Acute hyperinsulinemia is followed by increased serum concentrations of fibroblast growth factor 23 in type 2 diabetes patients

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 72, Issue 2, 2012, Pages 108-113

  Winther, Kristian ^a   Nybo, Mads ^a   Vind, Birgitte ^a   Pedersen, Susanne Møller ^a   Højlund, Kurt ^a   Rasmussen, Lars Melholt ^a  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Diabetes; Fibroblast growth factor 23; Insulin; Phosphate

Indexed keywords

FIBROBLAST GROWTH FACTOR 23; GLUCOSE; HEMOGLOBIN A1C; INSULIN; PHOSPHATE;

ADULT; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; HUMAN; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; FIBROBLAST GROWTH FACTORS; HUMANS; HYPERINSULINISM; MALE; MIDDLE AGED;

EID: 84858403830     PISSN: 00365513     EISSN: 15027686     Source Type: Journal    
DOI: 10.3109/00365513.2011.640407     Document Type: Article

References (23)

1. Foley RN. Phosphate levels and cardiovascular disease in the general population. Clin J Am Soc Nephrol 2009;4: 1136-9.
2. Adeney KL, Siscovick DS, Ix JH, Seliger SL, Shlipak MG, Jenny NS, Kestenbaum BR. Association of serum phosphate with vascular and valvular calcification in moderate CKD. J Am Soc Nephrol 2009;20:381-7.
3. Hammerman MR, Rogers S, Hansen VA, Gavin JR 3rd. Insulin stimulates Pi transport in brush border vesicles from proximal tubular segments. Am J Physiol 1984;247:E616-24. (Pubitemid 15219555)
4. Massara F, Camanni F. Propranolol block of adrenaline-induced hypophosphataemia in man. Clin Sci 1970;38: 245-50.
5. Foley RN, Collins AJ, Ishani A, Kalra PA. Calcium-phosphate levels and cardiovascular disease in community-dwelling adults: the Atherosclerosis Risk in Communities (ARIC) Study. Am Heart J 2008;156:556-63.
6. Tonelli M, Sacks F, Pfeffer M, Gao Z, Curhan G; Cholesterol And Recurrent Events Trial Investigators. Relation between serum phosphate level and cardiovascular event rate in people with coronary disease. Circulation 2005;112:2627-33. (Pubitemid 41532599)
7. Yamashita T, Yoshioka M, Itoh N. Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain. Biochem Biophys Res Commun 2000;277:494-8.
8. Beck-Nielsen SS, Pedersen SM, Kassem M, Rasmussen LM. Fibroblast growth factor 23-a phosphate regulating hormone. Ugeskr Laeger 2010;172:1521-7.
9. Mirams M, Robinson BG, Mason RS, Nelson AE. Bone as a source of FGF23: regulation by phosphate? Bone 2004;35:1192-9. (Pubitemid 39487366)
10. Saito H, Kusano K, Kinosaki M, Ito H, Hirata M, Segawa H, Miyamoto K, Fukushima N. Human fibroblast growth factor-23 mutants suppress Na +-dependent phosphate co-transport activity and 1alpha,25-dihydroxyvitamin D3 production. J Biol Chem 2003;278:2206-11. (Pubitemid 36801287)
11. Højlund K, Frystyk J, Levin K, Flyvbjerg A, Wojtaszewski JF, Beck-Nielsen H. Reduced plasma adiponectin concentrations may contribute to impaired insulin activation of glycogen synthase in skeletal muscle of patients with type 2 diabetes. Diabetologia 2006:49;1283-91.
12. Hother-Nielsen O, Henriksen JE, Holst JJ, Beck-Nielsen H. Effects of insulin on glucose turnover rates in vivo: isotope dilution versus constant specific activity technique. Metabolism 1996;45:82-91. (Pubitemid 26104272)
13. Hills SA, Balkau B, Coppack SW, Dekker JM, Mari A, Natali A, Walker M, Ferrannini E; EGIR-RISC Study Group. The EGIR-RISC STUDY (The European group for the study of insulin resistance: relationship between insulin sensitivity and cardiovascular disease risk): I. Methodology and objectives. Diabetologia 2004;47:566-70. (Pubitemid 38491256)
14. Yamazaki Y, Okazaki R, Shibata M, Hasegawa Y, Satoh K, Tajima T, Takeuchi Y, Fujita T, Nakahara K, Yamashita T, Fukumoto S. Increased circulatory level of biologically active full-length FGF-23 in patients with hypophosphatemic rickets/osteomalacia, J Clin Endocrinol Metab 2002;87: 4957-60. (Pubitemid 35316332)
15. Shimamoto K, Higashiura K, Nakagawa M, Masuda A, Shiiki M, Myazaki Y, Ise T, Fukuoka M, Hirata A, Iimura O. Effects of hyperinsulinemia under the euglycemic condition on calcium and phosphate metabolism in non-obese normotensive subjects. Tohoku J Exp Med 1995;177:271-8. (Pubitemid 26128226)
16. Prié D, Friedlander G. Reciprocal control of 1, 25-dihydroxyvitamin D and FGF23 formation involving the FGF23/Klotho system. Clin J Am Soc Nephrol 2010;5: 1717-22.
17. Urakawa I, Yamazaki Y, Shimada T, Lijima K, Hasegawa H, Okawa K, Fujita T, Fukumoto S, Yamashitta T. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 1997;444:770-4.
18. Haap JP, Heller E, Thamer C, Tschritter O, Stefan N, Fritsche A. Association of serum phosphate levels with glucose tolerance, insulin sensitivity and insulin secretion in non-diabetic subjects. Eur J Clin Nutr 2006;60:734-9. (Pubitemid 43842228)
19. Mrza MA, AlsiöJ, Hammarstedt A, Erben RG, Michaëlsson K, Tivesten A, Marsell R, Orwoll E, Karlsson MK, Ljunggren O, Mellström D, Lind L, Ohlsson C Larsson TE. Circulating fibroblast growth factor-23 is associated with fat mass and dyslipidemia in two independent cohorts of elderly individuals. Arterioscler Thromb Vasc Biol 2011;31: 219-27.
20. Haffner SM, Valdez R, Morales PA, Mitchell BD, Hazuda HP, Stern MP. Greater effect of glycemia on incidence of hypertension in women than in men. Diabetes Care 1992;15:1277-84.
21. Lehto S, Niskanen L, Suhonen M, Rönnemaa T, Laakso M. Medial artery calcification. A neglected harbinger of cardiovascular complications in non-insulin-dependent diabetes mellitus. Arterioscler Thromb Vasc Biol 1996;16: 978-83. (Pubitemid 26266896)
22. Foley RN, Collins AJ, Ishani A, Kalra PA. Calcium-phosphate levels and cardiovascular disease in community-dwelling adults: the Atherosclerosis Risk in Communities (ARIC) Study. Am Heart J 2008;156:556-63.
23. Jono S, McKee MD, Murry CE, Shioi A, Nishizawa Y, Mori K, Morii H, Giachelli CM. Phosphate regulation of vascular smooth muscle cell calcification. Circ Res 2000;87:E10-17.