Critically ill children: To transfuse or not to transfuse packed red blood cells, that is the question

Pediatric Critical Care Medicine

Volumn 13, Issue 2, 2012, Pages 204-209

  Tyrrell, Cornelius T ^a   Bateman, Scot T ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

critical care; erythrocyte transfusion; morbidity; mortality; pediatrics; red blood cell transfusions

Indexed keywords

FRESH FROZEN PLASMA; HEMOGLOBIN; INTERLEUKIN 6; INTERLEUKIN 8;

ANEMIA; ARTIFICIAL VENTILATION; BLEEDING; BURN; CHILDHOOD DISEASE; CRITICALLY ILL PATIENT; DISEASE SEVERITY; ERYTHROCYTE CONCENTRATE; ERYTHROCYTE TRANSFUSION; HEMATOCRIT; HEMODYNAMICS; HEMOGLOBIN BLOOD LEVEL; HUMAN; INTENSIVE CARE UNIT; LENGTH OF STAY; LEUKOCYTE; MORBIDITY; MORTALITY; PHLEBOTOMY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; REVIEW; RISK FACTOR; SEPSIS; TREATMENT OUTCOME;

ANEMIA; CHILD; CRITICAL ILLNESS; ERYTHROCYTE TRANSFUSION; EVIDENCE-BASED MEDICINE; HUMANS; INTENSIVE CARE UNITS, PEDIATRIC; PRACTICE GUIDELINES AS TOPIC;

EID: 84858298949     PISSN: 15297535     EISSN: 19473893     Source Type: Journal    
DOI: 10.1097/PCC.0b013e318219291c     Document Type: Review

References (32)

