The role of oxytocin in mating and pregnancy

Hormones and Behavior

Volumn 61, Issue 3, 2012, Pages 266-276

  Borrow, Amanda P ^a   Cameron, Nicole M ^a  

^a BINGHAMTON UNIVERSITY   (United States)

Author keywords

Female; Human; Mating; Oxytocin; Pregnancy; Prolactin; Rodent

Indexed keywords

ESTROGEN; OXYTOCIN; PROLACTIN; SEROTONIN;

AROUSAL; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HORMONE ACTION; HORMONE RELEASE; HUMAN; KNOCKOUT MOUSE; MATING; NONHUMAN; ORGASM; OXYTOCIN BLOOD LEVEL; PREGNANCY; PRIORITY JOURNAL; REVIEW; SEXUAL BEHAVIOR; SEXUALITY; SOCIAL BEHAVIOR; SPINAL CORD; VAGUS NERVE;

ANIMALS; AROUSAL; CENTRAL NERVOUS SYSTEM; ESTROGENS; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MICE; MICE, KNOCKOUT; OBJECT ATTACHMENT; ORGASM; OXYTOCIN; PREGNANCY; PREGNANCY, ANIMAL; PROLACTIN; REPRODUCTIVE BEHAVIOR; SEXUAL BEHAVIOR, ANIMAL; SOCIAL BEHAVIOR; SPINAL CORD; VAGUS NERVE;

EID: 84858690806     PISSN: 0018506X     EISSN: 10956867     Source Type: Journal    
DOI: 10.1016/j.yhbeh.2011.11.001     Document Type: Review

References (129)

