Quantification of optic disc edema during exposure to high altitude shows no correlation to acute mountain sickness

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Willmann, Gabriel ^a   Fischer, M Dominik ^a   Schatz, Andreas ^a   Schommer, Kai ^b   Messias, Andre ^c   Zrenner, Eberhart ^a   Bartz Schmidt, Karl U ^a   Gekeler, Florian ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ALTITUDE DISEASE; ARTICLE; CLINICAL ARTICLE; CLINICAL EVALUATION; CONTROLLED STUDY; DISEASE ASSOCIATION; HEART RATE; HUMAN; OPTIC DISK; OPTIC NERVE; OXYGEN SATURATION; PAPILLEDEMA; PATHOPHYSIOLOGY; QUANTITATIVE ANALYSIS; QUESTIONNAIRE; RETINA NERVE CELL; SCANNING LASER OPHTHALMOSCOPY; SCORING SYSTEM; SLIT LAMP; TISSUE STRUCTURE;

ACCLIMATIZATION; ACUTE DISEASE; ALTITUDE SICKNESS; HEART RATE; HEMOGLOBINS; HUMANS; OXIMETRY; OXYGEN CONSUMPTION; PAPILLEDEMA; PROSPECTIVE STUDIES;

EID: 84858161940     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027022     Document Type: Article

References (47)

