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1
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0024473777
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13N ammonia myocardial imaging at rest and with exercise in normal volunteers. Quantification of absolute myocardial perfusion with dynamic positron emission tomography
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The authors report the first application of non-invasive measurements of myocardial blood flow with N-13 ammonia and PET in normal human volunteers at rest and during supine bicycle exercise
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Krivokapich J, Smith GT, Huang SC, et al. 13N ammonia myocardial imaging at rest and with exercise in normal volunteers. Quantification of absolute myocardial perfusion with dynamic positron emission tomography. Circulation 1989;80:1328-37. The authors report the first application of non-invasive measurements of myocardial blood flow with N-13 ammonia and PET in normal human volunteers at rest and during supine bicycle exercise.
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(1989)
Circulation
, vol.80
, pp. 1328-1337
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Krivokapich, J.1
Smith, G.T.2
Huang, S.C.3
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2
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34249701087
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Quantification of myocardial blood flow with 82Rb dynamic PET imaging
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The authors demonstrate the feasibility of non-invasive measurements of myocardial blood flow with rubidium 8-82 and PET
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Lortie M, Beanlands RS, Yoshinaga K, et al. Quantification of myocardial blood flow with 82Rb dynamic PET imaging. Eur J Nucl Med Mol Imaging 2007;34:1765-74. The authors demonstrate the feasibility of non-invasive measurements of myocardial blood flow with rubidium 8-82 and PET.
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(2007)
Eur J Nucl Med Mol Imaging
, vol.34
, pp. 1765-1774
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Lortie, M.1
Beanlands, R.S.2
Yoshinaga, K.3
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3
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34547414555
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13N-ammonia and PET
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DOI 10.1007/s00259-007-0378-5
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Schindler TH, Zhang XL, Prior JO, et al. Assessment of intra- and interobserver reproducibility of rest and cold pressor test-stimulated myocardial blood flow with (13)N-ammonia and PET. Eur J Nucl Med Mol Imaging 2007;34:1178-88. In a series of normal human volunteers the research described in this manuscript demonstrates the reproducibility of PET measured myocardial blood flows. (Pubitemid 47290665)
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(2007)
European Journal of Nuclear Medicine and Molecular Imaging
, vol.34
, Issue.8
, pp. 1178-1188
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Schindler, T.H.1
Zhang, X.-L.2
Prior, J.O.3
Cadenas, J.4
Dahlbom, M.5
Sayre, J.6
Schelbert, H.R.7
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4
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0035088406
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Heterogeneity of resting and hyperemic myocardial blood flow in healthy humans
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DOI 10.1016/S0008-6363(01)00202-4, PII S0008636301002024
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Chareonthaitawee P, Kaufmann PA, Rimoldi O, et al. Heterogeneity of resting and hyperemic myocardial blood flow in healthy humans. Cardiovasc Res 2001;50:151-61. In a large series of normal human volunteers, the authors report on the heterogeneity of myocardial blood flow at rest and during vasodilator induced hyperaemia, indicating gender and age related differences in observed myocardial blood flows. (Pubitemid 32244395)
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(2001)
Cardiovascular Research
, vol.50
, Issue.1
, pp. 151-161
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Chareonthaitawee, P.1
Kaufmann, P.A.2
Rimoldi, O.3
Camici, P.G.4
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5
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0027195084
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Assessment of the effects of dobutamine on myocardial blood flow and oxidative metabolism in normal human subjects using nitrogen-13 ammonia and carbon-11 acetate
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In normal individuals studied with N-13 ammonia flow measurements and C-11 acetate, the close correlation between cardiac work, oxidative metabolism and myocardial blood flow is demonstrated
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Krivokapich J, Huang SC, Schelbert HR. Assessment of the effects of dobutamine on myocardial blood flow and oxidative metabolism in normal human subjects using nitrogen-13 ammonia and carbon-11 acetate. Am J Cardiol 1993;71:1351-6. In normal individuals studied with N-13 ammonia flow measurements and C-11 acetate, the close correlation between cardiac work, oxidative metabolism and myocardial blood flow is demonstrated.
