메뉴 건너뛰기




Volumn 129, Issue 4, 2012, Pages 441-446

CYP2C19*2 and other genetic variants affecting platelet response to clopidogrel in patients undergoing percutaneous coronary intervention

Author keywords

Clopidogrel; CYP2B65; CYP2C19; P2RY12; Percutaneous coronary intervention; Platelet reactivity

Indexed keywords

CLOPIDOGREL; CYTOCHROME P450 2C19; ANTITHROMBOCYTIC AGENT; CYTOKINE; DRUG DERIVATIVE; TICLOPIDINE;

EID: 84858340502     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2011.07.022     Document Type: Article
Times cited : (31)

References (43)
  • 1
    • 34047096264 scopus 로고    scopus 로고
    • Variability in individual responsiveness to clopidogrel: Clinical implications, management, and future perspectives
    • D.J. Angiolillo, A. Fernandez-Ortiz, E. Bernardo, F. Alfonso, C. Macaya, and T.A. Bass Variability in individual responsiveness to clopidogrel: clinical implications, management, and future perspectives J Am Coll Cardiol. 49 2007 1505 1516
    • (2007) J Am Coll Cardiol. , vol.49 , pp. 1505-1516
    • Angiolillo, D.J.1    Fernandez-Ortiz, A.2    Bernardo, E.3    Alfonso, F.4    MacAya, C.5    Bass, T.A.6
  • 2
    • 0038649988 scopus 로고    scopus 로고
    • Clopidogrel for coronary stenting: Response variability, drug resistance, and the effect of pretreatment platelet reactivity
    • P.A. Gurbel, K.P. Bliden, B.L. Hiatt, and C.M. O'Connor Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity Circulation. 107 2003 2908 2913
    • (2003) Circulation. , vol.107 , pp. 2908-2913
    • Gurbel, P.A.1    Bliden, K.P.2    Hiatt, B.L.3    O'Connor, C.M.4
  • 3
    • 73949100670 scopus 로고    scopus 로고
    • Early but not late stent thrombosis is influenced by residual platelet aggregation in patients undergoing coronary interventions
    • T. Geisler, C. Zurn, R. Simonenko, M. Rapin, H. Kraibooj, and A. Kilias Early but not late stent thrombosis is influenced by residual platelet aggregation in patients undergoing coronary interventions Eur Heart J. 31 2010 59 66
    • (2010) Eur Heart J. , vol.31 , pp. 59-66
    • Geisler, T.1    Zurn, C.2    Simonenko, R.3    Rapin, M.4    Kraibooj, H.5    Kilias, A.6
  • 4
    • 60949083948 scopus 로고    scopus 로고
    • Platelet reactivity after clopidogrel treatment assessed with point-of-care analysis and early drug-eluting stent thrombosis
    • D. Sibbing, S. Braun, T. Morath, J. Mehilli, W. Vogt, and A. Schomig Platelet reactivity after clopidogrel treatment assessed with point-of-care analysis and early drug-eluting stent thrombosis J Am Coll Cardiol. 53 2009 849 856
    • (2009) J Am Coll Cardiol. , vol.53 , pp. 849-856
    • Sibbing, D.1    Braun, S.2    Morath, T.3    Mehilli, J.4    Vogt, W.5    Schomig, A.6
  • 5
    • 77249113768 scopus 로고    scopus 로고
    • Comparison of platelet function tests in predicting clinical outcome in patients undergoing coronary stent implantation
    • N.J. Breet, J.W. van Werkum, H.J. Bouman, J.C. Kelder, H.J. Ruven, and E.T. Bal Comparison of platelet function tests in predicting clinical outcome in patients undergoing coronary stent implantation JAMA. 303 2010 754 762
    • (2010) JAMA. , vol.303 , pp. 754-762
    • Breet, N.J.1    Van Werkum, J.W.2    Bouman, H.J.3    Kelder, J.C.4    Ruven, H.J.5    Bal, E.T.6
  • 6
    • 77958105401 scopus 로고    scopus 로고
    • Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: A pharmacogenetic analysis