1. Singh I, Khanna PK, Srivastava MC, Lal M, Roy SB, et al. (1969) Acute mountain sickness. N Engl J Med 280: 175-184.
2. Houston CS, Dickinson J, (1975) Cerebral form of high-altitude illness. Lancet 2: 758-761.
3. Dickinson J, Heath D, Gosney J, Williams D, (1983) Altitude-related deaths in seven trekkers in the Himalayas. Thorax 38: 646-656.
4. Frayser R, Houston CS, Bryan AC, Rennie ID, Gray G, (1970) Retinal hemorrhage at high altitude. N Engl J Med 282: 1183-1184.
5. Rennie D, Morrissey J, (1975) Retinal changes in Himalayan climbers. Arch Ophthalmol 93: 395-400.
6. Shults WT, Swan KC, (1975) High altitude retinopathy in mountain climbers. Arch Ophthalmol 93: 404-408.
7. McFadden DM, Houston CS, Sutton JR, Powles AC, Gray GW, et al. (1981) High-altitude retinopathy. Jama 245: 581-586.
8. MacLaren RE, (1995) Retinal haemorrhage in Himalayan mountaineers. J R Army Med Corps 141: 25-28.
9. Wiedman M, Tabin GC, (1999) High-altitude retinopathy and altitude illness. Ophthalmology 106: 1924-1926; discussion 1927.
10. Bosch MM, Barthelmes D, Merz TM, Bloch KE, Turk AJ, et al. (2008) High incidence of optic disc swelling at very high altitudes. Arch Ophthalmol 126: 644-650.
11. Roach RC, Hackett PH, (2001) Frontiers of hypoxia research: acute mountain sickness. J Exp Biol 204: 3161-3170.
12. Hackett PH, Roach RC, (2001) High-altitude illness. N Engl J Med 345: 107-114.
13. Wilson MH, Newman S, Imray CH, (2009) The cerebral effects of ascent to high altitudes. Lancet Neurol 8: 175-191.
14. Fagenholz PJ, Gutman JA, Murray AF, Noble VE, Camargo CA Jr, et al. (2009) Optic nerve sheath diameter correlates with the presence and severity of acute mountain sickness: evidence for increased intracranial pressure. J Appl Physiol 106: 1207-1211.
15. Sutherland AI, Morris DS, Owen CG, Bron AJ, Roach RC, (2008) Optic nerve sheath diameter, intracranial pressure and acute mountain sickness on Mount Everest: a longitudinal cohort study. Br J Sports Med 42: 183-188.
16. Bailey DM, Roukens R, Knauth M, Kallenberg K, Christ S, et al. (2006) Free radical-mediated damage to barrier function is not associated with altered brain morphology in high-altitude headache. J Cereb Blood Flow Metab 26: 99-111.
17. Levin LA, (2003) Optic Nerve. In: Kaufman PLA, A., editors. Adler's Physiology of the eye St. Louis Mosby pp. 603-638.
18. Roach R, Bartsch P, Hackett P, Oelz O, (1993) The Lake Louise acute mountain sickness scoring system. In: Sutton JR, Coates G, Huston CS, editors. The Lake Louise AMS Scoring Consensus Committee.
19. Sampson JB, Cymerman A, Burse RL, Maher JT, Rock PB, (1983) Procedures for the measurement of acute mountain sickness. Aviat Space Environ Med 54: 1063-1073.
20. Walsh FB, WF H, (1969) The ophthalmoscopic diagnosis of papilledema. In: Walsh FB, Hoyt WF, editors. Clinical Neuro-opthalmology Baltimore, MD Williams & Wilkins Co; 1969.
21. Weinreb RN, Lusky M, Bartsch DU, Morsman D, (1993) Effect of repetitive imaging on topographic measurements of the optic nerve head. Arch Ophthalmol 111: 636-638.
22. Lusky M, Bosem ME, Weinreb RN, (1993) Reproducibility of optic nerve head topography measurements in eyes with undilated pupils. J Glaucoma 2: 104-109.
23. Rohrschneider K, Burk RO, Kruse FE, Volcker HE, (1994) Reproducibility of the optic nerve head topography with a new laser tomographic scanning device. Ophthalmology 101: 1044-1049.
24. Brigatti L, Weitzman M, Caprioli J, (1995) Regional test-retest variability of confocal scanning laser tomography. Am J Ophthalmol 120: 433-440.
25. Lichter PR, (1976) Variability of expert observers in evaluating the optic disc. Trans Am Ophthalmol Soc 74: 532-572.
26. Spencer AF, Vernon SA, (1996) Optic disc height measurement with the Zeiss 4-mirror contact lens and 78 dioptre lens compared. Eye (Lond) 10 (Pt 3): 371-376.
27. Mikelberg FS, Wijsman K, Schulzer M, (1993) Reproducibility of topographic parameters obtained with the heidelberg retina tomograph. J Glaucoma 2: 101-103.
28. Tamburrelli C, Salgarello T, Caputo CG, Giudiceandrea A, Scullica L, (2000) Ultrasonographic evaluation of optic disc swelling: comparison with CSLO in idiopathic intracranial hypertension. Invest Ophthalmol Vis Sci 41: 2960-2966.
29. Danesh-Meyer H, Savino PJ, Spaeth GL, Gamble GD, (2005) Comparison of arteritis and nonarteritic anterior ischemic optic neuropathies with the Heidelberg Retina Tomograph. Ophthalmology 112: 1104-1112.
30. Pro MJ, Pons ME, Liebmann JM, Ritch R, Zafar S, et al. (2006) Imaging of the optic disc and retinal nerve fiber layer in acute optic neuritis. J Neurol Sci 250: 114-119.
31. Schneider M, Bernasch D, Weymann J, Holle R, Bartsch P, (2002) Acute mountain sickness: influence of susceptibility, preexposure, and ascent rate. Med Sci Sports Exerc 34: 1886-1891.
32. Bosch MM, Barthelmes D, Merz TM, Knecht PB, Truffer F, et al. (2010) New insights into changes in corneal thickness in healthy mountaineers during a very-high-altitude climb to Mount Muztagh Ata. Arch Ophthalmol 128: 184-189.
33. Bosch MM, Merz TM, Barthelmes D, Petrig BL, Truffer F, et al. (2009) New insights into ocular blood flow at very high altitudes. J Appl Physiol 106: 454-460.
34. Wilson MH, Edsell M, Imray C, Wright A, (2008) Changes in pupil dynamics at high altitude-an observational study using a handheld pupillometer. High Alt Med Biol 9: 319-325.
35. Bosch MM, Barthelmes D, Merz TM, Truffer F, Knecht PB, et al. (2009) Intraocular pressure during a very high altitude climb. Invest Ophthalmol Vis Sci 51: 1609-1613.
36. O'Connor T, Dubowitz G, Bickler PE, (2004) Pulse oximetry in the diagnosis of acute mountain sickness. High Alt Med Biol 5: 341-348.
37. Wagner DR, Fargo JD, Parker D, Tatsugawa K, Young TA, (2006) Variables contributing to acute mountain sickness on the summit of Mt Whitney. Wilderness Environ Med 17: 221-228.
38. Ikram MA, Vrooman HA, Vernooij MW, van der Lijn F, Hofman A, et al. (2008) Brain tissue volumes in the general elderly population. The Rotterdam Scan Study. Neurobiol Aging 29: 882-890.
39. Hackett PH, (1999) High altitude cerebral edema and acute mountain sickness. A pathophysiology update. Adv Exp Med Biol 474: 23-45.
40. Hackett PH, Yarnell PR, Hill R, Reynard K, Heit J, et al. (1998) High-altitude cerebral edema evaluated with magnetic resonance imaging: clinical correlation and pathophysiology. Jama 280: 1920-1925.
41. Morocz IA, Zientara GP, Gudbjartsson H, Muza S, Lyons T, et al. (2001) Volumetric quantification of brain swelling after hypobaric hypoxia exposure. Exp Neurol 168: 96-104.
42. Fischer R, Vollmar C, Thiere M, Born C, Leitl M, et al. (2004) No evidence of cerebral oedema in severe acute mountain sickness. Cephalalgia 24: 66-71.
43. Kallenberg K, Bailey DM, Christ S, Mohr A, Roukens R, et al. (2007) Magnetic resonance imaging evidence of cytotoxic cerebral edema in acute mountain sickness. J Cereb Blood Flow Metab 27: 1064-1071.
44. Keller HR, Maggiorini M, Bartsch P, Oelz O, (1995) Simulated descent v dexamethasone in treatment of acute mountain sickness: a randomised trial. Bmj 310: 1232-1235.
45. Modesti PA, Rapi S, Paniccia R, Bilo G, Revera M, et al. (2011) Index measured at an intermediate altitude to predict impending Acute Mountain Sickness. Med Sci Sports Exerc.
46. Boniuk M, (1972) The ocular manifestations of ophthalmic vein and aseptic cavernous sinus thrombosis. Transactions- American Academy of Ophthalmology and Otolaryngology American Academy of Ophthalmology and Otolaryngology 76: 1519-1534.
47. Naumann GOHA, D.J., Wenkel H, (1997) Nervus opticus. In: Naumann GOH, editors. Pathologie des Auges II Berlin Springer pp. 1179-1244.