1. Anderson-Hunt M., Dennerstein L. Increased female sexual response after oxytocin. BMJ 1994, 309:929.
2. Arey B.J., Freeman M.E. Hypothalamic factors involved in the endogenous stimulatory rhythm regulating prolactin secretion. Endocrinology 1989, 124:878-883.
3. Arey B.J., Freeman M.E. Oxytocin, vasoactive-intestinal peptide, and serotonin regulate the mating-induced surges of prolactin secretion in the rat. Endocrinology 1990, 126:279-284.
4. Arey B.J., Freeman M.E. Activity of oxytocinergic neurons in the paraventricular nucleus mirrors the periodicity of the endogenous stimulatory rhythm regulating prolactin secretion. Endocrinology 1992, 130:126-132.
5. Aron A., Fisher H., Mashek D.J., Strong G., Li H., Brown L.L. Reward, motivation, and emotion systems associated with early-stage intense romantic love. J. Neurophysiol. 2005, 94:327-337.
6. Arzate D.M., Portillo W., Rodríguez C., Corona R., Paredes R.G. Extended paced mating tests induces conditioned place preference without affecting sexual arousal. Horm. Behav. 2011, 59:674-680.
7. Bale T.L., Dorsa D.M., Johnston C.A. Oxytocin receptor mRNA expression in the ventromedial hypothalamus during the estrous cycle. J. Neurosci. 1995, 15:5058-5064.
8. Barfield R.J., Thomas D.A. The role of ultrasonic vocalizations in the regulation of reproduction in rats. Ann. N.Y. Acad. Sci. 1986, 474:33-43.
9. Bartels A., Zeki S. The neural basis of romantic love. NeuroReport 2000, 11:3829-3834.
10. Blaicher W., Gruber D., Bieglmayer C., Blaicher A.M., Knogler W., Huber J.C. The role of oxytocin in relation to female sexual arousal. Gynecol. Obstet. Invest. 1999, 47:125-126.
11. Bohlen J.G., Held J.P., Sanderson M.O., Ahlgren A. The female orgasm: pelvic contractions. Arch. Sex. Behav. 1982, 11:367-386.
12. Breton C., Zingg H.H. Expression and region-specific regulation of the oxytocin receptor gene in rat brain. Endocrinology 1997, 138:1857-1862.
13. Brody S., Krüger T.H. The post-orgasmic prolactin increase following intercourse is greater than following masturbation and suggests greater satiety. Biol. Psychol. 2006, 71:313-315.
14. Bruce H.M. An exteroceptive block to pregnancy in the mouse. Nature 1959, 184:105.
15. Brunetti M., Babiloni C., Ferretti A., Del Gratta C., Merla A., Belardinelli M.O., Romani G.L. Hypothalamus, sexual arousal and psychosexual identity in human males: a functional magnetic resonance imaging study. Eur. J. Neurosci. 2008, 27:2922-2927.
16. Burbach J.P.H., Young L.J., Russell J.A. Oxytocin: synthesis, secretion, and reproductive functions. Physiology of Reproduction, 2 2006, 3055-3128. Elsevier, St. Louis. E. Knobil, J.D. Neill (Eds.).
17. Burgdorf J., Wood P.L., Kroes R.A., Moskal J.R., Panksepp J. Neurobiology of 50-kHz ultrasonic vocalizations in rats: electrode mapping, lesion, and pharmacology studies. Behav. Brain Res. 2007, 182:274-283.
18. Burri A., Heinrichs M., Schedlowski M., Kruger T.H.C. The acute effects of intranasal oxytocin administration on endocrine and sexual function in males. Psychoneuroendocrinology 2008, 33:591-600.
19. Butcher R.L., Fugo N.W., Collins W.E. Semicardian rhythm in plasma levels of prolactin during early gestation in the rat. Endocrinology 1972, 90:1125-1127.
20. Caldwell J.D. A sexual arousability model involving steroid effects at the plasma membrane. Neurosci. Biobehav. Rev. 2002, 26:13-30.
21. Caldwell J.D., Jirikowski G.F., Greer E.R., Stumpf W.E., Pederson C.A. Ovarian steroids and sexual interaction alter oxytocinergic content and distribution in the basal forebrain. Brain Res. 1988, 446:236-244.
22. Cameron N., Erskine M.S. c-Fos expression in the forebrain after mating in the female rat is altered by adrenalectomy. Neuroendocrinology 2003, 77:305-313.
23. Canli T., Gabrieli J.D.E. Imaging gender differences in sexual arousal. Nat. Neurosci. 2004, 7:325-326.
24. Card J.P. Practical considerations for the use of pseudorabies virus in transneuronal studies of neural circuitry. Neurosci. Biobehav. Rev. 1998, 22:685-694.
