The CETP I405V polymorphism is associated with an increased risk of Alzheimer's disease

Aging Cell

Volumn 11, Issue 2, 2012, Pages 228-233

  Yu, Lei ^a,b   Shulman, Joshua M ^c,d,e   Chibnik, Lori ^c,d,e   Leurgans, Sue ^a,b   Schneider, Julie A ^a,b   De Jager, Philip L ^c,d,e   Bennett, David A ^a,b  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

Alzheimer's disease; Association study; Cholesteryl ester transfer protein; Cognitive decline

Indexed keywords

CHOLESTEROL ESTER TRANSFER PROTEIN;

AGED; ALZHEIMER DISEASE; ARTICLE; AUTOPSY; COGNITION; CONTROLLED STUDY; EUROPEAN AMERICAN; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL DETERIORATION; NEUROPATHOLOGY; PRIORITY JOURNAL; SENILE PLAQUE; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; ALZHEIMER DISEASE; AUTOPSY; CHOLESTEROL ESTER TRANSFER PROTEINS; FEMALE; HUMANS; MALE; POLYMORPHISM, GENETIC; RISK FACTORS;

EID: 84858335612     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2011.00777.x     Document Type: Article

References (40)

1. Arias-Vasquez A, Isaacs A, Aulchenko YS, Hofman A, Oostra BA, Breteler M, van Duijn CM (2007) The cholesteryl ester transfer protein (CETP) gene and the risk of Alzheimer's disease. Neurogenetics 8, 189-193.
2. Barter PJ, Kastelein JJ (2006) Targeting cholesteryl ester transfer protein for the prevention and management of cardiovascular disease. J. Am. Coll. Cardiol. 47, 492-499.
3. Bennett DA, Wilson RS, Schneider JA, Evans DA, Aggarwal NT, Arnold SE, Cochran EJ, Berry-Kravis E, Bienias JL (2003) Apolipoprotein E epsilon4 allele, AD pathology, and the clinical expression of Alzheimer's disease. Neurology 60, 246-252.
4. Bennett DA, Schneider JA, Buchman AS, Mendes de Leon C, Bienias JL, Wilson RS (2005a) The Rush Memory and Aging Project: study design and baseline characteristics of the study cohort. Neuroepidemiology 25, 163-175.
5. Bennett DA, Schneider JA, Bienias JL, Evans DA, Wilson RS (2005b) Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions. Neurology 64, 834-841.
6. Bennett DA, Schneider JA, Arvanitakis Z, Kelly JF, Aggarwal NT, Shah RC, Wilson RS (2006a) Neuropathology of older persons without cognitive impairment from two community-based studies. Neurology 66, 1837-1844.
7. Bennett DA, Schneider JA, Aggarwal NT, Arvanitakis Z, Shah RC, Kelly JF, Fox JH, Cochran EJ, Arends D, Treinkman AD, Wilson RS (2006b) Decision rules guiding the clinical diagnosis of Alzheimer's disease in two community-based cohort studies compared to standard practice in a clinic-based cohort study. Neuroepidemiology 27, 169-176.
8. Bennett DA, Schneider JA, Tang Y, Arnold SE, Wilson RS (2006c) The effect of social networks on the relation between Alzheimer's disease pathology and level of cognitive function in old people: a longitudinal cohort study. Lancet Neurol. 5, 406-412.
9. Bennett DA, De Jager PL, Leurgans SE, Schneider JA (2009) Neuropathologic intermediate phenotypes enhance association to Alzheimer susceptibility alleles. Neurology 72, 1495-1503.
10. Blankenberg S, Rupprecht HJ, Bickel C, Jiang XC, Poirier O, Lackner KJ, Meyer J, Cambien F, Tiret L (2003) Common genetic variation of the cholesteryl ester transfer protein gene strongly predicts future cardiovascular death in patients with coronary artery disease. J. Am. Coll. Cardiol. 41, 1983-1989.
11. Brewer HB (2004) Increasing HDL cholesterol levels. N. Engl. J. Med. 350, 1491-1494.
12. Castellano JM, Kim J, Stewart FR, Jiang H, DeMattos RB, Patterson BW, Fagan AM, Morris JC, Mawuenyega KG, Cruchaga C, Goate AM, Bales KR, Paul SM, Bateman RJ, Holtzman DM (2011) Human apoE isoforms differentially regulate brain amyloid-beta peptide clearance. Sci. Transl. Med. 3, 89ra57.
13. Chen D, Yang J, Tang Z, Dong X, Feng Z, Yu S, Chan P (2008) Cholesteryl ester transfer protein polymorphism D442G associated with a potential decreased risk for Alzheimer's disease as a modifier for APOE ε4 in Chinese. Brain Res. 1187, 52-57.
14. Chibnik LB, Shulman JM, Leurgans SE, Schneider JA, Wilson RS, Tran D, Aubin C, Buchman AS, Heward CB, Myers AJ, Hardy JA, Huentelman MJ, Corneveaux JJ, Reiman EM, Evans DA, Bennett DA, De Jager PL (2011) CR1 is associated with amyloid plaque burden and age-related cognitive decline. Ann. Neurol. 69, 560-569.
15. Dachet C, Poirier O, Cambien F, Chapman J, Rouis M (2000) New functional promoter polymorphism, CETP/-629, in cholesteryl ester transfer protein (CETP) gene related to CETP mass and high density lipoprotein cholesterol levels (role of SP1/Sp3 in transcriptional regulation). Aterioscler. Thromb. Vasc. Biol. 20, 507-515.
