Risk factors for elevated INR values during warfarin therapy in hospitalized pediatric patients

Pediatric Blood and Cancer

Volumn 58, Issue 6, 2012, Pages 941-944

  Moffett, Brady S ^a   Ung, Meng ^a   Bomgaars, Lisa ^b  

^a TEXAS CHILDREN S HOSPITAL   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

International normalized ratio; Pediatric; Warfarin

Indexed keywords

AMIODARONE; BOSENTAN; CEPHALOSPORIN; CIPROFLOXACIN; CORTICOSTEROID; COTRIMAZINE; COTRIMOXAZOLE; FLUCONAZOLE; LANSOPRAZOLE; METRONIDAZOLE; SEROTONIN UPTAKE INHIBITOR; VITAMIN K GROUP; WARFARIN;

ADOLESCENT; ADULT; ANTIBIOTIC THERAPY; AORTA VALVE REPLACEMENT; ARTICLE; ARTIFICIAL VENTILATION; ASIAN; CEREBROVASCULAR ACCIDENT; CHILD; CLINICAL EVALUATION; COMORBIDITY; DEEP VEIN THROMBOSIS; ETHNICITY; FEMALE; FONTAN PROCEDURE; HEART ATRIUM FIBRILLATION; HEART ATRIUM FLUTTER; HEART SURGERY; HOSPITAL PATIENT; HUMAN; INFANT; INTERNATIONAL NORMALIZED RATIO; INTRAATRIAL REENTRANT TACHYCARDIA; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; MITRAL VALVE REPLACEMENT; NEWBORN; OBESITY; PEDIATRIC HOSPITAL; PRESCRIPTION; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RISK ASSESSMENT; RISK FACTOR; TACHYCARDIA; TREATMENT DURATION; TREATMENT INDICATION;

ANTICOAGULANTS; CHILD; CHILD, PRESCHOOL; FEMALE; HOSPITALIZATION; HUMANS; INFANT; INTERNATIONAL NORMALIZED RATIO; MALE; RETROSPECTIVE STUDIES; RISK FACTORS; WARFARIN;

EID: 84858653012     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.23308     Document Type: Article

References (17)

1. Streif W, Andrew M, Marzinotto V, et al. Analysis of warfarin therapy in pediatric patients: A prospective cohort study of 319 patients. Blood 1999; 94: 3007-3014.
2. Lee J, Lee B, Kim K, et al. Factors affecting warfarin therapy following cardiac valve surgery. Ann Pharmacother 2002; 36: 1845-1850.
3. Hughes M, Lip GY. Risk factors for anticoagulation-related bleeding complications in patients with atrial fibrillation: A systematic review. QJM 2007; 100: 599-607.
4. Hylek EM, Heiman H, Skates SJ, et al. Acetaminophen and other risk factors for excessive warfarin anticoagulation. JAMA 1998; 279: 657-662.
5. Johnson MC, Wood M, Vaughn V, et al. Interaction of antibiotics and warfarin in pediatric cardiology patients. Pediatr Cardiol 2005; 26: 589-592.
6. Monagle P, Chalmers E, Chan A, et al. Antithrombotic therapy in neonates and children: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edition). Chest 2008; 133: 887S-968S.
7. Moffett BS, Parham AL, Caudilla CD, et al. Oral anticoagulation in a pediatric hospital: Impact of a quality improvement initiative on warfarin management strategies. Qual Saf Health Care 2006; 15: 240-243.
8. CDC: Centers for Disease Control and Prevention. About BMI for children and teens [Internet]; Atlanta, GA. Available from: Accessed on July 27, 2010.
9. Wittkowsky AK, Devine EB. Frequency and causes of overanticoagulation and underanticoagulation in patients treated with warfarin. Pharmacotherapy 2004; 24: 1311-1316.
10. Rossano JW, Smith EO, Fraser CD Jr, et al. Adults undergoing cardiac surgery at a children's hospital: An analysis of perioperative morbidity. Ann Thorac Surg 2007; 83: 606-612.
11. Webb GD. Challenges in the care of adult patients with congenital heart defects. Heart 2003; 89: 465-469.
12. Fischer HD, Juurlink DN, Mamdani MM, et al. Hemorrhage during warfarin therapy associated with cotrimoxazole and other urinary tract anti-infective agents: A population-based study. Arch Intern Med 2010; 170: 617-621.
13. Wittkowsky AK, Boccuzzi SJ, Wogen J, et al. Frequency of concurrent use of warfarin with potentially interacting drugs. Pharmacotherapy 2004; 24: 1668-1674.
14. Hata M, Hayasaka M, Sezai A, et al. Proton pump inhibitors may increase the risk of delayed bleeding complications after open heart surgery if used concomitantly with warfarin. Thorac Cardiovasc Surg 2008; 56: 274-277.
15. Hazlewood KA, Fugate SE, Harrison DL. Effect of oral corticosteroids on chronic warfarin therapy. Ann Pharmacother 2006; 40: 2101-2106.
16. Lu Y, Won KA, Nelson BJ, et al. Characteristics of the amiodarone-warfarin interaction during long-term follow-up. Am J Health Syst Pharm 2008; 65: 947-952.
17. Ross KA, Bigham AW, Edwards M, et al. Worldwide allele frequency distribution of four polymorphisms associated with warfarin dose requirements. J Hum Genet 2010; 55: 582-589.