25. Carmichael M.S., Humbert R., Dixen J., Palmisano G., Greenleaf W., Davidson J.M. Plasma oxytocin increases in human sexual response. J. Clin. Endocrinol. Metab. 1987, 64:27-31.
26. Carmichael M.S., Warburton V.L., Dixen J., Davidson J.M. Relationships among cardiovascular, muscular, and oxytocin responses during human sexual activity. Arch. Sex. Behav. 1994, 23:59-79.
27. Carter C.S. Oxytocin and sexual behavior. Neurosci. Biobehav. Rev. 1992, 16:131-144.
28. Carter C.S. Sex differences in oxytocin and vasopressin: implications for autism spectrum disorders?. Behav. Brain Res. 2007, 176:170-186.
29. Champagne F., Diorio J., Sharma S., Meaney M.J. Naturally occurring variations in maternal behavior in the rat are associated with differences in estrogen-inducible central oxytocin receptors. Proc. Natl. Acad. Sci. 2001, 98:12736-12741.
30. Choleris E., Gustafsson J.A., Korach K.S., Muglia L.J., Pfaff D.W., Ogawa S. An estrogen-dependent four-gene micronet regulating social recognition: a study with oxytocin and estrogen receptor-alpha and -beta knockout mice. Proc. Natl. Acad. Sci. 2003, 100:6192-6197.
31. Daniel P.M., Prichard M.M. Studies of the hypothalamus and the pituitary gland with special reference to the effects of transection of the pituitary stalk. Acta Endocrinol. Suppl. 1975, 201:1-216.
32. Dantzer R., Tazi A., Bluthé R.M. Cerebral lateralization of olfactory-mediated affective process in rats. Behav. Brain Res. 1990, 40:53-60.
33. De Kloet E.R., Voorhuis T.A., Elands J. Estradiol induces oxytocin binding sites in rat hypothalamic ventromedial nucleus. Eur. J. Pharmacol. 1985, 118:185-186.
34. Donner N., Neumann I.D. Effect of chronic intracerebral prolactin on the oxytonergic and vasopressinergic system of virgin ovariectomized rats. Neuroendocrinology 2009, 90:315-322.
35. Douglas A.J., Meddle S.L. Fast delivery: a central role of oxytocin. Neurobiology of the Parental Brain 2008, 223-232. Elsevier, Amsterdam. R.S. Bridges (Ed.).
36. Egli M., Bertram R., Sellix M.T., Freeman M.E. Rhythmic secretion of prolactin in rats: action of oxytocin coordinated by vasoactive intestinal polypeptide of suprachiasmatic nucleus origin. Endocrinology 2004, 145:3386-3394.
37. Egli M., Bertram R., Toporikova N., Sellix M.T., Blanco W., Freeman M.E. Prolactin secretory rhythm of mated rats induced by a single injection of oxytocin. Am. J. Physiol. Endocrinol. Metab. 2006, 290:E566-E572.
38. Egli M., Leeners B., Kruger T.H. Prolactin secretion patterns: basic mechanisms and clinical implications for reproduction. Reproduction 2010, 140:643-654.
39. Erskine M.S. Solicitation behavior in the estrous female rat: a review. Horm. Behav. 1989, 23:473-502.
40. Erskine M.S., Lehmann M.L., Cameron N.M., Polston E.K. Co-regulation of female sexual behavior and pregnancy induction: an exploratory synthesis. Behav. Brain Res. 2004, 153:295-315.
41. Evans J.J. Oxytocin in the human-regulation of derivations and destinations. Eur. J. Endocrinol. 1997, 137:559-571.
42. Exton M.S., Krüger T.H., Koch M., Paulson E., Knapp W., Hartmann U., Schedlowski M. Coitus-induced orgasm stimulates prolactin secretion in healthy subjects. Psychoneuroendocrinology 2001, 26:287-294.
43. Ferretti A., Caulo M., Del Gratta C., Di Matteo R., Merla A., Montorsi F., Pizzella V., Pompa P., Rigatti P., Rossini P.M., Salonia A., Tartaro A., Romani G.L. Dynamics of male sexual arousal: distinct components of brain activation revealed by fMRI. NeuroImage 2005, 26:1086-1096.
44. Ferri-Kolwicz, S.L., Flanagan-Cato, L.M., this issue. Oxytocin and dendrite remodeling in the hypothalamus. Hormones and Behavior.
45. Freeman M.E., Smith M.S., Nazian S.J., Neill J.D. Ovarian and hypothalamic control of the daily surges of prolactin secretion during pseudopregnancy in the rat. Endocrinology 1974, 94:875-882.
46. Freeman M.E., Kanyicska B., Lerant A., Nagy G. Prolactin: structure, function, and regulation of secretion. Physiol. Rev. 2000, 80:1523-1631.
