Synthesis and evaluation of 2-amido-3-carboxamide thiophene CB 2 receptor agonists for pain management

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 7, 2012, Pages 2604-2608

  Nelson, Derek W ^a   Frost, Jennifer M ^a   Tietje, Karin R ^a   Florjancic, Alan S ^a   Ryther, Keith ^a   Carroll, William A ^a   Dart, Michael J ^a   Daza, Anthony V ^a   Hooker, Bradley A ^a   Grayson, George K ^a   Fan, Yihong ^a   Garrison, Tiffany R ^a   El Kouhen, Odile F ^a   Yao, Betty ^a   Pai, Madhavi ^a   Chandran, Prasant ^a   Zhu, Chang ^a   Hsieh, Gin C ^a   Meyer, Michael D ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

CB2 agonists; Pain management

Indexed keywords

2 AMIDO 3 CARBOXAMIDE THIOPHENE CANNABOID RECEPTOR 2 RECEPTOR AGONIST; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID 1 RECEPTOR AGONIST; CANNABINOID 2 RECEPTOR; CANNABINOID 2 RECEPTOR AGONIST; RADIOLIGAND; UNCLASSIFIED DRUG;

ALLODYNIA; ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG EFFICACY; DRUG HALF LIFE; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYPERALGESIA; MAXIMUM PLASMA CONCENTRATION; NEUROPATHIC PAIN; NONHUMAN; POSTOPERATIVE PAIN; STRUCTURE ACTIVITY RELATION;

AMIDES; ANALGESICS; ANIMALS; BIOLOGICAL AVAILABILITY; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYPERALGESIA; NEURALGIA; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 84858699262     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.01.121     Document Type: Article

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