Pathogenic anti-desmoglein 3 mAbs cloned from a paraneoplastic pemphigus patient by phage display

Journal of Investigative Dermatology

Volumn 132, Issue 4, 2012, Pages 1141-1148

  Saleh, Marwah A ^a,b   Ishii, Ken ^a,c   Yamagami, Jun ^a   Shirakata, Yuji ^d   Hashimoto, Koji ^d   Amagai, Masayuki ^a  

^a KEIO UNIVERSITY   (Japan)

^b CAIRO UNIVERSITY   (Egypt)

^c TEIKYO UNIVERSITY CHIBA MEDICAL CENTER   (Japan)

^d EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; DESMOGLEIN 2; DESMOGLEIN 3; DESMOGLEIN 3 ANTIBODY; MONOCLONAL ANTIBODY;

ACANTHOLYSIS; AGED; ARTICLE; BLISTER; CASE REPORT; COMPLEMENTARITY DETERMINING REGION; COMPLEMENTARITY DETERMINING REGION 3; EPIDERMIS; EPITOPE MAPPING; EXTRACELLULAR SPACE; FRAGMENTATION REACTION; GENETIC ANALYSIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; KERATINOCYTE; MALE; PARANEOPLASTIC PEMPHIGUS; PATHOGENICITY; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN DOMAIN; SKIN CULTURE;

EID: 84858285073     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2011.449     Document Type: Article

References (31)

1. Amagai M (1996) Pemphigus: Autoimmunity to epidermal cell adhesion molecules. Adv Dermatol 11:319-52
2. Amagai M, Ishii K, Hashimoto T et al. (1995) Conformational epitopes of pemphigus antigens (Dsg1 and Dsg3) are calcium dependent and glycosylation independent. J Invest Dermatol 105:243-7
3. Amagai M, Klaus-Kovtun V, Stanley JR (1991) Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion. Cell 67:869-77
4. Amagai M, Matsuyoshi N, Wang ZH et al. (2000) Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1. Nat Med 6:1275-7
5. Amagai M, Nishikawa T, Nousari HC et al. (1998) Antibodies against desmoglein 3 (pemphigus vulgaris antigen) are present in sera from patients with paraneoplastic pemphigus and cause acantholysis in vivo in neonatal mice. J Clin Invest 102:775-82
6. Anhalt GJ, Kim SC, Stanley JR et al. (1990) Paraneoplastic pemphigus. An autoimmune mucocutaneous disease associated with neoplasia. N Engl J Med 323:1729-35
7. Barbas CF (2001) Phage Display: A Laboratory Manual. Cold Spring Harbor Laboratory Press: Cold Spring
8. Harbor, NY Borradori L, Trueb RM, Jaunin F et al. (1998) Autoantibodies from a patient with paraneoplastic pemphigus bind periplakin, a novel member of the plakin family. J Invest Dermatol 111:338-40
9. Futei Y, Amagai M, Hashimoto T et al. (2003) Conformational epitope mapping and IgG subclass distribution of desmoglein 3 in paraneoplastic pemphigus. J Am Acad Dermatol 49:1023-8
10. Hanakawa Y, Schechter NM, Lin C et al. (2004) Enzymatic and molecular characteristics of the efficiency and specificity of exfoliative toxin cleavage of desmoglein 1. J Biol Chem 279:5268-77
11. Hashimoto T, Amagai M, Watanabe K et al. (1995) Characterization of paraneoplastic pemphigus autoantigens by immunoblot analysis. J Invest Dermatol 104:829-34
12. Ishii K, Harada R, Matsuo I et al. (2005) In vitro keratinocyte dissociation assay for evaluation of the pathogenicity of anti-desmoglein 3 IgG autoantibodies in pemphigus vulgaris. J Invest Dermatol 124:939-45
13. Ishii K, Lin C, Siegel DL et al. (2008) Isolation of pathogenic monoclonal antidesmoglein 1 human antibodies by phage display of pemphigus foliaceus autoantibodies. J Invest Dermatol 128:939-48
14. Joly P, Thomine E, Gilbert D et al. (1994) Overlapping distribution of autoantibody specificities in paraneoplastic pemphigus and pemphigus vulgaris. J Invest Dermatol 103:65-72
15. Kawasaki H, Tsunoda K, Hata T et al. (2006) Synergistic pathogenic effects of combined mouse monoclonal anti-desmoglein 3 IgG antibodies on pemphigus vulgaris blister formation. J Invest Dermatol 126:2621-30
16. Kim SC, Kwon YD, Lee IJ et al. (1997) cDNA cloning of the 210-kDa paraneoplastic pemphigus antigen reveals that envoplakin is a component of the antigen complex. J Invest Dermatol 109:365-9
17. Kiyokawa C, Ruhrberg C, Nie Z et al. (1998) Envoplakin and periplakin are components of the paraneoplastic pemphigus antigen complex. J Invest Dermatol 111:1236-8
18. Mahoney MG, Aho S, Uitto J et al. (1998) The members of the plakin family of proteins recognized by paraneoplastic pemphigus antibodies include periplakin. J Invest Dermatol 111:308-13
19. Mehregan DR, Oursler JR, Leiferman KM et al. (1993) Paraneoplastic pemphigus: A subset of patients with pemphigus and neoplasia. J Cutan Pathol 20:203-10
20. Nishifuji K, Shimizu A, Ishiko A et al. (2010) Removal of amino-terminal extracellular domains of desmoglein 1 by staphylococcal exfoliative toxin is sufficient to initiate epidermal blister formation. J Dermatol Sci 59:184-91
21. Ohyama B, Nishifuji K, Chan P et al. (2012) Epitope spreading is rarely found in pemphigus vulgaris by large scale longitudinal study using desmoglein 2-based swapped molecules. J Invest Dermatol (in press)
22. Oursler JR, Labib RS, Ariss-Abdo L et al. (1992) Human autoantibodies against desmoplakins in paraneoplastic pemphigus. J Clin Invest 89:1775-82
23. Payne AS, Ishii K, Kacir S et al. (2005) Genetic and functional characterization of human pemphigus vulgaris monoclonal autoantibodies isolated by phage display. J Clin Invest 115:888-99
24. Payne AS, Siegel DL, Stanley JR (2007) Targeting pemphigus autoantibodies through their heavy-chain variable region genes. J Invest Dermatol 127:1681-91
25. Proby C, Fujii Y, Owaribe K et al. (1999) Human autoantibodies against HD1/ plectin in paraneoplastic pemphigus. J Invest Dermatol 112:153-5
26. Qian Y, Diaz LA, Ye J et al. (2007) Dissecting the anti-desmoglein autoreactive B cell repertoire in pemphigus vulgaris patients. J Immunol 178:5982-90
27. Stanley JR (1993) Cell adhesion molecules as targets of autoantibodies in pemphigus and pemphigoid, bullous diseases due to defective epidermal cell adhesion. Adv Immunol 53:291-325
28. Stanley JR, Amagai M (2006) Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome. N Engl J Med 355:1800-10
29. Tsunoda K, Ota T, Aoki M et al. (2003) Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3. J Immunol 170:2170-8
30. Yamagami J, Payne AS, Kacir S et al. (2010) Homologous regions of autoantibody heavy chain complementarity-determining region 3 (HCDR3) in patients with pemphigus cause pathogenicity. J Clin Invest 120:4111-7
31. Yamagami J, Takahashi H, Ota T et al. (2008) Genetic characterization of human Dsg3-specific B cells isolated by flow cytometry from the peripheral blood of patients with pemphigus vulgaris. J Dermatol Sci 52:98-107