Prognostic role of lymph node metastases in vulvar cancer and implications for adjuvant treatment

International Journal of Gynecological Cancer

Volumn 22, Issue 3, 2012, Pages 503-508

  Woelber, Linn ^a   Eulenburg, Christine ^a   Choschzick, Matthias ^a   Kruell, Andreas ^a   Petersen, Cordula ^a   Gieseking, Friederike ^a   Jaenicke, Fritz ^a   Mahner, Sven ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Adjuvant radiotherapy; Lymph node metastases; Prognosis; Recurrence; Vulvar cancer

Indexed keywords

ADULT; AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER GRADING; CANCER INVASION; CANCER PROGNOSIS; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SIZE; CANCER STAGING; CANCER SURVIVAL; DISEASE FREE SURVIVAL; EVENT FREE SURVIVAL; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; INCISION; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; PRIMARY TUMOR; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; SURVIVAL RATE; SURVIVAL TIME; VULVA CANCER;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; COHORT STUDIES; DECISION MAKING; FEMALE; FOLLOW-UP STUDIES; HUMANS; LYMPH NODE EXCISION; LYMPH NODES; LYMPHATIC METASTASIS; MIDDLE AGED; PROGNOSIS; RADIOTHERAPY, ADJUVANT; VULVAR NEOPLASMS; YOUNG ADULT;

EID: 84858198234     PISSN: 1048891X     EISSN: 15251438     Source Type: Journal    
DOI: 10.1097/IGC.0b013e31823eed4c     Document Type: Article

References (15)

1. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2007. CA Cancer J Clin. 2007;57:43-66. (Pubitemid 46148091)
2. Judson PL, Habermann EB, Baxter NN, et al. Trends in the incidence of invasive and in situ vulvar carcinoma. Obstet Gynecol. 2006;107:1018-1022.
3. Gadducci A, Cionini L, Romanini A, et al. Old and new perspectives in the management of high-risk, locally advanced or recurrent, and metastatic vulvar cancer. Crit Rev Oncol Hematol. 2006;60:227-241. (Pubitemid 44709620)
4. Woelber L, Mahner S, Voelker K, et al. Clinicopathological prognostic factors and patterns of recurrence in vulvar cancer. Anticancer Res. 2009;29:545-552.
5. Homesley HD, Bundy BN, Sedlis ALA. Radiation therapy versus pelvic node resection for carcinoma of the vulva with positive groin nodes. Obstet Gynecol. 1986;68:733-740. (Pubitemid 17190208)
6. Woelber L, Kock L, Gieseking F, et al. Clinical management of primary vulvar cancer. Eur J Cancer. 2011 Oct;47:2315-21.
7. van der Velden J, van Lindert AC, Lammes FB, et al. Extracapsular growth of lymph node metastases in squamous cell carcinoma of the vulva. The impact on recurrence and survival. Cancer. 1995;75:2885-2890.
8. Lataifeh I, Carraro Nascimento M, Nicklin JL, et al. Patterns of recurrence and disease-free survival in advanced squamous cell carcinoma of the vulva. Gynecol Oncol. 2004;95:701-705. (Pubitemid 39610412)
9. Paladini D, Cross P, Lopes A, et al. Prognostic significance of lymph node variables in squamous cell carcinoma of the vulva. Cancer. 1994;74:2491-2496. (Pubitemid 24320853)
10. AGO. Interdisziplinäre S2k Leitlinie für die Diagnostik und Therapie des Vulvakarzinoms und seiner Vorstufen. München, Germany: W. Zuckschwerdt Verlag; 2009.
11. Oonk MH, de Hullu JA, van der Zee AG. Current controversies in the management of patients with early-stage vulvar cancer. Curr Opin Oncol. 2010;22:481-486.
12. Origoni M, Sideri M, Garsia S, et al. Prognostic value of pathological patterns of lymph node positivity in squamous cell carcinoma of the vulva stage III and IVA FIGO. Gynecol Oncol. 1992;45:313-316.
13. Oonk MH, van Hemel BM, Hollema H, et al. Size of sentinel-node metastasis and chances of non-sentinel-node involvement and survival in early stage vulvar cancer: results from GROINSS-V, a multicentre observational study. Lancet Oncol. 2010;11:646-652.
14. Fons G, Groenen SMA, Oonk MHM, et al. Adjuvant radiotherapy in patients with vulvar cancer and one intra capsular lymph node metastasis is not beneficial. Gynecol Oncol. 2009;114:343-345.
15. Parthasarathy A, Cheung MK, Osann K, et al. The benefit of adjuvant radiation therapy in single-node-positive squamous cell vulvar carcinoma. Gynecol Oncol. 2006;103:1095-1099. (Pubitemid 44830072)