47. Freund-Mercier M.J., Stoeckel M.E., Palacios J.M., Pazos A., Reichhart J.M., Porte A., Richard P. Pharmacological characteristics and anatomical distribution of 3H oxytocin-binding sites in the Wistar rat brain studied by autoradiography. Neuroscience 1987, 20:599-614.
48. Garzia E., Borgato S., Cozzi V., Doi P., Bulfamante G., Persani L., Cetin I. Lack of expression of endometrial prolactin in early implantation failure: a pilot study. Hum. Reprod. 2004, 19:1911-1916.
49. Gelez H., Poirier S., Facchinetti P., Allers K.A., Wayman C., Alexandre L., Giuliano F. Neuroanatomical evidence for a role of central melanocortin-4 receptors and oxytocin in the efferent control of the rodent clitoris and vagina. J. Sex. Med. 2010, 7:2056-2067.
50. Georgiadis J.R., Reinders A.A.T., Paans A.M.J., Renken R., Kortekaas R. Men versus women on sexual brain function: prominent differences during tactile genital stimulation, but not during orgasm. Hum. Brain Mapp. 2009, 30:3089-3101.
51. Gerhold L.M., Sellix M.T., Freeman M.E. Anatgonism of vasoactive intestinal peptide mRNA in the suprachiasmatic nucleus disrupts the rhythm of FRAs expression in neuroendocrine dopaminergic neurons. J. Comp. Neurol. 2002, 450:135-143.
52. Ghosh R., Sladek C.D. Role of prolactin and gonadal steroids in regulation of oxytocin mRNA during lactation. Am. J. Physiol. 1995, 269:E76-E84.
53. Gimpl G., Fahrenholz F. The oxytocin receptor system: structure, function, and regulation. Physiol. Rev. 2001, 81:629-683.
54. Grattan D.R., Kokay I.C. Prolactin: a pleiotropic neuroendocrine hormone. J. Neuroendocrinol. 2008, 20:752-763.
55. Grewen K.M., Girdler S.S., Amico J., Light K.C. Effects of partner support on resting oxytocin, cortisol, norepinephrine, and blood pressure before and after warm partner contact. Psychosom. Med. 2005, 67:531-538.
56. Guevara-Guzman R., Barrera-Mera B., Weiss M.L. Effect of the estrous cycle on olfactory bulb response to vaginocervical stimulation in the rat: results from electrophysiology and Fos immunocytochemistry experiments. Brain Res. Bull. 1997, 44:141-149.
57. Halem H.A., Cherry J.A., Baum M.J. Central forebrain Fos responses to familiar male odours are attenuated in recently mated female mice. Eur. J. Neurosci. 2001, 13:389-399.
58. Hurlemann R., Patin A., Onur O.A., Cohen M.X., Baumgartner T., Metzler S., Dziobek I., Gallinat J., Wagner M., Maier W., Kendrick K.M. Oxytocin enhances amygdala-dependent, socially reinforced learning and emotional empathy in humans. J. Neurosci. 2010, 30:4999-5007.
59. Imwalle D.B., Scordalakes E.M., Rissman E.F. Estrogen receptor alpha influences socially motivated behaviors. Horm. Behav. 2002, 42:484-491.
60. Insel T.R. Oxytocin-a neuropeptide for affiliation: evidence from behavioral, receptor autoradiographic, and comparative studies. Psychoneuroendocrinology 1992, 17:3-35.
61. Insel T.R., Young L., Witt D.M., Crews D. Gonadal steroids have paradoxical effects on brain oxytocin receptors. J. Neuroendocrinol. 1993, 5:619-628.
62. Ishak W.W., Berman D.S., Peters A. Male anorgasmia treated with oxytocin. J. Sex. Med. 2008, 5:1022-1024.
63. Jabbour H.N., Critchley H.O. Potential roles of decidual prolactin in early pregnancy. Reproduction 2001, 121:197-205.
64. Karama S., Lecours A.R., Leroux J.M., Bourgouin P., Beaudoin G., Joubert S., Beauregard M. Areas of brain activation in males and females during viewing of erotic film excerpts. Hum. Brain Mapp. 2002, 16:1-13.
65. Kendrick K.M., Lévy F., Keverne E.B. Importance of vaginocervical stuimulation for the formation of maternal bonding in primiparous and multiparous parturient ewes. Physiol. Behav. 1991, 50:595-600.
66. Keverne E.B. Vomeronasal/accessory olfactory system and pheromonal recognition. Chem. Senses 1998, 23:491-494.
67. Kiss A., Mikkelsen J.D. Oxytocin-anatomy and functional assignments: a minireview. Endocr. Regul. 2005, 39:97-105.
68. Kokay I.C., Bull P.M., Davis R.L., Ludwig M., Grattan D.R. Expression of the long form of the prolactin receptor in magnocellular oxytocin neurons is associated with specific prolactin regulation of oxytocin neurons. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2006, 290:R1216-R1225.
