Respiratory problems in children with Down syndrome

Journal of Paediatrics and Child Health

Volumn 48, Issue 3, 2012, Pages

  Pandit, Chetan ^a   Fitzgerald, Dominic A ^a  

^a CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

Author keywords

obstructive sleep apnoea; pneumonia; pulmonary aspiration; structural lung abnormalities; suppurative lung disease

Indexed keywords

ANESTHETIC AGENT; ANTIBIOTIC AGENT; DIPHTHERIA VACCINE; HAEMOPHILUS INFLUENZAE TYPE B VACCINE; PALIVIZUMAB; PENICILLIN DERIVATIVE; PNEUMOCOCCUS VACCINE; TETANUS TOXOID; THYROXINE;

AIRWAY OBSTRUCTION; ALZHEIMER DISEASE; ANTIBIOTIC RESISTANCE; BRONCHIOLITIS; BRONCHOMALACIA; BRONCHOSCOPY; CARDIOPULMONARY HEMODYNAMICS; CHILD; COMORBIDITY; COMPUTER ASSISTED TOMOGRAPHY; CONGENITAL HEART DISEASE; DIPHTHERIA; DISEASE ASSOCIATION; DOWN SYNDROME; DRUG MEGADOSE; ENDOTRACHEAL TUBE; GASTROESOPHAGEAL REFLUX; HAEMOPHILUS INFECTION; HUMAN; HYPOTHYROIDISM; HYPOXEMIA; IMMUNOPATHOLOGY; LARYNGOMALACIA; LOWER RESPIRATORY TRACT INFECTION; LUNG ASPIRATION; LUNG HYPOPLASIA; MAGNETIC RESONANCE ANGIOGRAPHY; MUCOID OTITIS MEDIA; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHENOTYPE; PNEUMOCOCCAL INFECTION; PNEUMONIA; POLYSOMNOGRAPHY; PREVALENCE; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RESPIRATORY TRACT DISEASE; REVIEW; SLEEP APNEA SYNDROME; SNORING; SUBGLOTTIC STENOSIS; TETANUS; THYROID FUNCTION TEST; TONSILLITIS; TRACHEOMALACIA; TRACHEOSTOMY; VASCULAR RESISTANCE;

CHILD; DOWN SYNDROME; HUMANS; RESPIRATORY INSUFFICIENCY;

EID: 84858450509     PISSN: 10344810     EISSN: 14401754     Source Type: Journal    
DOI: 10.1111/j.1440-1754.2011.02077.x     Document Type: Review

References (50)