    • J.L. Mega, S.L. Close, S.D. Wiviott, L. Shen, J.R. Walker, and T. Simon Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis Lancet. 376 2010 1312 1319
    • (2010) Lancet. , vol.376 , pp. 1312-1319
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3    Shen, L.4    Walker, J.R.5    Simon, T.6
  • 8
    • 77949907998 scopus 로고    scopus 로고
    • Common variation in the platelet receptor P2RY12 gene is associated with residual on-clopidogrel platelet reactivity in patients undergoing elective percutaneous coronary interventions
    • G. Rudez, H.J. Bouman, J.W. van Werkum, F.W. Leebeek, A. Kruit, and H.J. Ruven Common variation in the platelet receptor P2RY12 gene is associated with residual on-clopidogrel platelet reactivity in patients undergoing elective percutaneous coronary interventions Circ Cardiovasc Genet. 2 2009 515 521
    • (2009) Circ Cardiovasc Genet. , vol.2 , pp. 515-521
    • Rudez, G.1    Bouman, H.J.2    Van Werkum, J.W.3    Leebeek, F.W.4    Kruit, A.5    Ruven, H.J.6
  • 11
    • 79955110460 scopus 로고    scopus 로고
    • Prasugrel Overcomes High On-Clopidogrel Platelet Reactivity Post-Stenting More Effectively Than High-Dose (150-mg) Clopidogrel the Importance of CYP2C19*2 Genotyping
    • D. Alexopoulos, G. Dimitropoulos, P. Davlouros, I. Xanthopoulou, G. Kassimis, and E.F. Stavrou Prasugrel Overcomes High On-Clopidogrel Platelet Reactivity Post-Stenting More Effectively Than High-Dose (150-mg) Clopidogrel The Importance of CYP2C19*2 Genotyping JACC Cardiovasc Interv. 4 2011 403 410
    • (2011) JACC Cardiovasc Interv. , vol.4 , pp. 403-410
    • Alexopoulos, D.1    Dimitropoulos, G.2    Davlouros, P.3    Xanthopoulou, I.4    Kassimis, G.5    Stavrou, E.F.6
  • 12
    • 33749339075 scopus 로고    scopus 로고
    • Cytochrome P450 2 C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects
    • J.S. Hulot, A. Bura, E. Villard, M. Azizi, V. Remones, and C. Goyenvalle Cytochrome P450 2 C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects Blood. 108 2006 2244 2247
    • (2006) Blood. , vol.108 , pp. 2244-2247
    • Hulot, J.S.1    Bura, A.2    Villard, E.3    Azizi, M.4    Remones, V.5    Goyenvalle, C.6
  • 13
    • 67649645191 scopus 로고    scopus 로고
    • Genetic variation of CYP2C19 affects both pharmacokinetic and pharmacodynamic responses to clopidogrel but not prasugrel in aspirin-treated patients with coronary artery disease
    • C. Varenhorst, S. James, D. Erlinge, J.T. Brandt, O.O. Braun, and M. Man Genetic variation of CYP2C19 affects both pharmacokinetic and pharmacodynamic responses to clopidogrel but not prasugrel in aspirin-treated patients with coronary artery disease Eur Heart J. 30 2009 1744 1752
    • (2009) Eur Heart J. , vol.30 , pp. 1744-1752
    • Varenhorst, C.1    James, S.2    Erlinge, D.3    Brandt, J.T.4    Braun, O.O.5    Man, M.6
  • 14
    • 36348943475 scopus 로고    scopus 로고
    • Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel
    • J.T. Brandt, S.L. Close, S.J. Iturria, C.D. Payne, N.A. Farid, and C.S. Ernest 2nd Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel J Thromb Haemost. 5 2007 2429 2436
    • (2007) J Thromb Haemost. , vol.5 , pp. 2429-2436
    • Brandt, J.T.1    Close, S.L.2    Iturria, S.J.3    Payne, C.D.4    Farid, N.A.5    Ernest II, C.S.6
  • 15
    • 73949119561 scopus 로고    scopus 로고
