Unique metabolic pathway of [ 14C]lenvatinib after oral administration to male cynomolgus monkey

Drug Metabolism and Disposition

Volumn 40, Issue 4, 2012, Pages 662-670

  Inoue, Kazuko ^a   Asai, Naoki ^a   Mizuo, Hitoshi ^a   Fukuda, Katsuyuki ^a   Kusano, Kazutomi ^a   Yoshimura, Tsutomu ^a  

^a EISAI CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 14; CYSTEINE CONJUGATE; CYSTEINYLGLYCINE; DIPEPTIDASE; DRUG METABOLITE; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; LENVATINIB;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIMERIZATION; DISULFIDE BOND; DRUG HYDROLYSIS; DRUG METABOLISM; DRUG STRUCTURE; DRUG TRANSFORMATION; HAPLORHINI; HUMAN; HUMAN CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUBSTITUTION REACTION;

ADMINISTRATION, ORAL; ANIMALS; BILE; BIOTRANSFORMATION; CARBON RADIOISOTOPES; CHROMATOGRAPHY, LIQUID; GALLBLADDER; HUMANS; LIVER; MACACA FASCICULARIS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; METABOLIC NETWORKS AND PATHWAYS; MOLECULAR STRUCTURE; PHENYLUREA COMPOUNDS; QUINOLINES; RATS; TIME FACTORS;

MACACA FASCICULARIS;

EID: 84858402093     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.111.043281     Document Type: Article

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