Diverse mobilized class 1 integrons are common in the chromosomes of pathogenic Pseudomonas aeruginosa clinical isolates

Antimicrobial Agents and Chemotherapy

Volumn 56, Issue 4, 2012, Pages 2169-2172

  Martinez, Elena ^a   Marquez, Carolina ^b   Ingold, Ana ^c   Merlino, John ^d   Djordjevic, Steven P ^a   Stokes, H W ^a   Roy Chowdhury, Piklu ^a  

^a UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

^b UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^c UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^d Department of Microbiology and Infectious Diseases   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; AUSTRALIA; BACTERIUM ISOLATE; GENE TRANSFER; INTEGRON; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; TRANSPOSON; URUGUAY;

AUSTRALIA; CHROMOSOMES, BACTERIAL; DRUG RESISTANCE, BACTERIAL; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ELECTROPHORESIS, GEL, PULSED-FIELD; GENES, BACTERIAL; GENOMIC ISLANDS; INTEGRONS; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; URUGUAY;

EID: 84858631261     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.06048-11     Document Type: Article

References (26)

1. Abdelraouf K, Kabbara S, Ledesma KR, Poole K, Tam VH. 2011. Effect of multidrug resistance-conferring mutations on the fitness and virulence of Pseudomonas aeruginosa. J. Antimicrob. Chemother. 66:1311-1317.
2. Andrade SS, Jones RN, Gales AC, Sader HS. 2003. Increasing prevalence of antimicrobial resistance among Pseudomonas aeruginosa isolates in Latin American medical centres: 5 year report of the SENTRY Antimicrobial Surveillance Program (1997-2001). J. Antimicrob. Chemother. 52: 140-141. (Pubitemid 36850103)
3. Cain AK, Liu X, Djordjevic SP, Hall RM. 2010. Transposons related to Tn1696 in IncHI2 plasmids in multiply antibiotic resistant Salmonella enterica serovar Typhimurium from Australian animals. Microb. Drug Resist. 16:197-202.
4. Driscoll JA, Brody SL, Kollef MH. 2007. The epidemiology, pathogenesis and treatment of Pseudomonas aeruginosa infections. Drugs 67:351-368. (Pubitemid 46425550)
5. Fournier P-E, et al. 2006. Comparative genomics of multidrug resistance in Acinetobacter baumannii. PLoS Genet. 2:e7.
6. Gutierrez O, et al. 2007. Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa isolates from Spanish hospitals. Antimicrob. Agents Chemother. 51:4329-4335. (Pubitemid 350209885)
7. Hayden HS, et al. 2008. Large-insert genome analysis technology detects structural variation in Pseudomonas aeruginosa clinical strains from cystic fibrosis patients. Genomics 91:530-537.
8. Klockgether J, Reva O, Larbig K, Tummler B. 2004. Sequence analysis of the mobile genome island pKLC102 of Pseudomonas aeruginosa C. J. Bacteriol. 186:518-534. (Pubitemid 38076442)
9. Klockgether J, Wurdemann D, Reva O, Wiehlmann L, Tummler B. 2007. Diversity of the abundant pKLC102/PAGI-2 family of genomic islands in Pseudomonas aeruginosa. J. Bacteriol. 189:2443-2459. (Pubitemid 46411359)
10. Larbig KD, et al. 2002. Gene islands integrated into tRNA(Gly) genes confer genome diversity on a Pseudomonas aeruginosa clone. J. Bacteriol. 184:6665-6680. (Pubitemid 35332571)
11. Levings RS, Lightfoot D, Partridge SR, Hall RM, Djordjevic SP. 2005. The genomic island SGI1, containing the multiple antibiotic resistance region of Salmonella enterica serovar Typhimurium DT104 or variants of it, is widely distributed in other S. enterica serovars. J. Bacteriol. 187:4401-4409. (Pubitemid 40880950)
12. Lister PD, Wolter DJ, Hanson ND. 2009. Antibacterial-resistant Pseudomonas aeruginosa: clinical impact and complex regulation of chromosomally encoded resistance mechanisms. Clin. Microbiol. Rev. 22:582-610.
13. Livermore DM. 2002. Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: our worst nightmare? Clin. Infect. Dis. 34:634-640. (Pubitemid 34165326)
14. Michael GB, Cardoso M, Schwarz S. 2008. Molecular analysis of multi-resistant porcine Salmonella enterica subsp. enterica serovar Bredeney isolates from Southern Brazil: identification of resistance genes, integrons and a group II intron. Int. J. Antimicrob. Agents 32:120-129.
15. Miyoshi-Akiyama T, Kuwahara T, Tada T, Kitao T, Kirikae T. 2011. Complete genome sequence of highly multidrug-resistant Pseudomonas aeruginosa NCGM2.S1, a representative strain of a cluster endemic to Japan. J. Bacteriol. 193:7010.
16. Muller D, et al. 2007. A tale of two oxidation states: bacterial colonization of arsenic-rich environments. PLoS Genet. 3:e53.
17. Naas T, Poirel L, Nordmann P. 1999. Molecular characterisation of In51, a class 1 integron containing a novel aminoglycoside adenylyltransferase gene cassette, aadA6, in Pseudomonas aeruginosa. Biochim. Biophys. Acta 1489:445-451.
18. Rezsöhazy R, Hallet B, Delcour J, Mahillon J. 1993. The IS4 family of insertion sequences: evidence for a conserved transposase motif. Mol. Microbiol. 9:1283-1295. (Pubitemid 23286260)
19. Riccio ML, et al. 2005. Clonal relatedness and conserved integron structures in epidemiologically unrelated Pseudomonas aeruginosa strains producing the VIM-1 metallo-β-lactamase from different Italian hospitals. Antimicrob. Agents Chemother. 49:104-110. (Pubitemid 40065779)
20. Riccio ML, Pallecchi L, Fontana R, Rossolini GM. 2001. In70 of plasmid pAX22, a bla(VIM-1)-containing integron carrying a new aminoglycoside phosphotransferase gene cassette. Antimicrob. Agents Chemother. 45: 1249-1253. (Pubitemid 32231008)
21. Roy Chowdhury P, et al. 2009. Tn6060, a transposon from a genomic island in a Pseudomonas aeruginosa clinical isolate that includes two class 1 integrons. Antimicrob. Agents Chemother. 53:5294-5296.
22. Tenover FC, et al. 1995. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J. Clin. Microbiol. 33:2233-2239.
23. Tetu SG, Holmes AJ. 2008. A family of insertion sequences that impacts integrons by specific targeting of gene cassette recombination sites, the IS1111-attC group. J. Bacteriol. 190:4959-4970. (Pubitemid 351991064)
24. Toleman MA, Biedenbach D, Bennett DM, Jones RN, Walsh TR. 2005. Italian metallo-β-lactamases: a national problem? Report from the SENTRY Antimicrobial Surveillance Programme. J. Antimicrob. Chemother. 55:61-70. (Pubitemid 40192615)
25. Wang J, et al. 2010. Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa isolates from Chinese hospitals. Int. J. Antimicrob. Agents 35:486-491.
26. Winstanley C, et al. 2009. Newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the Liverpool Epidemic Strain of Pseudomonas aeruginosa. Genome Res. 19:12-23.