1. Jones KL,. Smiths' Recognizable Patterns of Human Malformations, 4th edn. Philadelphia, PA: WB Saunders, 1988.
2. Center for Disease Control and Prevention (CDC). Down syndrome prevalence at birth-United States 1983-1990. MMWR Morb. Mortal. Wkly. Rep. 1994; 43: 617-22.
3. Bell JA, Pearn JH, Firman D,. Childhood deaths in Down syndrome. Survival curves and causes of death from a total population study in Queensland, Australia, 1976-85. J. Med. Genet. 1989; 26: 764-8.
4. Morris JK, Alberman E,. Trends in Down's syndrome live births and antenatal diagnoses in England and Wales from 1989 to 2008: analysis of data from the National Down Syndrome Cytogenetic Register. BMJ 2009; 339: b3794. doi:10.1136/bmj.b3794.
5. Halliday J, Collins V, Riley M, Youssef D, Muggli E,. Has prenatal screening influenced the prevalence of comorbidities associated with Down syndrome and subsequent survival rates? Pediatrics 2009; 123: 256-61.
6. Bittles AH, Bower C, Hussain R, Glasson EJ,. The four ages of Down syndrome. Eur. J. Public Health 2009; 17: 221-5.
7. Glasson EJ, Sullivan SG, Hussain R, et al,. The changing survival profile of people with Down's syndrome: implications for genetic counselling. Clin. Genet. 2002; 62: 390-3.
8. Penrose LS,. The incidence of Mongolism in the general population. J. Ment. Sci. 1949; 95: 685-8.
9. Bittles AH, Glasson EJ,. Clinical, social and ethical implications of changing life expectancy in Down syndrome. Dev. Med. Child Neurol. 2004; 46: 282-6.
10. Committee on Genetics. Health supervision for children with Down syndrome. Pediatrics 2001; 107: 442-9.
11. Richmond S, Wren C,. Early diagnosis of congenital heart disease. Semin. Neonatol. 2001; 6: 27-35.
12. Loh RK, Harth SC, Thong YH, Ferrante A,. Immunoglobulin G subclass deficiency and predisposition to infection in Down's syndrome. Pediatr. Inf. Dis. J. 1990; 9: 547-51.
13. Kusters MAA, Verstegen RHJ, Gemen EFA, de Vries E,. Intrinsic defect of the immune system in children with Down syndrome: a review. Clin. Exp. Immunol. 2009; 156: 189-93.
14. Karroll K, Arbogast P, Dudley J, Cooper W,. Increase in incidence of medically treated thyroid disease in children with Down syndrome following release of American Academy of Pediatrics Health Supervision Guidelines. Pediatrics 2008; 122: e493-8.
15. Rosen D,. Severe hypothyroidism presenting as obstructive sleep apnoea. Clin. Pediatr. (Phila) 2010; 49: 381-3.
16. Fitzgerald DA, Paul A, Richmond C,. Severity of obstructive sleep apnoea in children with Down syndrome who snore. Arch. Dis. Child. 2007; 92: 423-5.
17. Lam DJ, Jensen CC, Mueller BA, Starr JR, Cunningham ML, Weaver EM,. Pediatric sleep apnea and craniofacial anomalies: a population-based case-control study. Laryngoscope 2010; 120: 2098-105.
18. Bertrand P, Navarro H, Caussade S, Holmgren N, Sanchez I,. Airway anomalies in children with Down syndrome: endoscopic findings. Pediatr. Pulmonol. 2003; 36: 137-41.
19. Cooney TP, Thurlbeck WM,. Pulmonary hypoplasia in Down syndrome. N. Engl. J. Med. 1982; 307: 1170-3.
20. Schloo BL, Vawter GF, Reid LM,. Down syndrome: patterns of disturbed lung growth. Hum. Pathol. 1991; 22: 919-23.
21. Mitchell RB, Call E, Kelly J,. Diagnosis and therapy for airway obstruction in children with Down syndrome. Arch. Otolaryngol. Head Neck Surg. 2003; 129: 642-5.
22. Wells TR, Landing BH, Shamszadeh M, Thompson JW, Bove KE, Caron KH,. Association of Down syndrome and segmental tracheal stenosis with ring tracheal cartilages: a review of nine cases. Pediatr. Pathol. Lab. Med. 1992; 12: 673-82.
23. Bravo MN, Kaur A, Rutter MJ, et al,. Down syndrome and complete rings. J. Pediatr. 2006; 148: 392-5.
24. Miller R, Gray SD, Cotton RT, Myer CM III, Neterville J,. Subglottic stenosis and Down syndrome. Am. J. Otolaryngol. 1990; 11: 274-7.
