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Volumn 12, Issue 4, 2012, Pages 479-490

Immunotherapy of breast cancer

Author keywords

Adoptive T cells; Antibodies; Breast cancer; Immune modulatory agents; Immunotherapy; Vaccines

Indexed keywords

AGATOLIMOD; CANCER VACCINE; CAPECITABINE; CARCINOEMBRYONIC ANTIGEN; CYCLOPHOSPHAMIDE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DNA VACCINE; EMEPEPIMUT S; ERTUMAXOMAB; FALIMAREV; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR VACCINE; INALIMAREV; INTERLEUKIN 2; IPILIMUMAB; LAPATINIB; MONOCLONAL ANTIBODY; MUCIN 1; NEU DIFFERENTIATION FACTOR; PACLITAXEL; PERTUZUMAB; POLYADENYLIC POLYURIDYLIC ACID; RESIQUIMOD; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR AGONIST; TRASTUZUMAB; TRASTUZUMAB EMTANSINE; TUMOR ANTIGEN; TUMOR VACCINE; UNINDEXED DRUG; VASCULOTROPIN RECEPTOR 2;

EID: 84858657759     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.2012.665445     Document Type: Review
Times cited : (33)

References (88)
  • 1
    • 75649120787 scopus 로고    scopus 로고
    • Immunotherapy of cancer: Key findings and commentary on the third tegernsee conference
    • Ruttinger D, Winter H, Van den Engel NK, et al. Immunotherapy of cancer: key findings and commentary on the Third Tegernsee Conference. Oncologist 2010;15:112-18
    • (2010) Oncologist , vol.15 , pp. 112-118
    • Ruttinger, D.1    Winter, H.2    Van Den Engel, N.K.3
  • 2
    • 41149132993 scopus 로고    scopus 로고
    • Twelve immunotherapy drugs that could cure cancers
    • Cheever MA. Twelve immunotherapy drugs that could cure cancers. Immunol Rev 2008;222:347-68
    • (2008) Immunol. Rev. , vol.222 , pp. 347-368
    • Cheever, M.A.1
  • 4
    • 33646170120 scopus 로고    scopus 로고
    • Breast cancer vaccines: A clinical reality or fairy tale
    • Curigliano G, Spitaleri G, Pietri E, et al. Breast cancer vaccines: a clinical reality or fairy tale? Ann Oncol 2006;17:750-62
    • (2006) Ann. Oncol. , vol.17 , pp. 750-762
    • Curigliano, G.1    Spitaleri, G.2    Pietri, E.3
  • 5
    • 69049089548 scopus 로고    scopus 로고
    • The prioritization of cancer antigens: A national cancer institute pilot project for the acceleration of translational research
    • Cheever MA, Allison JP, Ferris AS, et al. The prioritization of cancer antigens: a National Cancer Institute pilot project for the acceleration of translational research. Clin Cancer Res 2009;15:5323-237
    • (2009) Clin. Cancer Res. , vol.15 , pp. 5323-237
    • Cheever, M.A.1    Allison, J.P.2    Ferris, A.S.3
  • 6
    • 84858639382 scopus 로고    scopus 로고
    • Report of the Immune Response Modifier Pathway Prioritization Working Group (IRMP WG National Cancer Institute NIH (Presented to CTAC); 4 November Available from:[Last accessed 18 February 2012]
    • Cheever MA, Matrisian LM; Report of the Immune Response Modifier Pathway Prioritization Working Group (IRMP WG). A working group of the Clinical Trials and Translational Research Advisory Committee (CTAC). National Cancer Institute, NIH (Presented to CTAC); 4 November 2009. Available from: http://deainfo.nci. nih.gov/advisory/ ctac/workgroup/- IRM%20Prioritization%20Working%20Group%20FINAL%20REPORT.pdf [Last accessed 18 February 2012]