1. Armano R, Gauvin F, Ducruet T, et al: Determinants of red blood cell transfusions in a pediatric critical care unit: A prospective, descriptive epidemiological study. Crit Care Med 2005; 33:2637-2644 (Pubitemid 41682119)
2. Morris KP, Naqvi N, Davies P, et al: A new formula for blood transfusion volume in the critically ill. Arch Dis Child 2005; 90: 724-728 (Pubitemid 40922506)
3. Bateman ST, Lacroix J, Boven K, et al: Anemia, blood loss, and blood transfusions in North American children in the intensive care unit. Am J Respir Crit Care Med 2008; 178:26-33 (Pubitemid 351919190)
4. Wang JK, Klein HG: Red blood cell transfusion in the treatment and management of anaemia: The search for the elusive transfusion trigger. Vox Sang 2010; 98:2-11
5. Vincent JL, Baron JF, Reinhart K, et al: Anemia and blood transfusion in critically ill patients. JAMA 2002; 288:1499-1507
6. Kneyber MC, Hersi MI, Twisk JW, et al: Red blood cell transfusion in critically ill children is independently associated with increased mortality. Intensive Care Med 2007; 33: 1414-1422 (Pubitemid 47101723)
7. Weiskopf RB, Viele MK, Feiner J, et al: Human cardiovascular and metabolic response to acute, severe isovolemic anemia. JAMA 1998; 279:217-221 (Pubitemid 28133784)
8. Lackritz EM, Campbell CC, Ruebush TK 2nd, et al: Effect of blood transfusion on survival among children in a Kenyan hospital. Lancet 1992; 340:524-528
9. Lackritz EM, Hightower AW, Zucker JR, et al: Longitudinal evaluation of severely anemic children in Kenya: The effect of transfusion on mortality and hematologic recovery. AIDS 1997; 11:1487-1494 (Pubitemid 27421180)
10. English M, Ahmed M, Ngando C, et al: Blood transfusion for severe anaemia in children in a Kenyan hospital. Lancet 2002; 359: 494-495 (Pubitemid 34164299)
11. Hébert PC, Wells G, Blajchman MA, et al: A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med 1999; 340: 409-417 (Pubitemid 29084771)
12. Roseff SD, Luban NL, Manno CS: Guidelines for assessing appropriateness of pediatric transfusion. Transfusion 2002; 42: 1398-1413
13. Laverdière C, Gauvin F, Hébert PC, et al: Survey on transfusion practices of pediatric intensivists. Pediatr Crit Care Med 2002; 3:335-340
14. Lacroix J, Hébert PC, Hutchison JS, et al: Transfusion strategies for patients in pediatric intensive care units. N Engl J Med 2007; 356:1609-1619 (Pubitemid 46631670)
15. Willems A, Harrington K, Lacroix J, et al: Comparison of two red-cell transfusion strategies after pediatric cardiac surgery: A subgroup analysis. Crit Care Med 2010; 38: 649-656
16. Rouette J, Trottier H, Ducruet T, et al: Red blood cell transfusion threshold in postsurgical pediatric intensive care patients: A randomized clinical trial. Ann Surg 2010; 251: 421-427
17. Stone TJ, Riesenman PJ, Charles AG: Red blood cell transfusion within the first 24 hours of admission is associated with increased mortality in the pediatric trauma population: A retrospective cohort study. J Trauma Manag Outcomes 2008; 2:9
18. Cornet AD, Zwart E, Kingma SD, et al: Pulmonary effects of red blood cell transfusion in critically ill, non-bleeding patients. Transfus Med 2010; 20:221-226
19. Jeschke MG, Chinkes DL, Finnerty CC, et al: Blood transfusions are associated with increased risk for development of sepsis in severely burned pediatric patients. Crit Care Med 2007; 35:579-583 (Pubitemid 46148551)
20. Koch CG, Li L, Sessler DI, et al: Duration of red-cell storage and complications after cardiac surgery. N Engl J Med 2008; 358: 1229-1239 (Pubitemid 351439224)
21. Zallen G, Offner PJ, Moore EE, et al: Age of transfused blood is an independent risk factor for postinjury multiple organ failure. Am J Surg 1999; 178:570-572 (Pubitemid 30058313)
22. Offner PJ, Moore EE, Biffl WL, et al: Increased rate of infection associated with transfusion of old blood after severe injury. Arch Surg 2002; 137:711-716
23. Weinberg JA, McGwin G Jr, Griffin RL, et al: Age of transfused blood: An independent predictor of mortality despite universal leukoreduction. J Trauma 2008; 65:279-282
24. van de Watering L, Lorinser J, Versteegh M, et al: Effects of storage time of red blood cell transfusions on the prognosis of coronary artery bypass graft patients. Transfusion 2006; 46:1712-1718 (Pubitemid 44435723)
25. Leal-Noval SR, Jara-López I, García-Garmendia JL, et al: Influence of erythrocyte concentrate storage time on postsurgical morbidity in cardiac surgery patients. Anesthesiology 2003; 98:815-822 (Pubitemid 36373213)
26. Yap CH, Lau L, Krishnaswamy M, et al: Age of transfused red cells and early outcomes after cardiac surgery. Ann Thorac Surg 2008; 86:554-559 (Pubitemid 351978040)
27. Dessertaine G, Hammer L, Chenais F, et al: [Does red blood cell storage time still influence ICU survival?] Transfus Clin Biol 2008; 15:154-159
28. Kneyber MC, Gazendam RP, Markhorst DG, et al: Length of storage of red blood cells does not affect outcome in critically ill children. Intensive Care Med 2009; 35:179-180
29. Gauvin F, Spinella PC, Lacroix J, et al: Association between length of storage of transfused red blood cells and multiple organ dysfunction syndrome in pediatric intensive care patients. Transfusion 2010; 50: 1902-1913
30. Karam O, Tucci M, Bateman ST, et al: Association between length of storage of red blood cell units and outcome of critically ill children: A prospective observational study. Crit Care 2010; 14:R57
31. Napolitano LM, Kurek S, Luchette FA, et al: Clinical practice guideline: Red blood cell transfusion in adult trauma and critical care. Crit Care Med 2009; 37:3124-3157
32. Spinella PC, Dressler A, Tucci M, et al: Survey of transfusion policies at US and Canadian children's hospitals in 2008 and 2009. Transfusion 2010; 50:2328-2335