In Vitro and In Vivo antimalarial activities of T-2307, a novel arylamidine

Antimicrobial Agents and Chemotherapy

Volumn 56, Issue 4, 2012, Pages 2191-2193

  Kimura, Akiko ^a   Nishikawa, Hiroshi ^a   Nomura, Nobuhiko ^a   Mitsuyama, Junichi ^a   Fukumoto, Shinya ^b   Inoue, Noboru ^b   Kawazu, Shin Ichiro ^b  

^a TOYAMA CHEMICAL CO LTD   (Japan)

^b OBIHIRO UNIVERSITY OF AGRICULTURE AND VETERINARY MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; CHLOROQUINE; PENTAMIDINE; PRIMAQUINE; T 2307; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; BLOODSTREAM INFECTION; CONTROLLED STUDY; DRUG SCREENING; HEPATITIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PLASMODIUM BERGHEI; PLASMODIUM BERGHEI INFECTION; PLASMODIUM CHABAUDI; PLASMODIUM FALCIPARUM; PLASMODIUM VINCKEI INFECTION; PRIORITY JOURNAL;

AMIDINES; ANIMALS; ANTIMALARIALS; HUMANS; INHIBITORY CONCENTRATION 50; LIVER; MALARIA; MALE; MICE; MICE, INBRED BALB C; PARASITE LOAD; PLASMODIUM BERGHEI; PLASMODIUM CHABAUDI; PLASMODIUM FALCIPARUM;

EID: 84858668945     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.05856-11     Document Type: Article

References (17)

1. Angulo-Barturen I, et al. 2008. A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes. PLoS One 3:e2252.
2. Bakunova SM, et al. 2009. Structure-activity study of pentamidine analogues as antiprotozoal agents. J. Med. Chem. 52:2016-2035.
3. Bell CA, et al. 1990. Structure-activity relationships of analogs of pentamidine against Plasmodium falciparum and Leishmania mexicana amazonensis. Antimicrob. Agents Chemother. 34:1381-1386. (Pubitemid 20215778)
4. Gelb HM. 2007. Drug discovery for malaria: a very challenging and timely endeavor. Curr. Opin. Chem. Biol. 11:440-445.
5. Greenwood BM, et al. 2008. Malaria: progress, perils, and prospects for eradication. J. Clin. Invest. 118:1266-1276. (Pubitemid 351500419)
6. Lambros C, Vanderberg JP. 1979. Synchronization of Plasmodium falciparum erythrocytic stage in culture. J. Parasitol. 65:418-420. (Pubitemid 10222999)
7. Mitsuyama J, et al. 2008. In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. Antimicrob. Agents Chemother. 52:1318-1324. (Pubitemid 351521993)
8. Nishikawa H, et al. 2010. Uptake of T-2307, a novel arylamidine, in Candida albicans. J. Antimicrob. Chemother. 65:1681-1687.
9. Purfield AE, Tidwell RR, Meshnick SR. 2009. The diamidine DB75 targets the nucleus of Plasmodium falciparum. Malar. J. 8:104.
10. Shibata T, et al. 2007. Abstr. 47th Intersci. Conf. Antimicrob. Agents Chemother., abstr F1-943.
11. Singh AP, et al. 2010. Lipophilic bisphosphonates are potent inhibitors of Plasmodium liver stage growth. Antimicrob. Agents Chemother. 54:2987-2993.
12. Smilkstein M, Sriwilaijaroen N, Kelly JX, Wilairat P, Riscoe M. 2004. Simple and inexpensive fluorescence-based technique for high-throughput antimalarial drug screening. Antimicrob. Agents Chemother. 48:1803-1806. (Pubitemid 38544392)
13. Stead AM, et al. 2001. Diamidine compounds: selective uptake and targeting in Plasmodium falciparum. Mol. Pharmacol. 59:1298-1306. (Pubitemid 32381609)
14. Werbovetz K. 2006. Diamidine as antitrypanosomal, antileishmanial and antimalarial agents. Curr. Opin. Investig. Drugs 7:147-157. (Pubitemid 43230911)
15. World Health Organization. 2010. World Malaria Report 2010. World Health Organization, Geneva, Switzerland.
16. Yamada E, Nishikawa H, Nomura N, Mitsuyama J. 2010. T-2307 shows efficacy in a murine model of Candida glabrata infection despite in vitro trailing growth phenomena. Antimicrob. Agents Chemother. 54:3630-3634.
17. Yano K, et al. 2008. Disruption of the Plasmodium berghei 2-Cys peroxiredoxin TPx-1 gene hinders the sporozoite development in the vector mosquito. Mol. Biochem. Parasitol. 159:142-145. (Pubitemid 351621905)