    • (2009) A Working Group of the Clinical Trials and Translational Research Advisory Committee CTAC
    • Cheever, M.A.1    Matrisian, L.M.2
  • 7
    • 77953469710 scopus 로고    scopus 로고
    • Toll-like receptor agonists in cancer therapy
    • Adams S. Toll-like receptor agonists in cancer therapy. Immunotherapy 2009;1:949-64
    • (2009) Immunotherapy , vol.1 , pp. 949-964
    • Adams, S.1
  • 8
    • 77957982756 scopus 로고    scopus 로고
    • Toll-like receptor agonists: Are they good adjuvants
    • Gnjatic S, Sawhney NB, Bhardwaj N. Toll-like receptor agonists: are they good adjuvants? Cancer J 2010;16:382-91
    • (2010) Cancer J. , vol.16 , pp. 382-391
    • Gnjatic, S.1    Sawhney, N.B.2    Bhardwaj, N.3
  • 9
    • 0018828863 scopus 로고
    • Adjuvant treatment with polyadenylic-polyuridylic acid (PolyA.PolyU) in operable breast cancer
    • Lacour J, Lacour F, Spira A, et al. Adjuvant treatment with polyadenylic-polyuridylic acid (Polya. Polyu) in operable breast cancer. Lancet 1980;2:161-4 (Pubitemid 10084713)
    • (1980) Lancet , vol.2 , Issue.8187 , pp. 161-164
    • Lacour, J.1    Lacour, F.2    Spira, A.3
  • 10
    • 77954230122 scopus 로고    scopus 로고
    • Tremelimumab in combination with exemestane in patients with advanced breast cancer and treatment-associated modulation of inducible costimulator expression on patient T Cells
    • Vonderheide RH, LoRusso PM, Khalil M, et al. Tremelimumab in combination with exemestane in patients with advanced breast cancer and treatment-associated modulation of inducible costimulator expression on patient T Cells. Clin Cancer Res 2010;16:3785-94
    • (2010) Clin. Cancer Res. , vol.16 , pp. 3785-3794
    • Vonderheide, R.H.1    LoRusso, P.M.2    Khalil, M.3
  • 11
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O'Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010;363:711-23
    • (2010) N. Engl. J. Med. , vol.363 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 12
    • 84858690921 scopus 로고    scopus 로고
    • Pre-operative single-dose ipilimumab and/or cryoablation in early stage/resectable breast cancer
    • Memorial Sloan-Kettering Cancer Center gov NCT01502592. Available from:
    • Memorial Sloan-Kettering Cancer Center. Pre-Operative, Single-Dose Ipilimumab and/or Cryoablation in Early Stage/Resectable Breast Cancer. ClinicalTrials.gov NCT01502592. Available from: http://clinicaltrials.gov/ ct2/show/NCT01502592? erm=NCT01502592&rank=1
    • Clinical. Trials
  • 13
    • 84858690923 scopus 로고    scopus 로고
    • National institutes of health clinical center (cc) ct-011 and p53 genetic vaccine for advanced solid tumors
    • National Cancer Institute (NCI).gov NCT01386502. Available from:
    • National Cancer Institute (NCI). National Institutes of Health Clinical Center (CC) CT-011 and p53 Genetic Vaccine for Advanced Solid Tumors. ClinicalTrials.gov NCT01386502. Available from: http://clinicaltrials.gov/ ct2/show/NCT01386502? term=NCT01386502&rank=1
    • Clinical. Trials.
