The significance of preserving the energy status and microcirculation in liver grafts from non-heart-beating donor

Cell Transplantation

Volumn 17, Issue 1-2, 2008, Pages 173-178

  Miyagi, Shigehito ^a   Iwane, Takeru ^a   Akamatsu, Yorihiro ^a   Nakamura, Atsushi ^a   Sato, Akira ^a   Satomi, Susumu ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Energy status; Microcirculation; Non heart beating donor; Pre cold preservation perfusion

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; BILIVERDIN; FREE RADICAL; NAFAMSTAT MESILATE; TUMOR NECROSIS FACTOR ALPHA; UNIVERSITY OF WISCONSIN SOLUTION;

ANIMAL EXPERIMENT; ANIMAL TISSUE; BILE; CADAVER DONOR; CONFERENCE PAPER; CONTROLLED STUDY; ENERGY BALANCE; HEART ARREST; ISCHEMIA; LIVER FUNCTION; LIVER GRAFT; LIVER HISTOLOGY; LIVER PRESERVATION; LIVER TRANSPLANTATION; MALE; MICROCIRCULATION; NONHUMAN; PORTAL VEIN BLOOD FLOW; PRIORITY JOURNAL; RAT;

RATTUS; RATTUS NORVEGICUS;

EID: 42249094372     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/000000008783906874     Document Type: Conference Paper

References (14)

1. Fondevila, C.; Shen, X. D.; Tsuchiyashi, S.; Yamashita, K.; Csizmadia, E.; Lassman, C.; Busuttil, R. W.; Kupiec-Weqlinski, J. W.; Bach, F. H. Biliverdin therapy protects rat livers from ischemia and reperfusion injury. Hepatology 40(6):1333-1341; 2004.
2. i, and cytotoxicity in rat hepatocytes. J. Biol. Chem. 267(10):6654-6663; 1992.
3. Gores, G. J.; Kost, L. J.; LaRusso, N. F. The isolated perfused rat liver: Conceptual and practical considerations. Hepatology 6:511-517; 1985.
4. Kamiike, W.; Burdelski, M.; Steinhoff, G.; Ringe, B.; Lauchart, W.; Pichlmayr, R. Adenine nucleotide metabolism and its relation to organ viability in human liver transplantation. Transplantation 45(1):138-143; 1988.
5. Matsumoto, S.; Riqley, T. H.; Qualley, S. A.; Kuroda, Y.; Reems, J. A.; Stevens, R. B. Efficacy of the oxygen-charged static two-layer method for short-term pancreas preservation and islet isolation from nonhuman primate and human pancreata. Cell Transplant. 11(8):769-777; 2002.
6. Miyagi, S.; Ohkohchi, N.; Oikawa, K.; Satoh, M.; Tsukamoto, S.; Satomi, S. Effects of anti-inflammatory cytokine agent (FR167653) and serine protease inhibitor on warm ischemia-reperfusion injury of the liver graft. Transplantation 77(10):1487-1493; 2004.
7. Reddy, S.; Zilvetti, M.; Brockmann, J.; McLaren, A.; Friend, P. Liver transplantation from non-heart-beating donors: Current status and future prospects. Liver Transpl. 10(10):1223-1232; 2004.
8. Shibuya, H.; Ohkohchi, N.; Seya, K.; Satomi, S. Kupffer cells generate superoxide anions and modulate reperfusion injury in rat livers after cold preservation. Hepatology 25(2):356-360; 1997.
9. Shibuya, H.; Ohkohchi, N.; Tsukamoto, S.; Satomi, S. Tumor necrosis factor-induced, superoxide-mediated neutrophil accumulation in cold ischemic/reperfused rat liver. Hepatology 26(1):113-120; 1997.
10. Tanaka, T.; Suzuki, Y.; Tanioka, Y.; Sakai, T.; Kakinoki, K.; Goto, T.; Li, S.; Yoshikawa, T.; Matsumoto, I.; Fujino, Y.; Kuroda, Y. Possibility of islet transplantation from a nonheartbeating donor pancreas resuscitated by the two-layer method. Transplantation 80(6):738-742; 2005.
11. Totsuka, E.; Fung, J. J.; Hakamada, K.; Narumi, S.; Sasaki, M. Experience of orthotopic liver transplantation from non-heart-beating donors at the University of Pittsburgh Medical Center. Nippon Geka Gakkai Zasshi 100(12):818-821; 1999.
12. Tsujimura, T.; Kuroda, Y.; Churchill, T. A.; Avila, J. G.; Kin, T.; Shapiro, A. M.; Lakey, J. R. Short-term storage of the ischemically damaged human pancreas by the two-layer method prior to islet isolation. Cell Transplant. 13(1):67-73; 2004.
13. Tsukamoto, S.; Ohkohchi, N.; Fukumori, T.; Orii, T.; Asakura, T.; Takayama, J.; Shibuya, H.; Kato, H.; Satomi, S. Elimination of Kupffer cells and nafamostat mesilate rinse prevent reperfusion injury in liver grafts from agonal non-heart beating donors. Transplantation 67(11):1396-1403; 1999.
14. Zhang, Y.; Ohkohchi, N.; Oikawa, K.; Sasaki, K.; Satomi, S. Assessment of viability of the liver graft in different cardiac arrest models. Transplant. Proc. 32:2345-2347; 2000.