A computational mechanism for unified gain and timing control in the cerebellum

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Yamazaki, Tadashi ^a   Nagao, Soichi ^a  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTATION; ARTICLE; BRAIN FUNCTION; CEREBELLUM; CLIMBING FIBER; COMPUTER SIMULATION; EYE MOVEMENT; EYELID REFLEX; GAIN CONTROL; LEARNING; MATHEMATICAL ANALYSIS; MOTOR CONTROL; NERVE CELL STIMULATION; NEUROTRANSMISSION; PURKINJE CELL; SPIKE WAVE; TIMING CONTROL; VESTIBULAR NUCLEUS; WAVEFORM; ACTION POTENTIAL; ANIMAL; BIOLOGICAL MODEL; CONDITIONING; MOTONEURON; MOVEMENT (PHYSIOLOGY); NERVE CELL NETWORK; OPTOKINETIC NYSTAGMUS; PHYSIOLOGY; RABBIT; TIME;

ACTION POTENTIALS; ANIMALS; CEREBELLUM; COMPUTER SIMULATION; CONDITIONING, EYELID; EYE MOVEMENTS; MODELS, NEUROLOGICAL; MOTOR NEURONS; MOVEMENT; NERVE NET; NYSTAGMUS, OPTOKINETIC; PURKINJE CELLS; RABBITS; TIME FACTORS;

EID: 84858114237     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033319     Document Type: Article

References (65)

