ionization mass spectrometry of cocaine and its metabolites in biological fluids. J Anal Toxicol 4:37-42 (Pubitemid 10148690)
17. Needleman SB, Goodin K (1991) Liquid-liquid extraction systems for THC-COOH and benzoylecgonine. J Anal Toxicol 15:179-191
18. Jatlow P (1988) Cocaine: analysis, pharmacokinetics, and metabolic disposition. Yale J Biol Med 61:105-113
19. Langel K, Gunnar T, Ariniemi K, Rajamaki O, Lillsunde P (2011) A validated method for the detection and quantitation of 50 drugs of abuse and medicinal drugs in oral fluid by gas chromatography-mass spectrometry. J Chromatogr B 879:859-870. doi:10.1016/j.jchromb.2011.02.027