Evaluation of (R)-(-)-α-methoxy phenyl acetic acid as a chiral shift reagent for resolution and determination of R and S enantiomers of modafinil in bulk drugs and formulations by 1H NMR spectroscopy

Chirality

Volumn 24, Issue 4, 2012, Pages 339-344

  Rao, Ramisetti Nageswara ^a   Ramachandra, Bondigalla ^a   Santhakumar, Kondapalli ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

chiral shift reagent; enantiomeric purity; intramolecular and intermolecular hydrogen bonding; modafinil; narcolepsy; NMR solvent titration

Indexed keywords

2,2' DIHYDROXY 1,1' BINAPHTHYL; ALPHA METHOXY ALPHA TRIFLUOROMETHYLPHENYLACETIC ACID; ALPHA METHOXYPHENYLACETIC ACID; MODAFINIL; PHENYLACETIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; CONCENTRATION RESPONSE; DRUG CONFORMATION; DRUG DETERMINATION; DRUG FORMULATION; DRUG PURITY; DRUG SCREENING; DRUG STRUCTURE; ENANTIOMER; HYDROGEN BOND; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS; TABLET;

BENZHYDRYL COMPOUNDS; CHEMISTRY, PHARMACEUTICAL; HYDROGEN BONDING; INDICATORS AND REAGENTS; LIMIT OF DETECTION; LINEAR MODELS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; MOLECULAR WEIGHT; PHENYLACETATES; REPRODUCIBILITY OF RESULTS; SOLVENTS; STEREOISOMERISM; TABLETS;

EID: 84858082534     PISSN: 08990042     EISSN: 1520636X     Source Type: Journal    
DOI: 10.1002/chir.22002     Document Type: Article

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