    • Besides CYP2C19*2, the variant allele CYP2C9*3 is associated with higher on-clopidogrel platelet reactivity in patients on dual antiplatelet therapy undergoing elective coronary stent implantation
    • A. Harmsze, J.W. van Werkum, H.J. Bouman, H.J. Ruven, N.J. Breet, and J.M. Ten Berg Besides CYP2C19*2, the variant allele CYP2C9*3 is associated with higher on-clopidogrel platelet reactivity in patients on dual antiplatelet therapy undergoing elective coronary stent implantation Pharmacogenet Genomics. 20 2010 18 25
    • (2010) Pharmacogenet Genomics. , vol.20 , pp. 18-25
    • Harmsze, A.1    Van Werkum, J.W.2    Bouman, H.J.3    Ruven, H.J.4    Breet, N.J.5    Ten Berg, J.M.6
  • 16
    • 43049179414 scopus 로고    scopus 로고
    • Cytochrome P450 2 C19 681G>A polymorphism and high on-clopidogrel platelet reactivity associated with adverse 1-year clinical outcome of elective percutaneous coronary intervention with drug-eluting or bare-metal stents
    • D. Trenk, W. Hochholzer, M.F. Fromm, L.E. Chialda, A. Pahl, and C.M. Valina Cytochrome P450 2 C19 681G>A polymorphism and high on-clopidogrel platelet reactivity associated with adverse 1-year clinical outcome of elective percutaneous coronary intervention with drug-eluting or bare-metal stents J Am Coll Cardiol. 51 2008 1925 1934
    • (2008) J Am Coll Cardiol. , vol.51 , pp. 1925-1934
    • Trenk, D.1    Hochholzer, W.2    Fromm, M.F.3    Chialda, L.E.4    Pahl, A.5    Valina, C.M.6
  • 17
    • 65249145201 scopus 로고    scopus 로고
    • Cytochrome P450 2 C19 loss-of-function polymorphism and stent thrombosis following percutaneous coronary intervention
    • D. Sibbing, J. Stegherr, W. Latz, W. Koch, J. Mehilli, and K. Dorrler Cytochrome P450 2 C19 loss-of-function polymorphism and stent thrombosis following percutaneous coronary intervention Eur Heart J. 30 2009 916 922
    • (2009) Eur Heart J. , vol.30 , pp. 916-922
    • Sibbing, D.1    Stegherr, J.2    Latz, W.3    Koch, W.4    Mehilli, J.5    Dorrler, K.6
  • 18
    • 78049326068 scopus 로고    scopus 로고
    • Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: A meta-analysis
    • J.L. Mega, T. Simon, J.P. Collet, J.L. Anderson, E.M. Antman, and K. Bliden Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysis JAMA. 304 2010 1821 1830
    • (2010) JAMA. , vol.304 , pp. 1821-1830
    • Mega, J.L.1    Simon, T.2    Collet, J.P.3    Anderson, J.L.4    Antman, E.M.5    Bliden, K.6
  • 19
    • 58249135635 scopus 로고    scopus 로고
    • Cytochrome P450 2 C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: A cohort study
    • J.P. Collet, J.S. Hulot, A. Pena, E. Villard, J.B. Esteve, and J. Silvain Cytochrome P450 2 C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study Lancet. 373 2009 309 317
    • (2009) Lancet. , vol.373 , pp. 309-317
    • Collet, J.P.1    Hulot, J.S.2    Pena, A.3    Villard, E.4    Esteve, J.B.5    Silvain, J.6
  • 20
    • 69249219296 scopus 로고    scopus 로고
    • Association of cytochrome P450 2 C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy
    • A.R. Shuldiner, J.R. O'Connell, K.P. Bliden, A. Gandhi, K. Ryan, and R.B. Horenstein Association of cytochrome P450 2 C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy JAMA. 302 2009 849 857
    • (2009) JAMA. , vol.302 , pp. 849-857
    • Shuldiner, A.R.1    O'Connell, J.R.2    Bliden, K.P.3    Gandhi, A.4    Ryan, K.5    Horenstein, R.B.6
  • 21
    • 55449137355 scopus 로고    scopus 로고
