Hydrocortisone normalizes oxygenation and cGMP regulation in lambs with persistent pulmonary hypertension of the newborn

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 302, Issue 6, 2012, Pages

  Perez, Marta ^a   Lakshminrusimha, Satyan ^b   Wedgwood, Stephen ^a   Czech, Lyubov ^a   Gugino, Sylvia F ^b   Russell, James A ^b   Farrow, Kathryn N ^a   Steinhorn, Robin H ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

Phosphodiesterase 5; Reactive oxygen species; Soluble guanylate cyclase

Indexed keywords

CYCLIC GMP; HYDROCORTISONE; PHOSPHODIESTERASE V; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MEGADOSE; ENZYME ACTIVITY; LAMB; LOADING DRUG DOSE; NEWBORN; NEWBORN DISEASE; NONHUMAN; OXIDATIVE STRESS; OXYGEN BREATHING; PERSISTENT PULMONARY HYPERTENSION; PRIORITY JOURNAL;

ANIMALS; ANIMALS, NEWBORN; CYCLIC GMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; GUANYLATE CYCLASE; HUMANS; HYDROCORTISONE; HYPEROXIA; INFANT, NEWBORN; OXIDATIVE STRESS; OXYGEN; PERSISTENT FETAL CIRCULATION SYNDROME; PULMONARY ARTERY; REACTIVE OXYGEN SPECIES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SHEEP; SUPEROXIDE DISMUTASE;

EID: 84858180867     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00145.2011     Document Type: Article

References (41)

