Modification of the Ferret Model for Pneumonia From Seasonal Human Influenza A Virus Infection

Veterinary Pathology

Volumn 49, Issue 3, 2012, Pages 562-568

  van den Brand, J M A ^a   Stittelaar, K J ^b   Leijten, L M E ^a   van Amerongen, G ^a,b   Simon, J H ^b   Osterhaus, A D M E ^a   Kuiken, T ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b Viroclinics Biosciences BV   (Netherlands)

Author keywords

animal model; ferrets; immunohistochemistry; lung; pathology; pneumonia; seasonal influenza

Indexed keywords

ANIMAL; ARTICLE; COMPARATIVE STUDY; DISEASE MODEL; FERRET; HUMAN; IMMUNOHISTOCHEMISTRY; INFLUENZA; INFLUENZA VIRUS A H1N1; INFLUENZA VIRUS A H3N2; ORTHOMYXOVIRUS INFECTION; PATHOLOGY; TRACHEA; VIROLOGY; VIRUS PNEUMONIA;

ANIMALS; DISEASE MODELS, ANIMAL; FERRETS; HUMANS; IMMUNOHISTOCHEMISTRY; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H3N2 SUBTYPE; INFLUENZA, HUMAN; ORTHOMYXOVIRIDAE INFECTIONS; PNEUMONIA, VIRAL; TRACHEA;

ANIMALIA; INFLUENZA A VIRUS; MUSTELA; ORTHOMYXOVIRIDAE;

EID: 84858404924     PISSN: 03009858     EISSN: 15442217     Source Type: Journal    
DOI: 10.1177/0300985811429812     Document Type: Article

References (17)

1. Baras B,Stittelaar KJ,Simon JH, et al.Cross-protection against lethal H5N1 challenge in ferrets with an adjuvanted pandemic influenza vaccine.PLoS One. 2008;3:e1401.
2. Bodewes R.Kuiken T. Pathogenesis of influenza A/H5N1 virus infection in ferrets differs between intranasal and intratracheal routes of inoculation.Am J Pathol. 2011;179:30-36.
3. Guarner J,Falcon-Escobedo R.Comparison of the pathology caused by H1N1, H5N1, and H3N2 influenza viruses.Arch Med Res. 2009;40:655-661.
4. Guarner J,Shieh WJ,Dawson J, et al.Immunohistochemical and in situ hybridization studies of influenza A virus infection in human lungs.Am J Clin Pathol. 2000;114:227-233.
5. Herfst S,van den Brand JM,Schrauwen EJ, et al.Pandemic 2009 H1N1 influenza virus causes diffuse alveolar damage in cynomolgus macaques.Vet Pathol. 2010;47:1040-1047.
6. Itoh Y,Shinya K,Kiso M, et al.In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses.Nature. 2009;460:1021-1025.
7. Kuiken T,Taubenberger JK.Pathology of human influenza revisited.Vaccine. 2008;26 Suppl 4:D59-D66.
8. Kuiken T,van den BJ,van Riel D, et al.Comparative pathology of select agent influenza a virus infections.Vet Pathol. 2010;47:893-914.
9. Maher JA,DeStefano J.The ferret: an animal model to study influenza virus.Lab Anim (NY). 2004;33:50-53.
10. Munster VJ,de Wit E,van den Brand JM, et al.Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets.Science. 2009;325:481-483.
11. Rimmelzwaan GF,Baars M,Claas ECJ, et al.Comparison of RNA hybridization, hemagglutination assay, titration of infectious virus and immunofluorescence as methods for monitoring influenza virus replication in vitro.J Virol Methods. 1998;74:57-66.
12. Rimmelzwaan GF,Kuiken T,van Amerongen G, et al.Pathogenesis of influenza A (H5N1) virus infection in a primate model.J Virol. 2001;75:6687-6691.
13. Svitek N,Rudd PA,Obojes K, et al.Severe seasonal influenza in ferrets correlates with reduced interferon and increased IL-6 induction.Virol. 2008;376:53-59.
14. van den Brand JM,Kreijtz JH,Bodewes R, et al.Efficacy of vaccination with different combinations of MF59-adjuvanted and non-adjuvanted seasonal and pandemic influenza vaccines against pandemic H1N1 (2009) influenza in ferrets.J Virol. 2011;85:2851-2858.
15. van den Brand JM,Stittelaar KJ,van Amerongen G, et al.Severity of pneumonia due to new H1N1 influenza virus in ferrets is intermediate between that due to seasonal H1N1 virus and highly pathogenic avian influenza H5N1 virus.J Infect Dis. 2010;201:993-999.
16. van Riel D,Munster VJ,de Wit E, et al.Human and avian influenza viruses target different cells in the lower respiratory tract of humans and other mammals.Am J Pathol. 2007;171:1215-1223.
17. World Health Organization. Influenza (seasonal) [fact sheet No. 211]. http://www.who.int/mediacentre/factsheets/fs211/en/index.html. Accessed May 15, 2011.