16. Fidani L, Goulas A, Crook R, Peterson RC, Tangalos E, Kotsis A, Hardy J (2004) An association study of the cholesteryl ester transfer protein TaqI B polymorphism with late onset Alzheimer's disease. Neurosci. Lett. 357, 152-154.
17. Harold D, Abraham R, Hollingworth P et al. (2009) Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat. Genet. 41, 1088-1093.
18. Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM (2011) Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat. Genet. 43, 429-435. Epub 2011 Apr 3.
19. Johnson W, Harris SE, Collins P, Starr JM, Whalley LJ, Deary IJ (2007) No association of CETP genotype with cognitive function or age-related cognitive change. Neurosci. Lett. 420, 189-192.
20. Kennedy JL, Farrer LA, Andreasen NC, Mayeux R, St George-Hyslop P (2003) The genetics of adult-onset neuropsychiatric disease: complexities and conundra? Science 302, 822-826.
21. Lambert JC, Heath S, Even G et al. (2009) Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat. Genet. 41, 1094-1099.
22. McQueen MB, Bertram L, Lange C, Becker KD, Albert MS, Tanzi RE, Blacker D (2007) Exploring candidate gene associations with neuropsychological performance. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B, 987-991.
23. Merched A, Xia Y, Visvikis S, Serot JM, Siest G (2000) Decreased high density lipoprotein cholesterol and serum apolipoprotein AI concentrations are highly correlated with severity of Alzheimer's disease. Neurobiol. Aging 21, 27-30.
24. Michikawa M (2003) The role of cholesterol in pathogenesis of Alzheimer's disease. Dual metabolic interaction between amyloid β-protein and cholesterol. Mol. Neurobiol. 27, 1-12.
25. Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J (2011) Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat. Genet. 43, 436-441. Epub 2011 Apr 3.
26. Qureischie H, Heun R, Lütjohann D, Popp J, Jessen F, Ledschbor-Frahnert C, Thiele H, Maier W, Hentschel F, Kelemen P, Kölsch H (2008) CETP polymorphisms influence cholesterol metabolism but not Alzheimer's disease risk. Brain Res. 1232, 1-6.
27. Rodriguez E, Mateo I, Infante J, Llorca J, Berciano J, Combarros O (2006) Cholesteryl ester transfer protein (CETP) polymorphism modifies the Alzheimer's disease risk associated with APOE epsilon 4 allele. J. Neurol. 253, 181-185.
28. Sanders AE, Wang G, Katz M, Derby CA, Bazilai N, Ozelius L, Lipton RB (2010) Association of a functional polymorphism in the cholesteryl ester transfer protein (CETP) gene with memory decline and incidence of dementia. JAMA 303, 150-158.
29. SAS Institute Inc (2008) SAS/STAT® 9.2 User's Guide. Cary, NC: SAS Institute Inc.
30. Schneider JA, Wilson RS, Bienias JL, Evans DA, Bennett DA (2004) Cerebral infarctions and the likelihood of dementia from Alzheimer disease pathology. Neurology 62, 1148-1155.
31. Seshadri S, Fitzpatrick AL, Ikram MA et al. (2010) Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA 303, 1832-1840.
32. Shulman JM, Chibnik LB, Aubin C, Schneider JA, Bennett DA, De Jager PL (2010) Intermediate phenotypes identify divergent pathways to Alzheimer's disease. PLoS ONE 5, e11244.
33. Sparks DL, Scheff SW, Hunsaker III JC, Liu H, Landers T, Gross DR (1994) Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol. Exp. Neurol. 126, 88-94.
34. Tall AR (1993) Plasma cholesteryl ester transfer protein. J. Lipid Res. 34, 1255-1274.
35. The International HapMap Consortium (2007) A second generation human haplotype map of over 3.1 million SNPs. Nature 449, 851-861.
36. Wilson RS, Beckett LA, Barnes LL, Schneider JA, Bach J, Evans DA, Bennett DA (2002) Individual differences in rates of change in cognitive abilities of older persons. Psychol. Aging 17, 179-193.
37. Wilson RS, Bienias JL, Evans DA, Bennett DA (2004) Religious order study: overview and change in cognitive and motor speed. Aging Neuropsychol. Cogn. 11, 280-303.
38. Wilson RS, Barnes LL, Krueger KR, Hoganson G, Bienias JL, Bennett DA (2005) Early and late life cognitive activity and cognitive systems in old age. J. Int. Neuropsychol. Soc. 11, 400-407.
39. Wilson RS, Schneider JA, Boyle PA, Arnold SE, Tang Y, Bennett DA (2007) Chronic distress and incidence of mild cognitive impairment. Psychosom. Med. 69, 47-53.
40. Zhu H, Gopalraj RK, Kelly JF, Bennett DA, Estus S (2005) Lack of genetic association of cholesteryl ester transfer protein polymorphisms with late onset Alzheimer's disease. Neurosci. Lett. 381, 36-41.