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(1993)
Am J Cardiol
, vol.71
, pp. 1351-1356
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Krivokapich, J.1
Huang, S.C.2
Schelbert, H.R.3
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6
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50449111231
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Regulation of coronary blood flow during exercise
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This review article provides a detailed account of the determinants of coronary blood flow and its response to physical stress
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Duncker DJ, Bache RJ. Regulation of coronary blood flow during exercise. Physiol Rev 2008;88:1009-86. This review article provides a detailed account of the determinants of coronary blood flow and its response to physical stress.
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(2008)
Physiol Rev
, vol.88
, pp. 1009-1086
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Duncker, D.J.1
Bache, R.J.2
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7
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77954242261
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Therapeutic advances in myocardial microvascular resistance: Unravelling the enigma
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This review article emphasises the importance of microvascular disease as a cause of myocardial ischaemia and reviews potential therapeutic strategies
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Patel B, Fisher M. Therapeutic advances in myocardial microvascular resistance: unravelling the enigma. Pharmacol Ther 2010;127:131-47. This review article emphasises the importance of microvascular disease as a cause of myocardial ischaemia and reviews potential therapeutic strategies.
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(2010)
Pharmacol Ther
, vol.127
, pp. 131-147
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Patel, B.1
Fisher, M.2
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8
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0041385743
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Coronary microvascular dysfunction and prognosis in hypertrophic cardiomyopathy
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DOI 10.1056/NEJMoa025050
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Cecchi F, Olivotto I, Gistri R, et al. Coronary microvascular dysfunction and prognosis in hypertrophic cardiomyopathy. N Engl J Med 2003;349:1027-35. This study, similar to the immediate following two studies, emphasises the importance of assessing microvascular dysfunction and its prognostic value for assessing cardiac risk and long term clinical outcome. (Pubitemid 37087617)
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(2003)
New England Journal of Medicine
, vol.349
, Issue.11
, pp. 1027-1035
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Cecchi, F.1
Olivotto, I.2
Gistri, R.3
Lorenzoni, R.4
Chiriatti, G.5
Camici, P.G.6
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9
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0037080528
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Prognostic role of myocardial blood flow impairment in idiopathic left ventricular dysfunction
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DOI 10.1161/hc0202.102119
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Neglia D, Michelassi C, Trivieri MG, et al. Prognostic role of myocardial blood flow impairment in idiopathic left ventricular dysfunction. Circulation 2002;105:186-93. (Pubitemid 34084317)
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(2002)
Circulation
, vol.105
, Issue.2
, pp. 186-193
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Neglia, D.1
Michelassi, C.2
Giovanna, T.M.3
Sambuceti, G.4
Giorgetti, A.5
Pratali, L.6
Gallopin, M.7
Salvadori, P.8
Sorace, O.9
Carpeggiani, C.10
Poddighe, R.11
L'Abbate, A.12
Parodi, O.13
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10
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59249089319
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Comparison between the prognostic value of left ventricular function and myocardial perfusion reserve in patients with ischemic heart disease
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Tio RA, Dabeshlim A, Siebelink HM, et al. Comparison between the prognostic value of left ventricular function and myocardial perfusion reserve in patients with ischemic heart disease. J Nucl Med 2009;50:214-19.
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(2009)
J Nucl Med
, vol.50
, pp. 214-219
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Tio, R.A.1
Dabeshlim, A.2
Siebelink, H.M.3
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11
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0035818565
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Influence of nitric oxide synthase and adrenergic inhibition on adenosine-induced myocardial hyperemia
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Buus NH, Bottcher M, Hermansen F, et al. Influence of nitric oxide synthase and adrenergic inhibition on adenosine-induced myocardial hyperemia. Circulation 2001;104:2305-10. This study demonstrates in normal human volunteers the contribution of the endothelium to the total vasodilator capacity. (Pubitemid 33049513)
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(2001)
Circulation
, vol.104
, Issue.19
, pp. 2305-2310
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Buus, N.H.1
Bottcher, M.2
Hermansen, F.3
Sander, M.4
Nielsen, T.T.5
Mulvany, M.J.6
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12
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0028935335
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Relation among stenosis severity, myocardial blood flow, and flow reserve in patients with coronary artery disease
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The authors of this study report a statistically significant correlation between coronary stenosis severity as determined by quantitative angiography and myocardial flow reserve. This correlation observed in human coronary artery disease was similar to that reported previously in animal experimental studies
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Di Carli M, Czernin J, Hoh CK, et al. Relation among stenosis severity, myocardial blood flow, and flow reserve in patients with coronary artery disease. Circulation 1995;91:1944-51. The authors of this study report a statistically significant correlation between coronary stenosis severity as determined by quantitative angiography and myocardial flow reserve. This correlation observed in human coronary artery disease was similar to that reported previously in animal experimental studies.