  • 14
    • 45949097211 scopus 로고    scopus 로고
    • Clinical and immunological evaluation of anti-apoptosis protein, survivin-derived peptide vaccine in phase I clinical study for patients with advanced or recurrent breast cancer
    • Tsuruma T, Iwayama Y, Ohmura T, et al. Clinical and immunological evaluation of anti-apoptosis protein, survivin-derived peptide vaccine in phase I clinical study for patients with advanced or recurrent breast cancer. J Transl Med 2008;6:24
    • (2008) J. Transl. Med. , vol.6 , pp. 24
    • Tsuruma, T.1    Iwayama, Y.2    Ohmura, T.3
  • 15
    • 10744221022 scopus 로고    scopus 로고
    • Vaccination of cancer patients against telomerase induces functional antitumor CD8+ lymphocytes
    • Vonderheide RH, Domchek SM, Schultze JL, et al. Vaccination of cancer patients against telomerase induces functional antitumor CD8+ lymphocytes. Clin Cancer Res 2004;10:828-40
    • (2004) Clin. Cancer Res. , vol.10 , pp. 828-840
    • Vonderheide, R.H.1    Domchek, S.M.2    Schultze, J.L.3
  • 17
    • 22144483806 scopus 로고    scopus 로고
    • Vaccination with BLP25 liposome vaccine to treat non-small cell lung and prostate cancers
    • DOI 10.1586/14760584.4.3.249
    • Butts C, North S. Vaccination with BLP25 liposome vaccine to treat non-small cell lung and prostate cancers. Expert Rev Vaccines 2005;4:249-57 (Pubitemid 40978689)
    • (2005) Expert Review of Vaccines , vol.4 , Issue.3 , pp. 249-257
    • North, S.1    Butts, C.2
  • 18
    • 79955862560 scopus 로고    scopus 로고
    • Safety of BLP25 liposome vaccine (L-BLP25) in Japanese patients with unresectable stage III NSCLC after primary chemoradiotherapy: Preliminary results from a Phase I/II study
    • Ohyanagi F, Horai T, Sekine I, et al. Safety of BLP25 liposome vaccine (L-BLP25) in Japanese patients with unresectable stage III NSCLC after primary chemoradiotherapy: preliminary results from a Phase I/II study. Jpn J Clin Oncol 2011;41:718-22
    • (2011) Jpn. J. Clin. Oncol. , vol.41 , pp. 718-722
    • Ohyanagi, F.1    Horai, T.2    Sekine, I.3
  • 19
    • 84858644715 scopus 로고    scopus 로고
    • A study of stimuvax in combination with hormonal treatment versus hormonal treatment alone for first-line therapy of endocrine-sensitive advanced breast cancer
    • EMD Serono. gov NCT00925548. Available from:
    • EMD Serono. A Study of Stimuvax in Combination With Hormonal Treatment versus Hormonal Treatment Alone for First-line Therapy of Endocrine-sensitive Advanced Breast Cancer. ClinicalTrials. gov NCT00925548. Available from: http://clinicaltrials.gov/ct2/show/NCT00925548?term=NCT00925548&rank=1
    • Clinical. Trials.
  • 20
    • 0034331218 scopus 로고    scopus 로고
    • Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells
    • Brossart P, Wirths S, Stuhler G, et al. Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells. Blood 2000;96:3102-8
    • (2000) Blood , vol.96 , pp. 3102-3108
    • Brossart, P.1    Wirths, S.2    Stuhler, G.3
  • 21
    • 70350435441 scopus 로고    scopus 로고
    • Concurrent trastuzumab and HER2/neu-specific vaccination in patients with metastatic breast cancer
    • Disis ML, Wallace DR, Gooley TA, et al. Concurrent trastuzumab and HER2/neu-specific vaccination in patients with metastatic breast cancer. J Clin Oncol 2009;27:4685-92