    • CYP2C19 and nongenetic factors predict poor responsiveness to clopidogrel loading dose after coronary stent implantation
    • T. Geisler, E. Schaeffeler, J. Dippon, S. Winter, V. Buse, and C. Bischofs CYP2C19 and nongenetic factors predict poor responsiveness to clopidogrel loading dose after coronary stent implantation Pharmacogenomics. 9 2008 1251 1259
    • (2008) Pharmacogenomics. , vol.9 , pp. 1251-1259
    • Geisler, T.1    Schaeffeler, E.2    Dippon, J.3    Winter, S.4    Buse, V.5    Bischofs, C.6
  • 22
    • 76349098199 scopus 로고    scopus 로고
    • Cytochrome 2 C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement
    • D. Sibbing, W. Koch, D. Gebhard, T. Schuster, S. Braun, and J. Stegherr Cytochrome 2 C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement Circulation. 121 2010 512 518
    • (2010) Circulation. , vol.121 , pp. 512-518
    • Sibbing, D.1    Koch, W.2    Gebhard, D.3    Schuster, T.4    Braun, S.5    Stegherr, J.6
  • 23
    • 77958100874 scopus 로고    scopus 로고
    • Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: A genetic substudy of the PLATO trial
    • L. Wallentin, S. James, R.F. Storey, M. Armstrong, B.J. Barratt, and J. Horrow Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trial Lancet. 376 2010 1320 1328
    • (2010) Lancet. , vol.376 , pp. 1320-1328
    • Wallentin, L.1    James, S.2    Storey, R.F.3    Armstrong, M.4    Barratt, B.J.5    Horrow, J.6
  • 25
    • 80052790906 scopus 로고    scopus 로고
    • Paraoxonase-1 Q192R Polymorphism and Antiplatelet Effects of Clopidogrel in Patients Undergoing Elective Coronary Stent Placement
    • D. Trenk, W. Hochholzer, M.F. Fromm, O. Zolk, C.M. Valina, and C. Stratz Paraoxonase-1 Q192R Polymorphism and Antiplatelet Effects of Clopidogrel in Patients Undergoing Elective Coronary Stent Placement Circ Cardiovasc Genet 2011
    • (2011) Circ Cardiovasc Genet
    • Trenk, D.1    Hochholzer, W.2    Fromm, M.F.3    Zolk, O.4    Valina, C.M.5    Stratz, C.6
  • 27
    • 33845490833 scopus 로고    scopus 로고
    • Genetic polymorphisms of the platelet receptors P2Y(12), P2Y(1) and GP IIIa and response to aspirin and clopidogrel
    • E.I. Lev, R.T. Patel, S. Guthikonda, D. Lopez, P.F. Bray, and N.S. Kleiman Genetic polymorphisms of the platelet receptors P2Y(12), P2Y(1) and GP IIIa and response to aspirin and clopidogrel Thromb Res. 119 2007 355 360
    • (2007) Thromb Res. , vol.119 , pp. 355-360
    • Lev, E.I.1    Patel, R.T.2    Guthikonda, S.3    Lopez, D.4    Bray, P.F.5    Kleiman, N.S.6
  • 28
    • 33644972034 scopus 로고    scopus 로고
    • P2Y1 gene A1622G dimorphism is not associated with adenosine diphosphate-induced platelet activation and aggregation after administration of a single high dose of clopidogrel
    • D. Sibbing, O. von Beckerath, A. Schomig, A. Kastrati, and N. von Beckerath P2Y1 gene A1622G dimorphism is not associated with adenosine diphosphate-induced platelet activation and aggregation after administration of a single high dose of clopidogrel J Thromb Haemost. 4 2006 912 914
    • (2006) J Thromb Haemost. , vol.4 , pp. 912-914
    • Sibbing, D.1    Von Beckerath, O.2    Schomig, A.3    Kastrati, A.4    Von Beckerath, N.5
  • 30
    • 44949173754 scopus 로고    scopus 로고
    • Prognostic significance of post-clopidogrel platelet reactivity assessed by a point-of-care assay on thrombotic events after drug-eluting stent implantation