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(1995)
Circulation
, vol.91
, pp. 1944-1951
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Di Carli, M.1
Czernin, J.2
Hoh, C.K.3
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13
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4344684086
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Potential utility of rubidium 82 PET quantification in patients with 3-vessel coronary artery disease
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DOI 10.1016/j.nuclcard.2004.04.005, PII S1071358104001436
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Parkash R, deKemp RA, Ruddy TD, et al. Potential utility of rubidium 82 PET quantification in patients with 3-vessel coronary artery disease. J Nucl Cardiol 2004;11:440-9. This study demonstrates the value of quantitative measurements of myocardial blood flow for identifying left main equivalent or triple vessel disease. (Pubitemid 39115288)
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(2004)
Journal of Nuclear Cardiology
, vol.11
, Issue.4
, pp. 440-449
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Parkash, R.1
DeKemp, R.A.2
Ruddy, T.D.3
Kitsikis, A.4
Hart, R.5
Beauschene, L.6
Williams, K.7
Davies, R.A.8
Labinaz, M.9
Beanlands, R.S.B.10
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14
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0031048375
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Effects of cardiac allograft vasculopathy on myocardial blood flow, vasodilatory capacity, and coronary vasomotion
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Kofoed KF, Czernin J, Johnson J, et al. Effects of cardiac allograft vasculopathy on myocardial blood flow, vasodilatory capacity, and coronary vasomotion. Circulation 1997;95:600-6. The inverse correlation between the severity of vasculopathy and myocardial flow responses and allograft vasculopathy as reported in this research suggests the utility of flow measurements in patients with cardiac transplants. (Pubitemid 27063035)
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(1997)
Circulation
, vol.95
, Issue.3
, pp. 600-606
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Kofoed, K.F.1
Czernin, J.2
Johnson, J.3
Kobashigawa, J.4
Phelps, M.E.5
Laks, H.6
Schelbert, H.R.7
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15
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0037192310
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Noninvasive assessment of coronary microcirculatory function in postmenopausal women and effects of short-term and long-term estrogen administration
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DOI 10.1161/hc0402.102860
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Campisi R, Nathan L, Pampaloni MH, et al. Noninvasive assessment of coronary microcirculatory function in postmenopausal women and effects of short-term and long-term estrogen administration. Circulation 2002;105:425-30. This research assesses through quantitative blood flow measurements the coronary responsiveness in postmenopausal women. This responsiveness was determined by the total vasodilator response as well as by responses to cold pressor testing as a measure of endothelial function. The findings suggest that long term oestrogen administration in women without other coronary factors may restore impaired coronary vessel reactivity. (Pubitemid 34141697)
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(2002)
Circulation
, vol.105
, Issue.4
, pp. 425-430
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Campisi, R.1
Nathan, L.2
Pampaloni, M.H.3
Schoder, H.4
Sayre, J.W.5
Chaudhuri, G.6
Schelbert, H.R.7
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16
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0027998787
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Early detection of abnormal coronary flow reserve in asymptomatic men at high risk for coronary artery disease using positron emission tomography
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Dayanikli F, Grambow D, Muzik O, et al. Early detection of abnormal coronary flow reserve in asymptomatic men at high risk for coronary artery disease using positron emission tomography. Circulation 1994;90:808-17. As demonstrated in this study, hyperlipidaemia in young normal volunteers is associated with impaired coronary vessel reactivity. (Pubitemid 24242749)
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(1994)
Circulation
, vol.90
, Issue.2
, pp. 808-817
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Dayanikli, F.1
Grambow, D.2
Muzik, O.3
Mosca, L.4
Rubenfire, M.5
Schwaiger, M.6
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17
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0030725383
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Reduced myocardial flow reserve in non-insulin-dependent diabetes mellitus
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Elevated glucose levels in patients with poorly controlled type 2 diabetes are associated with a diminished myocardial flow reserve
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Yokoyama I, Momomura S, Ohtake T, et al. Reduced myocardial flow reserve in non-insulin-dependent diabetes mellitus. J Am Coll Cardiol 1997;30:1472-7. Elevated glucose levels in patients with poorly controlled type 2 diabetes are associated with a diminished myocardial flow reserve.