25. Sherry KM,. Post-extubation stridor in Down's syndrome. Br. J. Anaesth. 1983; 55: 53-5.
26. Kobel M, Creighton RE, Steward DJ,. Anesthetic considerations in Down's syndrome: experience with 100 patients and a review of the literature. Can. Anaesth Soc. J. 1982; 29: 593-9.
27. Strome M,. Down's syndrome: a modern otorhinolaryngological perspective. Laryngoscope 1981; 91: 1581-94.
28. Shott SR,. Down syndrome: analysis of airway size and a guide for appropriate intubation. Laryngoscope 2000; 110: 585-92.
29. Fitzgerald DA, Kilham HA,. Croup: evidence based management. Med. J. Aust. 2003; 179: 372-7.
30. O'Sullivan BP, Frassica JJ, Rayder SM,. Tracheal bronchus. A cause of prolonged atelectasis in intubated children. Chest 1998; 113: 537-40.
31. Yamaki S, Horiuchi T, Takahashi T,. Pulmonary changes in congenital heart disease with Down's syndrome: their significance as a cause of postoperative respiratory failure. Thorax 1985; 40: 380-6.
32. Smith LJ, van Asperen PP, McKay KM, Selvadurai H, Fitzgerald DA,. Normal development of the lung and premature birth. Paediatr. Respir. Rev. 2010; 11: 135-42. Epub 2010 Jan 25.
33. Fitzgerald DA, Evans N, Van Asperen P, Henderson-Smart D,. Subclinical persisting pulmonary hypertension in infants with chronic neonatal lung disease. Arch. Dis. Child Fetal. Neonatal. Ed. 1994; 70: F118-22.
34. Marcus CL, Keens TG, Bautista DB, von Pechmann S, Davidson Ward SL,. Obstructive sleep apnea in children with Down syndrome. Pediatrics 1991; 88: 132-9.
35. Fink GB, Madaus WK, Walker GF,. A quantitative study of the face in Down's syndrome. Am. J. Orthod. 1975; 67: 540-53.
36. Shott SR, Amin R, Chini B, Heubi C, Hotze S, Ackers R,. Obstructive sleep apnea: should all children with Down syndrome be tested? Arch. Otolaryngol. Head Neck Surg. 2006; 132: 432-6.
37. Schieve LA, Boulet SL, Boyle C, Rasmussen SA, Schendel D,. Health of children 3 to 17 years of age with Down syndrome in the 1997 2005 National Health Interview Survey. Pediatrics 2009; 123: e253-60.
38. Selikowitz M,. Health problems and health checks in school-aged children with Down syndrome. J. Pediatr. Child Health 1992; 28: 383-6.
39. Hata T, Todd MM,. Cervical spine considerations when anesthetizing patients with Down syndrome. Anesthesiology 2005; 102: 680-5.
40. Taggard DA, Menezes AH, Ryken TC,. Treatment of Down syndrome associated craniovertebral junction abnormalities. J. Neurosurg. 2000; 95: 203-13.
41. Frazier JB, Friedman B,. Swallow function in children with Down syndrome: a retrospective study. Dev. Med. Child Neurol. 1996; 38: 695-703.
42. Fitzgerald DA, Hilton J, Cooper DM,. Respiratory morbidity in hospitalized children with Down syndrome. J. Paediatr. Child Health 1999; 35: 383-6.
43. Weir K, McMahon S, Barry L, Masters IB, Chang AB,. Oropharyngeal aspiration and pneumonia in children. Pediatr. Pulmonol. 2007; 42: 1024-31.
44. Brumbaugh DE, Accurso FJ,. Persitent silent aspiration in a child with Trisomy 21. Curr. Opin. Pediatr. 2002; 14: 231-3.
45. Lau KF, Jayaram R, Fitzgerald DA,. Diagnosing inhaled foreign bodies in children. Med. J. Aust. 2001; 174: 194-6.
46. Bloemers BL, van Furth AM, Weijerman ME, et al,. Down syndrome: a novel risk factor for respiratory syncytial virus bronchiolitis-a prospective birth-cohort study. Pediatrics 2007; 120: e1076-81.
47. Fitzgerald DA,. Viral bronchiolitis for the clinician. J. Paediatr. Child Health 2010 [Epub ahead of print]. doi: 10.1111/j.1440-1754.2010.01735
48. Fitzgerald DA,. Preventing RSV bronchiolitis in vulnerable infants: the role of palivizumab. Paediatr. Respir. Rev. 2009; 10: 143-7.
49. Megged O, Schlesinger Y,. Down syndrome and respiratory syncytial virus infection. Pediatr. Inf. Dis. J. 2010; 29: 672-3.
50. Grant GB, Campbell H, Dowell SF, et al,. Guidelines for the treatment of childhood non-severe pneumonia. Lancet Infect. Dis. 2009; 9: 185-96.