    • M.J. Price, S. Endemann, R.R. Gollapudi, R. Valencia, C.T. Stinis, and J.P. Levisay Prognostic significance of post-clopidogrel platelet reactivity assessed by a point-of-care assay on thrombotic events after drug-eluting stent implantation Eur Heart J. 29 2008 992 1000
    • (2008) Eur Heart J. , vol.29 , pp. 992-1000
    • Price, M.J.1    Endemann, S.2    Gollapudi, R.R.3    Valencia, R.4    Stinis, C.T.5    Levisay, J.P.6
  • 31
    • 77953911457 scopus 로고    scopus 로고
    • Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate
    • L. Bonello, U.S. Tantry, R. Marcucci, R. Blindt, D.J. Angiolillo, and R. Becker Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate J Am Coll Cardiol. 56 2010 919 933
    • (2010) J Am Coll Cardiol. , vol.56 , pp. 919-933
    • Bonello, L.1    Tantry, U.S.2    Marcucci, R.3    Blindt, R.4    Angiolillo, D.J.5    Becker, R.6
  • 32
    • 79960160555 scopus 로고    scopus 로고
    • Variability in on-treatment platelet reactivity explained by CYP2C19*2 genotype is modest in clopidogrel pretreated patients undergoing coronary stenting
    • H.J. Bouman, A.M. Harmsze, J.W. van Werkum, N.J. Breet, T.O. Bergmeijer, and H. Ten Cate Variability in on-treatment platelet reactivity explained by CYP2C19*2 genotype is modest in clopidogrel pretreated patients undergoing coronary stenting Heart. 2011
    • (2011) Heart.
    • Bouman, H.J.1    Harmsze, A.M.2    Van Werkum, J.W.3    Breet, N.J.4    Bergmeijer, T.O.5    Ten Cate, H.6
  • 33
    • 77952591958 scopus 로고    scopus 로고
    • Impact of cytochrome P450 2 C19 loss-of-function polymorphism and of major demographic characteristics on residual platelet function after loading and maintenance treatment with clopidogrel in patients undergoing elective coronary stent placement
    • W. Hochholzer, D. Trenk, M.F. Fromm, C.M. Valina, C. Stratz, and H.P. Bestehorn Impact of cytochrome P450 2 C19 loss-of-function polymorphism and of major demographic characteristics on residual platelet function after loading and maintenance treatment with clopidogrel in patients undergoing elective coronary stent placement J Am Coll Cardiol. 55 2010 2427 2434
    • (2010) J Am Coll Cardiol. , vol.55 , pp. 2427-2434
    • Hochholzer, W.1    Trenk, D.2    Fromm, M.F.3    Valina, C.M.4    Stratz, C.5    Bestehorn, H.P.6
  • 36
    • 77956353400 scopus 로고    scopus 로고
    • Protective effect of the CYP2C19*17 polymorphism with increased activation of clopidogrel on cardiovascular events
    • K.A. Tiroch, D. Sibbing, W. Koch, T. Roosen-Runge, J. Mehilli, and A. Schomig Protective effect of the CYP2C19*17 polymorphism with increased activation of clopidogrel on cardiovascular events Am Heart J. 160 2010 506 512
    • (2010) Am Heart J. , vol.160 , pp. 506-512
    • Tiroch, K.A.1    Sibbing, D.2    Koch, W.3    Roosen-Runge, T.4    Mehilli, J.5    Schomig, A.6
  • 37
    • 79952435294 scopus 로고    scopus 로고
    • The relation between CYP2C19 genotype and phenotype in stented patients on maintenance dual antiplatelet therapy
    • P.A. Gurbel, A.R. Shuldiner, K.P. Bliden, K. Ryan, R.E. Pakyz, and U.S. Tantry The relation between CYP2C19 genotype and phenotype in stented patients on maintenance dual antiplatelet therapy Am Heart J. 161 2011 598 604
    • (2011) Am Heart J. , vol.161 , pp. 598-604
    • Gurbel, P.A.1    Shuldiner, A.R.2    Bliden, K.P.3    Ryan, K.4    Pakyz, R.E.5    Tantry, U.S.6