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(1997)
J Am Coll Cardiol
, vol.30
, pp. 1472-1477
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Yokoyama, I.1
Momomura, S.2
Ohtake, T.3
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18
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0034043491
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Coronary microangiopathy in type 2 diabetic patients: Relation to glycemic control, sex, and microvascular angina rather than to coronary artery disease
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The findings of this study indicate a more severe impairment in the triple coronary vasodilator capacity when microvascular disease coexists with type 2 diabetes
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Yokoyama I, Yonekura K, Ohtake T, et al. Coronary microangiopathy in type 2 diabetic patients: relation to glycemic control, sex, and microvascular angina rather than to coronary artery disease. J Nucl Med 2000;41:978-85. The findings of this study indicate a more severe impairment in the triple coronary vasodilator capacity when microvascular disease coexists with type 2 diabetes.
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(2000)
J Nucl Med
, vol.41
, pp. 978-985
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Yokoyama, I.1
Yonekura, K.2
Ohtake, T.3
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19
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18444406621
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Coronary circulatory dysfunction in insulin resistance, impaired glucose tolerance, and type 2 diabetes mellitus
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As shown in this study in insulin resistant individuals, the total integrated vasodilator capacity remains normal up to the most severe state of insulin resistance-that is, type 2 diabetes. However, there was evidence of endothelial dysfunction in individuals with milder forms of insulin resistance-for example, euglycaemic individuals and individuals with impaired glucose handling
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Prior JO, Quinones MJ, Hernandez-Pampaloni M, et al. Coronary circulatory dysfunction in insulin resistance, impaired glucose tolerance, and type 2 diabetes mellitus. Circulation 2005;111:2291-8. As shown in this study in insulin resistant individuals, the total integrated vasodilator capacity remains normal up to the most severe state of insulin resistance-that is, type 2 diabetes. However, there was evidence of endothelial dysfunction in individuals with milder forms of insulin resistance-for example, euglycaemic individuals and individuals with impaired glucose handling.
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(2005)
Circulation
, vol.111
, pp. 2291-2298
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Prior, J.O.1
Quinones, M.J.2
Hernandez-Pampaloni, M.3
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20
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58349112528
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Fractional flow reserve versus angiography for guiding percutaneous coronary intervention
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Tonino PA, De Bruyne B, Pijls NH, et al. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med 2009;360:213-24.
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(2009)
N Engl J Med
, vol.360
, pp. 213-224
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Tonino, P.A.1
De Bruyne, B.2
Pijls, N.H.3
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21
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77953677660
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Lack of correlation between noninvasive stress tests and invasive coronary vasomotor dysfunction in patients with nonobstructive coronary artery disease
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Cassar A, Chareonthaitawee P, Rihal CS, et al. Lack of correlation between noninvasive stress tests and invasive coronary vasomotor dysfunction in patients with nonobstructive coronary artery disease. Circ Cardiovasc Interv 2009;2:237-44.
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(2009)
Circ Cardiovasc Interv
, vol.2
, pp. 237-244
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Cassar, A.1
Chareonthaitawee, P.2
Rihal, C.S.3
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22
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77953298714
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Coronary microvascular reactivity to adenosine predicts adverse outcome in women evaluated for suspected ischemia: Results from the National Heart, Lung and Blood Institute WISE (Women's Ischemia Syndrome Evaluation) study
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Pepine CJ, Anderson RD, Sharaf BL, et al. Coronary microvascular reactivity to adenosine predicts adverse outcome in women evaluated for suspected ischemia: results from the National Heart, Lung and Blood Institute WISE (Women's Ischemia Syndrome Evaluation) study. J Am Coll Cardiol 2010;55:2825-32.
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(2010)
J Am Coll Cardiol
, vol.55
, pp. 2825-2832
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Pepine, C.J.1
Anderson, R.D.2
Sharaf, B.L.3
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