EGFR-mutant lung adenocarcinomas treated first-line with the novel EGFR inhibitor, XL647, can subsequently retain moderate sensitivity to erlotinib

Journal of Thoracic Oncology

Volumn 7, Issue 2, 2012, Pages 434-442

  Chmielecki, Juliann ^a   Pietanza, M Catherine ^b   Aftab, Dana ^c   Shen, Ronglai ^d   Zhao, Zhiguo ^e   Chen, Xi ^e   Hutchinson, Katherine ^f   Viale, Agnes ^d   Kris, Mark G ^b   Stout, Thomas ^c   Miller, Vincent ^b   Rizvi, Naiyer ^b   Pao, William ^f  

^a Weill Cornell Medical Center   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c EXELIXIS INC   (United States)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^e VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^f VANDERBILT INGRAM CANCER CENTER   (United States)

Author keywords

Acquired resistance; Afatinib; EGFR mutations; EGFR tyrosine kinase inhibitors; Erlotinib; Gefitinib; Non small cell lung cancer; XL647

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; MESSENGER RNA; XL 647;

ARTICLE; CANCER INHIBITION; CLINICAL ARTICLE; DISEASE COURSE; DRUG DOSE REDUCTION; DRUG EFFECT; DRUG SENSITIVITY; DRUG STRUCTURE; FEMALE; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG ADENOCARCINOMA; PRIORITY JOURNAL; TUMOR BIOPSY;

EID: 84858342654     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1097/JTO.0b013e31823c5aee     Document Type: Article

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