Simultaneous determination of methadone, heroin, cocaine and their metabolites in urine by GC-MS

Analytical Letters

Volumn 39, Issue 7, 2006, Pages 1393-1399

  Alvarez I ^a   Palos, F ^a   Bermejo, A M ^a   Fernandez P ^a   Tabernero, M J ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Derivatization; Drugs of abuse; GC MS; Liquid liquid extraction; Urine

Indexed keywords

EID: 33744994126     PISSN: 00032719     EISSN: 1532236X     Source Type: Journal    
DOI: 10.1080/00032710600668699     Document Type: Article

References (14)

1. Armbruster, D.A., Tillman, M.D., and Hubbs, L.M. 1994. Limit of detection (LOD)/limit of quantitation (LOQ): comparison of the empirical and the statistical methods exemplified with GC-MS assays of abused drugs. Clin. Chem., 40: 1233-1238.
2. Barrio, G., de la Fuente, L., Royuela, L., Díaz, A., and Rodríguez Artalejo, F.J. 1998. Cocaine use among heroin users in Spain: the diffusion of crack and cocaine smoking. Spanish group for the study on the route of administration of drugs. Epidemiol. Community Health 52: 172-180.
3. Baselt, R.C. 2000. Disposition of Toxic Drugs and Chemicals in Man; Chemical Toxicology Institute: Foster City, CA, USA.
4. Bermejo, A.M., Lucas, A.C.S., Tabernero, M.J., and Fernández, P. 2000. Simultaneous determination of methadone, heroin and their metabolites in hair by GC-MS. Anal. Lett., 33: 739-752.
5. Bressolle, F., Bromet-Petit, M., and Audran, M.M. 1996. Validation of liquid chromatographic and gas chromatographic methods. Applications to pharmacokinetics. J. Chromatogr. B, 686: 3-10.
6. Buján, L., Fernández, P., Lafuente, N., Aldonza, M., and Bermejo, A.M. 2001. Comparison of two chromatographic methods for the determination of cocaine and its metabolites in blood and urine. Anal. Lett., 34 (13): 2263-2275.
7. Dart, R.C. 2004. Medical Toxicology; Lippincott Williams & Wilkins: Philadelphia, USA.
8. Klaassen, C.D. and Watkins, J.B., III Eds.; 2003. Casarett & Doull's Essentials of Toxicology. McGraw-Hill: New York, USA.
9. Mills, T., III and Roberson, J.C. 1987. Instrumental Data for Drug Analysis. Elsevier: New York, USA.
10. Moffat, A.C., Osselton, M.D., and Widdop, B. Eds.; 2004. Clarke's Analysis of Drugs and Poisons in Pharmaceuticals, Body Fluids and Postmortem Material. Pharmaceutical Press: London, UK.
11. Navarro, J. and Sánchez, L. 2002. Observatorio de Galicia sobre Drogas. Informe General 2002. Xunta de Galicia: Santiago de Compostela, Spain.
12. Observatorio Español sobre Drogas (OED). Informe no 5. Ministerio del Interior: Madrid, Spain, 2002.
13. Pfleger, K. and Weber, M.A. 1992. Mass Spectral and GC Data of Drugs, Poisons, Pesticides, Pollutants and Their Metabolites. VCH: Weinheim, Germany.
14. Wang, W.-L., Darwin, W.D., and Cone, E.J. 1994. Simultaneous assay of cocaine, heroin and metabolites in hair, plasma, saliva and urine by gas chromatographymass spectrometry. J. Chromatogr. B, 660: 279-290.