69. Komisaruk B.R., Sansone G. Neural pathways mediating vaginal function: the vagus nerves and spinal cord oxytocin. Scand. J. Psychol. 2003, 44:241-250.
70. Komisaruk B.R., Whipple B. Functional MRI of the brain during orgasm in women. Annu. Rev. Sex Res. 2005, 16:62-86.
71. Komisaruk B.R., Whipple B., Crawford A., Liu W.C., Kalnin A., Mosier K. Brain activation during vaginocervical self-stimulation and orgasm in women with complete spinal cord injury: fMRI evidence of mediation by the vagus nerves. Brain Res. 2004, 1024:77-88.
72. Krémarik P., Freund-Mercier M.J., Stoeckel M.E. Estrogen-sensitive oxytocin binding sites are differently regulated by progesterone in the telencephalon and the hypothalamus of the rat. J. Neuroendocrinol. 1995, 7:281-289.
73. Krémarik P., Freund-Mercier M.J., Stoeckel M.E. Oxytocin and vasopressin binding sites in the hypothalamus of the rat: histoautoradiographic detection. Brain Res. Bull. 1995, 36:195-203.
74. Kunz G., Noe M., Herbertz M., Leyendecker G. Uterine peristalsis during the follicular phase of the menstrual cycle: effects of oestrogen, antioestrogen and oxytocin. Hum. Reprod. Update 1998, 4:647-654.
75. Lamberts S.W., Macleod R.M. Regulation of prolactin secretion at the level of the lactotroph. Physiol. Rev. 1990, 70:279-318.
76. Larrazolo-López A., Kendrick K.M., Aburto-Arciniega M., Arriaga-Avila V., Morimoto S., Frias M., Guevara-Guzmán R. Vaginocervical stimulation enhances social recognition memory in rats via oxytocin release in the olfactory bulb. Neuroscience 2008, 152:585-593.
77. Leng G., Meddle S.L., Douglas A.J. Oxytocin and the maternal brain. Curr. Opin. Pharmacol. 2008, 8:731-734.
78. Levin R.J. Can the controversy about the putative role of the human female orgasm in sperm transport be settled with our current physiological knowledge of coitus?. J. Sex. Med. 2011, 8:1566-1578.
79. Loup F., Tribollet E., Dubois-Dauphin M., Dreifuss J.J. Localization of high-affinity binding sites for oxytocin and vasopressin in the human brain. An autoradiographic study. Brain Res. 1991, 555:220-232.
80. Marson L., McKenna E. Stimulation of the hypothalamus initiates the urethrogenital reflex in male rats. Brain Res. 1994, 638:103-108.
81. McKee D.T., Poletini M.O., Bertram R., Freeman M.E. Oxytocin action at the lactotroph is required for prolactin surges in cervically stimulated ovariectomized rats. Endocrinology 2007, 148:4649-4657.
82. McKenna K.E., Chung S.K., McVary K.R. A model for the study of sexual function in anesthetized male and female rats. Am. J. Phys. 1991, 261:R1276-R1285.
83. Meddle S.L., Bull P.M., Leng G., Russell J.A., Ludwig M. Somatostatin actions on rat supraoptic nucleus oxytocin and vasopressin neurones. J. Neuroendocrinol. 2010, 22:438-445.
84. Mens W.B., Witter A., Van Wimersma Greidanus T.B. Penetration of neurohypophyseal hormones from plasma into cerebrospinal fluid (CSF): half-times of disappearance of these neuropeptides from CSF. Brain Res. 1983, 262:143-149.
85. Metson C.M., Levin R.J., Sipski M.L., Hull E.M., Heiman J.R. Women's orgasm. Annu. Rev. Sex Res. 2004, 15:173-257.
86. Moos F., Richard P. Level of oxytocin release induced by vaginal dilation (Ferguson reflex) and vagal stimulation (vago-pituitary reflex) in lactating rats. J. Physiol. Paris 1975, 70:307-314.
87. Murphy M.R., Seckl J.R., Burton S., Checkley S.A., Lightman S.L. Changes in oxytocin and vasopressin secretion during sexual activity in men. J. Clin. Endocrinol. Metab. 1987, 65:738-741.
88. Neumann I.D. Oxytocin: the neuropeptide of love reveals some of its secrets. Cell Metab. 2007, 5:231-233.
89. Neumann I., Ludwig M., Engelmann M., Pittman Q.J., Landgraf R. Simultaneous microdialysis in blood and brain: oxytocin and vasopressin release in response to central and peripheral osmotic stimulation and suckling in the rat. Neuroendocrinology 1993, 58:637-645.
90. Nishimori K., Young L.J., Guo Q., Wang Z., Insel T.R., Matzuk M.M. Oxytocin is required for nursing but is not essential for parturition or reproductive behavior. Proc. Natl. Acad. Sci. 1996, 93:11699-11704.
