Bax gene G(-248)A promoter polymorphism and chronic lymphocytic leukemia: Lack of association with incidence, disease stage and progression-free survival [1]

Leukemia

Volumn 20, Issue 4, 2006, Pages 724-

  Nückel, Holger ^a   Frey, U H ^a   Sellmann, L ^a   Bau, M ^a   Durig J ^a   Duhrsen U ^a   Siffert, W ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD38 ANTIGEN; PROTEIN BAX; PROTEIN KINASE ZAP 70;

AGE; BLOOD SAMPLING; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER RISK; CANCER STAGING; CANCER SURVIVAL; CANCER SUSCEPTIBILITY; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; CYTOGENETICS; DISEASE FREE SURVIVAL; DISEASE MARKER; FOLLOW UP; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; INCIDENCE; LETTER; MAJOR CLINICAL STUDY; OVERALL SURVIVAL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RESTRICTION MAPPING; RETROSPECTIVE STUDY; RISK ASSESSMENT; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SURVIVAL RATE; SURVIVAL TIME; TREATMENT OUTCOME;

EID: 33646493520     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2404126     Document Type: Letter

References (4)

1. Starczynski J, Pepper C, Pratt G, Hooper L, Thomas A, Milligan D et al. Common polymorphism G(-248)A in the promoter region of the bax gene results in significantly shorter survival in patients with chronic lymphocytic Leukemia once treatment is initiated. J Clin Oncol 2005; 23: 1514-1521.
2. Schena M, Larsson LG, Gottardi D, Gaidano G, Carlsson M, Nilsson K et al. Growth- and differentiation-associated expression of bcl-2 in B-chronic lymphocytic leukemia cells. Blood 1992; 79: 2981-2989.
3. Kitada S, Andersen J, Akar S, Zapata JM, Takayama S, Krajewski S et al. Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: Correlations with In vitro and In vivo chemoresponses. Blood 1998; 91: 3379-3389.
4. Skogsberg A, Tobin G, Krober A, Kienle D, Thunberg U, Aleskog A et al. The G(-248)A polymorphism in the promoter region of the Bax gene does not correlate with prognostic markers or overall survival in chronic lymphocytic leukemia. Leukemia 2005.