Synthesis and evaluation of 17α-(dimethylphenyl)vinyl estradiols as probes of the estrogen receptor-α ligand binding domain

Steroids

Volumn 77, Issue 5, 2012, Pages 471-476

  Hanson, Robert N ^a   McCaskill, Emmett ^a   Tongcharoensirikul, Pakamas ^a   Dilis, Robert ^a   Labaree, David ^b   Hochberg, Richard B ^b  

^a NORTHEASTERN UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Binding assay; Estrogen receptor; Ligand binding domain; Molecular modeling; Steroidal estrogens; Synthesis

Indexed keywords

17ALPHA (DIMETHYLPHENYL)VINYL ESTRADIOL; ALKALINE PHOSPHATASE; BENZENE DERIVATIVE; ESTRADIOL DERIVATIVE; ESTROGEN RECEPTOR ALPHA; METHYL GROUP; UNCLASSIFIED DRUG; VINYL DERIVATIVE;

ARTICLE; BINDING COMPETITION; CHEMICAL MODIFICATION; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INDUCTION; ESTROGEN ACTIVITY; LIGAND BINDING; MOLECULAR MODEL; QUANTUM YIELD; RECEPTOR AFFINITY; STILLE REACTION;

ALKALINE PHOSPHATASE; BINDING SITES; BINDING, COMPETITIVE; CELL LINE, TUMOR; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; HUMANS; ISOMERISM; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; VINYL COMPOUNDS;

EID: 84858342759     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2012.01.003     Document Type: Article

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