91. Northrop L.E., Erskine M.S. Selective oxytocin receptor activation in the ventrolateral portion of the ventromedial hypothalamus is required for mating-induced pseudopregnancy in the female rat. Endocrinology 2008, 149:836-842.
92. Nyuyki K.D., Waldherr M., Baeumi S., Neumann I.D. Yes, I am ready now: differential effects of paced versus unpaced mating on anxiety and central oxytocin release in female rats. PLoS One 2011, 6:e23599.
93. Ortigue S., Bianchi-Demicheli F., Patel N., Frum C., Lewis J.W. Neuroimaging of love: fMRI meta-analysis evidence toward new perspectives in sexual medicine. J. Sex. Med. 2010, 7:3541-3552.
94. Osei-Owusu P., James A., Crane J., Scrogin K.E. 5-Hydroxytryptamine 1A receptors in the paraventricular nucleus of the hypothalamus mediate oxytocin and adrenocorticotropin hormone release and some behavioral components of the serotonin syndrome. J. Pharmacol. Exp. Ther. 2005, 313:1324-1330.
95. Palm I.F., van der Beek E.M., Swarts H.J., van der Vliet J., Wiegant V.M., Buijs R.M., Kalsbeek A. Control of the estradiol-induced prolactin surge by the suprachiasmatic nucleus. Endocrinology 2001, 142:2296-2302.
96. Parker S.L., Armstrong W.E., Sladek C.D., Grosvenor C.E., Crowley W.R. Prolactin stimulates the release of oxytocin in lactating rats: evidence for a physiological role via an action at the neural lobe. Neuroendocrinology 1991, 53:503-510.
97. Pincus D., Kose S., Arana A., Johnson K., Morgan P.S., Borckardt J., Herbsman T., Hardaway F., George M.S., Panksepp J., Nahas Z. Inverse effects of oxytocin on attributing mental activity to others in depressed and healthy subjects: a double-blind placebo controlled fMRI study. Front. Psychiatry 2010, 1:134.
98. Polston E.K., Centorino K.M., Erskine M.S. Diurnal fluctuations in mating-induced oxytocinergic activity within the paraventricular and supraoptic nuclei do not influence prolactin secretion. Endocrinology 1998, 139:4849-4859.
99. Pow D.V., Morris J.F. Dendrites of hypothalamic magnocellular neurons release neurohypophysial peptides by exocytosis. Neuroscience 1989, 32:435-439.
100. Revankar C.M., Cimino D.F., Sklar L.A., Arterburn J.B., Prossnitz E.R. A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science 2005, 307:1625-1630.
101. Ross H.E., Cole C.D., Smith Y., Neumann I.D., Landgraf R., Murphy A.Z., Young L.J. Characterization of the oxytocin system regulating affiliative behavior in female prairie voles. Neuroscience 2009, 162:892-903.
102. Ross H.E., Freeman S.M., Spiegel L.L., Ren X., Terwilliger E.F., Young L.J. Variation in oxytocin receptor density in the nucleus accumbens has differential effects on affiliative behaviors in monogamous and polygamus voles. J. Neurosci. 2009, 29:1312-1318.
103. Rossi D.V., Dai Y., Thomas P., Carrasco G.A., DonCarlos L.L., Muma N.A., Li Q. Estradiol-induced desensitization of 5-HT1A receptor signaling in the paraventricular nucleus of the hypothalamus is independent of estrogen receptor-beta. Psychoneuroendocrinology 2010, 35:1023-1033.
104. Rubin L.H., Carter C.S., Drogos L., Jamadar R., Pournajafi-Nazarloo H., Sweeney J.A., Maki P.M. Sex-specific associations between peripheral oxytocin and emotion perception in schizophrenia. Schizophr. Res. 2011, 130:266-270.
105. Sabatier N. Alpha-Melanocyte-stimulating hormone and oxytocin: a peptide signalling cascade in the hypothalamus. J. Neuroendocrinol. 2006, 18:703-710.
106. Sansone G.R., Gerdes C.A., Steinman J.L., Winslow J.T., Ottenweller J.E., Komisaruk B.R., Insel T.R. Vaginocervical stimulation releases oxytocin within the spinal cord in rats. Neuroendocrinology 2002, 75:306-315.
107. Sawchenko P.E., Swanson L.W. Immunohistochemical identification of neurons in the paraventricular nucleus of the hypothalamus that project to the medulla or to the spinal cord in the rat. J. Comp. Neurol. 1982, 205:260-272.
108. Sayani A.P., Chien Y.W. Systemic delivery of peptides and proteins across absorptive mucosae. Crit. Rev. Ther. Drug Carrier Syst. 1996, 13:85-184.
