Single nucleotide polymorphisms in the p21 and bcl2 cancer susceptibility genes and breast cancer risk in saudi arabia

Asian Pacific Journal of Cancer Prevention

Volumn 12, Issue 10, 2011, Pages 2607-2610

  Alshatwi, Ali A ^a   Shafi, Gowhar ^a   Hasan, Tarique ^a   Lsaif, Dulaziz ^b   Hazzani, Al ^c   Lsaif, Mohammed ^d   Lei, David Ky ^e  

^a KING FAISAL UNIVERSITY   (Saudi Arabia)

^b BMT College of Medicine   (Saudi Arabia)

^c College of Science   (Saudi Arabia)

^d KING SAUD UNIVERSITY   (Saudi Arabia)

^e UNIVERSITY OF MARYLAND   (United States)

Author keywords

Bcl2; Breast cancer; P21; Saudia arabia; Snps

Indexed keywords

EID: 84858226322     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Bin Amer SM, Maqbool Z, Nirmal MS, et al (2008). Gene expression profiling in women with with breast cancer in Saudi population. Saudi Med J, 29, 507-13.
2. Chedid M, Michieli P, Lengel C, Huppi K, Givol D (1994). A single nucleotide substitution at codon 31 (Ser/Arg) defines a polymorphism in a highly-conserved region of the p53-inducible gene WAF1/CIP1. Oncogene, 9, 3021-4.
3. Elkum N, Dermime S, Tulbah A, et al (2007). Age 40 and younger is an independent risk factor for relapse in operable breast cancer patients: The Saudi Arabia experience. BMC Cancer, 7, 222.
4. Facher EA, Becich MJ, Deka A, Law JC (1997). Association between human cancer and two polymorphisms occurring together in the p21WAF1/Cip1 cyclin-dependent kinase inhibitor gene. Cancer, 79, 2424-9.
5. Hachiya T, Kuriaki Y, Ueoka Y, et al (1999). WAF1 genotype and endometrial cancer susceptibility, Gynecol Oncol, 72, 187-92.
6. Hockenbery D, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ (1990). Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature, 348, 334-6.
7. Huang SP, Wu WJ, Chang WS, et al (2004). p53 Codon 72 and p21 codon 31 polymorphisms in prostate cancer. Cancer Epidemiol Biomarkers Prev, 13, 2217-24.
8. Jain M, Kumar S Lal P, et al (2007). Role of BCL2 (ala43thr), CCND1 (G870A) and FAS (A-670G)polymorphisms in modulating the risk of developing esophageal cancer. Cancer Detect Prev, 21, 225-32.
9. Keshava C, Frye BL, Wolff MS, McCanlies EC, Weston A (2002). Waf-1 (p21) and p53 polymorphisms in breast cancer. Cancer Epidemiol Biomarkers Prev, 11, 127-30.
10. Lukas J, Groshen S, Saffari B, et al (1997). WAF1/CIP1 gene polymorphism and expression in carcinomas of the breast, ovary and endometrium. Am J Pathol, 150, 167-75.
11. Koopman J, Manitz D, Schild S, et al (1995). Multiple polymorphisms, but no mutations, in the WAF1/CIP1 gene in human brain tumors. Br J Cancer, 72, 1230-3.
12. Metzger R, Schneider PM, Warnecke-Eberz U, Brabender J, Holscher AH (2004). Molecular biology of esophageal cancer. Onkologie, 27, 200-6.
13. Nuckel H, Frey UH, Sellmann L, et al (2006). Bax gene G(-248) A promoter polymorphism and chronic lymphocytic leukemia: lack of association with incidence, disease stage and progression-free survival. Leukemia, 20, 724.
14. Park BL, Kim LH, Cheong HS, et al (2004). Identification of variants in cyclin D1 (CCND1) and B-cell CLL/lymphoma 2 (BCL2). J Hum Genet, 49, 449-54.
15. Roh J, Kim M, Kim J, et al (2001). Polymorphisms in codon 31 of p21 and cervical cancer susceptibility in Korean women. Urol Oncol, 7, 63-6.
16. Staalesen V, Knappskog S, Chrisanthar R, et al (2006). The novel p21 polymorphism p21G251A is associated with locally advanced breast cancer. Clin Cancer Res, 1, 6000-4
17. Wu GY, Hasenberg T, Magdeburg R, et al (2009). Association between EGF, TGF-beta1, VEGF gene polymorphism and colorectal cancer. World J Surg, 33, 124-9.