GlmS and NagB regulate amino sugar metabolism in opposing directions and affect streptococcus mutans virulence

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Kawada Matsuo, Miki ^a   Mazda, Yusuke ^a   Oogai, Yuichi ^a   Kajiya, Mikihito ^b   Kawai, Toshihisa ^b   Yamada, Sakuo ^c,d   Miyawaki, Shouichi ^a   Oho, Takahiko ^a   Komatsuzawa, Hitoshi ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b FORSYTH INSTITUTE   (United States)

^c KAWASAKI MEDICAL SCHOOL   (Japan)

^d Kawasaki Medical Welfare ^*  (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; BACTERIAL ENZYME; CELL SURFACE PROTEIN; GLUCOSYLTRANSFERASE; N ACETYLGLUCOSAMINE; PROTEIN GLMS; PROTEIN NAGB; UNCLASSIFIED DRUG; VIRULENCE FACTOR; AMINOSUGAR; GLUCOSAMINE 6 PHOSPHATE ISOMERASE; GLUCOSAMINE-6-PHOSPHATE ISOMERASE; GLUTAMINE FRUCTOSE 6 PHOSPHATE AMINOTRANSFERASE; ISOMERASE;

ARTICLE; BACTERIAL GENE; BACTERIAL VIRULENCE; BACTERIUM ADHERENCE; BIOFILM; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME REGULATION; GENE INACTIVATION; GLMS GENE; GLUCOSE METABOLISM; NAGB GENE; NONHUMAN; PROTEIN EXPRESSION; STREPTOCOCCUS MUTANS; BIOLOGICAL MODEL; DRUG ANTAGONISM; GENE EXPRESSION REGULATION; GENETIC COMPLEMENTATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; METABOLISM; MUTATION; PATHOGENICITY; PHYSIOLOGY; VIRULENCE;

BACTERIA (MICROORGANISMS); STREPTOCOCCUS MUTANS;

ALDOSE-KETOSE ISOMERASES; AMINO SUGARS; BIOFILMS; GENE EXPRESSION REGULATION, BACTERIAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE KNOCKOUT TECHNIQUES; GENES, BACTERIAL; GENETIC COMPLEMENTATION TEST; GLUTAMINE-FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING); HUMANS; MODELS, BIOLOGICAL; MUTATION; STREPTOCOCCUS MUTANS; VIRULENCE; VIRULENCE FACTORS;

EID: 84858403229     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033382     Document Type: Article

References (40)