109. Schultz W.W., van Andel P., Sabelis I., Mooyaart E. Magnetic resonance imaging of male and female genitals during coitus and female sexual arousal. BMJ 1999, 319:1596-1600.
110. Shafik A. Vagino-levator reflex: description of a reflex and its role in sexual performance. Eur. J. Obstet. Gynecol. Reprod. Biol. 1995, 60:161-164.
111. Shinohara K., Tominaga K., Isobe Y., Inouye S.T. Photic regulation of peptides located in the ventrolateral subdivision of the suprachiasmatic nucleus of the rat: daily variations of vasoactive intestinal polypeptide, gastrin-releasing peptide, and neuropeptide Y. J. Neurosci. 1993, 13:793-800.
112. Simonian S.X., Herbison A.E. Differential expression of estrogen receptor and neuropeptide Y by brainstem A1 and A2 noradrenaline neurons. Neuroscience 1997, 76:517-529.
113. Smith M.S., Neill J.D. A "critical period" for cervically-stimulated prolactin release. Endocrinology 1976, 98:324-328.
114. Snowdon C.T., Pieper B.A., Boe C.Y., Cronin K.A., Kurian A.V., Ziegler T.E. Variation in oxytocin is related to variation in affiliative behavior in monogamous, pairbonded tamarins. Horm. Behav. 2010, 58:614-618.
115. Swanson L.W., Sawchenko P.E. Hypothalamic integration: organization of the paraventricular and supraoptic nuclei. Annu. Rev. Neurosci. 1983, 6:269-324.
116. Takayanagi Y., Yoshida M., Bielsky I.F., Ross H.E., Kawamata M., Onaka T., Yanagisawa T., Kimura T., Matzuk M.M., Young L.J., Nishimori K. Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice. Proc. Natl. Acad. Sci. 2005, 102:16096-16101.
117. Thor D.H., Holloway W.R. Persistence of social investigatory behavior in the male rat: evidence for long-term memory of initial copulatory experience. Learn. Behav. 1981, 9:561-565.
118. Todd K., Lightman S.L. Oxytocin release during coitus in male and female rabbits: effect of opiate receptor blockade with naloxone. Psychoneuroendocrinology 1986, 11:367-371.
119. Tom N., Assinder S.J. Oxytocin in health and disease. Int. J. Biochem. Cell Biol. 2010, 42:202-205.
120. Vignozzi L., Filippi S., Morelli A., Luconi M., Jannini E., Forti G., Maggi M. Regulation of epididymal contractility during semen emission, the first part of the ejaculatory process: a role for estrogen. J. Sex. Med. 2008, 5:2010-2016.
121. Weaver D.R. The suprachiasmatic nucleus: a 25-year retrospective. J. Biol. Rhythms 1998, 13:100-112.
122. Wersinger S.R., Temple J.L., Caldwell H.K., Young W.S. Inactivation of the oxytocin and the vasopressin (Avp) 1b receptor genes, but not the Avp 1a receptor gene, differentially impairs the Bruce effect in laboratory mice (Mus musculus). Endocrinology 2008, 149:116-121.
123. Whipple B., Komisaruk B.R. Brain (PET) responses to vaginal-cervical self-stimulation in women with complete spinal cord injury: preliminary findings. J. Sex Marital Ther. 2002, 28:79-86.
124. Wildt L., Kissler S., Licht P., Becker W. Sperm transport in the human female genital tract and its modulation by oxytocin as assessed by hysterosalpingoscintigraphy, hysterotonography, electrohysterography and Doppler sonography. Hum. Reprod. Update 1998, 4:655-666.
125. Xu H., Qin S., Carrasco G.A., Dai Y., Filardo E.J., Prossnitz E.R., Battaglia G., Doncarlos L.L., Muma N.A. Extra-nuclear estrogen receptor GPR30 regulates serotonin function in rat hypothalamus. Neuroscience 2009, 158:1599-1607.
126. Young L., Zingg H.H. Oxytocin. Molecular Mechanisms of Hormone Actions on Behavior 2009, 783-802. Elsevier, New York. A.M. Etgen, D.W. Pfaff (Eds.).
127. Young W.S., Shepard E., Amico J., Hennighausen L., Wagner K.U., LaMarca M.E., McKinney C., Ginns E.I. Deficiency in mouse oxytocin prevents milk ejection, but not fertility or parturition. J. Neuroendocrinol. 1996, 8:847-853.
128. Zeki S., Romaya J.P. The brain reaction to viewing faces of opposite- and same-sex romantic partners. PLoS One 2010, 5:e15802.
129. Zingg H.H., Laporte S.A. The oxytocin receptor. Trends Endocrinol. Metab. 2003, 14:222-227.