In vitro-in vivo correlation for intrinsic clearance for CP-409,092 and sumatriptan: A case study to predict the in vivo clearance for compounds metabolized by monoamine oxidase

Xenobiotica

Volumn 42, Issue 4, 2012, Pages 355-362

  Kamel, Amin ^a,b   Colizza, Kevin ^a,b   Gunduz, Mithat ^a,b   Harriman, Shawn ^a,b   Obach, R Scott ^a  

^a PFIZER INC   (United States)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

CP 409,092; GABAA receptor; in vitro in vivo correlation (IVIVC); intrinsic clearance; Metabolism; monoamine oxidase; oral clearance; oxidative deamination reactions; pharmacokinetics; sumatriptan

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; CLORGYLINE; CP 409092; SELEGILINE; SUMATRIPTAN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG METABOLISM; ENZYME INHIBITION; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; IN VIVO STUDY; LIVER MITOCHONDRION; NORMAL HUMAN;

ANILIDES; CLORGYLINE; DRUG INTERACTIONS; DRUG PARTIAL AGONISM; GABA-A RECEPTOR AGONISTS; HUMANS; INDOLES; KINETICS; METABOLIC CLEARANCE RATE; MITOCHONDRIA, LIVER; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; SELEGILINE; SUMATRIPTAN;

EID: 84858408598     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2011.630490     Document Type: Article

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