1. Ito M, (1984) The Cerebellum and Neural Control New York Raven Press.
2. Ito M, (1998) Cerebellar learning in the vestibulo-ocular reflex. Trends Cog Sci 2: 313-321.
3. Mauk MD, Donegan NH, (1997) A model of Pavlovian eyelid conditioning based on the synaptic organization of the cerebellum. Learn Mem 3: 130-158.
4. Christian KM, Thompson RF, (2003) Neural substrates of eyeblink conditioning: Acquisition and retention. Learn Mem 11: 427-455.
5. Fujita M, (1982) Adaptive filter model of the cerebellum. Biol Cybern 45: 195-206.
6. Fujita M, (1982) Simulation of adaptive modification of the vestibulo-ocular reflex with an adaptive filter model of the cerebellum. Biol Cybern 45: 207-214.
7. Gomi H, Kawato M, (1992) Adaptive feedback control models of the vestibulocerebellum and spinocerebellum. Biol Cybern 68: 105-114.
8. Lisberger S, Sejnowski T, (1992) Motor learning in a recurrent network model based on the vestibulo-ocular reflex. Nature 360: 159-161.
9. Lisberger S, (1994) Neural basis for motor learning in the vestibuloocular reflex of primates. III. computational and behavioral analysis of the sites of learning. J Neurophysiol 72: 974-998.
10. Raymond J, Lisberger S, (1998) Neural learning rules for the vestibulo-ocular reflex. J Neurosci 18: 9112-9129.
11. Dean P, Porrill J, Stone J, (2002) Decorrelation control by the cerebellum achieves oculomotor plant compensation in simulated vestibulo-ocular reflex. Proc Biol Sci 269: 1895-1904.
12. Tabata H, Yamamoto K, Kawato M, (2002) Computational study on monkey VOR adaptation and smooth pursuit based on the parallel control-pathway theory. J Neurophysiol 87: 2176-2189.
13. Desmond J, Moore J, (1988) Adaptive timing in neural networks: The conditioned response. Biol Cybern 58: 405-415.
14. Gluck MA, Reifsnider ES, Thompson RF, (1990) Adaptive signal processing and the cerebellum: Models of classical conditioning and VOR adaptation. In: Gluck MA, Rumelhart DE, editors. Neuroscience and Connectionist Theory pp. 131-186 New Jersey: Erlbaum, Hillsdale.
15. Chapeau-Blondeau F, Chauvet G, (1991) A neural network model of the cerebellar cortex performing dynamic associations. Biol Cybern 65: 267-279.
16. Bullock D, Fiala JC, Grossberg S, (1994) A neural model of timed response learning in the cerebellum. Neural Netw 7: 1101-1114.
17. Buonomano DV, Mauk MD, (1994) Neural network model of the cerebellum: Temporal discrimination and the timing of motor responses. Neural Comput 6: 38-55.
18. Fiala JC, Grossberg S, Bullock D, (1996) Metabotropic glutamate receptor activation in cerebellar Purkinje cells as substrate for adaptive timing of the classically conditioned eye-blink response. J Neurosci 16: 3760-3774.
19. Braitenberg V, Heck D, Sultan F, (1997) The detection and generation of sequences as a key to cerebellar function: Experiments and theory. Behav Brain Sci 20: 229-277.
20. Medina JF, Garcia KS, Nores WL, Taylor NM, Mauk MD, (2000) Timing mechanisms in the cerebellum: Testing predictions of a large-scale computer simulation. J Neurosci 20: 5516-5525.
21. Hofstötter C, Mintz M, Verschure P, (2002) The cerebellum in action: A simulation and robotics study. Eur J Neurosci 16: 1361-76.
22. Garenne A, Chauvet G, (2004) A discrete approach for a model of temporal learning by the cerebellum: In silico classical conditioning of the eyeblink reflex. J Integr Neurosci 3: 301-318.
23. Steuber V, Willshaw D, (2004) A biophysical model of synaptic delay learning and temporal pattern recognition in a cerebellar Purkinje cell. J Comput Neurosci 17: 149-164.
24. Yamazaki T, Tanaka S, (2005) Neural modeling of an internal clock. Neural Comput 17: 1032-1058.
25. Yamazaki T, Tanaka S, (2007) A spiking network model for passage-of-time representation in the cerebellum. Eur J Neurosci 26: 2279-2292.
26. Hong S, Optican L, (2008) Interaction between Purkinje cells and inhibitory interneurons may create adjustable output waveforms to generate timed cerebellar output. PLoS ONE 3: e2770.
27. Honda T, Yamazaki T, Tanaka S, Nagao S, Nishino T, (2011) Stimulus-Dependent State Transition between Synchronized Oscillation and Randomly Repetitive Burst in a Model Cerebellar Granular Layer. PLoS Comput Biol 7: e1002087.
28. Jirenhed DA, Bengtsson F, Hesslow G, (2007) Acquisition, extinction, and reacquisition of a cerebellar cortical memory trace. J Neurosci 27: 2493-502.
29. Nagao S, (1988) Behavior of floccular Purkinje cells correlated with adaptation of horizontal optokinetic eye movement response in pigmented rabbits. Exp Brain Res 73: 489-497.
30. Miyashita Y, Nagao S, (1984) Contribution of cerebellar intracortical inhibition to Purkinje cell response during vestibulo-ocular reflex of alert rabbits. J Physiol 351: 251-62.
31. Lisberger S, Miles F, Optican L, (1983) Frequency-selective adaptation: evidence for channels in the vestibulo-ocular reflex? J Neurosci 3: 1234-44.
32. Nagao S, (1983) Effects of vestibulocerebellar lesions upon dynamic characteristics and adaptation of vestibulo-ocular and optokinetic responses in pigmented rabbits. Exp Brain Res 53: 36-46.