    • (2009) J. Clin. Oncol. , vol.27 , pp. 4685-4692
    • Disis, M.L.1    Wallace, D.R.2    Gooley, T.A.3
  • 22
    • 77953036244 scopus 로고    scopus 로고
    • Vaccination with a plasmid DNA encoding HER-2/neu together with low doses of GM-CSF and IL-2 in patients with metastatic breast carcinoma: A pilot clinical trial
    • Norell H, Poschke I, Charo J, et al. Vaccination with a plasmid DNA encoding HER-2/neu together with low doses of GM-CSF and IL-2 in patients with metastatic breast carcinoma: a pilot clinical trial. J Transl Med 2010;8:53
    • (2010) J. Transl. Med. , vol.8 , pp. 53
    • Norell, H.1    Poschke, I.2    Charo, J.3
  • 23
    • 49649090374 scopus 로고    scopus 로고
    • Pilot Study of vaccination with recombinant CEA-MUC-1-TRICOM Poxviral-based vaccines in patients withmetastatic carcinoma
    • Gulley JL, Arlen PM, Tsang K-Y, et al. Pilot Study of vaccination with recombinant CEA-MUC-1-TRICOM Poxviral-based vaccines in patients withmetastatic carcinoma. Clin Cancer Res 2008;14:3060-9
    • (2008) Clin. Cancer Res. , vol.14 , pp. 3060-3069
    • Gulley, J.L.1    Arlen, P.M.2    Tsang, K.-Y.3
  • 26
    • 35649005398 scopus 로고    scopus 로고
    • Long term disease-free survival and T cell and antibody responses in women with high-risk Her2+ breast cancer following vaccination against Her2
    • Morse MA, Hobeika A, Osada T, et al. Long term disease-free survival and T cell and antibody responses in women with high-risk Her2+ breast cancer following vaccination against Her2. J Transl Med 2007;5:42
    • (2007) J. Transl. Med. , vol.5 , pp. 42
    • Morse, M.A.1    Hobeika, A.2    Osada, T.3
  • 28
    • 79251503953 scopus 로고    scopus 로고
    • Use of booster inoculations to sustain the clinical effect of an adjuvant breast cancer vaccine
    • Holmes JP, Clifton GT, Patil R, et al. Use of booster inoculations to sustain the clinical effect of an adjuvant breast cancer vaccine. Cancer 2011;117:463-71
    • (2011) Cancer , vol.117 , pp. 463-471
    • Holmes, J.P.1    Clifton, G.T.2    Patil, R.3
  • 29
    • 33745126667 scopus 로고    scopus 로고
    • Pilot phase III immunotherapy study in early-stage breast cancer patients using oxidized mannan-MUC1 [ISRCTN71711835
    • Apostolopoulos V, Pietersz GA, Tsibanis A, et al. Pilot phase III immunotherapy study in early-stage breast cancer patients using oxidized mannan-MUC1 [ISRCTN71711835]. Breast Cancer Res 2006;8(3):R27
    • (2006) Breast Cancer Res. , vol.8 , Issue.3
    • Apostolopoulos, V.1    Pietersz, G.A.2    Tsibanis, A.3
  • 30
    • 51349116036 scopus 로고    scopus 로고
    • Strategies used for MUC1 immunotherapy: Human clinical studies
    • Tang CK, Katsara M, Apostolopoulos V. Strategies used for MUC1 immunotherapy: human clinical studies. Expert Rev Vaccines 2008;7:963-75
    • (2008) Expert Rev. Vaccines , vol.7 , pp. 963-975
    • Tang, C.K.1    Katsara, M.2    Apostolopoulos, V.3
  • 31
    • 78149249609 scopus 로고    scopus 로고
    • Retention of immunogenicity produced by mucin 1 peptides with glycosylation site substitutions
    • Wright SE, Quinlin IS, Rewers-Felkins KA, et al. Retention of immunogenicity produced by mucin 1 peptides with glycosylation site substitutions. Immunopharmacol Immunotoxicol 2010;32:647-55
