Effects of an agonist interleukin-2/Fc fusion protein, a mutant antagonist interleukin-15/Fc fusion protein, and sirolimus on cardiac allograft survival in non-human primates

Journal of Heart and Lung Transplantation

Volumn 31, Issue 4, 2012, Pages 427-435

  Millington, Timothy ^a   Koulmanda, Maria ^a   Ng, Choo ^a   Boskovic, Svjetlan ^a   Nadazdin, Ognjenka M ^a   Benichou, Gilles ^a   Zheng, Xin Xiao ^a   Strom, Terry B ^a   Madsen, Joren C ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

heart; interleukin 15; primates; rejection; transplantation

Indexed keywords

FUSION PROTEIN INTERLEUKIN 2 FC; FUSION PROTEIN MUTANT INTERLEUKIN 15 FC; IMMUNOSUPPRESSIVE AGENT; RAPAMYCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD; CARDIAC GRAFT REJECTION; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL EXPANSION; CELL POPULATION; CONTROLLED STUDY; DIARRHEA; DRUG BLOOD LEVEL; DRUG DOSE INCREASE; DRUG DOSE TITRATION; DRUG EFFECT; GRAFT RECIPIENT; GRAFT SURVIVAL; HAPLORHINI; HEART TRANSPLANTATION; HETEROTOPIC TRANSPLANTATION; IMMUNOSUPPRESSIVE TREATMENT; MEMORY; NONHUMAN; POSTOPERATIVE PERIOD; PRIMATE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

ANIMALS; BIOPSY; CD4-POSITIVE T-LYMPHOCYTES; GRAFT SURVIVAL; HEART TRANSPLANTATION; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-15; INTERLEUKIN-2; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; MACACA FASCICULARIS; MODELS, ANIMAL; MYOCARDIUM; PHENOTYPE; RECOMBINANT FUSION PROTEINS; SIROLIMUS; TRANSPLANTATION, HOMOLOGOUS;

EID: 84858333416     PISSN: 10532498     EISSN: 15573117     Source Type: Journal    
DOI: 10.1016/j.healun.2012.01.864     Document Type: Article

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