33. Iwashita M, Kanai R, Funabiki K, Matsuda K, Hirano T, (2001) Dynamic properties, interactions and adaptive modifications of vestibulo-ocular reflex and optokinetic response in mice. Neurosci Res 39: 299-311.
34. Yamazaki T, Tanaka S, (2007) The cerebellum as a liquid state machine. Neural Netw 20: 290-297.
35. Barmack NH, Yakhnitsa V, (2008) Functions of interneurons in mouse cerebellum. J Neurosci 28: 1140-52.
36. Jirenhed DA, Hesslow G, (2011) Time course of classically conditioned Purkinje cell response is determined by initial part of conditioned stimulus. J Neurosci 31: 9070-9074.
37. Larson-Prior LJ, Morrison PD, Bushey RM, Slater NT, (1995) Frequency dependent activation of a slow N-methyl-D-aspartate-dependent excitatory postsynaptic potential in turtle cerebellum by mossy fibre afferents. Neuroscience 67: 867-879.
38. Svensson P, Jirenhed DA, Bengtsson F, Hesslow G, (2010) Effect of conditioned stimulus parameters on timing of conditioned Purkinje cell responses. J Neurophysiol 10: 1329-36.
39. Chadderton P, Margrie TW, Häusser M, (2004) Integration of quanta in cerebellar granule cells during sensory processing. Nature 428: 856-860.
40. Rancz EA, Ishikawa T, Duguid I, Chadderton P, Mahon S, et al. (2007) High-fidelity transmission of sensory information by single cerebellar mossy fibre boutons. Nature 450: 1245-1249.
41. Arenz A, Silver RA, Schaefer AT, Margrie TW, (2007) The contribution of single synapses to sensory representation in vivo. Science 321: 977-980.
42. Bengtsson F, Jörnntell H, (2007) Ketamine and xylazine depress sensory-evoked parallel fiber and climbing fiber responses. J Neurophysiol 98: 1697-1705.
43. Jörntell H, Ekerot CF, (2006) Properties of somatosensory synaptic integration in cerebellar granule cells in vivo. J Neurosci 26: 11786-97.
44. Bengtsson F, Jörntell H, (2009) Sensory transmission in cerebellar granule cells relies on similarly coded mossy fiber inputs. Proc Nat Acad Sci USA 106: 2389-2394.
45. De Zeeuw CI, Berrebi AS, (1995) Postsynaptic targets of Purkinje cell terminals in the cerebellar and vestibular nuclei of the rat. Eur J Neurosci 7: 2322-2233.
46. Dean P, Porril J, Ekerot CF, Jörntell H, (2010) The cerebellar microcircuit as an adaptive filter: experimental and computational evidence. Nature Rev Neurosci 11: 30-43.
47. Moore JW, Desmond JE, Berthier NE, (1989) Adaptively timed conditioned responses and the cerebellum: a neural network approach. Biol Cybern 62: 17-28.
48. Marr D, (1969) A theory of cerebellar cortex. J Physiol (Lond) 202: 437-470.
49. Albus JS, (1971) A theory of cerebellar function. Math Biosci 10: 25-61.
50. Ito M, (2008) Control of mental activities by internal models in the cerebellum. Nat Rev Neurosci 9: 304-13.
51. Shutoh F, Ohki M, Kitazawa H, Itohara S, Nagao S, (2006) Memory trace of motor learning shifts transsynaptically from cerebellar cortex to nuclei for consolidation. Neuroscience 139: 767-777.
52. Sugihara I, Shinoda Y, (2004) Molecular, topographic, and functional organization of the cerebellar cortex: a study with combined aldolase C and olivocerebellar labeling. J Neurosci 24: 8771-8785.
53. Gerstner W, Kistler WM, (2002) Spiking Neuron Models Cambridge University Press.
54. Thach W, (1968) Discharge of Purkinje and cerebellar nuclear neurons during rapidly alternating arm movements in the monkey. J Neurophysiol 31: 785-797.
55. Mouginot D, Gähwiler BH, (1995) Characterization of synaptic connections between cortex and deep nuclei of the rat cerebellum in vitro. Neuroscience 64: 699-712.
56. Häusser M, Clark BA, (1997) Tonic synaptic inhibition modulates neuronal output pattern and spatiotemporal synaptic integration. Neuron 19: 665-678.
57. Aizenmann CD, Linden DJ, (1999) Regulation of the rebound depolarization and spontaneous firing patterns of deep nuclear neurons in slices of rat cerebellum. J Neurophysiol 82: 1697-1709.
58. Maekawa K, Takeda T, Kimura M, (1981) Neural activity of nucleus reticularis tegmenti pontis - the origin of visual mossy fiber afferents to the cerebellar flocculus of rabbits. Brain Res 210: 17-30.
59. Mathy A, Ho SS, Davie JT, Duguid IC, Clark BA, et al. (2009) Encoding of oscillations by axonal bursts in inferior olive neurons. Neuron 62: 388-399.
60. Sakurai M, (1987) Synaptic modification of parallel fibre-Pukinje cell transmission in in vitro guinea pig-cerebellar slices. J Physiol (Lond) 394: 463-480.
61. Lev-Ram V, Mehta SB, Kleinfeld D, Tsien RY, (2003) Reversing cerebellar long-term depression. Proc Natl Acad Sci USA 100: 15989-15993.
62. Coesmans M, Weber JT, De Zeeuw CI, Hansel C, (2004) Bidirectional parallel fiber plasticity in the cerebellum under climbing fiber control. Neuron 44: 691-700.
63. Ito M, (1989) Long-term depression. Annu Rev Neurosci 12: 85-102.
64. Chen C, Thompson RF, (1995) Temporal specificity of long-term depression in parallel fiber-Purkinje synapses in rat cerebellar slice. Learn Mem 2: 185-198.
65. Cerebellar Platform website. Available: http://cerebellum.neuroinf.jp/Accessed 2012 Feb 14.