1. Ahlstrom M, Pekkinen M, Huttunen M, Lamberg-Allardt C. Dexamethasone down-regulates cAMP-phosphodiesterase in human osteosarcoma cells. Biochem Pharmacol 69: 267-275, 2005.
2. Basu S, Kumar A, Bhatia BD, Satya K, Singh TB. Role of steroids on the clinical course and outcome of meconium aspiration syndrome-a randomized controlled trial. J Trop Pediatr 53: 331-337, 2007.
3. Black SM, Johengen MJ, Soifer SJ. Coordinated regulation of genes of the nitric oxide and endothelin pathways during the development of pulmonary hypertension in fetal lambs. Pediatr Res 44: 821-830, 1998.
4. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
5. Brennan LA, Steinhorn RH, Wedgwood S, Mata-Greenwood E, Roark EA, Russell JA, Black SM. Increased superoxide generation is associated with pulmonary hypertension in fetal lambs: a role for NADPH oxidase. Circ Res 92: 683-691, 2003.
6. Cayabyab RG, Kwong K, Jones C, Minoo P, Durand M. Lung inflammation and pulmonary function in infants with meconium aspiration syndrome. Pediatr Pulmonol 42: 898-905, 2007.
7. Chandrasekar I, Eis A, Konduri GG. Betamethasone attenuates oxidant stress in endothelial cells from fetal lambs with persistent pulmonary hypertension. Pediatr Res 63: 67-72, 2008.
8. Clark RH, Kueser TJ, Walker MW, Southgate WM, Huckaby JL, Perez JA, Roy BJ, Keszler M, Kinsella JP. Low-dose nitric oxide therapy for persistent pulmonary hypertension of the newborn. Clinical Inhaled Nitric Oxide Research Group. N Engl J Med 342: 469-474, 2000.
9. Crocker IC, Church MK, Ohia SE, Townley RG. Beclomethasone decreases elevations in phosphodiesterase activity in human T lymphocytes. Int Arch Allergy Immunol 121: 151-160, 2000.
10. da Costa DE, Nair AK, Pai MG, Al Khusaiby SM. Steroids in full term infants with respiratory failure and pulmonary hypertension due to meconium aspiration syndrome. Eur J Pediatr 160: 150-153, 2001.
11. Farrow KN, Groh BS, Schumacker PT, Lakshminrusimha S, Czech L, Gugino SF, Russell JA, Steinhorn RH. Hyperoxia increases phosphodiesterase 5 expression and activity in ovine fetal pulmonary artery smooth muscle cells. Circ Res 102: 226-233, 2008.
12. Farrow KN, Lakshminrusimha S, Czech L, Groh BS, Gugino SF, Davis JM, Russell JA, Steinhorn RH. SOD and inhaled nitric oxide normalize phosphodiesterase 5 expression and activity in neonatal lambs with persistent pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 299: L109-L116, 2010.
13. Farrow KN, Lakshminrusimha S, Reda WJ, Wedgwood S, Czech L, Gugino SF, Davis JM, Russell JA, Steinhorn RH. Superoxide dismutase restores eNOS expression and function in resistance pulmonary arteries from neonatal lambs with persistent pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 295: L979-L987, 2008.
14. Farrow KN, Wedgwood S, Lee KJ, Czech L, Gugino SF, Lakshminrusimha S, Schumacker PT, Steinhorn RH. Mitochondrial oxidant stress increases PDE5 activity in persistent pulmonary hypertension of the newborn. Respir Physiol Neurobiol 174: 272-281, 2010.
15. Finer NN, Barrington KJ. Nitric oxide for respiratory failure in infants born at or near term. Cochrane Database Syst Rev CD000399, 2006.
16. Frank L, Lewis PL, Sosenko IR. Dexamethasone stimulation of fetal rat lung antioxidant enzyme activity in parallel with surfactant stimulation. Pediatrics 75: 569-574, 1985.
17. Hanson KA, Ziegler JW, Rybalkin SD, Miller JW, Abman SH, Clarke WR. Chronic pulmonary hypertension increases fetal lung cGMP phosphodiesterase activity. Am J Physiol Lung Cell Mol Physiol 275: L931-L941, 1998.
18. Hermsdorf T, Richter W, Dettmer D. Effects of dexamethosone and glucagon after long-term exposure on cyclic AMP phosphodiesterase 4 in cultured rat hepatocytes. Cell Signal 11: 685-690, 1999.
19. Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med 163: 1723-1729, 2001.
20. Kim HT, Kim YH, Nam JW, Lee HJ, Rho HM, Jung G. Study of 5'-flanking region of human Cu/Zn superoxide dismutase. Biochem Biophys Res Commun 201: 1526-1533, 1994.
21. Konduri GG, Bakhutashvili I, Eis A, Pritchard K Jr. Oxidant stress from uncoupled nitric oxide synthase impairs vasodilation in fetal lambs with persistent pulmonary hypertension. Am J Physiol Heart Circ Physiol 292: H1812-H1820, 2007.
22. Konduri GG, Kim UO. Advances in the diagnosis and management of persistent pulmonary hypertension of the newborn. Pediatr Clin North Am 56: 579-600, 2009.
23. Lakshminrusimha S, Russell JA, Steinhorn RH, Ryan RM, Gugino SF, Morin FC, Swartz DD III, Kumar VH. Pulmonary arterial contractility in neonatal lambs increases with 100% oxygen resuscitation. Pediatr Res 59: 137-141, 2006.
24. Lakshminrusimha S, Russell JA, Wedgwood S, Gugino SF, Kazzaz JA, Davis JM, Steinhorn RH. Superoxide dismutase improves oxygenation and reduces oxidation in neonatal pulmonary hypertension. Am J Respir Crit Care Med 174: 1370-1377, 2006.
25. Lewko B, Wendt U, Stepinski J, Angielski S. Dexamethasone sensitizes soluble guanylate cyclase in the rat renal glomeruli. Biochem Biophys Res Commun 197: 826-832, 1993.
26. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2[-delta delta C(T)] method. Methods 25: 402-408, 2001.
27. Majori M, Vachier I, Godard P, Farce M, Bousquet J, Chanez P. Superoxide anion production by monocytes of corticosteroid-treated asthmatic patients. Eur Respir J 11: 133-138, 1998.
28. Marnane WG, Tai YH, Decker RA, Boedeker EC, Charney AN, Donowitz M. Methylprednisolone stimulation of guanylate cyclase activity in rat small intestinal mucosa: possible role in electrolyte transport. Gastroenterology 81: 90-100, 1981.
29. The Neonatal Inhaled Nitric Oxide Study Group. Inhaled nitric oxide in full-term, and nearly full-term infants with hypoxic respiratory failure. N Engl J Med 336: 597-604, 1997.
30. Smith ID. Breed differences in the duration of gestation in sheep. Aust Vet J 43: 63-64, 1967.
31. Soukka H, Halkola L, Aho H, Rautanen M, Kero P, Kaapa P. Methylprednisolone attenuates the pulmonary hypertensive response in porcine meconium aspiration. Pediatr Res 42: 145-150, 1997.
32. Stasch JP, Schmidt PM, Nedvetsky PI, Nedvetskaya TY, HSA, Meurer S, Deile M, Taye A, Knorr A, Lapp H, Muller H, Turgay Y, Rothkegel C, Tersteegen A, Kemp-Harper B, Muller-Esterl W, Schmidt HH. Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels. J Clin Invest 116: 2552-2561, 2006.
33. Tripathi S, Saili A. The effect of steroids on the clinical course and outcome of neonates with meconium aspiration syndrome. J Trop Pediatr 53: 8-12, 2007.
34. Tzao C, Nickerson PA, Russell JA, Gugino SF, Steinhorn RH. Pulmonary hypertension alters soluble guanylate cyclase activity and expression in pulmonary arteries isolated from fetal lambs. Pediatr Pulmonol 31: 97-105, 2001.
35. Vento M, Asensi M, Sastre J, Garcia-Sala F, Pallardo FV, Vina J. Resuscitation with room air instead of 100% oxygen prevents oxidative stress in moderately asphyxiated term neonates. Pediatrics 107: 642-647, 2001.
36. Vidyasagar D, Zagariya A. Studies of meconium-induced lung injury: inflammatory cytokine expression and apoptosis. J Perinatol 28, Suppl 3: S102-107, 2008.
37. Walther FJ, David-Cu R, Mehta EI, Polk DH, Jobe AH, Ikegami M. Higher lung antioxidant enzyme activity persists after single dose of corticosteroids in preterm lambs. Am J Physiol Lung Cell Mol Physiol 271: L187-L191, 1996.
38. Ward M, Sinn J. Steroid therapy for meconium aspiration syndrome in newborn infants. Cochrane Database Syst Rev CD003485, 2003.
39. Weber M, Lauer N, Mulsch A, Kojda G. The effect of peroxynitrite on the catalytic activity of soluble guanylyl cyclase. Free Radic Biol Med 31: 1360-1367, 2001.
40. Wedgwood S, Lakshminrusimha S, Fukai T, Russell JA, Schumacker PT, Steinhorn RH. Hydrogen peroxide regulates extracellular superoxide dismutase activity and expression in neonatal pulmonary hypertension. Antioxid Redox Signal 15: 1497-1506, 2010.
41. Wedgwood S, Steinhorn RH, Bunderson M, Wilham J, Lakshminrusimha S, Brennan LA, Black SM. Increased hydrogen peroxide downregulates soluble guanylate cyclase in the lungs of lambs with persistent pulmonary hypertension of the newborn. Am J Physiol Lung Cell Mol Physiol 289: L660-L666, 2005.