    • (2010) Immunopharmacol. Immunotoxicol. , vol.32 , pp. 647-655
    • Wright, S.E.1    Quinlin, I.S.2    Rewers-Felkins, K.A.3
  • 34
    • 70350113820 scopus 로고    scopus 로고
    • Identification of a broad coverage HLA-DR degenerate epitope pool derived from carcinoembryonic antigen
    • Karyampudi L, Krco CJ, Kalli KR, et al. Identification of a broad coverage HLA-DR degenerate epitope pool derived from carcinoembryonic antigen. Cancer Immunol Immunother 2010;59:161-71
    • (2010) Cancer Immunol. Immunother. , vol.59 , pp. 161-171
    • Karyampudi, L.1    Krco, C.J.2    Kalli, K.R.3
  • 37
    • 75149145066 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy with trastuzumab followed by adjuvant trastuzumab versus neoadjuvant chemotherapy alone, in patients with HER2-positive locally advanced breast cancer (the NOAH trial): A randomized controlled superiority trial with a parallel HER2-negative cohort
    • Gianni L, Eiermann W, Semiglazov V, et al. Neoadjuvant chemotherapy with trastuzumab followed by adjuvant trastuzumab versus neoadjuvant chemotherapy alone, in patients with HER2-positive locally advanced breast cancer (the NOAH trial): a randomized controlled superiority trial with a parallel HER2-negative cohort. Lancet 2010;365:377-84
    • (2010) Lancet , vol.365 , pp. 377-384
    • Gianni, L.1    Eiermann, W.2    Semiglazov, V.3
  • 38
    • 80052728749 scopus 로고    scopus 로고
    • Four-year follow-up of trastuzumab plus adjuvant chemotherapy for operable human epidermal growth factor receptor 2-positive breast cancer: Joint analysis of data from NCCTG N9831 and NSABP B-31
    • Perez EA, Romond EH, Suman VJ, et al. Four-year follow-up of trastuzumab plus adjuvant chemotherapy for operable human epidermal growth factor receptor 2-positive breast cancer: joint analysis of data from NCCTG N9831 and NSABP B-31. J Clin Oncol 2011;29:3366-73
    • (2011) J. Clin. Oncol. , vol.29 , pp. 3366-3373
    • Perez, E.A.1    Romond, E.H.2    Suman, V.J.3
  • 41
    • 80051751593 scopus 로고    scopus 로고
    • Phase I/II study of trastuzumab in combination with everolimus (RAD001) in patients with HER2-overexpressing metastatic breast cancer who progressed on trastuzumab-based therapy
    • Morrow PK, Wulf GM, Ensor J, et al. Phase I/II study of trastuzumab in combination with everolimus (RAD001) in patients with HER2-overexpressing metastatic breast cancer who progressed on trastuzumab-based therapy. J Clin Oncol 2011;29:3126-32
    • (2011) J. Clin. Oncol. , vol.29 , pp. 3126-3132
    • Morrow, P.K.1    Wulf, G.M.2    Ensor, J.3
  • 42
    • 33744803712 scopus 로고    scopus 로고
    • Phase I trial of the trifunctional anti-HER2 Anti-CD3 antibody ertumaxomab in metastatic breast cancer
    • Kiewe P, Hasmuller S, Kahlert S, et al. Phase I trial of the trifunctional anti-HER2 Anti-CD3 antibody ertumaxomab in metastatic breast cancer. Clin Cancer Res 2006;12:3085-91
    • (2006) Clin. Cancer Res. , vol.12 , pp. 3085-3091
    • Kiewe, P.1    Hasmuller, S.2    Kahlert, S.3
  • 43
    • 33644600485 scopus 로고    scopus 로고
    • Humanization of a recombinant monoclonal antibody to produce a herapeutic HER dimerization inhibitor, pertuzumab
    • Adams C, Allison D, Flagella K, et al. Humanization of a recombinant monoclonal antibody to produce a herapeutic HER dimerization inhibitor, pertuzumab. Cancer Immunol Immunother 2006;55:717-28