1. Hamada S, Slade HD, (1980) Biology, immunology, and cariogenicity of Streptococcus mutans. Microbiol Rev 44: 331-384.
2. Loesche WJ, (1986) Role of Streptococcus mutans in human dental decay. Microbiol Rev 50: 353-380.
3. Houte J, (1994) Role of micro-organisms in caries etiology. J Dent Res 73: 672-681.
4. Donlan RM, Costerton JW, (2002) Biofilms: survival mechanisms of clinically relevant microorganisms. Clin Microbiol Rev 15: 167-193.
5. Kuramitsu HK, (1993) Virulence factors of mutans streptococci: role of molecular genetics. Crit Rev Oral Biol Med 4: 159-176.
6. Lemos JA, Abranches J, Burne RA, (2005) Responses of cariogenic streptococci to environmental stresses. Curr Issues Mol Biol 7: 95-107.
7. Plumbridge JA, Cochet O, Souza JM, Altamirano MM, Calcagno ML, et al. (1993) Coordinated regulation of amino sugar-synthesizing and-degrading enzymes in Escherichia coli K-12. J Bacteriol 175: 4951-4956.
8. Komatsuzawa H, Fujiwara T, Nishi H, Yamada S, Ohara M, et al. (2004) The gate controlling cell wall synthesis in Staphylococcus aureus. Mol Microbiol 53: 1221-1231.
9. Banas JA, Vickerman MM, (2003) Glucan-binding proteins of the oral streptococci. Crit Rev Oral Biol Med 14: 89-99.
10. Banas JA, (2004) Virulence properties of Streptococcus mutans. Front Biosci 9: 1267-1277.
11. Jakubovics NS, Strömberg N, van Dolleweerd CJ, Kelly CG, Jenkinson HF, (2005) Differential binding specificities of oral streptococcal antigen I/II family adhesins for human or bacterial ligands. Mol Microbiol 55: 1591-1605.
12. Plumbridge J, (1995) Co-ordinated regulation of amino sugar biosynthesis and degradation: the NagC repressor acts as both an activator and a repressor for the transcription of the glmUS operon and requires two separated NagC binding sites. EMBO J 14: 3958-3965.
13. Alvarez-Añorve LI, Bustos-Jaimes I, Calcagno ML, Plumbridge J, (2009) Allosteric regulation of glucosamine-6-phosphate deaminase (NagB) and growth of Escherichia coli on glucosamine. J Bacteriol 191: 6401-6407.
14. Liu C, Li D, Liang YH, Li LF, Su XD, (2008) Ring-opening mechanism revealed by crystal structures of NagB and its ES intermediate complex. J Mol Biol 379: 73-81.
15. Hussain M, Hastings JG, White PJ, (1991) A chemically defined medium for slime production by coagulase-negative staphylococci. J Med Microbiol 34: 143-147.
16. Kawada-Matsuo M, Shibata Y, Yamashita Y, (2009) Role of two component signaling response regulators in acid tolerance of Streptococcus mutans. Oral Microbiol Immunol 24: 173-176.
17. Shiroza T, Kuramitsu HK, (1993) Construction of a model secretion system for oral streptococci. Infect Immun 61: 3745-3755.
18. LeBlanc DJ, Lee LN, Inamine JM, (1991) Cloning and nucleotide base sequence analysis of a spectinomycin adenyltransferase AAD(9) determinant from Enterococcus faecalis. Antimicrob Agents Chemother 35: 1804-1810.
19. Sambrook J, Fritsch EF, Maniatis T, (1989) Molecular cloning: a laboratory mannual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
20. Yu H, Nakano Y, Yamashita Y, Oho T, Koga T, (1997) Effects of antibodies against cell surface protein antigen SpaP-glucosyltransferase fusion proteins on glucan synthesis and cell adhesion of Streptococcus mutans. Infect Immun 65: 2292-2298.
21. Shibata Y, Kawada M, Nakano Y, Toyoshima K, Yamashita Y, (2005) Identification and characterization of an autolysin-encoding gene of Streptococcus mutans. Infect Immun 73: 3512-3520.
22. Oho T, Yu H, Yamashita Y, Koga T, (1998) Binding of salivary glycoprotein-secretory immunoglobulin A complex to the surface protein antigen of Streptococcus mutans. Infect Immun 66: 115-121.
23. Matsui R, Cvitkovitch D, (2010) Acid tolerance mechanisms utilized by Streptococcus mutans. Future Microbiol 5: 403-417.
24. Idone V, Brendtro S, Gillespie R, Kocaj S, Peterson E, et al. (2003) Effect of an orphan response regulator on Streptococcus mutans sucrose-dependent adherence and cariogenesis. Infect Immun 71: 4351-4360.
25. Senadheera MD, Guggenheim B, Spatafora GA, Huang YC, Choi J, et al. (2005) A VicRK signal transduction system in Streptococcus mutans affects gtfBCD, gbpB, and ftf expression, biofilm formation, and genetic competence development. J Bacteriol 187: 4064-4076.
26. Shemesh M, Tam A, Feldman M, Steinberg D, (2006) Differential expression profiles of Streptococcus mutans ftf, gtf and vicR genes in the presence of dietary carbohydrates at early and late exponential growth phases. Carbohydr Res 341: 2090-2097.
27. Wu C, Ayala EA, Downey JS, Merritt J, Goodman SD, et al. (2010) Regulation of ciaXRH operon expression and identification of the CiaR regulon in Streptococcus mutans. J Bacteriol 192: 4669-4679.
28. Abranches J, Nascimento MM, Zeng L, Browngardt CM, Wen ZT, et al. (2008) CcpA regulates central metabolism and virulence gene expression in Streptococcus mutans. J Bacteriol 190: 2340-2349.
29. Nakano K, Tsuji M, Nishimura K, Nomura R, Ooshima T, (2006) Contribution of cell surface protein antigen SpaP of Streptococcus mutans to bacteremia. Microbes Infect 8: 114-121.
30. Bernheim NJ, Dobrogosz WJ, (1970) Amino sugar sensitivity in Escherichia coli mutants unable to grow on N-acetylglucosamine. J Bacteriol 101: 384-391.
31. Kadner RJ, Murphy GP, Stephens CM, (1992) Two mechanisms for growth inhibition by elevated transport of sugar phosphates in Escherichia coli. J Gen Microbiol 138: 2007-2014.
32. Winkler WC, Nahvi A, Roth A, Collins JA, Breaker RR, (2004) Control of gene expression by a natural metabolite-responsive ribozyme. Nature 428: 281-286.
33. Scott WG, (2007) Ribozymes. Curr Opin Struct Biol 17: 280-286.
34. Tinsley RA, Furchak JR, Walter NG, (2007) Trans-acting glmS catalytic riboswitch: locked and loaded. RNA 13: 468-477.
35. Görke B, Vogel J, (2008) Noncoding RNA control of the making and breaking of sugars. Genes Dev 22: 2914-25.
36. Reichenbach B, Göpel Y, Görke B, (2009) Dual control by perfectly overlapping sigma 54- and sigma 70- promoters adjusts small RNA GlmY expression to different environmental signals. Mol Microbiol 74: 1054-1070.
37. Göpel Y, Lüttmann D, Heroven AK, Reichenbach B, Dersch P, et al. (2011) Common and divergent features in transcriptional control of the homologous small RNAs GlmY and GlmZ in Enterobacteriaceae. Nucleic Acids Res 39: 1294-1309.
38. Duque C, Stipp RN, Wang B, Smith DJ, Höfling JF, et al. (2011) Downregulation of GbpB, a component of the VicRK regulon, affects biofilm formation and cell surface characteristics of Streptococcus mutans. Infect Immun 79: 786-796.
39. Koga T, Okahashi N, Takahashi I, Kanamoto T, Asakawa H, et al. (1990) Surface hydrophobicity, adherence, and aggregation of cell surface protein antigen mutants of Streptococcus mutans serotype c. Infect Immun 58: 289-296.
40. Brady LJ, Maddocks SE, Larson MR, Forsgren N, Persson K, et al. (2010) The changing faces of Streptococcus antigen I/II polypeptide family adhesins. Mol Microbiol 77: 276-286.