  • 38
    • 78049492640 scopus 로고    scopus 로고
    • Carriage of cytochrome 2 C19 polymorphism is associated with risk of high post-treatment platelet reactivity on high maintenance-dose clopidogrel of 150 mg/day: Results of the ACCEL-DOUBLE (Accelerated Platelet Inhibition by a Double Dose of Clopidogrel According to Gene Polymorphism) study
    • Y.H. Jeong, I.S. Kim, Y. Park, M.K. Kang, J.S. Koh, and S.J. Hwang Carriage of cytochrome 2 C19 polymorphism is associated with risk of high post-treatment platelet reactivity on high maintenance-dose clopidogrel of 150 mg/day: results of the ACCEL-DOUBLE (Accelerated Platelet Inhibition by a Double Dose of Clopidogrel According to Gene Polymorphism) study JACC Cardiovasc Interv. 3 2010 731 741
    • (2010) JACC Cardiovasc Interv. , vol.3 , pp. 731-741
    • Jeong, Y.H.1    Kim, I.S.2    Park, Y.3    Kang, M.K.4    Koh, J.S.5    Hwang, S.J.6
  • 40
    • 34249058785 scopus 로고    scopus 로고
    • ABCB1 genotype and PGP expression, function and therapeutic drug response: A critical review and recommendations for future research
    • G.D. Leschziner, T. Andrew, M. Pirmohamed, and M.R. Johnson ABCB1 genotype and PGP expression, function and therapeutic drug response: a critical review and recommendations for future research Pharmacogenomics J. 7 2007 154 179
    • (2007) Pharmacogenomics J. , vol.7 , pp. 154-179
    • Leschziner, G.D.1    Andrew, T.2    Pirmohamed, M.3    Johnson, M.R.4
  • 41
    • 24944465039 scopus 로고    scopus 로고
    • Lack of association between the P2Y12 receptor gene polymorphism and platelet response to clopidogrel in patients with coronary artery disease
    • D.J. Angiolillo, A. Fernandez-Ortiz, E. Bernardo, C. Ramirez, U. Cavallari, and E. Trabetti Lack of association between the P2Y12 receptor gene polymorphism and platelet response to clopidogrel in patients with coronary artery disease Thromb Res. 116 2005 491 497
    • (2005) Thromb Res. , vol.116 , pp. 491-497
    • Angiolillo, D.J.1    Fernandez-Ortiz, A.2    Bernardo, E.3    Ramirez, C.4    Cavallari, U.5    Trabetti, E.6
  • 42
    • 38449103046 scopus 로고    scopus 로고
    • Cytochrome P450 2 C19 loss-of-function polymorphism, but not CYP3A4 IVS10 + 12 G/A and P2Y12 T744C polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients
    • B. Giusti, A.M. Gori, R. Marcucci, C. Saracini, I. Sestini, and R. Paniccia Cytochrome P450 2 C19 loss-of-function polymorphism, but not CYP3A4 IVS10 + 12 G/A and P2Y12 T744C polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients Pharmacogenet Genomics. 17 2007 1057 1064
    • (2007) Pharmacogenet Genomics. , vol.17 , pp. 1057-1064
    • Giusti, B.1    Gori, A.M.2    Marcucci, R.3    Saracini, C.4    Sestini, I.5    Paniccia, R.6
  • 43
    • 79951956275 scopus 로고    scopus 로고
    • Identification of P2Y12 single-nucleotide polymorphisms and their influences on the variation in ADP-induced platelet aggregation
    • S.J. Lee, I.S. Jung, E.J. Jung, J.Y. Choi, C.W. Yeo, and D.Y. Cho Identification of P2Y12 single-nucleotide polymorphisms and their influences on the variation in ADP-induced platelet aggregation Thromb Res. 127 2011 220 227
    • (2011) Thromb Res. , vol.127 , pp. 220-227
    • Lee, S.J.1    Jung, I.S.2    Jung, E.J.3    Choi, J.Y.4    Yeo, C.W.5    Cho, D.Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.