    • (2006) Cancer Immunol. Immunother. , vol.55 , pp. 717-728
    • Adams, C.1    Allison, D.2    Flagella, K.3
  • 44
    • 77949903478 scopus 로고    scopus 로고
    • Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy
    • Baselga J, Gelmon KA, Verma S, et al. Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy. J Clin Oncol 2010;28:1138-44
    • (2010) J. Clin. Oncol. , vol.28 , pp. 1138-1144
    • Baselga, J.1    Gelmon, K.A.2    Verma, S.3
  • 45
    • 79952092706 scopus 로고    scopus 로고
    • Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy
    • Burris HA, Rugo HS, Vukelja SJ, et al. Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy. J Clin Oncol 2011;29:398-405
    • (2011) J. Clin. Oncol. , vol.29 , pp. 398-405
    • Burris, H.A.1    Rugo, H.S.2    Vukelja, S.J.3
  • 46
    • 77449106552 scopus 로고    scopus 로고
    • Phase I dose escalation pharmacokinetic assessment of intravenous humanized anti-MUC1 antibody AS1402 in patients with advanced breast cancer
    • Pegram MD, Borges VF, Ibrahim N, et al. Phase I dose escalation pharmacokinetic assessment of intravenous humanized anti-MUC1 antibody AS1402 in patients with advanced breast cancer. Breast Cancer Res 2009;11(5):R73
    • (2009) Breast Cancer Res. , vol.11 , Issue.5
    • Pegram, M.D.1    Borges, V.F.2    Ibrahim, N.3
  • 47
    • 84858690925 scopus 로고    scopus 로고
    • Monoclonal antibody therapy in treating women with locally advanced or metastatic breast cancer previously treated with combination chemotherapy
    • Jonsson Comprehensive Cancer Center, National Cancer Institute (NCI)gov NCT00066547. Available from:
    • Jonsson Comprehensive Cancer Center, National Cancer Institute (NCI). Monoclonal Antibody Therapy in Treating Women With Locally Advanced or Metastatic Breast Cancer Previously Treated With Combination Chemotherapy. ClinicalTrials.gov NCT00066547. Available from: http:// clinicaltrials.gov/ct2/ show/ NCT00066547? term=NCT00066547&rank=1
    • Clinical. Trials.
  • 51
    • 34848857596 scopus 로고    scopus 로고
    • Profound graft-versus-tumor response in metastatic breast cancer with nonmyeloablative allografting [6]
    • DOI 10.1093/annonc/mdm461
    • Carella AM, Ferrara R, Orcioni GF, et al. Profound graft-versus-tumor response in metastatic breast cancer with nonmyeloablative allografting. Ann Oncol 2007;18:1751-4 (Pubitemid 47506269)
    • (2007) Annals of Oncology , vol.18 , Issue.10 , pp. 1751-1754
    • Carella, A.M.1    Ferrara, R.2    Orcioni, G.F.3    Pepe, G.4    Villavecchia, G.5
  • 52
    • 34848906810 scopus 로고    scopus 로고
    • Current role of allogeneic stem cell transplantation in breast cancer
    • DOI 10.1093/annonc/mdm342
    • Carella AM, Bregni M. Current role of allogeneic stem cell transplantation in breast cancer. Ann Oncol 2007;18:1591-3 (Pubitemid 47506244)
    • (2007) Annals of Oncology , vol.18 , Issue.10 , pp. 1591-1593
    • Carella, A.M.1    Bregni, M.2
  • 53
    • 68149117281 scopus 로고    scopus 로고
    • Prolonged disease control by nonmyeloablative allogeneic transplantation for metastatic breast cancer
    • de Souza JA, Davis ML, Rondon G, et al. Prolonged disease control by nonmyeloablative allogeneic transplantation for metastatic breast cancer. Bone Marrow Transplant 2009;44:81-7
    • (2009) Bone Marrow. Transplant. , vol.44 , pp. 81-87
    • De Souza, J.A.1    Davis, M.L.2    Rondon, G.3
  • 54
    • 77949425235 scopus 로고    scopus 로고
    • HLA-matched allo-SCT after reduced intensity conditioning with fludarabine/CY in patients with metastatic breast cancer
    • Fleskens AJHM, Lalisang RI, Bos GMJ, et al. HLA-matched allo-SCT after reduced intensity conditioning with fludarabine/CY in patients with metastatic breast cancer. Bone Marrow Transplant 2010;45:464-7
    • (2010) Bone Marrow. Transplant. , vol.45 , pp. 464-467
    • Fleskens, A.J.H.M.1    Lalisang, R.I.2    Bos, G.M.J.3
  • 58
    • 70349456786 scopus 로고    scopus 로고
    • A Phase I trial of immunotherapy with lapuleucel-T (APC8024) in patients with refractory metastatic tumors that express HER-2/ neu
    • Peethambaram PP, Melisko ME, Rinn KJ, et al. A Phase I trial of immunotherapy with lapuleucel-T (APC8024) in patients with refractory metastatic tumors that express HER-2/ neu. Clin Cancer Res 2009;15:5937-44
    • (2009) Clin. Cancer Res. , vol.15 , pp. 5937-5944
    • Peethambaram, P.P.1    Melisko, M.E.2    Rinn, K.J.3
  • 59
    • 70350780494 scopus 로고    scopus 로고
    • Tumor burden influences cytotoxic T cell development in metastatic breast cancer patients - A phase I/II study
    • Wright SE, Rewers-Felkins KA, Quinlin IS, et al. Tumor burden influences cytotoxic T cell development in metastatic breast cancer patients - a Phase I/II study. Immunol Invest 2009;48:820-38
    • (2009) Immunol. Invest. , vol.48 , pp. 820-838
    • Wright, S.E.1    Rewers-Felkins, K.A.2    Quinlin, I.S.3
  • 60
    • 77957981209 scopus 로고    scopus 로고
    • Adoptive cell therapy: Genetic modification to redirect effector cell specificity
    • Morgan RA, Dudley ME, Rosenberg SA. Adoptive cell therapy: genetic modification to redirect effector cell specificity. Cancer J 2010;16:336-41
    • (2010) Cancer J. , vol.16 , pp. 336-341
    • Morgan, R.A.1    Dudley, M.E.2    Rosenberg, S.A.3
  • 61
    • 77950475517 scopus 로고    scopus 로고
    • Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2
    • Morgan RA, Yang JC, Kitano M, et al. Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2. Mol Ther 2010;18:843-51
    • (2010) Mol. Ther. , vol.18 , pp. 843-851
    • Morgan, R.A.1    Yang, J.C.2    Kitano, M.3
  • 62
    • 77954854070 scopus 로고    scopus 로고
    • Strategy escalation: An emerging paradigm for safe clinical development of T cell gene therapies
    • Junghans RP. Strategy escalation: an emerging paradigm for safe clinical development of T cell gene therapies. J Transl Med 2010;8:55
    • (2010) J. Transl. Med. , vol.8 , pp. 55
    • Junghans, R.P.1
  • 64
    • 76949091692 scopus 로고    scopus 로고
    • Results of chemotherapy alone, with sequential or concurrent addition of 52 weeks of trastuzumab in the NCCTG N9831 HER2-Positive adjuvant breast cancer trial
    • abstract nr 80
    • Perez E, Suman V, Davidson N, et al. Results of chemotherapy alone, with sequential or concurrent addition of 52 weeks of trastuzumab in the NCCTG N9831 HER2-Positive adjuvant breast cancer trial. Cancer Res 2009;69(24 Suppl):abstract nr 80
    • (2009) Cancer Res. , vol.69 , Issue.SUPPL.
    • Perez, E.1    Suman, V.2    Davidson, N.3
  • 65
    • 4644324025 scopus 로고    scopus 로고
    • Cancer immunotherapy: Moving beyond current vaccines
    • DOI 10.1038/nm1100
    • Rosenberg SA, Yang JC, Restifo NP. Cancer immunotherapy: moving beyond current vaccines. Nat Med 2004;10:909-15 (Pubitemid 39273730)
    • (2004) Nature Medicine , vol.10 , Issue.9 , pp. 909-915
    • Rosenberg, S.A.1    Yang, J.C.2    Restifo, N.P.3
  • 66
    • 84858690929 scopus 로고    scopus 로고
    • New York University School of Medicine, National Cancer Institute (NCI). ClinicalTrials.gov NCT01421017. Available from:
    • New York University School of Medicine, National Cancer Institute (NCI). Toll-like Receptor (TLR) 7 Agonist and Radiotherapy for Breast Cancer With Skin Metastases. ClinicalTrials.gov NCT01421017. Available from: http:// clinicaltrials.gov/ ct2/show/NCT01421017? term=NCT01421017&rank=1
    • Toll-like Receptor (TLR) 7 Agonist and Radiotherapy for Breast Cancer With Skin Metastases
  • 67
    • 84858695288 scopus 로고    scopus 로고
    • Case Comprehensive Cancer Center ClinicalTrials.gov NCT00986609. Available from:
    • Case Comprehensive Cancer Center. MUC1 Vaccine for Triple-negative Breast Cancer. ClinicalTrials.gov NCT00986609. Available from: http:// clinicaltrials.gov/ct2/show/ NCT00986609? term=NCT00986609&rank=1
    • MUC1 Vaccine for Triple-negative Breast Cancer
  • 68
    • 84891557208 scopus 로고    scopus 로고
    • Ohio State University Comprehensive Cancer Center, Pfizer ClinicalTrials.gov NCT00824733. Available from:
    • Ohio State University Comprehensive Cancer Center, Pfizer. Agatolimod and Trastuzumab in Treating Patients With Locally Advanced or Metastatic Breast Cancer. ClinicalTrials.gov NCT00824733. Available from: http:// clinicaltrials.gov/ct2/show/ NCT00824733?term=00824733&rank=1
    • Agatolimod and Trastuzumab in Treating Patients With Locally Advanced or Metastatic Breast Cancer
  • 69
    • 84858639396 scopus 로고    scopus 로고
    • Celldex Therapeutics. ClinicalTrials.gov NCT00948961. Available from:
    • Celldex Therapeutics. A Study of CDX-1401 in Patients With Malignancies Known to Express NYESO- 1. ClinicalTrials.gov NCT00948961. Available from: http:// clinicaltrials.gov/ct2/show/ NCT00948961? term=NCT00948961&rank=1
    • A Study of CDX-1401 in Patients With Malignancies Known to Express NYESO-1
  • 71
    • 84858644726 scopus 로고    scopus 로고
    • Ohio State University Comprehensive Cancer Centergov NCT01376505. Available from:
    • Ohio State University Comprehensive Cancer Center. Vaccine Therapy in Treating Patients With Metastatic Solid Tumors ClinicalTrials.gov NCT01376505. Available from: http:// clinicaltrials.gov/ct2/show/ NCT01376505? term=NCT01376505&rank=1
    • Vaccine Therapy in Treating Patients With Metastatic Solid Tumors ClinicalTrials
  • 72
    • 84858654118 scopus 로고    scopus 로고
    • Fred Hutchinson Cancer Research Center, National Cancer Institute (NCI)gov NCT00791037. Available from:
    • Fred Hutchinson Cancer Research Center, National Cancer Institute (NCI). Vaccine Therapy in Treating Patients Receiving Trastuzumab For HER2-Positive Stage IIIB-IV Breast Cancer. ClinicalTrials.gov NCT00343109. Available from: http:// clinicaltrials.gov/ct2/show/ NCT00343109? term=NCT00343109&rank=
    • Vaccine Therapy in Treating Patients With Stage IV Breast Cancer ClinicalTrials
  • 74
    • 84858691320 scopus 로고    scopus 로고
    • University of Pennsylvania, National Cancer Institute (NCI) ClinicalTrials.gov NCT00923143. Available from:
    • University of Pennsylvania, National Cancer Institute (NCI). Vaccine Therapy in Treating Patients With Ductal Carcinoma In Situ of the Breast. ClinicalTrials.gov NCT00923143. Available from: http://clinicaltrials.gov/ t2/show/NCT00923143? term=NCT00923143&rank=1
    • Vaccine Therapy in Treating Patients With Ductal Carcinoma In Situ of the Breast


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